Idiopathic nonspecific interstitial pneumonia: an interstitial lung disease associated with autoimmune disorders?

Recent evidence suggests that idiopathic nonspecific interstitial pneumonia (iNSIP) is a distinct clinical entity amongst other idiopathic interstitial pneumonias, and some data seem to suggest a possible pathogenetic role of autoimmunity. The aim of the present study was to assess if iNSIP might re...

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Published in:	The European respiratory journal Vol. 38; no. 2; pp. 384 - 391
Main Authors:	ROMAGNOLI, M, NANNINI, C, CARLONI, A, DUBINI, A, CANTINI, F, CHILOSI, M, POLETTI, V, PICIUCCHI, S, GIRELII, F, GURIOLI, C, CASONI, G, RAVAGLIA, C, TOMASSETTI, S, GURIOLI, Ch, GAVELLI, G
Format:	Journal Article
Language:	English
Published:	Leeds Maney 01-08-2011
Subjects:	Age Autoimmune Diseases - diagnosis Autoimmune Diseases - diagnostic imaging Autoimmune Diseases - epidemiology Biological and medical sciences Connective Tissue Diseases - diagnosis Connective Tissue Diseases - diagnostic imaging Connective Tissue Diseases - epidemiology Endocrinopathies Female Follow-Up Studies Humans Idiopathic Interstitial Pneumonias - diagnosis Idiopathic Interstitial Pneumonias - diagnostic imaging Idiopathic Interstitial Pneumonias - epidemiology Incidence Male Medical sciences Middle Aged Non tumoral diseases. Target tissue resistance. Benign neoplasms Pneumology Prevalence Pulmonary Fibrosis - diagnosis Pulmonary Fibrosis - diagnostic imaging Pulmonary Fibrosis - epidemiology Radiography Respiratory system : syndromes and miscellaneous diseases Retrospective Studies Smoking - epidemiology Thyroid. Thyroid axis (diseases) Thyroiditis, Autoimmune - diagnosis Thyroiditis, Autoimmune - diagnostic imaging Thyroiditis, Autoimmune - epidemiology Endocrinopathy Thyroiditis Immunopathology Lung disease Connective tissue disease Skin disease Respiratory disease Lung Thyroid diseases Idiopathic Autoimmune disease idiopathic interstitial pneumonia Interstitial pneumonitis Pneumology
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Summary:	Recent evidence suggests that idiopathic nonspecific interstitial pneumonia (iNSIP) is a distinct clinical entity amongst other idiopathic interstitial pneumonias, and some data seem to suggest a possible pathogenetic role of autoimmunity. The aim of the present study was to assess if iNSIP might represent an early lung manifestation of an autoimmune disease. After initial review of cases found in the medical records database by searching for the term "NSIP" (n = 63), 37 iNSIP cases were identified, and were re-evaluated using a dynamic integrated multidisciplinary approach. 27 cases with iNSIP were selected for the study. Mean ± sd age at first respiratory symptom was 54.2 ± 8 yrs, 70% were females, and 59% were never-smokers. At follow-up (mean ± sd 59.7 ± 29 months, range 12-138 months), autoimmune diseases occurred in 14 (52%) patients, with seven (26%) cases of autoimmune thyroiditis, six (22%) of undifferentiated connective tissue disease and three (11%) of connective tissue disease. Patients developing autoimmune diseases were older and more frequently never-smoking females. In >50% of patients diagnosed with iNSIP, evidence of autoimmune diseases develops within 2 yrs, suggesting a probable link between the clinical entity of iNSIP and autoimmune disorders.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0903-1936 1399-3003
DOI:	10.1183/09031936.00094910