Search Results - "GIRAUDEL, J. M."

Paw inflammation model in dogs for preclinical pharmacokinetic/pharmacodynamic investigations of nonsteroidal anti-inflammatory drugs by Jeunesse, E C, Bargues, I A, Toutain, C E, Lacroix, M Z, Letellier, I M, Giraudel, J M, Toutain, P L

“…The goal of the present study was to develop and validate a new canine model of inflammation. The motivation was to make available a scientifically appropriate…”
Get more information

Differential inhibition of cyclooxygenase isoenzymes in the cat by the NSAID robenacoxib by GIRAUDEL, J.M, TOUTAIN, P.-L, KING, J.N, LEES, P

“…Robenacoxib is a new nonsteroidal anti-inflammatory drug (NSAID) developed for use in companion animal medicine. The objectives of this study were: to quantify…”
Get full text

Population pharmacokinetic analysis of blood concentrations of robenacoxib in dogs with osteoarthritis by Fink, M., Letellier, I., Peyrou, M., Mochel, J.P., Jung, M., King, J.N., Gruet, P., Giraudel, J.M.

“…The purpose of this analysis was to investigate whether the recommended daily dosage of 1–2mg/kg robenacoxib provides consistent exposure when administered to…”
Get full text

Safety of a benazepril and pimobendan combination tablet in adult healthy dogs by Kuntz, E. A., Strehlau, G., Giraudel, J. M., King, J. N.

“…The objective of the study was to investigate the safety of a combination tablet of benazepril and pimobendan, Fortekor PLUS®, in a randomized, blinded,…”
Get full text

Development and validation of a new model of inflammation in the cat and selection of surrogate endpoints for testing anti-inflammatory drugs by Giraudel, J.M, Diquelou, A, Lees, P, Toutain, P.L

“…In laboratory animals many models of inflammation have been developed for preclinical evaluation of the pharmacological profiles of nonsteroidal…”
Get full text

Pharmacokinetics of monepantel and its sulfone metabolite, monepantel sulfone, after intravenous and oral administration in sheep by KARADZOVSKA, D, SEEWALD, W, BROWNING, A, SMAL, M, BOUVIER, J, GIRAUDEL, J.M

“…The pharmacokinetic properties of the developmental Amino-Acetonitrile Derivative (AAD), monepantel and its sulfone metabolite, monepantel sulfone were…”
Get full text

Capturing the dynamics of systemic Renin-Angiotensin-Aldosterone System (RAAS) peptides heightens the understanding of the effect of benazepril in dogs by MOCHEL, J. P., PEYROU, M., FINK, M., STREHLAU, G., MOHAMED, R., GIRAUDEL, J. M., PLOEGER, B., DANHOF, M.

“…Mochel, J. P., Peyrou, M, Fink, M, Strehlau, G, Mohamed, R, Giraudel, J. M., Ploeger, B, Danhof, M. Capturing the dynamics of systemic…”
Get full text

Use of a pharmacokinetic/pharmacodynamic approach in the cat to determine a dosage regimen for the COX-2 selective drug robenacoxib by GIRAUDEL, J.M, KING, J.N, JEUNESSE, E.C, LEES, P, TOUTAIN, P.-L

“…This study investigated the analgesic, anti-inflammatory and antipyretic efficacy of the new COX-2 selective inhibitor robenacoxib in the cat and established…”
Get full text

Effect of route of administration on the efficacy and pharmacokinetics of an experimental formulation of the amino-acetonitrile derivative monepantel in sheep by Hosking, B. C., Stein, P. A., Karadzovska, D., House, J. K., Seewald, W., Giraudel, J. M.

“…The effect of the route of administration (oral, intraruminal and intra-abomasal) on the efficacy and pharmacokinetics of the new anthelmintic monepantel in…”
Get full text

Pharmacokinetic/pharmacodynamic modelling of NSAIDs in a model of reversible inflammation in the cat by Giraudel, Jerome M, Diquelou, Armelle, Laroute, Valerie, Lees, Peter, Toutain, Pierre‐Louis

“…Data on the relationships between plasma concentration and analgesic and anti‐inflammatory effects of NSAIDs are limited because most inflammation models do…”
Get full text

Development of in vitro assays for the evaluation of cyclooxygenase inhibitors and predicting selectivity of nonsteroidal anti-inflammatory drugs in cats by Giraudel, J.M, Toutain, P.L, Lees, P

“…To develop and validate in cats suitable in vitro assays for screening and ranking nonsteroidal antiinflammatory drugs (NSAIDs) on the basis of their…”
Get full text

Monoclonal gammopathies in the dog: a retrospective study of 18 cases (1986-1999) and literature review by Giraudel, Jérĵme M, Pagès, Jean-Pierre, Guelfi, Jean-François

“…Eighteen dogs with monoclonal gammopathies were evaluated retrospectively. Most of the cases were associated with lymphoproliferative tumors (i.e., nine…”
Get more information