Search Results - "GIRARD, Luc"

ZEB1 drives epithelial-to-mesenchymal transition in lung cancer by Larsen, Jill E, Nathan, Vaishnavi, Osborne, Jihan K, Farrow, Rebecca K, Deb, Dhruba, Sullivan, James P, Dospoy, Patrick D, Augustyn, Alexander, Hight, Suzie K, Sato, Mitsuo, Girard, Luc, Behrens, Carmen, Wistuba, Ignacio I, Gazdar, Adi F, Hayward, Nicholas K, Minna, John D

“…Increased expression of zinc finger E-box binding homeobox 1 (ZEB1) is associated with tumor grade and metastasis in lung cancer, likely due to its role as a…”
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Evaluation of ion separation coefficients by foam flotation using a carboxylate surfactant by Micheau, Cyril, Schneider, Andreas, Girard, Luc, Bauduin, Pierre

“…•Selectivity coefficients between ions have been evaluated from ion flotation results using a polyethoxy-carboxylate surfactant.•Ion selectivity in the foam…”
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ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs by Borromeo, Mark D., Savage, Trisha K., Kollipara, Rahul K., He, Min, Augustyn, Alexander, Osborne, Jihan K., Girard, Luc, Minna, John D., Gazdar, Adi F., Cobb, Melanie H., Johnson, Jane E.

“…Small cell lung carcinoma (SCLC) is a high-grade pulmonary neuroendocrine tumor. The transcription factors ASCL1 and NEUROD1 play crucial roles in promoting…”
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Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells by Chen, Pei-Hsuan, Cai, Ling, Huffman, Kenneth, Yang, Chendong, Kim, Jiyeon, Faubert, Brandon, Boroughs, Lindsey, Ko, Bookyung, Sudderth, Jessica, McMillan, Elizabeth A., Girard, Luc, Chen, Dong, Peyton, Michael, Shields, Misty D., Yao, Bo, Shames, David S., Kim, Hyun Seok, Timmons, Brenda, Sekine, Ikuo, Britt, Rebecca, Weber, Stephanie, Byers, Lauren A., Heymach, John V., Chen, Jing, White, Michael A., Minna, John D., Xiao, Guanghua, DeBerardinis, Ralph J.

“…Intermediary metabolism in cancer cells is regulated by diverse cell-autonomous processes, including signal transduction and gene expression patterns, arising…”
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Cell Attachment and Laminin Immobilization on Hydrogels Coated by Plasma Deposited Nitrogen, Oxygen or Sulfur Based Organic Thin Films by Rout, Bishakh, Girard-Lauriault, Pierre-Luc

“…Hydrogels are surfaces suitable for use as biomedical devices. Contact lenses are commonly used biomedical devices made from hydrogels. To enhance the…”
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LCE: an open web portal to explore gene expression and clinical associations in lung cancer by Cai, Ling, Lin, ShinYi, Girard, Luc, Zhou, Yunyun, Yang, Lin, Ci, Bo, Zhou, Qinbo, Luo, Danni, Yao, Bo, Tang, Hao, Allen, Jeffrey, Huffman, Kenneth, Gazdar, Adi, Heymach, John, Wistuba, Ignacio, Xiao, Guanghua, Minna, John, Xie, Yang

“…We constructed a lung cancer-specific database housing expression data and clinical data from over 6700 patients in 56 studies. Expression data from 23…”
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Permeation‐resistant and flexible plasma‐polymerised films on 2‐hydroxyethyl methacrylate hydrogels by Rout, Bishakh, Girard‐Lauriault, Pierre‐Luc

“…This study focuses on the deposition of plasma polymer films (PPFs) on hydrogels that could act as permeation barriers for aqueous species. The deposited PPFs…”
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CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells by Kim, Jiyeon, Hu, Zeping, Cai, Ling, Li, Kailong, Choi, Eunhee, Faubert, Brandon, Bezwada, Divya, Rodriguez-Canales, Jaime, Villalobos, Pamela, Lin, Yu-Fen, Ni, Min, Huffman, Kenneth E., Girard, Luc, Byers, Lauren A., Unsal-Kacmaz, Keziban, Peña, Christopher G., Heymach, John V., Wauters, Els, Vansteenkiste, Johan, Castrillon, Diego H., Chen, Benjamin P. C., Wistuba, Ignacio, Lambrechts, Diether, Xu, Jian, Minna, John D., DeBerardinis, Ralph J.

“…In human cell lines with mutant KRAS and loss of LKB1, CPS1 expression correlates inversely with LKB1 expression; silencing CPS1 in these cells induces DNA…”
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Analysis of TP53 Mutation Status in Human Cancer Cell Lines: A Reassessment by Leroy, Bernard, Girard, Luc, Hollestelle, Antoinette, Minna, John D., Gazdar, Adi F., Soussi, Thierry

“…ABSTRACT Tumor‐derived cell lines play an important role in the investigation of tumor biology and genetics. Across a wide array of studies, they have been…”
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ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers by Augustyn, Alexander, Borromeo, Mark, Wang, Tao, Fujimoto, Junya, Shao, Chunii, Dospoy, Patrick D., Lee, Victoria, Tan, Christopher, Sullivan, James P., Larsen, Jill E., Girard, Luc, Behrens, Carmen, Wistuba, Ignacio I., Xie, Yang, Cobb, Melanie H., Gazdar, Adi F., Johnson, Jane E., Minna, John D.

“…Aggressive neuroendocrine lung cancers, including small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC), represent an understudied tumor subset…”
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SCLC-CellMiner: A Resource for Small Cell Lung Cancer Cell Line Genomics and Pharmacology Based on Genomic Signatures by Tlemsani, Camille, Pongor, Lorinc, Elloumi, Fathi, Girard, Luc, Huffman, Kenneth E., Roper, Nitin, Varma, Sudhir, Luna, Augustin, Rajapakse, Vinodh N., Sebastian, Robin, Kohn, Kurt W., Krushkal, Julia, Aladjem, Mirit I., Teicher, Beverly A., Meltzer, Paul S., Reinhold, William C., Minna, John D., Thomas, Anish, Pommier, Yves

“…CellMiner-SCLC (https://discover.nci.nih.gov/SclcCellMinerCDB/) integrates drug sensitivity and genomic data, including high-resolution methylome and…”
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Comparing statistical methods for constructing large scale gene networks by Allen, Jeffrey D, Xie, Yang, Chen, Min, Girard, Luc, Xiao, Guanghua

“…The gene regulatory network (GRN) reveals the regulatory relationships among genes and can provide a systematic understanding of molecular mechanisms…”
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Evasion of Innate Immunity Contributes to Small Cell Lung Cancer Progression and Metastasis by Zhu, Mingrui, Huang, Yi, Bender, Matthew E, Girard, Luc, Kollipara, Rahul, Eglenen-Polat, Buse, Naito, Yujiro, Savage, Trisha K, Huffman, Kenneth E, Koyama, Shohei, Kumanogoh, Atsushi, Minna, John D, Johnson, Jane E, Akbay, Esra A

“…Small cell lung cancer (SCLC) is a pulmonary neuroendocrine cancer with very poor prognosis and limited effective therapeutic options. Most patients are…”
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Breakdown of phonon glass paradigm in La- and Ce-filled Fe4Sb12 skutterudites by Koza, Michael Marek, Johnson, Mark Robert, Viennois, Romain, Mutka, Hannu, Girard, Luc, Ravot, Didier

“…The material class of skutterudites is believed to have strong potential for thermoelectric application due to the very low thermal conductivity of the filled…”
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Lung Cancer Cell Lines as Tools for Biomedical Discovery and Research by Gazdar, Adi F., Girard, Luc, Lockwood, William W., Lam, Wan L., Minna, John D.

“…Lung cancer cell lines have made a substantial contribution to lung cancer translational research and biomedical discovery. A systematic approach to initiating…”
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27-Hydroxycholesterol Promotes Cell-Autonomous, ER-Positive Breast Cancer Growth by Wu, Qian, Ishikawa, Tomonori, Sirianni, Rosa, Tang, Hao, McDonald, Jeffrey G., Yuhanna, Ivan S., Thompson, Bonne, Girard, Luc, Mineo, Chieko, Brekken, Rolf A., Umetani, Michihisa, Euhus, David M., Xie, Yang, Shaul, Philip W.

“…To date, estrogen is the only known endogenous estrogen receptor (ER) ligand that promotes ER+ breast tumor growth. We report that the cholesterol metabolite…”
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Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery by Kao, Jessica, Salari, Keyan, Bocanegra, Melanie, Choi, Yoon-La, Girard, Luc, Gandhi, Jeet, Kwei, Kevin A, Hernandez-Boussard, Tina, Wang, Pei, Gazdar, Adi F, Minna, John D, Pollack, Jonathan R

“…Breast cancer cell lines have been used widely to investigate breast cancer pathobiology and new therapies. Breast cancer is a molecularly heterogeneous…”
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Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1 by Byers, Lauren Averett, Wang, Jing, Nilsson, Monique B, Fujimoto, Junya, Saintigny, Pierre, Yordy, John, Giri, Uma, Peyton, Michael, Fan, You Hong, Diao, Lixia, Masrorpour, Fatemeh, Shen, Li, Liu, Wenbin, Duchemann, Boris, Tumula, Praveen, Bhardwaj, Vikas, Welsh, James, Weber, Stephanie, Glisson, Bonnie S, Kalhor, Neda, Wistuba, Ignacio I, Girard, Luc, Lippman, Scott M, Mills, Gordon B, Coombes, Kevin R, Weinstein, John N, Minna, John D, Heymach, John V

“…Small cell lung cancer (SCLC) is an aggressive malignancy distinct from non-small cell lung cancer (NSCLC) in its metastatic potential and treatment response…”
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SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers by Tagal, Vural, Wei, Shuguang, Zhang, Wei, Brekken, Rolf A., Posner, Bruce A., Peyton, Michael, Girard, Luc, Hwang, TaeHyun, Wheeler, David A., Minna, John D., White, Michael A., Gazdar, Adi F., Roth, Michael G.

“…Mutations in the SMARCA4/BRG1 gene resulting in complete loss of its protein (BRG1) occur frequently in non-small cell lung cancer (NSCLC) cells. Currently, no…”
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JAK1/STAT3 Activation through a Proinflammatory Cytokine Pathway Leads to Resistance to Molecularly Targeted Therapy in Non-Small Cell Lung Cancer by Shien, Kazuhiko, Papadimitrakopoulou, Vassiliki A, Ruder, Dennis, Behrens, Carmen, Shen, Li, Kalhor, Neda, Song, Juhee, Lee, J Jack, Wang, Jing, Tang, Ximing, Herbst, Roy S, Toyooka, Shinichi, Girard, Luc, Minna, John D, Kurie, Jonathan M, Wistuba, Ignacio I, Izzo, Julie G

“…Molecularly targeted drugs have yielded significant therapeutic advances in oncogene-driven non-small cell lung cancer (NSCLC), but a majority of patients…”
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