Search Results - "GIOVANNONI, Leonardo"

Intralesional administration of L19-IL2/L19-TNF in stage III or stage IVM1a melanoma patients: results of a phase II study by Danielli, Riccardo, Patuzzo, Roberto, Di Giacomo, Anna Maria, Gallino, Gianfranco, Maurichi, Andrea, Di Florio, Annabella, Cutaia, Ornella, Lazzeri, Andrea, Fazio, Carolina, Miracco, Clelia, Giovannoni, Leonardo, Elia, Giuliano, Neri, Dario, Maio, Michele, Santinami, Mario

“…The intratumoral injection of cytokines, in particular IL2, has shown promise for cutaneous melanoma patients with unresectable disease or continuous…”
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Antibody-Mediated Delivery of Interleukin-2 to the Stroma of Breast Cancer Strongly Enhances the Potency of Chemotherapy by MARLIND, Jessica, KASPAR, Manuela, TRACHSEL, Eveline, SOMMAVILLA, Roberto, HINDLE, Stuart, BACCI, Camilla, GIOVANNONI, Leonardo, NERI, Dario

“…Purpose: There is an interest in the discovery of biopharmaceuticals, which are well tolerated and which potentiate the action of anthracyclines and taxanes in…”
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Armed antibodies for cancer treatment: a promising tool in a changing era by Danielli, Riccardo, Patuzzo, Roberto, Ruffini, Pier Adelchi, Maurichi, Andrea, Giovannoni, Leonardo, Elia, Giuliano, Neri, Dario, Santinami, Mario

“…Advances in the understanding of tumor immunology and molecular biology of melanoma cells have favored a larger application of immunotherapy and targeted…”
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Phase 0 microdosing PET study using the human mini antibody F16SIP in head and neck cancer patients by Heuveling, Derrek A, de Bree, Remco, Vugts, Danielle J, Huisman, Marc C, Giovannoni, Leonardo, Hoekstra, Otto S, Leemans, C René, Neri, Dario, van Dongen, Guus A M S

“…The aim of this microdosing phase 0 clinical study was to obtain initial information about pharmacokinetics, biodistribution, and specific tumor targeting of…”
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Immunoscintigraphic Detection of the ED-B Domain of Fibronectin, a Marker of Angiogenesis, in Patients with Cancer by SANTIMARIA, Monica, MOSCATELLI, Giovanni, NERI, Dario, RIVA, Pietro, VIALE, Giuseppe L, GIOVANNONI, Leonardo, NERI, Giovanni, VITI, Francesca, LEPRINI, Alessandra, BORSI, Laura, CASTELLANI, Patrizia, ZARDI, Luciano

“…Purpose: ED-B fibronectin is expressed only during angiogenic processes and in tissues undergoing growth and/or extensive remodeling. We demonstrated…”
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Antibody-based delivery of interleukin-2 to neovasculature has potent activity against acute myeloid leukemia by Gutbrodt, Katrin L, Schliemann, Christoph, Giovannoni, Leonardo, Frey, Katharina, Pabst, Thomas, Klapper, Wolfram, Berdel, Wolfgang E, Neri, Dario

“…Acute myeloid leukemia (AML) is a rapidly progressing disease that is accompanied by a strong increase in microvessel density in the bone marrow. This…”
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A Dose-Escalation and Signal-Generating Study of the Immunocytokine L19-IL2 in Combination with Dacarbazine for the Therapy of Patients with Metastatic Melanoma by EIGENTLER, Thomas K, WEIDE, Benjamin, LOVATO, Valeria, KASPAR, Manuela, TRACHSEL, Eveline, MENSSEN, Hans D, NERI, Dario, GARBE, Claus, DE BRAUD, Filippo, SPITALERI, Gianluca, ROMANINI, Antonella, PFLUGFELDER, Annette, GONZALEZ-LGLESIAS, Reinerio, TASCIOTTI, Annaelisa, GIOVANNONI, Leonardo, SCHWAGER, Kathrin

“…L19-IL2 is an immunocytokine composed of an antibody fragment specific to the EDB domain of fibronectin, a tumor angiogenesis marker, and of human…”
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The tumour-targeting human L19-IL2 immunocytokine: Preclinical safety studies, phase I clinical trial in patients with solid tumours and expansion into patients with advanced renal cell carcinoma by Johannsen, Manfred, Spitaleri, Gianluca, Curigliano, Giuseppe, Roigas, Jan, Weikert, Steffen, Kempkensteffen, Carsten, Roemer, Andreas, Kloeters, Christian, Rogalla, Patrik, Pecher, Gabriele, Miller, Kurt, Berndt, Alexander, Kosmehl, Hartwig, Trachsel, Eveline, Kaspar, Manuela, Lovato, Valeria, González-Iglesias, Reinerio, Giovannoni, Leonardo, Menssen, Hans D, Neri, Dario, de Braud, Filippo

“…Abstract Background L19-IL2, a tumour-targeting immunocytokine composed of the recombinant human antibody fragment L19 (specific to the alternatively-spliced…”
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Radioimmunotherapy with radretumab in patients with relapsed hematologic malignancies by Erba, Paola A, Sollini, Martina, Orciuolo, Enrico, Traino, Claudio, Petrini, Mario, Paganelli, Giovanni, Bombardieri, Emilio, Grana, Chiara, Giovannoni, Leonardo, Neri, Dario, Menssen, Hans D, Mariani, Giuliano

“…We present here a systematic analysis of lymphoma and MM patients recruited into 2 clinical trials or treated with radretumab according to compassionate use,…”
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Intralesional treatment of stage III metastatic melanoma patients with L19-IL2 results in sustained clinical and systemic immunologic responses by Weide, Benjamin, Eigentler, Thomas K, Pflugfelder, Annette, Zelba, Henning, Martens, Alexander, Pawelec, Graham, Giovannoni, Leonardo, Ruffini, Pier Adelchi, Elia, Giuliano, Neri, Dario, Gutzmer, Ralf, Becker, Jürgen C, Garbe, Claus

“…L19-IL2 is a recombinant protein comprising the cytokine IL2 fused to the single-chain monoclonal antibody L19. In previous studies, intralesional injection…”
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Radretumab radioimmunotherapy in patients with brain metastasis: a 124I-L19SIP dosimetric PET study by Poli, Gian Luca, Bianchi, Claudia, Virotta, Giorgio, Bettini, Anna, Moretti, Renzo, Trachsel, Eveline, Elia, Giuliano, Giovannoni, Leonardo, Neri, Dario, Bruno, Andrea

“…Radioimmunotherapy (RIT) with (131)I-labeled L19SIP (radretumab; a small immunoprotein format antibody directed against the ED-B domain of fibronectin; ∼ 80…”
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Isolated limb perfusion with the tumor-targeting human monoclonal antibody-cytokine fusion protein L19-TNF plus melphalan and mild hyperthermia in patients with locally advanced extremity melanoma by Papadia, Francesco, Basso, Valeria, Patuzzo, Roberto, Maurichi, Andrea, Di Florio, Annabella, Zardi, Luciano, Ventura, Elisa, González-Iglesias, Reinerio, Lovato, Valeria, Giovannoni, Leonardo, Tasciotti, Annaelisa, Neri, Dario, Santinami, Mario, Menssen, Hans D., De Cian, Franco

“…Background L19‐TNF is a tumor‐targeting immunocytokine composed of the human L19 antibody binding to extra domain B (ED‐B) of fibronectin of newly formed blood…”
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Expression, engineering and characterization of the tumor-targeting heterodimeric immunocytokine F8-IL12 by Sommavilla, Roberto, Pasche, Nadine, Trachsel, Eveline, Giovannoni, Leonardo, Roesli, Christoph, Villa, Alessandra, Neri, Dario, Kaspar, Manuela

“…Proinflammatory cytokines have been used for several years in patients with advanced cancer but their administration is typically associated with severe…”
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A strategy for the isolation of catalytic activities from repertoires of enzymes displayed on phage 1 1Edited by J. Karn by Demartis, Salvatore, Huber, Adrian, Viti, Francesca, Lozzi, Luisa, Giovannoni, Leonardo, Neri, Paolo, Winter, Greg, Neri, Dario

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NMR studies on Ni(II) induced cyclization of a histidine-tagged peptide by Spiga, Ottavia, Bernini, Andrea, Scarselli, Maria, Ciutti, Arianna, Giovannoni, Leonardo, Laschi, Franco, Bracci, Luisa, Niccolai, Neri

“…A linear decapeptide, HGASYQDLGH, was synthesized and used as a model to evaluate the effect of nickel addition upon non‐covalent backbone cyclization. The NMR…”
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The tumor-targeting immunocytokine F16-IL2 in combination with doxorubicin: dose escalation in patients with advanced solid tumors and expansion into patients with metastatic breast cancer by Catania, Chiara, Maur, Michela, Berardi, Rossana, Rocca, Andrea, Giacomo, Anna Maria Di, Spitaleri, Gianluca, Masini, Cristina, Pierantoni, Chiara, González-Iglesias, Reinerio, Zigon, Giulia, Tasciotti, Annaelisa, Giovannoni, Leonardo, Lovato, Valeria, Elia, Giuliano, Menssen, Hans D, Neri, Dario, Cascinu, Stefano, Conte, Pier Franco, Braud, Filippo de

“…A phase Ib/II trial was performed to evaluate safety, tolerability, recommended dose (RD) and efficacy of F16-IL2, a recombinant antibody-cytokine fusion…”
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Abundant in vitro expression of the oncofetal ED-B-containing fibronectin translates into selective pharmacodelivery of (131)I-L19SIP in a prostate cancer patient by Locher, Ricarda, Erba, Paola A, Hirsch, Burkhard, Bombardieri, Emilio, Giovannoni, Leonardo, Neri, Dario, Dürkop, Horst, Menssen, Hans D

“…The extradomain B of fibronectin (ED-B) is a promising vascular target for selective pharmacodelivery in cancer patients. We analyzed a large series of…”
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Potentiating the activity of rituximab against mantle cell lymphoma in mice by targeting interleukin-2 to the neovasculature by Börschel, Niklas, Schwöppe, Christian, Zerbst, Caroline, Angenendt, Linus, Kessler, Torsten, Klapper, Wolfram, Giovannoni, Leonardo, Elia, Giuliano, Neri, Dario, Berdel, Wolfgang E, Mesters, Rolf M, Schliemann, Christoph

“…Highlights • L19-IL2 is a fully human immunocytokine that targets EDB-Fn positive blood vessels. • L19-IL2 efficiently homes to angiogenic vessels in mantle…”
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Targeting interleukin-2 to the bone marrow stroma for therapy of acute myeloid leukemia relapsing after allogeneic hematopoietic stem cell transplantation by Schliemann, Christoph, Gutbrodt, Katrin L, Kerkhoff, Andrea, Pohlen, Michele, Wiebe, Stefanie, Silling, Gerda, Angenendt, Linus, Kessler, Torsten, Mesters, Rolf M, Giovannoni, Leonardo, Schäfers, Michael, Altvater, Bianca, Rossig, Claudia, Grünewald, Inga, Wardelmann, Eva, Köhler, Gabriele, Neri, Dario, Stelljes, Matthias, Berdel, Wolfgang E

“…The antibody-based delivery of IL2 to extracellular targets expressed in the easily accessible tumor-associated vasculature has shown potent antileukemic…”
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Intralesional treatment of stage III metastatic melanoma patients with L19-IL2: Clinical and systemic immunological responses by Neri, Dario, Weide, Benjamin, Eigentler, Thomas K., Pflugfelder, Annette, Zelba, Henning, Pawelec, Graham P., Giovannoni, Leonardo, Ruffini, Pier Adelchi, Elia, Giuliano, Gutzmer, Ralf, Becker, Jürgen C., Garbe, Claus

“…Abstract only…”
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