Search Results - "GIOVANELLA, Beppino"

Sustained delivery of a camptothecin prodrug - CZ48 by nanosuspensions with improved pharmacokinetics and enhanced anticancer activity by Dong, Dong, Hsiao, Cheng-Hui, Giovanella, Beppino C, Wang, Yifei, Chow, Diana Sl, Li, Zhijie

“…We have synthesized a novel lactone-stabilized camptothecin (CPT) analog named CZ48 and demonstrated its potent anticancer effects via bioconversion to the…”
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TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal by Killela, Patrick J., Reitman, Zachary J., Jiao, Yuchen, Bettegowda, Chetan, Agrawal, Nishant, Diaz, Luis A., Friedman, Allan H., Friedman, Henry, Gallia, Gary L., Giovanella, Beppino C., Grollman, Arthur P., He, Tong-Chuan, He, Yiping, Hruban, Ralph H., Jallo, George I., Mandahl, Nils, Meeker, Alan K., Mertens, Fredrik, Netto, George J., Rasheed, B. Ahmed, Riggins, Gregory J., Rosenquist, Thomas A., Schiffman, Mark, Shih, Ie-Ming, Theodorescu, Dan, Torbenson, Michael S., Velculescu, Victor E., Wang, Tian-Li, Wentzensen, Nicolas, Wood, Laura D., Zhang, Ming, McLendon, Roger E., Bigner, Darell D., Kinzler, Kenneth W., Vogelstein, Bert, Papadopoulos, Nickolas, Yan, Hai

“…Malignant cells, like all actively growing cells, must maintain their telomeres, but genetic mechanisms responsible for telomere maintenance in tumors have…”
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PTEN, a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer by Li, Jing, Yen, Clifford, Liaw, Danny, Podsypanina, Katrina, Bose, Shikha, Wang, Steven I., Puc, Janusz, Miliaresis, Christa, Rodgers, Linda, McCombie, Richard, Bigner, Sandra H., Giovanella, Beppino C., Ittmann, Michael, Tycko, Ben, Hibshoosh, Hanina, Wigler, Michael H., Parsons, Ramon

“…Mapping of homozygous deletions on human chromosome 10q23 has led to the isolation of a candidate tumor suppressor gene, PTEN, that appears to be mutated at…”
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ISG15 as a novel tumor biomarker for drug sensitivity by Desai, Shyamal D, Wood, Laurence M, Tsai, Yu-Chen, Hsieh, Tao-Shih, Marks, Jeffrey R, Scott, Georgia L, Giovanella, Beppino C, Liu, Leroy F

“…Tumor cells are known to exhibit highly varied sensitivity to camptothecins (CPT; e.g., irinotecan and topotecan). However, the factors that determine CPT…”
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Metabolic difference of CZ48 in human and mouse liver microsomes by Liu, Xing, Dejesus, Albert, Cao, Zhisong, Vardeman, Dana, Giovanella, Beppino

“…CZ48, chemically camptothecin-20-O-propionate hydrate, is currently under clinical investigation. The kinetics of the metabolite camptothecin (CPT) formation…”
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Enhanced lactone stability of CZ48 in blood correlates to its lack of toxicity in mice by Liu, Xing, Wang, Yang, Cao, Zhisong, Zhan, Max, Vardeman, Dana, Giovanella, Beppino

“…The aim of this study was to correlate the relationship between the pharmacokinetic behaviors and the toxicity of a new investigational anticancer agent CZ48,…”
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Desmoplastic small round cell tumor (DSRCT) xenografts and tissue culture lines: Establishment and initial characterization by MARKIDES, CONSTANTINE S.A, COIL, DOUGLAS R, LUONG, LINH H, MENDOZA, JOHN, KOZIELSKI, TONY, VARDEMAN, DANA, GIOVANELLA, BEPPINO C

“…Desmoplastic small round cell tumor (DSRCT) is an extremely rare and aggressive neoplasm, which mainly affects young males and generally presents as a widely…”
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Anticancer activity of new haloalkyl camptothecin esters against human cancer cell lines and human tumor xenografts grown in nude mice by Cao, Zhisong, Mendoza, John, Kozielski, Anthony, Liu, Xing, Dejesus, Albert, Wang, Yang, Zhan, Chang-Guo, Vardeman, Dana, Giovanella, Beppino

“…All chemotherapeutic agents currently in use have a narrow window of therapeutic index of 1 to 1.2. Camptothecin ester compounds are reported to have a wider…”
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Development and validation of a reverse-phase HPLC with fluorescence detector method for simultaneous determination of CZ48 and its active metabolite camptothecin in mouse plasma by Liu, Xing, Wang, Yang, Vardeman, Dana, Cao, Zhisong, Giovanella, Beppino

“…A simple and sensitive high-performance liquid chromatography (HPLC) assay for the analysis of CZ48, a potent anticancer candidate, and its active metabolite…”
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Establishment and Characterization of Cancer Cell Cultures and Xenografts Derived from Primary or Metastatic Mullerian Cancers by VERSCHRAEGEN, Claire F, WEI HU, GIOVANELLA, Beppino C, YU DU, MENDOZA, John, EARLY, Janet, DEAVERS, Michael, FREEDMAN, Ralph S, BAST, Robert C, KUDELKA, Andrzej P, KAVANAGH, John J

“…Purpose: The purpose of this study was to characterize cell cultures and xenografts derived from patients with ovarian cancer. Experimental Design: Ninety…”
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Preclinical evaluation of the anticancer activity and toxicity of 9-nitro-20(S)-camptothecin (Rubitecan) by Giovanella, Beppino C, Stehlin, John S, Hinz, Hellmuth R, Kozielski, Anthony J, Harris, Nicholas J, Vardeman, Dana M

“…The purpose of this study is to establish the maximum tolerated dose of rubitecan in mice, dogs and men and to establish the anticancer activity of such dose…”
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DNA Topoisomerase I-Targeted Chemotherapy of Human Colon Cancer in Xenografts by Giovanella, Beppino C., Stehlin, John S., Wall, Monroe E., Wani, Mansukh C., Nicholas, Allan W., Liu, Leroy F., Silber, Robert, Potmesil, Milan

“…Drug development is needed to improve chemotherapy of patients with locally advanced or metastatic colon carcinoma, who otherwise have an unfavorable…”
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Complete growth inhibition of human cancer xenografts in nude mice by treatment with 20-(S)-camptothecin by GIOVANELLA, B. C, HINZ, H. R, KOZIELSKI, A. J, STEHLIN, J. S, SILBER, R, POTMESIL, M

“…20-(S)-Camptothecin (CAM), a plant alkaloid, was tested against 13 human cancer xenograft lines carried by immunodeficient (nude) mice. The drug, formulated in…”
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A phase I clinical and pharmacological study of oral 9-nitrocamptothecin, a novel water-insoluble topoisomerase I inhibitor by Verschraegen, C F, Natelson, E A, Giovanella, B C, Kavanagh, J J, Kudelka, A P, Freedman, R S, Edwards, C L, Ende, K, Stehlin, J S

“…9-Nitrocamptothecin (9NC) is a water-insoluble topoisomerase I inhibitor with a broad antitumor activity in animal models. To determine the maximum tolerated…”
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A phase II clinical and pharmacological study of oral 9-nitrocamptothecin in patients with refractory epithelial ovarian, tubal or peritoneal cancer by Verschraegen, C F, Gupta, E, Loyer, E, Kavanagh, J J, Kudelka, A P, Freedman, R S, Edwards, C L, Harris, N, Steger, M, Steltz, V, Giovanella, B C, Stehlin, J S

“…9-Nitrocamptothecin (9-NC) is a water-insoluble topoisomerase I inhibitor with a broad antitumor activity in animal models. A phase II study was performed in…”
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Pharmacokinetics of the in vivo and in vitro conversion of 9-nitro-20(S)-camptothecin to 9-amino-20(S)-camptothecin in humans, dogs, and mice by HINZ, H. R, HARRIS, N. J, NATELSON, E. A, GIOVANELLA, B. C

“…We have determined that 9-nitro-20(S)-camptothecin (9NC) converts to 9-amino-20(S)-camptothecin (9AC) in humans, dogs, and mice. Following a single oral dose…”
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Complete inhibition of growth followed by death of human malignant melanoma cells In vitro and regression of human melanoma xenografts in immunodeficient mice induced by camptothecins by PANTAZIS, P, HINZ, H. R, MENDOZA, J. T, KOZIELSKI, A. J, WILLIAMS, L. J, STEHLIN, J. S, GIOVANELLA, C

“…The plant alkaloid camptothecin and three camptothecin derivatives were used to study responses of human malignant melanoma (BRO) cells xenografted in…”
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Abstract 4337: In vitro biotransformation of and inhibitory effects of CZ48 in human liver microsomes by Liu, Xing, DeJesus, Albert, Vardeman, Dana, Cao, Zhisong, Giovanella, Beppino

“…BACKGROUND AND PURPOSE CZ48 is a novel potent anticancer agent currently in a phase I clinical trial. The absorption of CZ48 in humans is approximately less…”
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Cytotoxic efficacy of 9-nitrocamptothecin in the treatment of human malignant melanoma cells in vitro by PANTAZIS, P, EARLY, J. A, MENDOZA, J. T, DEJESUS, A. R, GIOVANELLA, B. C

“…In a recent study, we showed that the plant alkaloid camptothecin (CPT) and its derivatives 9-nitro-CPT (9NC) and 9-amino-CPT (9AC) inhibit growth of both…”
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Growth inhibition of human cancer metastases by camptothecins in newly developed xenograft models by POTMESIL, M, VARDEMAN, D, KOZIELSKI, A. J, MENDOZA, J, STEHLIN, J. S, GIOVANELLA, B. C

“…Several metastatic models have been developed using clonal selection of human malignant cells metastasizing into a specific organ in NIH-I Swiss…”
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