Search Results - "GIMOTTY, P"

Acquired cancer stem cell phenotypes through Oct4-mediated dedifferentiation by Kumar, S M, Liu, S, Lu, H, Zhang, H, Zhang, P J, Gimotty, P A, Guerra, M, Guo, W, Xu, X

“…There is enormous interest to target cancer stem cells (CSCs) for clinical treatment because these cells are highly tumorigenic and resistant to chemotherapy…”
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Long-term outcomes to neoadjuvant pembrolizumab based on pathological response for patients with resectable stage III/IV cutaneous melanoma by Sharon, C.E., Tortorello, G.N., Ma, K.L., Huang, A.C., Xu, X., Giles, L.R., McGettigan, S., Kreider, K., Schuchter, L.M., Mathew, A.J., Amaravadi, R.K., Gimotty, P.A., Miura, J.T., Karakousis, G.C., Mitchell, T.C.

“…While neoadjuvant immunotherapy for melanoma has shown promising results, the data have been limited by a relatively short follow-up time, with most studies…”
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Diagnostic accuracy of IgG‐specific versus polyspecific enzyme‐linked immunoassays in heparin‐induced thrombocytopenia: a systematic review and meta‐analysis by Husseinzadeh, H. D., Gimotty, P. A., Pishko, A. M., Buckley, M., Warkentin, T. E., Cuker, A.

“…Essentials Immunoassay specificity varies in heparin‐induced thrombocytopenia (HIT) testing. This meta‐analysis examined 9 studies that tested samples by both…”
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MEK inhibition affects STAT3 signaling and invasion in human melanoma cell lines by Vultur, A, Villanueva, J, Krepler, C, Rajan, G, Chen, Q, Xiao, M, Li, L, Gimotty, P A, Wilson, M, Hayden, J, Keeney, F, Nathanson, K L, Herlyn, M

“…Elevated activity of the mitogen-activated protein kinase (MAPK) signaling cascade is found in the majority of human melanomas and is known to regulate…”
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Prevalence of and risk factors for cerebral microbleeds among adult patients with haemophilia A or B by Husseinzadeh, H., Chiasakul, T., Gimotty, P. A., Pukenas, B., Wolf, R., Kelty, M., Chiang, E., Fogarty, P. F., Cuker, A.

“…Introduction Cerebral microbleeds (CMBs) represent clinically silent haemorrhagic events. Cerebral microbleeds (CMBs) portend negative neurovascular and…”
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Cellular senescence checkpoint function determines differential Notch1-dependent oncogenic and tumor-suppressor activities by Kagawa, S, Natsuizaka, M, Whelan, K A, Facompre, N, Naganuma, S, Ohashi, S, Kinugasa, H, Egloff, A M, Basu, D, Gimotty, P A, Klein-Szanto, A J, Bass, A J, Wong, K-K, Diehl, J A, Rustgi, A K, Nakagawa, H

“…Notch activity regulates tumor biology in a context-dependent and complex manner. Notch may act as an oncogene or a tumor-suppressor gene even within the same…”
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Correction of human hemophilia A whole blood abnormalities with a novel bypass agent: zymogen-like FXa(I16L) by George, L A, Thalji, N K, Raffini, L J, Gimotty, P A, Camire, R M

“…Approximately 30% of hemophilia A (HA) and 5% of hemophilia B patients develop inhibitors to protein replacement therapy, and this is the major cause of…”
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Interventional therapies and in‐hospital outcomes in acute coronary syndromes complicated by von Willebrand disease by Fogarty, P. F., Blair, A., Vega, R., Matthai, W. H., Gimotty, P. A.

“…Introduction von Willebrand disease (VWD) is one of the most common inherited bleeding disorders. Aim Investigate the impact of the VWD bleeding tendency on…”
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Correction of human hemophilia A whole blood abnormalities with a novel bypass agent: zymogen‐like FXaI16L by George, L. A., Thalji, N. K., Raffini, L. J., Gimotty, P. A., Camire, R. M.

“…Summary Background Approximately 30% of hemophilia A (HA) and 5% of hemophilia B patients develop inhibitors to protein replacement therapy, and this is the…”
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Melanoma progression exhibits a significant impact on connexin expression patterns in the epidermal tumor microenvironment by Haass, Nikolas K, Ripperger, D, Wladykowski, E, Dawson, P, Gimotty, P. A, Blome, C, Fischer, F, Schmage, P, Moll, I, Brandner, Johanna M

“…Melanoma depends on, interacts with and reacts to the stroma in which it is embedded, including fibroblasts, extracellular matrix, endothelial cells and immune…”
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Periostin cooperates with mutant p53 to mediate invasion through the induction of STAT1 signaling in the esophageal tumor microenvironment by Wong, G S, Lee, J-S, Park, Y-Y, Klein-Szanto, A J, Waldron, T J, Cukierman, E, Herlyn, M, Gimotty, P, Nakagawa, H, Rustgi, A K

“…Periostin (POSTN), a matricellular protein, has been reported to be important in supporting tumor cell dissemination. However, the molecular mechanisms…”
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Intratumoral T Cells, Recurrence, and Survival in Epithelial Ovarian Cancer by Zhang, Lin, Conejo-Garcia, Jose R, Katsaros, Dionyssios, Gimotty, Phyllis A, Massobrio, Marco, Regnani, Giorgia, Makrigiannakis, Antonis, Gray, Heidi, Schlienger, Katia, Liebman, Michael N, Rubin, Stephen C, Coukos, George

“…The outcome of treatment in advanced ovarian cancer can vary considerably among patients with similar clinical and pathological findings. In this…”
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CD8 T cell-mediated immune responses are critical to the increased efficacy of Doxil in BRCA1 deficient tumors by Mantia-Smaldone, G, Gamerman, V, Gimotty, P, Loomis, R, Orsulic, S, Rubin, S, Coukos, G, Adams, S

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Sentinel Lymph Node Biopsy in Patients With very Thin by Bartlett, E.K, Sinnamon, A.J, Wachtel, H, Elder, D.E, Xu, X, Schuchter, L.M, Ming, M.E, Gimotty, P, Roses, R, Czerniecki, B.J, Kelz, R.R, Fraker, D.L, Karakousis, G.C

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A phase I/II trial of IDD-6, an autologous dendritic cell vaccine for women with advanced ovarian cancer in remission by Chu, C, Boyer, J, Gimotty, P, Rubin, S, Coukos, G, Morgan, M, Bender, J, June, C

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Long-term event-free survivors after high-dose therapy and autologous stem-cell transplantation for low-grade follicular lymphoma by ANDREADIS, C, SCHUSTER, S. J, DOWNS, L. H, MANGAN, P. A, CUNNINGHAM, K. A, HUMMEL, K. A, GIMOTTY, P. A, SIEGEL, D. L, GLATSTEIN, E, STADTMAUER, E. A, CHONG, E. A, SVOBODA, J, LUGER, S. M, PORTER, D. L, TSAI, D. E, NASTA, S. D, ELSTROM, R. L, GOLDSTEIN, S. C

“…Although follicular lymphoma (FL) is generally responsive to conventional-dose chemotherapy, improved survival in patients with this disease has been difficult…”
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Multi-gene epigenetic silencing of tumor suppressor genes in T-cell lymphoma cells; delayed expression of the p16 protein upon reversal of the silencing by Nagasawa, T., Zhang, Q., Raghunath, P.N., Wong, H.Y., El-Salem, M., Szallasi, A., Marzec, M., Gimotty, P., Rook, A.H., Vonderheid, E.C., Odum, N., Wasik, M.A.

“…To understand better T-cell lymphomagenesis, we examined promoter CpG methylation and mRNA expression of closely related genes encoding p16, p15, and p14 tumor…”
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The effect of patient and physician reminders on use of screening mammography in a health maintenance organization: Results of a randomized controlled trial by Burack, Robert C., Gimotty, Phyllis A., George, Julie, Simon, Michael S., Dews, Peter, Moncrease, Anita

“…BACKGROUND Despite its demonstrated efficacy in reducing breast carcinoma mortality, screening mammography remains underutilized and its promotion in the…”
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Developmental role of the SNF1-related kinase Hunk in pregnancy-induced changes in the mammary gland by Gardner, H P, Belka, G K, Wertheim, G B, Hartman, J L, Ha, S I, Gimotty, P A, Marquis, S T, Chodosh, L A

“…The steroid hormones 17 beta-estradiol and progesterone play a central role in the pathogenesis of breast cancer and regulate key phases of mammary gland…”
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Prognostic influence on survival of increased ornithine decarboxylase activity in human breast cancer by MANNI, A, MAUGER, D, GIMOTTY, P, BADGER, B

“…Although considerable experimental evidence suggests an important role of polyamines in breast cancer biology, compelling supportive data in patients are…”
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