Search Results - "GILMORE, Thomas"

Evolutionary Origins of Toll-like Receptor Signaling by Brennan, Joseph J, Gilmore, Thomas D

“…Toll-like receptors (TLRs) are transmembrane pattern recognition receptors that are best known for their roles in innate immunity for the detection of and…”
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Looking Down on NF-κB by Williams, Leah M., Gilmore, Thomas D.

“…The diversified NF-κB transcription factor family has been extensively characterized in organisms ranging from flies to humans. However, homologs of NF-κB and…”
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NF-κB: where did it come from and why? by Gilmore, Thomas D., Wolenski, Francis S.

“…The vast majority of research on nuclear factor κB (NF‐κB) signaling in the past 25 years has focused on its roles in normal and disease‐related processes in…”
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Scaffold proteins as dynamic integrators of biological processes by DiRusso, Christopher J., Dashtiahangar, Maryam, Gilmore, Thomas D.

“…Scaffold proteins act as molecular hubs for the docking of multiple proteins to organize efficient functional units for signaling cascades. Over 300 human…”
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NF-κB and Human Cancer: What Have We Learned over the Past 35 Years? by Gilmore, Thomas D.

“…Transcription factor NF-κB has been extensively studied for its varied roles in cancer development since its initial characterization as a potent retroviral…”
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Control of nuclear localization of the nucleocapsid protein of SARS-CoV-2 by Wang, Mengrui, Valadez-Ingersoll, Maria, Gilmore, Thomas D.

“…The nucleocapsid (N) protein of coronaviruses is a structural protein that binds viral RNA for assembly into the mature virion, a process that occurs in the…”
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An innate ability: How do basal invertebrates manage their chronic exposure to microbes? by Williams, Leah M, Gilmore, Thomas D

“…Homologs of mammalian innate immune sensing and downstream pathway proteins have been discovered in a variety of basal invertebrates, including cnidarians and…”
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Innate immunity and cnidarian-Symbiodiniaceae mutualism by Mansfield, Katelyn M., Gilmore, Thomas D.

“…The phylum Cnidaria (sea anemones, corals, hydra, jellyfish) is one the most distantly related animal phyla to humans, and yet cnidarians harbor many of the…”
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Rapid profiling of transcription factor-cofactor interaction networks reveals principles of epigenetic regulation by Inge, Melissa M, Miller, Rebekah, Hook, Heather, Bray, David, Keenan, Jessica L, Zhao, Rose, Gilmore, Thomas D, Siggers, Trevor

“…Transcription factor (TF)-cofactor (COF) interactions define dynamic, cell-specific networks that govern gene expression; however, these networks are…”
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Histone acetyltransferases and histone deacetylases in B- and T-cell development, physiology and malignancy by Haery, Leila, Thompson, Ryan C, Gilmore, Thomas D

“…The development of B and T cells from hematopoietic precursors and the regulation of the functions of these immune cells are complex processes that involve…”
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Intraspecific variation in oxidative stress tolerance in a model cnidarian: Differences in peroxide sensitivity between and within populations of Nematostella vectensis by Friedman, Lauren E, Gilmore, Thomas D, Finnerty, John R

“…Nematostella vectensis is a member of the phylum Cnidaria, a lineage that includes anemones, corals, hydras, and jellyfishes. This estuarine anemone is an…”
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Sea anemone model has a single Toll-like receptor that can function in pathogen detection, NF-κB signal transduction, and development by Brennan, Joseph J., Messerschmidt, Jonathan L., Williams, Leah M., Matthews, Bryan J., Reynoso, Marinaliz, Gilmore, Thomas D.

“…In organisms from insects to vertebrates, Toll-like receptors (TLRs) are primary pathogen detectors that activate downstream pathways, specifically those that…”
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Microinjection of mRNA or morpholinos for reverse genetic analysis in the starlet sea anemone, Nematostella vectensis by Layden, Michael J, Röttinger, Eric, Wolenski, Francis S, Gilmore, Thomas D, Martindale, Mark Q

“…We describe a protocol for microinjection of embryos for an emerging model system, the cnidarian sea anemone, Nematostella vectensis . In addition, we provide…”
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The sensitivity of diffuse large B-cell lymphoma cell lines to histone deacetylase inhibitor-induced apoptosis is modulated by BCL-2 family protein activity by Thompson, Ryan C, Vardinogiannis, Iosif, Gilmore, Thomas D

“…Diffuse large B-cell lymphoma (DLBCL) is a genetically heterogeneous disease and this variation can often be used to explain the response of individual…”
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CRISPR/Cas9-based editing of a sensitive transcriptional regulatory element to achieve cell type-specific knockdown of the NEMO scaffold protein by Babaei, Milad, Liu, Yuekun, Wuerzberger-Davis, Shelly M, McCaslin, Ethan Z, DiRusso, Christopher J, Yeo, Alan T, Kagermazova, Larisa, Miyamoto, Shigeki, Gilmore, Thomas D

“…The use of alternative promoters for the cell type-specific expression of a given mRNA/protein is a common cell strategy. NEMO is a scaffold protein required…”
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Transcription factor cross-talk: the estrogen receptor and NF-κB by Kalaitzidis, Demetrios, Gilmore, Thomas D.

“…The NF-κB family of transcription factors regulates many genes that are essential primarily for the development, maintenance and function of the innate and…”
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A conserved core region of the scaffold NEMO is essential for signal-induced conformational change and liquid-liquid phase separation by DiRusso, Christopher J., DeMaria, Anthony M., Wong, Judy, Wang, Wei, Jordanides, Jack J., Whitty, Adrian, Allen, Karen N., Gilmore, Thomas D.

“…Scaffold proteins help mediate interactions between protein partners, often to optimize intracellular signaling. Herein, we use comparative, biochemical,…”
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Starvation differentially affects gene expression, immunity and pathogen susceptibility across symbiotic states in a model cnidarian by Valadez-Ingersoll, Maria, Aguirre Carrión, Pablo J, Bodnar, Caoimhe A, Desai, Niharika A, Gilmore, Thomas D, Davies, Sarah W

“…Mutualistic symbioses between cnidarians and photosynthetic algae are modulated by complex interactions between host immunity and environmental conditions…”
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Identification of an NF-κB p50/p65-responsive site in the human MIR155HG promoter by Thompson, Ryan C, Vardinogiannis, Iosif, Gilmore, Thomas D

“…MicroRNA-155 (miR-155) is the diced product of the MIR155HG gene. miR-155 regulates the expression of many immune-specific transcripts, is overexpressed in…”
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Transcription factor NF-κB is modulated by symbiotic status in a sea anemone model of cnidarian bleaching by Mansfield, Katelyn M., Carter, Nicole M., Nguyen, Linda, Cleves, Phillip A., Alshanbayeva, Anar, Williams, Leah M., Crowder, Camerron, Penvose, Ashley R., Finnerty, John R., Weis, Virginia M., Siggers, Trevor W., Gilmore, Thomas D.

“…Transcription factor NF-κB plays a central role in immunity from fruit flies to humans, and NF-κB activity is altered in many human diseases. To investigate a…”
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