Search Results - "GILLOTIN, Florian"

Coupling of Liquid Chromatography/Tandem Mass Spectrometry and Liquid Chromatography/Solid-Phase Extraction/NMR Techniques for the Structural Identification of Metabolites following In Vitro Biotransformation of SUR1-Selective ATP-Sensitive Potassium Channel Openers by GILLOTIN, Florian, CHIAP, Patrice, FREDERICH, Michel, VAN HEUGEN, Jean-Claude, FRANCOTTE, Pierre, LEBRUN, Philippe, PIROTTE, Bernard, DE TULLIO, Pascal

“…SUR1-selective ATP-sensitive potassium channel openers (PCOs) have been shown to be of clinical value for the treatment of several metabolic disorders,…”
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Deciphering the factors defining the pH-dependence of a commercial glycoside hydrolase family 8 enzyme by Barroca, Mário, Santos, Gustavo, Johansson, Björn, Gillotin, Florian, Feller, Georges, Collins, Tony

“…[Display omitted] •An in-depth analysis of the pH dependence of a commercial xylanase is described.•Diverse reversible and irreversible processes play varying…”
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New Fluorinated 1,2,4-Benzothiadiazine 1,1-Dioxides: Discovery of an Orally Active Cognitive Enhancer Acting through Potentiation of the 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors by Francotte, Pierre, Goffin, Eric, Fraikin, Pierre, Lestage, Pierre, Van Heugen, Jean-Claude, Gillotin, Florian, Danober, Laurence, Thomas, Jean-Yves, Chiap, Patrice, Caignard, Daniel-Henri, Pirotte, Bernard, de Tullio, Pascal

“…In the search of a potent cognitive enhancer, a series of 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides have been synthesized and evaluated as positive…”
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Hydroxylated Analogues of ATP-Sensitive Potassium Channel Openers Belonging to the Group of 6- and/or 7-Substituted 3-Isopropylamino-4H-1,2,4-benzothiadiazine 1,1-Dioxides: Toward an Improvement in Sulfonylurea Receptor 1 Selectivity and Metabolism Stability by de Tullio, Pascal, Servais, Anne-Catherine, Fillet, Marianne, Gillotin, Florian, Somers, Fabian, Chiap, Patrice, Lebrun, Philippe, Pirotte, Bernard

“…Diversely substituted 3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides are known to be potent KATP channel openers, with several drugs being selective…”
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Generic systems for the enantioseparation of basic drugs in NACE using single-isomer anionic CDs by Rousseau, Anne, Gillotin, Florian, Chiap, Patrice, Bodoki, Ede, Crommen, Jacques, Fillet, Marianne, Servais, Anne-Catherine

“…The enantioseparation of 10 basic drugs was evaluated in NACE systems using heptakis(2- O-methyl-3- O-acetyl-6- O-sulfo)-β-CD (HMAS-β-CD). For this purpose, a…”
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Association of two single-isomer anionic CD in NACE for the chiral and achiral separation of fenbendazole, its sulphoxide and sulphone metabolites: Application to their determination after in vitro metabolism by Rousseau, Anne, Gillotin, Florian, Chiap, Patrice, Crommen, Jacques, Fillet, Marianne, Servais, Anne-Catherine

“…A NACE method was developed for the separation of fenbendazole (FBZ), a prochiral drug giving rise to chiral (oxfendazole or OFZ) and nonchiral (FBZ sulphone…”
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Hydroxylated Analogues of ATP-Sensitive Potassium Channel Openers Belonging to the Group of 6- and/or 7-Substituted 3-Isopropylamino-4 H -1,2,4-benzothiadiazine 1,1-Dioxides: Toward an Improvement in Sulfonylurea Receptor 1 Selectivity and Metabolism Stability by de Tullio, Pascal, Servais, Anne-Catherine, Fillet, Marianne, Gillotin, Florian, Somers, Fabian, Chiap, Patrice, Lebrun, Philippe, Pirotte, Bernard

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