Search Results - "GILLILAND, Kathryn L"

Systemic Isotretinoin Therapy Normalizes Exaggerated TLR-2-Mediated Innate Immune Responses in Acne Patients by Dispenza, Melanie C., Wolpert, Ellen B., Gilliland, Kathryn L., Dai, Jenny P., Cong, Zhaoyuan, Nelson, Amanda M., Thiboutot, Diane M.

“…Retinoids are used in the treatment of inflammatory skin diseases and malignancies, but studies characterizing the in vivo actions of these drugs in humans are…”
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Neutrophil gelatinase-associated lipocalin mediates 13-cis retinoic acid-induced apoptosis of human sebaceous gland cells by Nelson, Amanda M, Zhao, Wei, Gilliland, Kathryn L, Zaenglein, Andrea L, Liu, Wenlei, Thiboutot, Diane M

“…13-cis retinoic acid (13-cis RA; also known as isotretinoin) is the most potent agent available for treatment of acne. It is known that the drug induces…”
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Peroxisome Proliferator-Activated Receptors Increase Human Sebum Production by Trivedi, Nishit R., Cong, Zhaoyuan, Nelson, Amanda M., Albert, Adam J., Rosamilia, Lorraine L., Sivarajah, Surendra, Gilliland, Kathryn L., Liu, Wenlei, Mauger, David T., Gabbay, Robert A., Thiboutot, Diane M.

“…Sebum production is key in the pathophysiology of acne, an extremely common condition, which when severe, may require treatment with isotretinoin, a known…”
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Insulin-Like Growth Factor-1 Induces Lipid Production in Human SEB-1 Sebocytes Via Sterol Response Element-Binding Protein-1 by Smith, Terry M., Cong, Zhaoyuan, Gilliland, Kathryn L., Clawson, Gary A., Thiboutot, Diane M.

“…An understanding of the molecular signaling involved in sebaceous gland lipid production is needed to develop therapeutic targets to improve acne. Treatment…”
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Selective Rho Kinase Inhibitor Allows for Expansion of Human Primary Sebocytes In Vitro by Nelson, Amanda M., Dispenza, Melanie C., Cong, Zhaoyuan, Moll, Matthew, Gilliland, Kathryn L., Thiboutot, Diane M.

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13-cis Retinoic Acid Induces Apoptosis and Cell Cycle Arrest in Human SEB-1 Sebocytes by Nelson, Amanda M., Gilliland, Kathryn L., Cong, Zhaoyuan, Thiboutot, Diane M.

“…Isotretinoin (13-cis retinoic acid (13-cis RA)) is the most potent inhibitor of sebum production, a key component in the pathophysiology of acne, yet its…”
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Inhibition of Sebum Production with the Acetyl Coenzyme A Carboxylase Inhibitor Olumacostat Glasaretil by Hunt, David W., Winters, Geoffrey C., Brownsey, Roger W., Kulpa, Jerzy E., Gilliland, Kathryn L., Thiboutot, Diane M., Hofland, Hans E.

“…Olumacostat glasaretil (OG) is a small molecule inhibitor of acetyl coenzyme A (CoA) carboxylase (ACC), the enzyme that controls the first rate-limiting step…”
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Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action by Nelson, Amanda M., Zhao, Wei, Gilliland, Kathryn L., Zaenglein, Andrea L., Liu, Wenlei, Thiboutot, Diane M.

“…Isotretinoin (13-cis RA) is the most potent agent in the treatment of acne.  Insights into its mechanism of action can lead to drug discovery of alternative…”
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Gene Array Expression Profiling in Acne Lesions Reveals Marked Upregulation of Genes Involved in Inflammation and Matrix Remodeling by Trivedi, Nishit R., Gilliland, Kathryn L., Zhao, Wei, Liu, Wenlei, Thiboutot, Diane M.

“…The pathogenesis of acne has been linked to multiple factors such as increased sebum production, inflammation, follicular hyperkeratinization, and the action…”
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Early gene changes induced by isotretinoin in the skin provide clues to its mechanism of action by Nelson, Amanda M., Zhao, Wei, Gilliland, Kathryn L., Zaenglein, Andrea L., Liu, Wenlei, Thiboutot, Diane M.

“…Gene expression analysis of patient skin at one-week of oral isotretinoin therapy for severe acne illustrates the initial changes caused by 13-cis RA. Focus on…”
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Isotretinoin Temporally Regulates Distinct Sets of Genes in Patient Skin by Nelson, Amanda M., Zhao, Wei, Gilliland, Kathryn L., Zaenglein, Andrea L., Liu, WenLei, Thiboutot, Diane M.

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13-cis retinoic acid induces apoptosis and cell cycle arrest in human SEB-1 sebocytes. Commentary by ZOUBOULIS, Christos C, NELSON, Amanda M, GILLILAND, Kathryn L, ZHAOYUAN CONG, THIBOUTOT, Diane M

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