Search Results - "GILLIES, J"

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  1. 1

    The role of carbonic anhydrase IX in cancer development: links to hypoxia, acidosis, and beyond by Pastorekova, Silvia, Gillies, Robert J

    Published in Cancer and metastasis reviews (15-06-2019)
    “…Cancer development is a complex process that follows an intricate scenario with a dynamic interplay of selective and adaptive steps and an extensive cast of…”
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    Deep learning for lung cancer prognostication: A retrospective multi-cohort radiomics study by Hosny, Ahmed, Parmar, Chintan, Coroller, Thibaud P, Grossmann, Patrick, Zeleznik, Roman, Kumar, Avnish, Bussink, Johan, Gillies, Robert J, Mak, Raymond H, Aerts, Hugo J W L

    Published in PLoS medicine (30-11-2018)
    “…Non-small-cell lung cancer (NSCLC) patients often demonstrate varying clinical courses and outcomes, even within the same tumor stage. This study explores deep…”
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  3. 3

    Radiomics Improves Cancer Screening and Early Detection by Gillies, Robert J, Schabath, Matthew B

    “…Imaging is a key technology in the early detection of cancers, including X-ray mammography, low-dose CT for lung cancer, or optical imaging for skin,…”
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  4. 4

    Systems analysis of intracellular pH vulnerabilities for cancer therapy by Persi, Erez, Duran-Frigola, Miquel, Damaghi, Mehdi, Roush, William R., Aloy, Patrick, Cleveland, John L., Gillies, Robert J., Ruppin, Eytan

    Published in Nature communications (31-07-2018)
    “…A reverse pH gradient is a hallmark of cancer metabolism, manifested by extracellular acidosis and intracellular alkalization. While consequences of…”
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  5. 5

    pH sensing and regulation in cancer by Damaghi, Mehdi, Wojtkowiak, Jonathan W, Gillies, Robert J

    Published in Frontiers in physiology (17-12-2013)
    “…Cells maintain intracellular pH (pHi) within a narrow range (7.1-7.2) by controlling membrane proton pumps and transporters whose activity is set by…”
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    Non-invasive decision support for NSCLC treatment using PET/CT radiomics by Mu, Wei, Jiang, Lei, Zhang, JianYuan, Shi, Yu, Gray, Jhanelle E., Tunali, Ilke, Gao, Chao, Sun, Yingying, Tian, Jie, Zhao, Xinming, Sun, Xilin, Gillies, Robert J., Schabath, Matthew B.

    Published in Nature communications (16-10-2020)
    “…Two major treatment strategies employed in non-small cell lung cancer, NSCLC, are tyrosine kinase inhibitors, TKIs, and immune checkpoint inhibitors, ICIs. The…”
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    Quantitative imaging of cancer in the postgenomic era: Radio(geno)mics, deep learning, and habitats by Napel, Sandy, Mu, Wei, Jardim‐Perassi, Bruna V., Aerts, Hugo J. W. L., Gillies, Robert J.

    Published in Cancer (15-12-2018)
    “…Although cancer often is referred to as “a disease of the genes,” it is indisputable that the (epi)genetic properties of individual cancer cells are highly…”
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  9. 9

    Acidity Generated by the Tumor Microenvironment Drives Local Invasion by ESTRELLA, Veronica, TINGAN CHEN, JOHNSON, Joseph, GATENBY, Robert A, GILLIES, Robert J, LLOYD, Mark, WOJTKOWIAK, Jonathan, CORNNELL, Heather H, IBRAHIM-HASHIM, Arig, BAILEY, Kate, BALAGURUNATHAN, Yoganand, ROTHBERG, Jennifer M, SLOANE, Bonnie F

    Published in Cancer research (Chicago, Ill.) (01-03-2013)
    “…The pH of solid tumors is acidic due to increased fermentative metabolism and poor perfusion. It has been hypothesized that acid pH promotes local invasive…”
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  10. 10

    Radiomics of 18F-FDG PET/CT images predicts clinical benefit of advanced NSCLC patients to checkpoint blockade immunotherapy by Mu, Wei, Tunali, Ilke, Gray, Jhanelle E., Qi, Jin, Schabath, Matthew B., Gillies, Robert J.

    “…Introduction Immunotherapy has improved outcomes for patients with non-small cell lung cancer (NSCLC), yet durable clinical benefit (DCB) is experienced in…”
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  11. 11

    Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy by Pilon-Thomas, Shari, Kodumudi, Krithika N, El-Kenawi, Asmaa E, Russell, Shonagh, Weber, Amy M, Luddy, Kimberly, Damaghi, Mehdi, Wojtkowiak, Jonathan W, Mulé, James J, Ibrahim-Hashim, Arig, Gillies, Robert J

    Published in Cancer research (Chicago, Ill.) (15-03-2016)
    “…Cancer immunotherapies, such as immune checkpoint blockade or adoptive T-cell transfer, can lead to durable responses in the clinic, but response rates remain…”
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  12. 12

    Hypoxia and acidosis: immune suppressors and therapeutic targets by Damgaci, Sultan, Ibrahim‐Hashim, Arig, Enriquez‐Navas, Pedro M., Pilon‐Thomas, Shari, Guvenis, Albert, Gillies, Robert J.

    Published in Immunology (01-07-2018)
    “…Summary Due to imbalances between vascularity and cellular growth patterns, the tumour microenvironment harbours multiple metabolic stressors including hypoxia…”
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    Impact of metabolic heterogeneity on tumor growth, invasion, and treatment outcomes by Robertson-Tessi, Mark, Gillies, Robert J, Gatenby, Robert A, Anderson, Alexander R A

    Published in Cancer research (Chicago, Ill.) (15-04-2015)
    “…Histopathologic knowledge that extensive heterogeneity exists between and within tumors has been confirmed and deepened recently by molecular studies. However,…”
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    Automatic prostate segmentation using deep learning on clinically diverse 3D transrectal ultrasound images by Orlando, Nathan, Gillies, Derek J., Gyacskov, Igor, Romagnoli, Cesare, D’Souza, David, Fenster, Aaron

    Published in Medical physics (Lancaster) (01-06-2020)
    “…Purpose Needle‐based procedures for diagnosing and treating prostate cancer, such as biopsy and brachytherapy, have incorporated three‐dimensional (3D)…”
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    Drug Resistance and Cellular Adaptation to Tumor Acidic pH Microenvironment by Wojtkowiak, Jonathan W, Verduzco, Daniel, Schramm, Karla J, Gillies, Robert J

    Published in Molecular pharmaceutics (05-12-2011)
    “…Despite advances in developing novel therapeutic strategies, a major factor underlying cancer related death remains resistance to therapy. In addition to…”
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  16. 16

    Adaptive Therapy by GATENBY, Robert A, SILVA, Ariosto S, GILLIES, Robert J, FRIEDEN, B. Roy

    Published in Cancer research (Chicago, Ill.) (01-06-2009)
    “…A number of successful systemic therapies are available for treatment of disseminated cancers. However, tumor response is often transient, and therapy…”
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    Metabolic Profiling of healthy and cancerous tissues in 2D and 3D by Russell, Shonagh, Wojtkowiak, Jonathan, Neilson, Andy, Gillies, Robert J.

    Published in Scientific reports (10-11-2017)
    “…Metabolism is a compartmentalized process, and it is apparent in studying cancer that tumors, like normal tissues, demonstrate metabolic cooperation between…”
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    Janus-faced tumor microenvironment and redox by Khramtsov, Valery V, Gillies, Robert J

    Published in Antioxidants & redox signaling (10-08-2014)
    “…Tumor microenvironment (TME) is a complex term that includes extracellular matrix, blood vessels, endothelial, stromal, and inflammatory cells, and other…”
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    Predicting Malignant Nodules from Screening CT Scans by Hawkins, Samuel, Wang, Hua, Liu, Ying, Garcia, Alberto, Stringfield, Olya, Krewer, Henry, Li, Qian, Cherezov, Dmitry, Gatenby, Robert A, Balagurunathan, Yoganand, Goldgof, Dmitry, Schabath, Matthew B, Hall, Lawrence, Gillies, Robert J

    Published in Journal of thoracic oncology (01-12-2016)
    “…The aim of this study was to determine whether quantitative analyses ("radiomics") of low-dose computed tomography lung cancer screening images at baseline can…”
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