Search Results - "GILLIES, J"
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The role of carbonic anhydrase IX in cancer development: links to hypoxia, acidosis, and beyond
Published in Cancer and metastasis reviews (15-06-2019)“…Cancer development is a complex process that follows an intricate scenario with a dynamic interplay of selective and adaptive steps and an extensive cast of…”
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Deep learning for lung cancer prognostication: A retrospective multi-cohort radiomics study
Published in PLoS medicine (30-11-2018)“…Non-small-cell lung cancer (NSCLC) patients often demonstrate varying clinical courses and outcomes, even within the same tumor stage. This study explores deep…”
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Radiomics Improves Cancer Screening and Early Detection
Published in Cancer epidemiology, biomarkers & prevention (01-12-2020)“…Imaging is a key technology in the early detection of cancers, including X-ray mammography, low-dose CT for lung cancer, or optical imaging for skin,…”
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Systems analysis of intracellular pH vulnerabilities for cancer therapy
Published in Nature communications (31-07-2018)“…A reverse pH gradient is a hallmark of cancer metabolism, manifested by extracellular acidosis and intracellular alkalization. While consequences of…”
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pH sensing and regulation in cancer
Published in Frontiers in physiology (17-12-2013)“…Cells maintain intracellular pH (pHi) within a narrow range (7.1-7.2) by controlling membrane proton pumps and transporters whose activity is set by…”
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Artificial intelligence in cancer imaging: Clinical challenges and applications
Published in CA: a cancer journal for clinicians (01-03-2019)“…Judgement, as one of the core tenets of medicine, relies upon the integration of multilayered data with nuanced decision making. Cancer offers a unique context…”
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Non-invasive decision support for NSCLC treatment using PET/CT radiomics
Published in Nature communications (16-10-2020)“…Two major treatment strategies employed in non-small cell lung cancer, NSCLC, are tyrosine kinase inhibitors, TKIs, and immune checkpoint inhibitors, ICIs. The…”
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Quantitative imaging of cancer in the postgenomic era: Radio(geno)mics, deep learning, and habitats
Published in Cancer (15-12-2018)“…Although cancer often is referred to as “a disease of the genes,” it is indisputable that the (epi)genetic properties of individual cancer cells are highly…”
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Acidity Generated by the Tumor Microenvironment Drives Local Invasion
Published in Cancer research (Chicago, Ill.) (01-03-2013)“…The pH of solid tumors is acidic due to increased fermentative metabolism and poor perfusion. It has been hypothesized that acid pH promotes local invasive…”
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Radiomics of 18F-FDG PET/CT images predicts clinical benefit of advanced NSCLC patients to checkpoint blockade immunotherapy
Published in European journal of nuclear medicine and molecular imaging (01-05-2020)“…Introduction Immunotherapy has improved outcomes for patients with non-small cell lung cancer (NSCLC), yet durable clinical benefit (DCB) is experienced in…”
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Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy
Published in Cancer research (Chicago, Ill.) (15-03-2016)“…Cancer immunotherapies, such as immune checkpoint blockade or adoptive T-cell transfer, can lead to durable responses in the clinic, but response rates remain…”
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Hypoxia and acidosis: immune suppressors and therapeutic targets
Published in Immunology (01-07-2018)“…Summary Due to imbalances between vascularity and cellular growth patterns, the tumour microenvironment harbours multiple metabolic stressors including hypoxia…”
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Impact of metabolic heterogeneity on tumor growth, invasion, and treatment outcomes
Published in Cancer research (Chicago, Ill.) (15-04-2015)“…Histopathologic knowledge that extensive heterogeneity exists between and within tumors has been confirmed and deepened recently by molecular studies. However,…”
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Automatic prostate segmentation using deep learning on clinically diverse 3D transrectal ultrasound images
Published in Medical physics (Lancaster) (01-06-2020)“…Purpose Needle‐based procedures for diagnosing and treating prostate cancer, such as biopsy and brachytherapy, have incorporated three‐dimensional (3D)…”
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Drug Resistance and Cellular Adaptation to Tumor Acidic pH Microenvironment
Published in Molecular pharmaceutics (05-12-2011)“…Despite advances in developing novel therapeutic strategies, a major factor underlying cancer related death remains resistance to therapy. In addition to…”
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Adaptive Therapy
Published in Cancer research (Chicago, Ill.) (01-06-2009)“…A number of successful systemic therapies are available for treatment of disseminated cancers. However, tumor response is often transient, and therapy…”
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Metabolic Profiling of healthy and cancerous tissues in 2D and 3D
Published in Scientific reports (10-11-2017)“…Metabolism is a compartmentalized process, and it is apparent in studying cancer that tumors, like normal tissues, demonstrate metabolic cooperation between…”
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Janus-faced tumor microenvironment and redox
Published in Antioxidants & redox signaling (10-08-2014)“…Tumor microenvironment (TME) is a complex term that includes extracellular matrix, blood vessels, endothelial, stromal, and inflammatory cells, and other…”
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Predicting Malignant Nodules from Screening CT Scans
Published in Journal of thoracic oncology (01-12-2016)“…The aim of this study was to determine whether quantitative analyses ("radiomics") of low-dose computed tomography lung cancer screening images at baseline can…”
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T-cells produce acidic niches in lymph nodes to suppress their own effector functions
Published in Nature communications (17-08-2020)“…The acidic pH of tumors profoundly inhibits effector functions of activated CD8 + T-cells. We hypothesize that this is a physiological process in immune…”
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