Search Results - "GILLET, Germain"

Subcellular Localization and Dynamics of the Bcl-2 Family of Proteins by Popgeorgiev, Nikolay, Jabbour, Lea, Gillet, Germain

“…Bcl-2 family proteins are recognized as major regulators of the mitochondrial pathway of apoptosis. They control the mitochondrial outer membrane…”
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The apoptosis inhibitor Bcl-xL controls breast cancer cell migration through mitochondria-dependent reactive oxygen species production by Bessou, Margaux, Lopez, Jonathan, Gadet, Rudy, Deygas, Mathieu, Popgeorgiev, Nikolay, Poncet, Delphine, Nougarède, Adrien, Billard, Pauline, Mikaelian, Ivan, Gonzalo, Philippe, Rimokh, Ruth, Gillet, Germain

“…The Bcl-xL apoptosis inhibitor plays a major role in vertebrate development. In addition to its effect on apoptosis, Bcl-xL is also involved in cell migration…”
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Bcl-2 Family of Proteins in the Control of Mitochondrial Calcium Signalling: An Old Chap with New Roles by Morris, Jordan L, Gillet, Germain, Prudent, Julien, Popgeorgiev, Nikolay

“…Bcl-2 family proteins are considered as one of the major regulators of apoptosis. Indeed, this family is known to control the mitochondrial outer membrane…”
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Non-apoptotic roles of Bcl-2 family: The calcium connection by Bonneau, Benjamin, Prudent, Julien, Popgeorgiev, Nikolay, Gillet, Germain

“…The existence of the bcl-2 (B-cell lymphoma-2) gene was reported nearly 30years ago. Yet, Bcl-2 family group of proteins still surprises us with their…”
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Involvement of Bcl-xL in Neuronal Function and Development by Bas, Julie, Nguyen, Trang, Gillet, Germain

“…The B-cell lymphoma (Bcl-2) family of proteins are mainly known for their role in the regulation of apoptosis by preventing pore formation at the mitochondrial…”
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Caspases in the Developing Central Nervous System: Apoptosis and Beyond by Nguyen, Trang Thi Minh, Gillet, Germain, Popgeorgiev, Nikolay

“…The caspase family of cysteine proteases represents the executioners of programmed cell death (PCD) type I or apoptosis. For years, caspases have been known…”
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Breast Cancer Targeting through Inhibition of the Endoplasmic Reticulum-Based Apoptosis Regulator Nrh/BCL2L10 by Nougarede, Adrien, Popgeorgiev, Nikolay, Kassem, Loay, Omarjee, Soleilmane, Borel, Stephane, Mikaelian, Ivan, Lopez, Jonathan, Gadet, Rudy, Marcillat, Olivier, Treilleux, Isabelle, Villoutreix, Bruno O, Rimokh, Ruth, Gillet, Germain

“…Drug resistance and metastatic relapse remain a top challenge in breast cancer treatment. In this study, we present preclinical evidence for a strategy to…”
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Redox regulation of EGFR steers migration of hypoxic mammary cells towards oxygen by Deygas, Mathieu, Gadet, Rudy, Gillet, Germain, Rimokh, Ruth, Gonzalo, Philippe, Mikaelian, Ivan

“…Aerotaxis or chemotaxis to oxygen was described in bacteria 130 years ago. In eukaryotes, the main adaptation to hypoxia currently described relies on HIF…”
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Nrh L11R single nucleotide polymorphism, a new prediction biomarker in breast cancer, impacts endoplasmic reticulum-dependent Ca2+ traffic and response to neoadjuvant chemotherapy by Duong, Minh Quang, Gadet, Rudy, Treilleux, Isabelle, Borel, Stéphane, Nougarède, Adrien, Marcillat, Olivier, Gonzalo, Philippe, Mikaelian, Ivan, Popgeorgiev, Nikolay, Rimokh, Ruth, Gillet, Germain

“…Overexpression of Bcl-2 proteins such as Bcl2L10, also referred to as Nrh, is associated with resistance to therapy and poor survival in various cancers,…”
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EGFR-dependent aerotaxis is a common trait of breast tumour cells by Mikaelian, Ivan, Gadet, Rudy, Deygas, Mathieu, Bertolino, Philippe, Hennino, Anca, Gillet, Germain, Rimokh, Ruth, Berremila, Sid-Ali, Péoc'h, Michel, Gonzalo, Philippe

“…Aerotaxis, the chemotactism to oxygen, is well documented in prokaryotes. We previously reported for the first time that non-tumorigenic breast epithelial…”
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Bcl-wav and the mitochondrial calcium uniporter drive gastrula morphogenesis in zebrafish by Prudent, Julien, Popgeorgiev, Nikolay, Bonneau, Benjamin, Thibaut, Julien, Gadet, Rudy, Lopez, Jonathan, Gonzalo, Philippe, Rimokh, Ruth, Manon, Stephen, Houart, Corinne, Herbomel, Philippe, Aouacheria, Abdel, Gillet, Germain

“…Bcl-2 proteins are acknowledged as key regulators of programmed cell death. However, increasing data suggest additional roles, including regulation of the cell…”
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The endoplasmic reticulum pool of Bcl-xL prevents cell death through IP3R-dependent calcium release by Gadet, Rudy, Jabbour, Lea, Nguyen, Trang Thi Minh, Lohez, Olivier, Mikaelian, Ivan, Gonzalo, Philippe, Luyten, Tomas, Chalabi-Dchar, Mounira, Wierinckx, Anne, Marcillat, Olivier, Bultynck, Geert, Rimokh, Ruth, Popgeorgiev, Nikolay, Gillet, Germain

“…Apoptosis plays a role in cell homeostasis in both normal development and disease. Bcl-xL, a member of the Bcl-2 family of proteins, regulates the intrinsic…”
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A new ChEMBL dataset for the similarity-based target fishing engine FastTargetPred: Annotation of an exhaustive list of linear tetrapeptides by Tanwar, Shivalika, Auberger, Patrick, Gillet, Germain, DiPaola, Mario, Tsaioun, Katya, Villoutreix, Bruno O.

“…Drug discovery often requires the identification of off-targets as the binding of a compound to targets other than the intended target(s) can be beneficial in…”
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The Apoptotic Regulator Nrz Controls Cytoskeletal Dynamics via the Regulation of Ca2+ Trafficking in the Zebrafish Blastula by Popgeorgiev, Nikolay, Bonneau, Benjamin, Ferri, Karine F., Prudent, Julien, Thibaut, Julien, Gillet, Germain

“…Bcl-2 family members are key regulators of apoptosis. Their involvement in other cellular processes has been so far overlooked. We have studied the role of the…”
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Mitochondrial Bcl-xL promotes brain synaptogenesis by controlling non-lethal caspase activation by Nguyen, Trang Thi Minh, Gadet, Rudy, Lanfranchi, Marine, Lahaye, Romane A., Yandiev, Sozerko, Lohez, Olivier, Mikaelian, Ivan, Jabbour, Lea, Rimokh, Ruth, Courchet, Julien, Saudou, Frédéric, Popgeorgiev, Nikolay, Gillet, Germain

“…Non-lethal caspase activation (NLCA) has been linked to neurodevelopmental processes. However, how neurons control NLCA remains elusive. Here, we focused on…”
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Data-driven modeling of SRC control on the mitochondrial pathway of apoptosis: implication for anticancer therapy optimization by Ballesta, Annabelle, Lopez, Jonathan, Popgeorgiev, Nikolay, Gonzalo, Philippe, Doumic, Marie, Gillet, Germain

“…Src tyrosine kinases are deregulated in numerous cancers and may favor tumorigenesis and tumor progression. We previously described that Src activation in…”
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Keeping Cell Death Alive: An Introduction into the French Cell Death Research Network by Ichim, Gabriel, Gibert, Benjamin, Adriouch, Sahil, Brenner, Catherine, Davoust, Nathalie, Desagher, Solange, Devos, David, Dokudovskaya, Svetlana, Dubrez, Laurence, Estaquier, Jérôme, Gillet, Germain, Guénal, Isabelle, Juin, Philippe P., Kroemer, Guido, Legembre, Patrick, Levayer, Romain, Manon, Stéphen, Mehlen, Patrick, Meurette, Olivier, Micheau, Olivier, Mignotte, Bernard, Nguyen-Khac, Florence, Popgeorgiev, Nikolay, Poyet, Jean-Luc, Priault, Muriel, Ricci, Jean-Ehrland, Riquet, Franck B., Susin, Santos A., Suzanne, Magali, Vacher, Pierre, Walter, Ludivine, Mollereau, Bertrand

“…Since the Nobel Prize award more than twenty years ago for discovering the core apoptotic pathway in C. elegans, apoptosis and various other forms of regulated…”
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A novel assay for the detection of anti-human platelet antigen antibodies (HPA-1a) based on peptide aptamer technology by THIBAUT, Julien, MERIEUX, Yves, RIGAL, Dominique, GILLET, Germain

“…Neonatal alloimmune thrombocytopenia is mostly due to the presence of maternal antibodies against the fetal platelet antigen HPA-1a on the platelet integrin…”
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µ-Calpain conversion of antiapoptotic Bfl-1 (BCL2A1) into a prodeath factor reveals two distinct alpha-helices inducing mitochondria-mediated apoptosis by Valero, Juan García, Cornut-Thibaut, Aurélie, Jugé, Romain, Debaud, Anne-Laure, Giménez, Diana, Gillet, Germain, Bonnefoy-Bérard, Nathalie, Salgado, Jesús, Salles, Gilles, Aouacheria, Abdel, Kucharczak, Jérôme

“…Anti-apoptotic Bfl-1 and pro-apoptotic Bax, two members of the Bcl-2 family sharing a similar structural fold, are classically viewed as antagonist regulators…”
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Rounding of aggregates of biological cells: Experiments and simulations by Mombach, José C.M., Robert, Damien, Graner, François, Gillet, Germain, Thomas, Gilberto L., Idiart, Marco, Rieu, Jean-Paul

“…The influence of surface tension and size on rounding of cell aggregates is studied using chick embryonic cells and numerical simulations based on the cellular…”
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