Search Results - "GILLESPIE, K. M"

Validation of a frailty index in older cancer patients with solid tumours by McCarthy, A L, Peel, N M, Gillespie, K M, Berry, R, Walpole, E, Yates, P, Hubbard, R E

“…Frailty is an indicator of physiological reserve in older people. In non-cancer settings, frailty indices are reliable predictors of adverse health outcomes…”
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Diabetes and gender by GALE, E. A. M, GILLESPIE, K. M

“…It is often assumed that there is little or no sex bias within either Type I (insulin-dependent) or Type II (non-insulin-dependent) diabetes mellitus. This…”
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An association analysis of the HLA gene region in latent autoimmune diabetes in adults by DESAI, M, ZEGGINI, E, HOLMAN, R. R, MCCARTHY, M. I, CLARK, A, HORTON, V. A, OWEN, K. R, HATTERSLEY, A. T, LEVY, J. C, WALKER, M, GILLESPIE, K. M, BINGLEY, P. J, HITMAN, G. A

“…Pathophysiological similarities between latent autoimmune diabetes in adults (LADA) and type 1 diabetes indicate an overlap in genetic susceptibility. HLA-DRB1…”
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An increased frequency of NK cell receptor and HLA-C group 1 combinations in early-onset type 1 diabetes by Mehers, K. L., Long, A. E., van der Slik, A. R., Aitken, R. J., Nathwani, V., Wong, F. S., Bain, S., Gill, G., Roep, B. O., Bingley, P. J., Gillespie, K. M.

“…Aims/hypothesis Natural killer (NK) cells serve as primary immune surveillance and are partially regulated by combinations of killer immunoglobulin-like…”
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The interleukin-10-1082 G/A polymorphism: allele frequency in different populations and functional significance by Rees, L E N, Wood, N A P, Gillespie, K M, Lai, K N, Gaston, K, Mathieson, P W

“…Genotypic variation in the human interleukin-10 (IL-10) promoter may account for marked inter-individual variation in IL-10 production and may influence…”
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Autoantibodies to islet antigen-2 are associated with HLA-DRB107 and DRB109 haplotypes as well as DRB104 at onset of type 1 diabetes: the possible role of HLA-DQA in autoimmunity to IA-2 by Williams, A. J. K, Aitken, R. J, Chandler, M. A.-M, Gillespie, K. M, Lampasona, V, Bingley, P. J

“…Aims/hypothesis To further our understanding of antigen presentation by HLA class II molecules, we have examined the influence of HLA class II genotype on…”
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Sensory-processing sensitivity, parenting styles, and adult attachment patterns in parents of young children by Branjerdporn, G., Gillespie, K.M., Green, M., Strong, J., Meredith, P.

“…Increased sensitivity to internal and external stimuli, known as sensory-processing sensitivity (SPS), has been linked to attachment insecurity and less…”
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Estimating hedgerow length and pattern characteristics in Great Britain using Countryside Survey data by Barr, C.J, Gillespie, M.K

“…A chequer-board pattern of fields is characteristic of much of lowland Britain and other parts of western Europe. The field boundaries are often composed of…”
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A quarter of patients with type 1 diabetes have co‐existing non‐islet autoimmunity: the findings of a UK population‐based family study by Kozhakhmetova, A., Wyatt, R. C., Caygill, C., Williams, C., Long, A. E., Chandler, K., Aitken, R. J., Wenzlau, J. M., Davidson, H. W., Gillespie, K. M., Williams, A. J. K.

“…Summary Individuals with type 1 diabetes (T1D) are at increased risk of coeliac disease (CD), autoimmune thyroiditis and autoimmune gastritis, but the absolute…”
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Growth at elevated ozone or elevated carbon dioxide concentration alters antioxidant capacity and response to acute oxidative stress in soybean (Glycine max) by Gillespie, Kelly M, Rogers, Alistair, Ainsworth, Elizabeth A

“…Soybeans (Glycine max Merr.) were grown at elevated carbon dioxide concentration ([CO₂]) or chronic elevated ozone concentration ([O₃]; 90 ppb), and then…”
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Islet autoantibody profiles associated with higher diabetes risk in Lithuanian compared with English schoolchildren by Long, A. E., Caygill, C. H., Gillespie, K. M., Marčiulionytė, D., Williams, A. J. K.

“…This study used recently developed, more specific islet autoantibody tests, to characterise differences in humoral autoimmunity between two childhood general…”
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The longitudinal loss of islet autoantibody responses from diagnosis of type 1 diabetes occurs progressively over follow-up and is determined by low autoantibody titres, early-onset, and genetic variants by Williams, C L, Fareed, R, Mortimer, G L M, Aitken, R J, Wilson, I V, George, G, Gillespie, K M, Williams, A J K, Long, A E

“…The clinical usefulness of post-diagnosis islet autoantibody levels is unclear and factors that drive autoantibody persistence are poorly defined in type 1…”
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Levamisole induces interleukin‐18 and shifts type 1/type 2 cytokine balance by Szeto, C.‐C., Gillespie, K. M., Mathieson, P. W.

“…Immune responses can be classified, according to the predominant cytokines involved, into type 1 (featuring interferon-gamma, IFN-gamma) and type 2 (featuring…”
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Field boundaries in Great Britain: stock and change between 1984, 1990 and 1998 by Petit, S, Stuart, R.C, Gillespie, M.K, Barr, C.J

“…Field boundaries are man-made features found worldwide and their multiple functions in agricultural landscapes are now widely recognised. These landscape…”
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Diabetes in the parents of children with Type I diabetes by DOUEK, I. F, GILLESPIE, K. M, BINGLEY, P. J, GALE, E. A. M

“…Previous studies have reported an excess of Type II (non-insulin-dependent) diabetes mellitus in parents of children with Type I (insulin-dependent) diabetes…”
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The prevalence of insulin autoantibodies at the onset of Type 1 diabetes is higher in males than females during adolescence by WILLIAMS, A. J. K, NORCROSS, A. J, DIX, R. J, GILLESPIE, K. M, GALE, E. A. M, BINGLEY, P. J

“…The incidence of Type 1 diabetes shows little sex bias up to age 15 years, but more males are diagnosed in early adult life. Humoral responses to the beta cell…”
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The first 142 amino acids of glutamate decarboxylase do not contribute to epitopes recognized by autoantibodies associated with Type 1 diabetes by Wyatt, R. C., Brigatti, C., Liberati, D., Grace, S. L., Gillard, B. T., Long, A. E., Marzinotto, I., Shoemark, D. K., Chandler, K. A., Achenbach, P., Gillespie, K. M., Piemonti, L., Lampasona, V., Williams, A. J. K.

“…Aims Glutamate decarboxylase (GAD) antibodies are the most widely used predictive marker for Type 1 diabetes, but many individuals currently found to be GAD…”
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Progression to diabetes in relatives with islet autoantibodies. Is it inevitable? by GARDNER, S. G, GALE, E. A. M, WILLIAMS, A. J. K, GILLESPIE, K. M, LAWRENCE, K. E, BOTTAZZO, G. F, BINGLEY, P. J

“…Progression to diabetes in relatives with islet autoantibodies. Is it inevitable? S G Gardner , E A Gale , A J Williams , K M Gillespie , K E Lawrence , G F…”
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Type 1 diabetes: pathogenesis and prevention by Gillespie, Kathleen M

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Three generations of autoimmune diabetes: an extended family study by DOUEK, I. F, GILLESPIE, K. M, DIX, R. J, BINGLEY, P. J, GALE, E. A. M

“…One in four children with Type 1 diabetes in a population-based family study has an affected grandparent. We set out to study the clinical and immune features…”
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