Search Results - "GILLESPIE, J. S"

Selectivity of the multidrug resistance modulator, LY335979, for P-glycoprotein and effect on cytochrome P-450 activities by Dantzig, A H, Shepard, R L, Law, K L, Tabas, L, Pratt, S, Gillespie, J S, Binkley, S N, Kuhfeld, M T, Starling, J J, Wrighton, S A

“…Overexpression of ATP-dependent drug efflux pumps, P-glycoprotein (Pgp) or multidrug resistance-associated protein (MRP), confers multidrug resistance to tumor…”
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Three- and Four-Dimensional-Quantitative Structure Activity Relationship (3D/4D-QSAR) Analyses of CYP2C9 Inhibitors by EKINS, S, BRAVI, G, BINKLEY, S, GILLESPIE, J. S, RING, B. J, WIKEL, J. H, WRIGHTON, S. A

“…The interaction of competitive type inhibitors with the active site of cytochrome P450 (CYP) 2C9 has been predicted using three- and four-dimensional…”
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The effects of L‐arginine and NG‐monomethyl L‐arginine on the response of the rat anococcygeus muscle to NANC nerve stimulation by Gillespie, John S., Liu, Xiaorong, Martin, William

“…The effect of the competitive inhibitor of L‐arginine, NG‐monomethyl L‐arginine (L‐NMMA) on the response of the rat anococcygeus muscle to non‐adrenergic,…”
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Ferroelectric non-volatile memories for low-voltage, low-power applications by Jones, R.E., Maniar, P.D., Moazzami, R., Zurcher, P., Witowski, J.Z., Lii, Y.T., Chu, P., Gillespie, S.J.

“…Non-volatile ferroelectric random access memories (FERAM) offer substantial advantages over conventional floating-gate electrically erasable programmable read…”
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Identification of the human cytochromes p450 responsible for in vitro formation of R- and S-norfluoxetine by Ring, B J, Eckstein, J A, Gillespie, J S, Binkley, S N, VandenBranden, M, Wrighton, S A

“…The formation of R- and S-norfluoxetine was analyzed in vitro in human liver microsomes. Low apparent K(m) values for R-norfluoxetine formation of < or =8…”
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PNEUMOBILIA VERSUS PORTAL VENOUS GAS IN BLUNT ABDOMINAL TRAUMA by McGarry, K, McGrogan, D, Gillespie, JS, Clements, B

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The effects of pyrogallol and hydroquinone on the response to NANC nerve stimulation in the rat anococcygeus and the bovine retractor penis muscles by Gillespie, John S., Sheng, Hong

“…1 The effects of pyrogallol and hydroquinone on the bovine retractor penis (BRP) and rat anococcygeus muscles to non‐adrenergic, non‐cholinergic (NANC) nerve…”
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Alterations of the Catalytic Activities of Drug-Metabolizing Enzymes in Cultures of Human Liver Slices by VANDENBRANDEN, M, WRIGHTON, S. A, EKINS, S, GILLESPIE, J. S, BINKLEY, S. N, RING, B. J, GADBERRY, M. G, MULLINS, D. C, STROM, S. C, JENSEN, C. B

“…Precision-cut human liver slices are an important tool for defining the metabolism and hepatotoxicity of drug candidates early in development. Because of the…”
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Influence of haemoglobin and erythrocytes on the effects of EDRF, a smooth muscle inhibitory factor, and nitric oxide on vascular and non‐vascular smooth muscle by Gillespie, John S., Sheng, Hong

“…1 The relaxant action of endothelium‐derived relaxing factor (EDRF), the smooth muscle inhibitory factor (IF) isolated from the bovine retractor penis (BRP),…”
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Non‐adrenergic, non‐cholinergic relaxation of the bovine retractor penis muscle: role of S‐nitrosothiols by Liu, Xiaorong, Gillespie, John S., Martin, William

“…1 This study examined the possibility that an S‐nitrosothiol, rather than nitric oxide, functions as the non‐adrenergic, non‐cholinergic (NANC) inhibitory…”
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Bilateral traumatic caroticocavernous fistulae : total resolution following unilateral occlusion by KAMEL, H. A. M, CHOUDHARI, K. A, GILLESPIE, J. S. J

“…Balloon occlusion is the accepted treatment for direct posttraumatic caroticocavernous fistula. We present a case of bilateral traumatic fistulae associated…”
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Familial idiopathic methemoglobinemia revisited: original cases reveal 2 novel mutations in NADH-cytochrome b5 reductase by Percy, Melanie J., Gillespie, Matthew J.S., Savage, Geraldine, Hughes, Anne E., McMullin, Mary Frances, Lappin, Terry R.J.

“…In 1943, the first description of familial idiopathic methemoglobinemia in the United Kingdom was reported in 2 members of one family. Five years later,…”
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The rat anococcygeus muscle and its response to nerve stimulation and to some drugs by GILLESPIE, J. S.

“…Summary 1 . A new smooth muscle preparation, the rat anococcygeus muscle, is described. The muscle is paired, thin, consists of smooth muscle only and the…”
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Memory applications based on ferroelectric and high-permittivity dielectric thin films by Jones, R.E., Zurcher, P., Chu, P., Taylor, D.J., Lii, Y.T., Jiang, B., Maniar, P.D., Gillespie, S.J.

“…Several metal oxide perovskites and Bi layered perovskites are of substantial interest for integrated circuit memories. Strontium titanate, barium strontium…”
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A comparison of haemoglobin and erythrocytes as inhibitors of smooth muscle relaxation by the NANC transmitter in the BRP and rat anococcygeus and by EDRF in the rabbit aortic strip by Gillespie, John S., Sheng, Hong

“…1 The inhibitory effect of erythrocyte suspensions and haemoglobin solutions on the response of the bovine retractor penis muscle (BRP) and the rat…”
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The rat anococcygeus muscle and its response to nerve stimulation and to some drugs by GILLESPIE, J. S.

“…Summary 1 A new smooth muscle preparation, the rat anococcygeus muscle, is described. The muscle is paired, thin, consists of smooth muscle only and the muscle…”
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Three- and four-dimensional quantitative structure activity relationship analyses of cytochrome P-450 3A4 inhibitors by Ekins, S, Bravi, G, Binkley, S, Gillespie, J S, Ring, B J, Wikel, J H, Wrighton, S A

“…The program Catalyst was used to build three-dimensional quantitative structure activity relationship (3D-QSAR) pharmacophore models of the structural features…”
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The lack of involvement of cyclic nucleotides in the smooth muscle relaxant action of BRL 34915 by Gillespie, John S., Sheng, Hong

“…1 The relaxant effect of BRL 34915 has been examined on four isolated preparations, the bovine retractor penis (BRP), guinea‐pig taenia coli, guinea‐pig…”
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Further characterization of the expression in liver and catalytic activity of CYP2B6 by Ekins, S, Vandenbranden, M, Ring, B J, Gillespie, J S, Yang, T J, Gelboin, H V, Wrighton, S A

“…Previous studies in this laboratory have determined the lack of specificity of several antibody and substrate probes of CYP2B6. The goals of the current study…”
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Using Carbohydrate Counting in Diabetes Clinical Practice by GILLESPIE, SANDRA J, KULKARNI, KARMEEN D, DALY, ANNE E

“…Carbohydrate counting is a meal planning approach used with clients who have diabetes that focuses on carbohydrate as the primary nutrient affecting…”
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