Search Results - "GILL, Steven S"

Randomized trial of intermittent intraputamenal glial cell line-derived neurotrophic factor in Parkinson's disease by Whone, Alan, Luz, Matthias, Boca, Mihaela, Woolley, Max, Mooney, Lucy, Dharia, Sonali, Broadfoot, Jack, Cronin, David, Schroers, Christian, Barua, Neil U, Longpre, Lara, Barclay, C Lynn, Boiko, Chris, Johnson, Greg A, Fibiger, H Christian, Harrison, Rob, Lewis, Owen, Pritchard, Gemma, Howell, Mike, Irving, Charlie, Johnson, David, Kinch, Suk, Marshall, Christopher, Lawrence, Andrew D, Blinder, Stephan, Sossi, Vesna, Stoessl, A Jon, Skinner, Paul, Mohr, Erich, Gill, Steven S

“…Trials of GDNF in Parkinson's disease have yielded inconsistent results. In a randomised controlled trial, Whone et al. administer GDNF using a paradigm…”
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Convection-Enhanced Drug Delivery to the Brain: Therapeutic Potential and Neuropathological Considerations by Barua, Neil U., Gill, Steven S., Love, Seth

“…Convection‐enhanced delivery (CED) describes a direct method of drug delivery to the brain through intraparenchymal microcatheters. By establishing a pressure…”
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Bilateral deep brain stimulation of the pedunculopontine nucleus for Parkinsonʼs disease by Plaha, Puneet, Gill, Steven S

“…Gait disturbance and postural instability are some the most disabling symptoms of idiopathic Parkinsonʼs disease and in late stage disease can be resistant to…”
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Convection-Enhanced Delivery of Carboplatin PLGA Nanoparticles for the Treatment of Glioblastoma by Arshad, Azeem, Yang, Bin, Bienemann, Alison S, Barua, Neil U, Wyatt, Marcella J, Woolley, Max, Johnson, Dave E, Edler, Karen J, Gill, Steven S

“…We currently use Convection-Enhanced Delivery (CED) of the platinum-based drug, carboplatin as a novel treatment strategy for high grade glioblastoma in adults…”
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Chronic, intermittent convection-enhanced delivery devices by Lewis, Owen, Woolley, Max, Johnson, David, Rosser, Anne, Barua, Neil U., Bienemann, Alison S., Gill, Steven S., Evans, Sam

“…•State of the art review of catheter designs for convection-enhanced delivery.•Analysis of the design features, materials and methods of use which could be…”
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Intraputamenal infusion of glial cell line-derived neurotrophic factor in PD: A two-year outcome study by Patel, Nikunj K., Bunnage, Martin, Plaha, Puneet, Svendsen, Clive N., Heywood, Peter, Gill, Steven S.

“…We have shown previously that intraparenchymal infusion of glial cell line–derived neurotrophic factor (GDNF) continuously into the posterior putamen in five…”
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Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease by Gill, Steven S, Svendsen, Clive N, Patel, Nikunj K, Hotton, Gary R, O'Sullivan, Karen, McCarter, Renée, Bunnage, Martin, Brooks, David J, Heywood, Peter

“…Glial cell line-derived neurotrophic factor (GDNF) is a potent neurotrophic factor with restorative effects in a wide variety of rodent and primate models of…”
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Repurposing the anti-epileptic drug sodium valproate as an adjuvant treatment for diffuse intrinsic pontine glioma by Killick-Cole, Clare L, Singleton, William G B, Bienemann, Alison S, Asby, Daniel J, Wyatt, Marcella J, Boulter, Lisa J, Barua, Neil U, Gill, Steven S

“…Targeting epigenetic changes in diffuse intrinsic pontine glioma (DIPG) may provide a novel treatment option for patients. This report demonstrates that sodium…”
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Multifunctional receptor-targeted nanocomplexes for the delivery of therapeutic nucleic acids to the Brain by Kenny, Gavin D, Bienemann, Alison S, Tagalakis, Aristides D, Pugh, John A, Welser, Katharina, Campbell, Frederick, Tabor, Alethea B, Hailes, Helen C, Gill, Steven S, Lythgoe, Mark F, McLeod, Cameron W, White, Edward A, Hart, Stephen L

“…Abstract Convection enhanced delivery (CED) is a method of direct injection to the brain that can achieve widespread dispersal of therapeutics, including gene…”
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Stimulation of the subthalamic region for essential tremor by PLAHA, Puneet, PATEL, Nikunj K, GILL, Steven S

“…The goal of this study was to determine the safety and efficacy of bilateral subthalamic region stimulation in the treatment of essential tremor (ET)…”
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Intrastriatal convection-enhanced delivery results in widespread perivascular distribution in a pre-clinical model by Barua, Neil U, Bienemann, Alison S, Hesketh, Shirley, Wyatt, Marcella J, Castrique, Emma, Love, Seth, Gill, Steven S

“…Convection-enhanced delivery (CED), a direct method for drug delivery to the brain through intraparenchymal microcatheters, is a promising strategy for…”
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The new frenchay artificial cervical joint: Results from a two-year pilot study by WIGFIELD, Crispin C, GILL, Steven S, NELSON, Richard J, METCALF, Newton H, ROBERTSON, James T

“…A clinical prospective observational cohort study of 15 patients undergoing cervical intervertebral disc replacement. To assess the safety, clinical stability,…”
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Stimulation of the caudal zona incerta is superior to stimulation of the subthalamic nucleus in improving contralateral parkinsonism by Plaha, Puneet, Ben-Shlomo, Y., Patel, Nikunj K., Gill, Steven S.

“…Deep brain stimulation (DBS) has an increasing role in the treatment of idiopathic Parkinson's disease. Although, the subthalamic nucleus (STN) is the commonly…”
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Clinical Outcome of “Asleep” Deep Brain Stimulation for Parkinson Disease Using Robot-Assisted Delivery and Anatomic Targeting of the Subthalamic Nucleus: A Series of 152 Patients by Moran, Catherine H, Pietrzyk, Mariusz, Sarangmat, Nagaraja, Gerard, Carter S, Barua, Neil, Ashida, Reiko, Whone, Alan, Szewczyk-Krolikowski, Konrad, Mooney, Lucy, Gill, Steven S

“…ABSTRACT BACKGROUND Recent advances in methods used for deep brain stimulation (DBS) include subthalamic nucleus electrode implantation in the “asleep” patient…”
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Clinical Outcome of “Asleep” Deep Brain Stimulation for Parkinson Disease Using Robot-Assisted Delivery and Anatomic Targeting of the Subthalamic Nucleus: A Series of 152 Patients by Moran, Catherine H, Pietrzyk, Mariusz, Sarangmat, Nagaraja, Gerard, Carter S, Barua, Neil, Ashida, Reiko, Whone, Alan, Szewczyk-Krolikowski, Konrad, Mooney, Lucy, Gill, Steven S

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Benefits of putaminal GDNF infusion in Parkinson disease are maintained after GDNF cessation by Patel, Nikunj K., Pavese, Nicola, Javed, Shazia, Hotton, Gary R., Brooks, David J., Gill, Steven S.

“…We previously reported clinical improvement, increase in putamen [(18)F]-dopa uptake on PET imaging, and neuropathologic evidence of sprouting of dopaminergic…”
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Extended Treatment with Glial Cell Line-Derived Neurotrophic Factor in Parkinson's Disease by Whone, Alan L, Boca, Mihaela, Luz, Matthias, Woolley, Max, Mooney, Lucy, Dharia, Sonali, Broadfoot, Jack, Cronin, David, Schroers, Christian, Barua, Neil U, Longpre, Lara, Barclay, C Lynn, Boiko, Chris, Johnson, Greg A, Fibiger, H Christian, Harrison, Rob, Lewis, Owen, Pritchard, Gemma, Howell, Mike, Irving, Charlie, Johnson, David, Kinch, Suk, Marshall, Christopher, Lawrence, Andrew D, Blinder, Stephan, Sossi, Vesna, Stoessl, A Jon, Skinner, Paul, Mohr, Erich, Gill, Steven S

“…Intraputamenal glial cell line-derived neurotrophic factor (GDNF), administered every 4 weeks to patients with moderately advanced Parkinson's disease, did not…”
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The distribution, clearance, and brainstem toxicity of panobinostat administered by convection-enhanced delivery by Singleton, William G B, Bienemann, Alison S, Woolley, Max, Johnson, David, Lewis, Owen, Wyatt, Marcella J, Damment, Stephen J P, Boulter, Lisa J, Killick-Cole, Clare L, Asby, Daniel J, Gill, Steven S

“…OBJECTIVE The pan-histone deacetylase inhibitor panobinostat has preclinical efficacy against diffuse intrinsic pontine glioma (DIPG), and the oral formulation…”
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Maximising coverage of brain structures using controlled reflux, convection-enhanced delivery and the recessed step catheter by Lewis, Owen, Woolley, Max, Johnson, David E., Fletcher, Julia, Fenech, Johnathan, Pietrzyk, Mariusz W., Barua, Neil U., Bienemann, Alison S., Singleton, Will, Evans, Sam L., Gill, Steven S.

“…•The recessed step CED catheter can be used to optimise infusions in neurodegenerative or neuro-oncological indications.•The variable step length can be used…”
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Magnetic resonance imaging-directed method for functional neurosurgery using implantable guide tubes by Patel, Nikunj K, Plaha, Puneet, Gill, Steven S

“…We present a magnetic resonance imaging-directed stereotactic system using implantable guide tubes for targeting deep brain nuclei in functional neurosurgery…”
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