Search Results - "GILCHREST, Helen"
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Identification and characterization of splice variants of the human P2X7 ATP channel
Published in Biochemical and biophysical research communications (24-06-2005)“…The P2X7 channel is a member of the P2X family of ligand-gated ion channels which respond to ATP as the endogenous agonist. Studies suggest that P2X7 has a…”
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Biochemical characterization of desloratadine, a potent antagonist of the human histamine H1 receptor
Published in European journal of pharmacology (01-08-2002)Get full text
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Biochemical characterization of desloratadine, a potent antagonist of the human histamine H 1 receptor
Published in European journal of pharmacology (09-08-2002)“…We have characterized desloratadine (5 H-benzo[5,6]cyclohepta[1,2- b]pyridine, 8-chloro-6,11-dihydro-11-(4-piperidinylidene), CAS 100643-71-8) as a potent…”
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Differential plasma duration of antiplatelet-activating factor and antihistamine activities of oral Sch 37370 in humans
Published in Clinical pharmacology and therapeutics (01-08-1992)“…Preclinical studies have established that Sch 37370 (1-acetyl-4-(8-chloro-5,6-dihydro-11H-benzo[5,6]-cyclohepta [1,2-b]pyridin-11-ylidene)piperidine) is an…”
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Identification and characterization of splice variants of the human P2X 7 ATP channel
Published in Biochemical and biophysical research communications (2005)“…The P2X7 channel is a member of the P2X family of ligand-gated ion channels which respond to ATP as the endogenous agonist. Studies suggest that P2X7 has a…”
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Human cord blood-derived mast cells synthesize and release I-309 in response to IgE
Published in Life sciences (1973) (03-10-2003)“…Mast cells are the central mediating cells of allergic reactions. Binding of allergen specific IgE to high affinity IgE receptor (FcεRI) and subsequent binding…”
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Biochemical characterization of desloratadine, a potent antagonist of the human histamine H(1) receptor
Published in European journal of pharmacology (09-08-2002)“…We have characterized desloratadine (5H-benzo[5,6]cyclohepta[1,2-b]pyridine, 8-chloro-6,11-dihydro-11-(4-piperidinylidene), CAS 100643-71-8) as a potent…”
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Determination of plasma concentrations of SCH 44643 by a GC method and correlation of plasma concentration and anti-PAF activity in cynomolgus monkeys
Published in Journal of pharmaceutical and biomedical analysis (01-12-1996)“…Inhibiting the action of platelet-activating factor (PAF) is a new therapeutic approach for the treatment of allergic disorders. SCH 44643 is a new…”
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Effect of anti-inflammatory drugs on lysosomes and lysosomal enzymes from rat liver
Published in Biochemical pharmacology (01-10-1976)Get more information
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Edema formation and neutrophil mobilization in the neutropenic rat
Published in Agents and Actions (01-12-1977)“…The relationship between leucocyte mobilization and edema formation was evaluated in the carrageenan pleurisy model. In normal rats carrageenan was able to…”
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