Search Results - "GILBERT, Susan"

Propofol attenuates kinesin-mediated axonal vesicle transport and fusion by Frank, Madeline, Nabb, Alec T, Gilbert, Susan P, Bentley, Marvin

“…Propofol is a widely used general anesthetic, yet the understanding of its cellular effects is fragmentary. General anesthetics are not as innocuous as once…”
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KAP is the neuronal organelle adaptor for Kinesin-2 KIF3AB and KIF3AC by Garbouchian, Alex, Montgomery, Andrew C, Gilbert, Susan P, Bentley, Marvin

“…Kinesin-driven organelle transport is crucial for neuron development and maintenance, yet the mechanisms by which kinesins specifically bind their organelle…”
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Kinesin-2 motors: Kinetics and biophysics by Gilbert, Susan P., Guzik-Lendrum, Stephanie, Rayment, Ivan

“…Kinesin-2s are major transporters of cellular cargoes. This subfamily contains both homodimeric kinesins whose catalytic domains result from the same gene…”
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Mechanistic basis of propofol-induced disruption of kinesin processivity by Dutta, Mandira, Gilbert, Susan P., Onuchic, José N., Jana, Biman

“…Propofol is a widely used general anesthetic to induce and maintain anesthesia, and its effects are thought to occur through impact on the ligand-gated…”
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Fast or Slow, Either Head Can Start the Processive Run of Kinesin-2 KIF3AC by Zhang, Pengwei, Rayment, Ivan, Gilbert, Susan P.

“…Mammalian KIF3AC contains two distinct motor polypeptides and is best known for its role in organelle transport in neurons. Our recent studies showed that…”
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KIF3A accelerates KIF3C within the kinesin-2 heterodimer to generate symmetrical phosphate release rates for each processive step by Quinn, Sean M., Vargason, Troy, Pokhrel, Nilisha, Antony, Edwin, Hahn, Juergen, Gilbert, Susan P.

“…Heterodimeric KIF3AC is a mammalian kinesin-2 that is highly expressed in the central nervous system and associated with vesicles in neurons. KIF3AC is an…”
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Homodimeric Kinesin-2 KIF3CC Promotes Microtubule Dynamics by Guzik-Lendrum, Stephanie, Rayment, Ivan, Gilbert, Susan P.

“…KIF3C is one subunit of the functional microtubule-based kinesin-2 KIF3AC motor, an anterograde cargo transporter in neurons. However, KIF3C has also been…”
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Kinesin-2 KIF3AC and KIF3AB Can Drive Long-Range Transport along Microtubules by Guzik-Lendrum, Stephanie, Rank, Katherine C., Bensel, Brandon M., Taylor, Keenan C., Rayment, Ivan, Gilbert, Susan P.

“…Mammalian KIF3AC is classified as a heterotrimeric kinesin-2 that is best known for organelle transport in neurons, yet in vitro studies to characterize its…”
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The ability of the kinesin-2 heterodimer KIF3AC to navigate microtubule networks is provided by the KIF3A motor domain by Deeb, Stephanie K., Guzik-Lendrum, Stephanie, Jeffrey, Jasper D., Gilbert, Susan P.

“…Heterodimeric kinesin family member KIF3AC is a mammalian kinesin-2 that is highly expressed in the central nervous system and has been implicated in…”
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Kinesin-2 heterodimerization alters entry into a processive run along the microtubule but not stepping within the run by Quinn, Sean M., Howsmon, Daniel P., Hahn, Juergen, Gilbert, Susan P.

“…Heterodimeric KIF3AC and KIF3AB, two members of the mammalian kinesin-2 family, generate force for microtubule plus end–directed cargo transport. However, the…”
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The mechanochemistry of the kinesin-2 KIF3AC heterodimer is related to strain-dependent kinetic properties of KIF3A and KIF3C by Bensel, Brandon M., Woody, Michael S., Pyrpassopoulos, Serapion, Goldman, Yale E., Gilbert, Susan P., Ostap, E. Michael

“…KIF3AC is a mammalian neuron-specific kinesin-2 implicated in intracellular cargo transport. It is a heterodimer of KIF3A and KIF3C motor polypeptides which…”
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Family-specific Kinesin Structures Reveal Neck-linker Length Based on Initiation of the Coiled-coil by Phillips, Rebecca K., Peter, Logan G., Gilbert, Susan P., Rayment, Ivan

“…Kinesin-1, -2, -5, and -7 generate processive hand-over-hand 8-nm steps to transport intracellular cargoes toward the microtubule plus end. This processive…”
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Using social return on investment analysis to calculate the social impact of modified vehicles for people with disability by Hutchinson, Claire, Berndt, Angela, Cleland, Jenny, Gilbert‐Hunt, Susan, George, Stacey, Ratcliffe, Julie

“…Introduction Returning to driving is often a goal for people with acquired disabilities. Vehicle modifications make it possible for people with both acquired…”
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Assessment of anxiety in children with neurodevelopment disorders: Rasch analysis of the Spence Children's Anxiety Scale by Sparks, Alana, Gilbert Evans, Susan, Javadi, Mojib, Lasalandra, Bianca, Martens, Emily, Venkatesh, Raadhika, Vaccarino, Izzy T, Vaccarino, Anthony L

“…Anxiety is common in neurodevelopmental disorders (NDD). The parent version of the Spence Children's Anxiety Scale (SCAS-P) is a widely used measure to assess…”
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Sylvia Rodger's contribution to a dynamic and diverse curriculum and education evidence base by Gilbert Hunt, Susan

“…Occupational therapy academics have witnessed significant changes over the past thirty years. Education has moved from an apprenticeship training and education…”
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Common general anesthetic propofol impairs kinesin processivity by Bensel, Brandon M., Guzik-Lendrum, Stephanie, Masucci, Erin M., Woll, Kellie A., Eckenhoff, Roderic G., Gilbert, Susan P.

“…Propofol is the most widely used i.v. general anesthetic to induce and maintain anesthesia. It is now recognized that this small molecule influences…”
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Heterodimerization of Kinesin-2 KIF3AB Modulates Entry into the Processive Run by Albracht, Clayton D., Guzik-Lendrum, Stephanie, Rayment, Ivan, Gilbert, Susan P.

“…Mammalian KIF3AB is an N-terminal processive kinesin-2 that is best known for its roles in intracellular transport. There has been significant interest in…”
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Drosophila Ncd reveals an evolutionarily conserved powerstroke mechanism for homodimeric and heterodimeric kinesin-14s by Zhang, Pengwei, Dai, Wei, Hahn, Juergen, Gilbert, Susan P

“…Significance Kinesin molecular motors couple ATP turnover to force production to generate microtubule-based movement and microtubule dynamics. Kinesin-14s are…”
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The Biological Passport by GILBERT, SUSAN

“…Another loophole is that banned substances, for a variety of reasons, are sometimes impossible to detect: they can be designed to elude specific tests, new…”
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Individual dimers of the mitotic kinesin motor Eg5 step processively and support substantial loads in vitro by Block, Steven M, Valentine, Megan T, Fordyce, Polly M, Krzysiak, Troy C, Gilbert, Susan P

“…Eg5, a member of the kinesin superfamily of microtubule-based motors, is essential for bipolar spindle assembly and maintenance during mitosis, yet little is…”
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