Search Results - "GIEGERICH, G"

Differentiation between cellular apoptosis and necrosis by the combined use of in situ tailing and nick translation techniques by Gold, R, Schmied, M, Giegerich, G, Breitschopf, H, Hartung, H P, Toyka, K V, Lassmann, H

“…A number of enzymatic techniques have recently been developed to detect DNA fragmentation in apoptosis at the cellular level. However, since DNA fragmentation…”
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Targeting fibroblast growth factor-inducible-14 signaling protects from chronic relapsing experimental autoimmune encephalomyelitis by Mueller, A.M., Pedré, X., Kleiter, I., Hornberg, M., Steinbrecher, A., Giegerich, G.

“…The TNF-related weak inducer of apoptosis (TWEAK) is a TNF family member mediating proinflammatory effects by its receptor fibroblast growth…”
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Myelin Autoreactivity in Multiple Sclerosis: Recognition of Myelin Basic Protein in the Context of HLA-DR2 Products by T Lymphocytes of Multiple- Sclerosis Patients and Healthy Donors by Pette, Martin, Fujita, Kyoko, Wilkinson, David, Altmann, Daniel M., Trowsdale, John, Giegerich, Gerhard, Hinkkanen, Ari, Epplen, Jorg T., Kappos, Ludgwig, Wekerle, Hartmut

“…A panel of 20 human myelin basic protein (hMBP)-specific T-lymphocyte lines was generated from the peripheral blood of eight multiple sclerosis (MS) patients…”
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Heterogeneity of T-cell receptor usage in experimental autoimmune neuritis in the Lewis rat by Stienekemeier, M., Herrmann, T., Kruse, N., Weishaupt, A., Weilbach, F. X., Giegerich, G., Theofilopoulos, A., Jung, S., Gold, R.

“…In experimental autoimmune neuritis (EAN), T-cell receptor (TCR) variable (V)-region gene usage by neuritogenic T cells has been reported to be clonally…”
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Diversity of T cell receptor alpha and beta chain genes expressed by human T cells specific for similar myelin basic protein peptide/major histocompatibility complexes by Giegerich, G, Pette, M, Meinl, E, Epplen, J T, Wekerle, H, Hinkkanen, A

“…T cell receptor (TcR) alpha and beta nucleotide sequences involved in the human autoreactivity to myelin basic protein (MBP) were studied by screening cDNA…”
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T-cell receptor V β-element expression in peripheral nerves of Lewis rats suffering from experimental autoimmune neuritis by Weilbach, F.X., Jung, S., Hartung, H.-P., Toyka, K.V., Giegerich, G.

“…In experimental autoimmune neuritis (EAN), peripheral nerves are infiltrated by T-lymphocytes and macrophages. By RT-PCR and sequence analysis we characterized…”
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T-cell receptor (TCR) usage in Lewis rat experimental autoimmune encephalomyelitis: TCR beta-chain-variable-region V beta 8.2-positive T cells are not essential for induction and course of disease by Gold, R, Giegerich, G, Hartung, H P, Toyka, K V

“…Predominant usage of V beta 8.2 gene segments, encoding a T-cell receptor (TCR) beta chain variable region, has been reported for pathogenic Lewis rat T cells…”
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T cell antigenic and neuritogenic activity of recombinant human peripheral myelin P2 protein by Weishaupt, A., Giegerich, G., Jung, S., Gold, R., Enders, U., Pette, M., Hayasaka, K., Hartung, H.-P., Toyka, K.V.

“…The major neuritogenic protein of peripheral nerve myelin is the P2 protein. Human P2 is a candidate autoantigen in inflammatory demyelinating diseases of the…”
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Human T lymphocytes distinguish bovine from human P2 peripheral myelin protein: implications for immunological studies on inflammatory demyelinating neuropathies by Pette, M, Gengaroli, C, Hartung, H P, Greiner, A, Giegerich, G, Toyka, K V

“…In patients with inflammatory demyelinating neuropathy, which is possibly mediated by autoreactive, myelin-specific T lymphocytes, most studies focusing on…”
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Restricted expression of CD2 among subsets of sheep thymocytes and T lymphocytes by GIEGERICH, G. W, HEIN, W. R, MIYASAKA, M, TIEFENTHALER, G, HÜNIG, T

“…A monoclonal antibody (mAb) generated against sheep T-cell blasts, called I/35 A, blocks sheep autologous E rosetting and competes with purified T11 target…”
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Bacterial expression of a soluble T-cell receptor alpha chain by Stangel, M, Toyka, K V, Hartung, H P, Giegerich, G

“…A bacterial expression system was used to express the complete extracellular domain of a rat T-cell receptor alpha-chain, including variable-, joining and…”
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Structural analysis of the rat T-cell receptor Tcra V4 gene family by Stangel, M, Giegerich, G, Torres-Nagel, N E, Hünig, T, Hartung, H P

“…The rat Tcra V gene locus is only poorly characterized, although rats are widely used in a variety of T-cell-mediated experimental animal models. Recently, we…”
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CD137 is expressed by follicular dendritic cells and costimulates B lymphocyte activation in germinal centers by Pauly, Susanne, Broll, Karin, Wittmann, Margarethe, Giegerich, Gerhard, Schwarz, Herbert

“…CD137, a member of the TNF receptor family, and its ligand are expressed on T lymphocytes and antigen‐presenting cells (APC), respectively. During interaction…”
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Inhibition of Smad7, a negative regulator of TGF-beta signaling, suppresses autoimmune encephalomyelitis by Kleiter, Ingo, Pedré, Xiomara, Mueller, André M, Poeschl, Peter, Couillard-Despres, Sebastien, Spruss, Thilo, Bogdahn, Ulrich, Giegerich, Gerhard, Steinbrecher, Andreas

“…Abstract We studied the role of the Transforming growth factor (TGF)-β signaling antagonist Smad7 in autoimmune central nervous system (CNS) inflammation by…”
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Experimental Autoimmune Encephalomyelitis in the Rat Spinal Cord: Lesion Detection with High-Resolution MR Microscopy at 17.6 T by Steinbrecher, Andreas, Weber, Thomas, Neuberger, Thomas, Mueller, Andre M, Pedre, Xiomara, Giegerich, Gerhard, Bogdahn, Ulrich, Jakob, Peter, Haase, Axel, Faber, Cornelius

“…Experimental autoimmune encephalomyelitis (EAE) is an inflammatory demyelinating disorder of the CNS and an animal model of multiple sclerosis. We used…”
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Myelin basic protein-specific T lymphocyte repertoire in multiple sclerosis : complexity of the response and dominance of nested epitopes due to recruitment of multiple T cell clones by MEINL, E, WEBER, F, SCHÖNBECK, S, BANNWARTH, W, WEKERLE, H, HOHLFELD, R, DREXLER, K, MORELLE, C, OTT, M, SARUHAN-DIRESKENELI, G, GOEBELS, N, ERTI, B, JECHART, G, GIEGERICH, G

“…The human T cell response to the myelin basic protein (MBP) has been studied with respect to T cell receptor (TCR) usage, HLA class II restriction elements,…”
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The two in situ techniques do not differentiate between apoptosis and necrosis but rather reveal distinct patterns of DNA fragmentation in apoptosis by Mundle, S D, Raza, A

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Autoreactive T-cells in Goodpasture's syndrome recognize the N-terminal NC1 domain on alpha 3 type IV collagen by Merkel, F, Kalluri, R, Marx, M, Enders, U, Stevanovic, S, Giegerich, G, Neilson, E G, Rammensee, H G, Hudson, B G, Weber, M

“…Goodpasture's syndrome is mediated by immunopathogenic autoantibodies to the alpha 3 NC1 domain of type IV collagen. It is not known whether collaborating…”
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Rapid method based on reversed-phase high-performance liquid chromatography for purification of human myelin basic protein and its thrombic and endoproteinase Lys-C peptides by Giegerich, G, Pette, M, Fujita, K, Wekerle, H, Epplen, J T, Hinkkanen, A

“…Reversed-phase high-performance liquid chromatography was applied to isolate myelin basic protein from human brain, followed by separation of proteolytic…”
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Autoreactive T-cells in Goodpasture's syndrome recognize the N-terminal NC1 domain on α3 type IV collagen by Merkel, Frank, Kalluri, Raghuram, Marx, Martin, Enders, Uwe, Stevanovic, Stefan, Giegerich, Gerhard, Neilson, Eric G., Rammensee, Hans-G, Hudson, Billy G., Weber, Manfred

“…Autoreactive T-cells in Goodpasture's syndrome recognize the N-terminal NC1 domain on α3 type IV collagen. Goodpasture's syndrome is mediated by…”
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