Search Results - "GIEDZINSKI, Erich"

Elimination of microglia improves cognitive function following cranial irradiation by Acharya, Munjal M., Green, Kim N., Allen, Barrett D., Najafi, Allison R., Syage, Amber, Minasyan, Harutyun, Le, Mi T., Kawashita, Takumi, Giedzinski, Erich, Parihar, Vipan K., West, Brian L., Baulch, Janet E., Limoli, Charles L.

“…Cranial irradiation for the treatment of brain cancer elicits progressive and severe cognitive dysfunction that is associated with significant neuropathology…”
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Cosmic radiation exposure and persistent cognitive dysfunction by Parihar, Vipan K., Allen, Barrett D., Caressi, Chongshan, Kwok, Stephanie, Chu, Esther, Tran, Katherine K., Chmielewski, Nicole N., Giedzinski, Erich, Acharya, Munjal M., Britten, Richard A., Baulch, Janet E., Limoli, Charles L.

“…The Mars mission will result in an inevitable exposure to cosmic radiation that has been shown to cause cognitive impairments in rodent models, and possibly in…”
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Glia-Selective Deletion of Complement C1q Prevents Radiation-Induced Cognitive Deficits and Neuroinflammation by Markarian, Mineh, Krattli, Jr, Robert P, Baddour, Jabra D, Alikhani, Leila, Giedzinski, Erich, Usmani, Manal T, Agrawal, Anshu, Baulch, Janet E, Tenner, Andrea J, Acharya, Munjal M

“…The adverse neurocognitive sequelae following clinical radiotherapy (RT) for central nervous system (CNS) malignancies are often long-lasting without any…”
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Neuroprotection of Radiosensitive Juvenile Mice by Ultra-High Dose Rate FLASH Irradiation by Alaghband, Yasaman, Cheeks, Samantha N, Allen, Barrett D, Montay-Gruel, Pierre, Doan, Ngoc-Lien, Petit, Benoit, Jorge, Patrik Goncalves, Giedzinski, Erich, Acharya, Munjal M, Vozenin, Marie-Catherine, Limoli, Charles L

“…Major advances in high precision treatment delivery and imaging have greatly improved the tolerance of radiotherapy (RT); however, the selective sparing of…”
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Human neural stem cell-derived extracellular vesicles mitigate hallmarks of Alzheimer's disease by Apodaca, Lauren A, Baddour, Al Anoud D, Garcia, Jr, Camilo, Alikhani, Leila, Giedzinski, Erich, Ru, Ning, Agrawal, Anshu, Acharya, Munjal M, Baulch, Janet E

“…Regenerative therapies to mitigate Alzheimer's disease (AD) neuropathology have shown very limited success. In the recent era, extracellular vesicles (EVs)…”
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Cranial grafting of stem cell-derived microvesicles improves cognition and reduces neuropathology in the irradiated brain by Baulch, Janet E., Acharya, Munjal M., Allen, Barrett D., Ru, Ning, Chmielewski, Nicole N., Martirosian, Vahan, Giedzinski, Erich, Syage, Amber, Park, Audrey L., Benke, Sarah N., Parihar, Vipan K., Limoli, Charles L.

“…Cancer survivors face a variety of challenges as they cope with disease recurrence and a myriad of normal tissue complications brought on by radio- and…”
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Mitigation of helium irradiation-induced brain injury by microglia depletion by Allen, Barrett D, Syage, Amber R, Maroso, Mattia, Baddour, Al Anoud D, Luong, Valerie, Minasyan, Harutyun, Giedzinski, Erich, West, Brian L, Soltesz, Ivan, Limoli, Charles L, Baulch, Janet E, Acharya, Munjal M

“…Cosmic radiation exposures have been found to elicit cognitive impairments involving a wide-range of underlying neuropathology including elevated oxidative…”
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Human Neural Stem Cell Transplantation Ameliorates Radiation-Induced Cognitive Dysfunction by ACHARYA, Munjal M, CHRISTIE, Lori-Ann, LAN, Mary L, GIEDZINSKI, Erich, FIKE, John R, ROSI, Susanna, LIMOLI, Charles L

“…Cranial radiotherapy induces progressive and debilitating declines in cognition that may, in part, be caused by the depletion of neural stem cells. The…”
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Alterations in synaptic density and myelination in response to exposure to high‐energy charged particles by Dickstein, Dara L., Talty, Ronan, Bresnahan, Erin, Varghese, Merina, Perry, Bayley, Janssen, William G. M., Sowa, Allison, Giedzinski, Erich, Apodaca, Lauren, Baulch, Janet, Acharya, Munjal, Parihar, Vipan, Limoli, Charles L.

“…High‐energy charged particles are considered particularly hazardous components of the space radiation environment. Such particles include fully ionized…”
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Sex-Specific Cognitive Deficits Following Space Radiation Exposure by Parihar, Vipan K., Angulo, Maria C., Allen, Barrett D., Syage, Amber, Usmani, Manal T., Passerat de la Chapelle, Estrella, Amin, Amal Nayan, Flores, Lidia, Lin, Xiaomeng, Giedzinski, Erich, Limoli, Charles L.

“…The radiation fields in space define tangible risks to the health of astronauts, and significant work in rodent models has clearly shown a variety of exposure…”
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Functional equivalence of stem cell and stem cell‐derived extracellular vesicle transplantation to repair the irradiated brain by Smith, Sarah M., Giedzinski, Erich, Angulo, Maria C., Lui, Tiffany, Lu, Celine, Park, Audrey L., Tang, Sharon, Martirosian, Vahan, Ru, Ning, Chmielewski, Nicole N., Liang, Yaxuan, Baulch, Janet E., Acharya, Munjal M., Limoli, Charles L.

“…Cranial radiotherapy, although beneficial for the treatment of brain tumors, inevitably leads to normal tissue damage that can induce unintended neurocognitive…”
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Consequences of low dose ionizing radiation exposure on the hippocampal microenvironment by Acharya, Munjal M, Patel, Neal H, Craver, Brianna M, Tran, Katherine K, Giedzinski, Erich, Tseng, Bertrand P, Parihar, Vipan K, Limoli, Charles L

“…The response of the brain to irradiation is complex, involving a multitude of stress inducible pathways that regulate neurotransmission within a dynamic…”
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Extracellular Vesicles for the Treatment of Radiation-Induced Normal Tissue Toxicity in the Lung by Montay-Gruel, Pierre, Zhu, Yafeng, Petit, Benoit, Leavitt, Ron, Warn, Mike, Giedzinski, Erich, Ollivier, Jonathan, Sinclair, David A, Vozenin, Marie-Catherine, Limoli, Charles L

“…Human stem cell-derived extracellular vesicles (EV) provide many advantages over cell-based therapies for the treatment of functionally compromised tissue beds…”
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Attenuation of neuroinflammation reverses Adriamycin-induced cognitive impairments by Allen, Barrett D, Apodaca, Lauren A, Syage, Amber R, Markarian, Mineh, Baddour, Al Anoud D, Minasyan, Harutyun, Alikhani, Leila, Lu, Celine, West, Brian L, Giedzinski, Erich, Baulch, Janet E, Acharya, Munjal M

“…Numerous clinical studies have established the debilitating neurocognitive side effects of chemotherapy in the treatment of breast cancer, often referred as…”
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The Cannabinoid Receptor 1 Reverse Agonist AM251 Ameliorates Radiation-Induced Cognitive Decrements by Parihar, Vipan K., Syage, Amber, Flores, Lidia, Lilagan, Angelica, Allen, Barrett D., Angulo, Maria C., Song, Joseph, Smith, Sarah M., Arechavala, Rebecca J., Giedzinski, Erich, Limoli, Charles L.

“…Despite advancements in the radiotherapeutic management of brain malignancies, resultant sequelae include persistent cognitive dysfunction in the majority of…”
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Characterizing the radioresponse of pluripotent and multipotent human stem cells by Lan, Mary L, Acharya, Munjal M, Tran, Katherine K, Bahari-Kashani, Jessica, Patel, Neal H, Strnadel, Jan, Giedzinski, Erich, Limoli, Charles L

“…The potential capability of stem cells to restore functionality to diseased or aged tissues has prompted a surge of research, but much work remains to…”
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Cell-Density-Dependent Regulation of Neural Precursor Cell Function by Limoli, Charles L., Rola, Radoslaw, Giedzinski, Erich, Mantha, Sailaja, Huang, Ting-Ting, Fike, John R., Cleaver, James E.

“…Stress-induced reductions of neural precursor cells from the subgranular zone of the hippocampal dentate gyrus have been linked to impaired neurogenesis and…”
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Radiation Response of Neural Precursor Cells: Linking Cellular Sensitivity to Cell Cycle Checkpoints, Apoptosis and Oxidative Stress by Limoli, Charles L., Giedzinski, Erich, Rola, Radoslaw, Otsuka, Shinji, Palmer, Theo D., Fike, John R.

“…Limoli, C. L., Giedzinski, E., Rola, R., Otsuka, S., Palmer, T. D. and Fike, J. R. Radiation Response of Neural Precursor Cells: Linking Cellular Sensitivity…”
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Induction of Chromosomal Instability by Chronic Oxidative Stress by Limoli, Charles L., Giedzinski, Erich

“…Earlier studies using GM10115 cells analyzed the capability of different DNA-damaging agents to induce genomic instability and found that acute oxidative…”
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UV-Induced Replication Arrest in the Xeroderma Pigmentosum Variant Leads to DNA Double-Strand Breaks, γ-H2AX Formation, and Mre11 Relocalization by Limoli, Charles L., Giedzinski, Erich, Bonner, William M., Cleaver, James E.

“…UV-induced replication arrest in the xeroderma pigmentosum variant (XPV) but not in normal cells leads to an accumulation of the Mre11/Rad50/Nbs1 complex and…”
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