Search Results - "GIDDAY, J. M"

Nitric Oxide Mediates Cerebral Ischemic Tolerance in a Neonatal Rat Model of Hypoxic Preconditioning by Gidday, Jeffrey M., Shah, Aarti R., Maceren, Raymond G., Wang, Qiong, Pelligrino, Dale A., Holtzman, David M., Park, T. S.

“…Neuroprotection against cerebral ischemia can be realized if the brain is preconditioned by previous exposure to a brief period of sublethal ischemia. The…”
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Marked age-dependent neuroprotection by brain-derived neurotrophic factor against neonatal hypoxic-ischemic brain injury by Cheng, Y, Gidday, J M, Yan, Q, Shah, A R, Holtzman, D M

“…Hypoxic-ischemic brain injury in survivors of perinatal asphyxia is a frequently encountered clinical problem for which there is currently no effective…”
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Preconditioning provides complete protection against retinal ischemic injury in rats by Roth, S, Li, B, Rosenbaum, PS, Gupta, H, Goldstein, IM, Maxwell, KM, Gidday, JM

“…The objectives of this study were to examine whether preconditioning can decrease ischemic damage to the retina, by electroretinographic assessment of visual…”
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The purine nucleoside adenosine in retinal ischemia-reperfusion injury by Ghiardi, Greg J., Gidday, Jeffrey M., Roth, Steven

“…Adenosine, an intercellular messenger that is a product of the metabolism of ATP, plays a major role in neuronal and vascular responses of the retina to…”
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Neuroprotection from ischemic brain injury by hypoxic preconditioning in the neonatal rat by Gidday, J M, Fitzgibbons, J C, Shah, A R, Park, T S

“…Very recent studies in adult gerbils and rats have shown that exposure to sublethal ischemia can confer neuroprotection from subsequent lethal ischemic…”
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Nitric oxide does not mediate autoregulation of retinal blood flow in newborn pig by Gidday, J M, Zhu, Y

“…Isoflurane-anesthetized newborn pigs were used to test the hypothesis that nitric oxide mediates autoregulatory dilations of retinal arterioles. Fundus images…”
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Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain by Bergeron, Marcelle, Gidday, Jeffrey M., Yu, Aimee Y., Semenza, Gregg L., Ferriero, Donna M., Sharp, Frank R.

“…Hypoxia‐inducible factor‐1 (HIF‐1) is a heterodimer composed of HIF‐1α and HIF‐1β protein subunits. This transcription factor is essential for the activation…”
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Adenosine-mediated autoregulation of retinal arteriolar tone in the piglet by Gidday, JM, Park, TS

“…To determine if the purine vasodilator adenosine participates in mediating autoregulatory dilations of the retinal microcirculation in vivo. The retinal…”
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Xanthine oxidase-derived superoxide causes reoxygenation injury of ischemic cerebral endothelial cells by Beetsch, Joel W., Park, T.S., Dugan, Laura L., Shah, Aarti R., Gidday, Jeffrey M.

“…Oxygen free radicals, generated by cerebral ischemia, have been widely implicated in the damage of vascular endothelium. Endothelial cells have been proposed…”
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Hydroxyethyl starch reduces leukocyte adherence and vascular injury in the newborn pig cerebral circulation after asphyxia by Kaplan, S S, Park, T S, Gonzales, E R, Gidday, J M

“…Hydroxyethyl starch (HES) has beneficial effects on ischemic brain injury; however, its mechanism of action remains unclear. The present study was undertaken…”
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CD18-dependent leukocyte adherence and vascular injury in pig cerebral circulation after ischemia by Gidday, J M, Park, T S, Gonzales, E R, Beetsch, J W

“…Recent accumulating evidence indicates that leukocytes contribute importantly to ischemic brain injury. Although large numbers of leukocytes are present in the…”
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Mechanisms of Hyperoxia-Induced Reductions in Retinal Blood Flow in Newborn Pig by ZHU, YUN, PARK, T.S., GIDDAY, JEFFREY M.

“…Although reductions in retinal blood flow (RBF) in response to acute hyperoxia are well described, the mechanistic basis of this response has yet to be…”
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Platelet-Activating Factor Mediates Ischemia-Induced Leukocyte-Endothelial Adherence in Newborn Pig Brain by Park, T. S., Gonzales, Ernesto R., Gidday, Jeffrey M.

“…The authors examined the involvement of platelet-activating factor (PAF) in mediating leukocyte adherence to brain postcapillary pial venules and altering…”
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Neurochemical and morphological responses to acutely and chronically implanted brain microdialysis probes by Grabb, Margaret C, Sciotti, Veronica M, Gidday, Jeffrey M, Cohen, Steven A, Van Wylen, David G.L

“…The purpose of this study was to compare, in rats, brain microdialysis results obtained using microdialysis probes implanted acutely for 2 h versus probes…”
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Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury by Cheng, Y, Deshmukh, M, D'Costa, A, Demaro, J A, Gidday, J M, Shah, A, Sun, Y, Jacquin, M F, Johnson, E M, Holtzman, D M

“…Programmed cell death (apoptosis) is a normal process in the developing nervous system. Recent data suggest that certain features seen in the process of…”
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KATP channels mediate adenosine-induced hyperemia in retina by Gidday, JM, Maceren, RG, Shah, AR, Meier, JA, Zhu, Y

“…The authors and others have shown previously that the purine nucleoside adenosine is a potent vasodilator in the retinal microcirculation, mediating increases…”
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BDNF Protects against Spatial Memory Deficits Following Neonatal Hypoxia-Ischemia by Almli, C.Robert, Levy, Todd J., Han, Byung Hee, Shah, Aarti R., Gidday, Jeffrey M., Holtzman, David M.

“…Hypoxic-ischemic (H-I) brain injury in the human perinatal period often leads to significant long-term neurobehavioral dysfunction in the cognitive and…”
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Reduction in cerebral ischemic injury in the newborn rat by potentiation of endogenous adenosine by GIDDAY, J. M, FITZGIBBONS, J. C, SHAH, A. R, KRAUJALIS, M. J, PARK, T. S

“…Because of ontogenic influences on the pathophysiologic mechanisms of brain injury in the perinatal brain, and in particular, the incomplete development of…”
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BDNF Blocks Caspase-3 Activation in Neonatal Hypoxia–Ischemia by Hee Han, Byung, D'Costa, Anselm, Back, Stephen A., Parsadanian, Maia, Patel, Shilen, Shah, Aarti R., Gidday, Jeffrey M., Srinivasan, Anu, Deshmukh, Mohanish, Holtzman, David M.

“…Hypoxic–ischemic (H-I) injury to the brain in the perinatal period often leads to significant long-term neurological deficits. In a model of neonatal H-I…”
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Microcirculatory responses to adenosine in the newborn pig retina by GIDDAY, J. M, PARK, T. S

“…The reactivity of retinal arterioles and venules to exogenous and endogenous adenosine was investigated in the newborn piglet eye in vivo. The retinal…”
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