Search Results - "GIBSON WOOD, W"

Cholesterol as a causative factor in Alzheimer's disease: a debatable hypothesis by Wood, W. Gibson, Li, Ling, Müller, Walter E., Eckert, Gunter P.

“…High serum/plasma cholesterol levels have been suggested as a risk factor for Alzheimer's disease (AD). Some reports, mostly retrospective epidemiological…”
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Isoprenoids and protein prenylation: implications in the pathogenesis and therapeutic intervention of Alzheimer's disease by Jeong, Angela, Suazo, Kiall Francis, Wood, W Gibson, Distefano, Mark D, Li, Ling

“…The mevalonate-isoprenoid-cholesterol biosynthesis pathway plays a key role in human health and disease. The importance of this pathway is underscored by the…”
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Beneficial effects of dietary EGCG and voluntary exercise on behavior in an Alzheimer's disease mouse model by Walker, Jennifer M, Klakotskaia, Diana, Ajit, Deepa, Weisman, Gary A, Wood, W Gibson, Sun, Grace Y, Serfozo, Peter, Simonyi, Agnes, Schachtman, Todd R

“…Alzheimer's disease (AD) is a progressive, age-dependent neurodegenerative disorder affecting specific brain regions that control memory and cognitive…”
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Gallic acid inhibits migration and invasion in human osteosarcoma U-2 OS cells through suppressing the matrix metalloproteinase-2/-9, protein kinase B (PKB) and PKC signaling pathways by Liao, Ching-Lung, Lai, Kuang-Chi, Huang, An-Cheng, Yang, Jai-Sing, Lin, Jen-Jyh, Wu, Shin-Hwar, Gibson Wood, W., Lin, Jaung-Geng, Chung, Jing-Gung

“…► Gallic acid (GA)-suppressed migration and invasion of U-2 OS cells. ► Down-regulating the levels of MMP-2/-9 in GA-treated U-2 OS cells. ► Suppressing the…”
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Cholesterol asymmetry in synaptic plasma membranes by Gibson Wood, W, Igbavboa, Urule, Müller, Walter E, Eckert, Gunter P

“…J. Neurochem. (2011) 116, 684-689. ABSTRACT: Lipids are essential for the structural and functional integrity of membranes. Membrane lipids are not randomly…”
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DNA damage and endoplasmic reticulum stress mediated curcumin-induced cell cycle arrest and apoptosis in human lung carcinoma A-549 cells through the activation caspases cascade- and mitochondrial-dependent pathway by Lin, Song-Shei, Huang, Hsuan-Pang, Yang, Jai-Sing, Wu, Jeng-Yuan, Hsai, Te-Chun, Lin, Chin-Chung, Lin, Cheng-Wen, Kuo, Chao-Lin, Gibson Wood, W, Chung, Jing-Gung

“…Abstract Curcumin, a major component of the Curcuma species, is known to have antioxidant, anti-inflammatory properties and induce apoptosis of cancer cells,…”
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Effects of 7,8-Dihydroxyflavone on Lipid Isoprenoid and Rho Protein Levels in Brains of Aged C57BL/6 Mice by Ötzkan, Sarah, Muller, Walter E., Gibson Wood, W., Eckert, Gunter P.

“…Synaptic impairment may be the main cause of cognitive dysfunction in brain aging that is probably due to a reduction in synaptic contact between the axonal…”
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Green Tea Extract Ameliorates Learning and Memory Deficits in Ischemic Rats via Its Active Component Polyphenol Epigallocatechin-3-gallate by Modulation of Oxidative Stress and Neuroinflammation by Wood, W. Gibson, Wu, Chi-Rei, Hsieh, Ming-Tsuen, Wu, Kuo-Jen, Chen, Yuh-Fung

“…Ischemic stroke results in brain damage and behavioral deficits including memory impairment. Protective effects of green tea extract (GTex) and its major…”
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Berberine Induced Apoptosis via Promoting the Expression of Caspase-8, -9 and -3, Apoptosis-inducing Factor and Endonuclease G in SCC-4 Human Tongue Squamous Carcinoma Cancer Cells by HO, Yung-Tsuan, LU, Chi-Cheng, CHUNG, Jing-Gung, YANG, Jai-Sing, CHIANG, Jo-Hua, LI, Tsai-Chung, IP, Siu-Wan, HSIA, Te-Chun, LIAO, Ching-Lung, LIN, Jaung-Geng, GIBSON WOOD, W

“…Many phytochemicals have been recognized to have potential chemopreventive or chemotherapeutic efficacy in cancer treatment. In this study, we hypothesized…”
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Gypenosides induced G0/G1 arrest via CHk2 and apoptosis through endoplasmic reticulum stress and mitochondria-dependent pathways in human tongue cancer SCC-4 cells by Chen, Jung-Chou, Lu, Kung-Wen, Tsai, Ming-Li, Hsu, Shu-Chun, Kuo, Chao-Lin, Yang, Jai-Sing, Hsia, Te-Chun, Yu, Chun-Shu, Chou, Su-Tze, Kao, Ming-Ching, Chung, Jing-Gung, Gibson Wood, W

“…Summary Gypenosides (Gyp), a component of Gynostemma pentaphyllum Makino, was selected for examining the effects on the cell viability, cell cycle and…”
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Rutin inhibits human leukemia tumor growth in a murine xenograft model in vivo by Lin, Jing-Pin, Yang, Jai-Sing, Lin, Jen-Jyh, Lai, Kuang-Chi, Lu, Hsu-Feng, Ma, Chia-Yu, Sai-Chuen Wu, Rick, Wu, King-Chuan, Chueh, Fu-Shin, Gibson Wood, W., Chung, Jing-Gung

“…Numerous studies have shown that rutin has anticancer effects. We have previously reported that rutin induced cell cycle arrest and apoptosis in murine…”
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Regulation of the brain isoprenoids farnesyl- and geranylgeranylpyrophosphate is altered in male Alzheimer patients by Eckert, Gunter P, Hooff, Gero P, Strandjord, Dana M, Igbavboa, Urule, Volmer, Dietrich A, Müller, Walter E, Wood, W. Gibson

“…Abstract Post-translational modification of small GTPases by farnesyl- (FPP) and geranylgeranylpyrophosphate (GGPP) has generated much attention due to their…”
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Gypenosides inhibits migration and invasion of human oral cancer SAS cells through the inhibition of matrix metalloproteinase-2 -9 and urokinase-plasminogen by ERK1/2 and NF-kappa B signaling pathways by Lu, Kung-Wen, Chen, Jung-Chou, Lai, Tung-Yuan, Yang, Jai-Sing, Weng, Shu-Wen, Ma, Yi-Shih, Lu, Pei-Jung, Weng, Jing-Ru, Chueh, Fu-Shin, Wood, W Gibson, Chung, Jing-Gung

“…Gypenosides (Gyp), found in Gynostemma pentaphyllum Makino, has been used as a folk medicine in the Chinese population for centuries and is known to have…”
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Bcl-2 upregulation and neuroprotection in guinea pig brain following chronic simvastatin treatment by Franke, Cornelia, Nöldner, Michael, Abdel-Kader, Reham, Johnson-Anuna, Leslie N, Gibson Wood, W, Müller, Walter E, Eckert, Gunter P

“…Abstract The present study determined if chronic simvastatin administration in vivo would provide neuroprotection in brain cells isolated from guinea pigs…”
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Simvastatin protects neurons from cytotoxicity by up‐regulating Bcl‐2 mRNA and protein by Johnson‐Anuna, Leslie N., Eckert, Gunter P., Franke, Cornelia, Igbavboa, Urule, Müller, Walter E., Wood, W. Gibson

“…Statins are most commonly prescribed to reduce hypercholesterolemia; however, recent studies have shown that statins have additional benefits, including…”
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Prolonged exposure of cortical neurons to oligomeric amyloid-β impairs NMDA receptor function via NADPH oxidase-mediated ROS production: protective effect of green tea (-)-epigallocatechin-3-gallate by He, Yan, Cui, Jiankun, Lee, James C-M, Ding, Shinghua, Chalimoniuk, Malgorzata, Simonyi, Agnes, Sun, Albert Y, Gu, Zezong, Weisman, Gary A, Wood, W Gibson, Sun, Grace Y

“…Excessive production of Aβ (amyloid β-peptide) has been shown to play an important role in the pathogenesis of AD (Alzheimer's disease). Although not yet well…”
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Paeonia lactiflora Extract Attenuating Cerebral Ischemia and Arterial Intimal Hyperplasia Is Mediated by Paeoniflorin via Modulation of VSMC Migration and Ras/MEK/ERK Signaling Pathway by Chen, Yuh-Fung, Wu, Kuo-Jen, Wood, W. Gibson

“…Paeonia lactiflora is a well-known traditional Chinese medicine. Paeoniflorin is an active component found in Paeonia lactiflora, which is used to treat smooth…”
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Chronic administration of statins alters multiple gene expression patterns in mouse cerebral cortex by Johnson-Anuna, Leslie N, Eckert, Gunter P, Keller, Jan H, Igbavboa, Urule, Franke, Cornelia, Fechner, Thomas, Schubert-Zsilavecz, Manfred, Karas, Michael, Müller, Walter E, Wood, W Gibson

“…Statins have been reported to lower the risk of developing Alzheimer's disease; however, the mechanism of this potentially important neuroprotective action is…”
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Amyloid beta-protein interactions with membranes and cholesterol: causes or casualties of Alzheimer's disease by Gibson Wood, W., Eckert, Gunter P., Igbavboa, Urule, Müller, Walter E.

“…Amyloid beta-protein (Aβ) is thought to be one of the primary factors causing neurodegeneration in Alzheimer's disease (AD). This protein is an amphipathic…”
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Pipoxolan ameliorates cerebral ischemia via inhibition of neuronal apoptosis and intimal hyperplasia through attenuation of VSMC migration and modulation of matrix metalloproteinase-2/9 and Ras/MEK/ERK signaling pathways by Chen, Yuh-Fung, Tsai, Huei-Yann, Wu, Kuo-Jen, Siao, Lian-Ru, Wood, W Gibson

“…Pipoxolan (PIPO) has anti-spasmodic effects, and it is used clinically to relieve smooth muscle spasms. Cerebrovascular disease is one of the leading causes of…”
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