Search Results - "GIBSON, Peter G"

Macrophage dysfunction in the pathogenesis and treatment of asthma by Fricker, Michael, Gibson, Peter G

“…Asthma is a chronic respiratory condition frequently associated with aberrant airway and systemic inflammation. Various inflammatory phenotypes in asthmatic…”
Get full text

Treatable traits: toward precision medicine of chronic airway diseases by Agusti, Alvar, Bel, Elisabeth, Thomas, Mike, Vogelmeier, Claus, Brusselle, Guy, Holgate, Stephen, Humbert, Marc, Jones, Paul, Gibson, Peter G, Vestbo, Jørgen, Beasley, Richard, Pavord, Ian D

“…Asthma and chronic obstructive pulmonary disease (COPD) are two prevalent chronic airway diseases that have a high personal and social impact. They likely…”
Get full text

The Emerging Role of Neutrophil Extracellular Traps in Respiratory Disease by Twaddell, Scott H., Baines, Katherine J., Grainge, Christopher, Gibson, Peter G.

“…Neutrophil extracellular traps (NETs) are extrusions of intracellular DNA and attached granular material that enable bacterial killing. NETs are increasingly…”
Get full text

Spirometry, you have an image problem by Gibson, Peter G.

Get full text

A high-fat challenge increases airway inflammation and impairs bronchodilator recovery in asthma by Wood, Lisa G., PhD, Garg, Manohar L., PhD, Gibson, Peter G., MBBS

“…Background Dietary fat activates systemic innate immune responses, but the effect on airway responses is unknown. Objective To examine effects of a high-fat…”
Get full text

Gabapentin for refractory chronic cough: a randomised, double-blind, placebo-controlled trial by Ryan, Nicole M, Dr, Birring, Surinder S, MD, Gibson, Peter G, Prof

“…Summary Background Refractory chronic cough causes substantial symptoms and quality-of-life impairment. Similarities between central reflex sensitisation in…”
Get full text

Does maintenance azithromycin reduce asthma exacerbations? An individual participant data meta-analysis by Hiles, Sarah A, McDonald, Vanessa M, Guilhermino, Michelle, Brusselle, Guy G, Gibson, Peter G

“…Preventing exacerbations is an important goal of asthma treatment. Long-term treatment with azithromycin may help achieve this. Our aim was to conduct a…”
Get full text

Treatable traits: a new paradigm for 21st century management of chronic airway diseases: Treatable Traits Down Under International Workshop report by McDonald, Vanessa M, Fingleton, James, Agusti, Alvar, Hiles, Sarah A, Clark, Vanessa L, Holland, Anne E, Marks, Guy B, Bardin, Philip P, Beasley, Richard, Pavord, Ian D, Wark, Peter A B, Gibson, Peter G

“…"Treatable traits" have been proposed as a new paradigm for the management of airway diseases, particularly complex disease, which aims to apply personalised…”
Get full text

Asthma in older adults by Gibson, Peter G, Prof, McDonald, Vanessa M, B Nurs, Marks, Guy B, Prof

“…Summary Asthma in older people is common and is characterised by underdiagnosis and undertreatment. Ageing is associated with unique issues that modify…”
Get full text

Omalizumab Treatment Response in a Population With Severe Allergic Asthma and Overlapping COPD by Maltby, Steven, PhD, Gibson, Peter G., MBBS, Powell, Heather, MMedSc, McDonald, Vanessa M., PhD, B Nurs, RN

“…Background Asthma and COPD are common airway diseases. Individuals with overlapping asthma and COPD experience increased health impairment and severe disease…”
Get full text

Real-World Effectiveness of Omalizumab in Severe Allergic Asthma: A Meta-Analysis of Observational Studies by Bousquet, Jean, Humbert, Marc, Gibson, Peter G., Kostikas, Konstantinos, Jaumont, Xavier, Pfister, Pascal, Nissen, Francis

“…Assessment of clinical outcomes in the real-world corroborates findings from randomized controlled trials (RCTs). This meta-analysis evaluated real-world data…”
Get full text

Laryngeal Dysfunction: Assessment and Management for the Clinician by Hull, James H, Backer, Vibeke, Gibson, Peter G, Fowler, Stephen J

“…The larynx is one of the most highly innervated organs in humans and serves a number of vitally important, complex, and highly evolved biological functions. On…”
Get full text

Mepolizumab effectiveness and identification of super-responders in severe asthma by Harvey, Erin S, Langton, David, Katelaris, Constance, Stevens, Sean, Farah, Claude S, Gillman, Andrew, Harrington, John, Hew, Mark, Kritikos, Vicky, Radhakrishna, Naghmeh, Bardin, Philip, Peters, Matthew, Reynolds, Paul N, Upham, John W, Baraket, Melissa, Bowler, Simon, Bowden, Jeffrey, Chien, Jimmy, Chung, Li Ping, Grainge, Christopher, Jenkins, Christine, Katsoulotos, Gregory P, Lee, Joy, McDonald, Vanessa M, Reddel, Helen K, Rimmer, Janet, Wark, Peter A B, Gibson, Peter G

“…Severe asthma is a high-burden disease. Real-world data on mepolizumab in patients with severe eosinophilic asthma is needed to assess whether the data from…”
Get full text

Long-Term Azithromycin Reduces Haemophilus influenzae and Increases Antibiotic Resistance in Severe Asthma by Taylor, Steven L, Leong, Lex E X, Mobegi, Fredrick M, Choo, Jocelyn M, Wesselingh, Steve, Yang, Ian A, Upham, John W, Reynolds, Paul N, Hodge, Sandra, James, Alan L, Jenkins, Christine, Peters, Matthew J, Baraket, Melissa, Marks, Guy B, Gibson, Peter G, Rogers, Geraint B, Simpson, Jodie L

“…The macrolide antibiotic azithromycin reduces exacerbations in adults with persistent symptomatic asthma. However, owing to the pleotropic properties of…”
Get full text

Associations of symptoms of anxiety and depression with health-status, asthma control, dyspnoea, dysfunction breathing and obesity in people with severe asthma by Stubbs, Michelle A, Clark, Vanessa L, Gibson, Peter G, Yorke, Janelle, McDonald, Vanessa M

“…Anxiety and depression are comorbidities of severe asthma. However, clinical characteristics associated with coexisting severe asthma and anxiety/depression…”
Get full text

Precision medicine in airway diseases: moving to clinical practice by Agustí, Alvar, Bafadhel, Mona, Beasley, Richard, Bel, Elisabeth H, Faner, Rosa, Gibson, Peter G, Louis, Renaud, McDonald, Vanessa M, Sterk, Peter J, Thomas, Mike, Vogelmeier, Claus, Pavord, Ian D

“…On February 21, 2017, a European Respiratory Society research seminar held in Barcelona discussed how to best apply precision medicine to chronic airway…”
Get full text

Transcriptional phenotypes of asthma defined by gene expression profiling of induced sputum samples by Baines, Katherine J., PhD, BBiomedSci (Hons), Simpson, Jodie L., PhD, BSc (Hons), Wood, Lisa G., PhD, BSc (Hons), Scott, Rodney J., DSc, FRCPath, FHGSA, Gibson, Peter G., MBBS, FRACP

“…Background Previous studies have identified clinical or inflammatory phenotypes of asthma on the basis of clinical and demographic parameters or sputum cell…”
Get full text

Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypes by Baines, Katherine J., PhD, Simpson, Jodie L., PhD, Wood, Lisa G., PhD, Scott, Rodney J., PhD, Fibbens, Naomi L., DipPathTech, Powell, Heather, MMedSci, Cowan, Douglas C., PhD, Taylor, D. Robin, DSc, Cowan, Jan O, Gibson, Peter G., MBBS

“…Background Airway inflammation is associated with asthma exacerbation risk, treatment response, and disease mechanisms. Objective This study aimed to identify…”
Get full text

Saturated fatty acids, obesity, and the nucleotide oligomerization domain–like receptor protein 3 (NLRP3) inflammasome in asthmatic patients by Wood, Lisa G., Li, Qian, Scott, Hayley A., Rutting, Sandra, Berthon, Bronwyn S., Gibson, Peter G., Hansbro, Philip M., Williams, Evan, Horvat, Jay, Simpson, Jodie L., Young, Paul, Oliver, Brian G., Baines, Katherine J.

“…Both obesity and high dietary fat intake activate the nucleotide oligomerization domain–like receptor protein 3 (NLRP3) inflammasome. We aimed to examine NLRP3…”
Get full text

Sputum mast cell/basophil gene expression relates to inflammatory and clinical features of severe asthma by Winter, Natasha A., Qin, Ling, Gibson, Peter G., McDonald, Vanessa M., Baines, Katherine J., Faulkner, Jack, Evans, Tiffany-Jane, Fricker, Michael

“…Mast cells (MCs) and basophils are important in asthma pathophysiology, however direct measurement is difficult, and clinical and inflammatory associations in…”
Get full text