Search Results - "GIBSON, K. Michael"

Oesophageal carcinoma by Pennathur, Arjun, MD, Gibson, Michael K, MD, Jobe, Blair A, Prof, Luketich, James D, Prof

“…Summary Oesophageal carcinoma affects more than 450 000 people worldwide and the incidence is rapidly increasing. Squamous-cell carcinoma is the predominant…”
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Pembrolizumab for Platinum- and Cetuximab-Refractory Head and Neck Cancer: Results From a Single-Arm, Phase II Study by Bauml, Joshua, Seiwert, Tanguy Y, Pfister, David G, Worden, Francis, Liu, Stephen V, Gilbert, Jill, Saba, Nabil F, Weiss, Jared, Wirth, Lori, Sukari, Ammar, Kang, Hyunseok, Gibson, Michael K, Massarelli, Erminia, Powell, Steven, Meister, Amy, Shu, Xinxin, Cheng, Jonathan D, Haddad, Robert

“…Purpose There are no approved treatments for recurrent/metastatic head and neck squamous cell carcinoma refractory to platinum and cetuximab. In the…”
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Esophagectomy for T1 Esophageal Cancer: Outcomes in 100 Patients and Implications for Endoscopic Therapy by Pennathur, Arjun, MD, Farkas, Andrew, BA, Krasinskas, Alyssa M., MD, Ferson, Peter F., MD, Gooding, William E., MS, Gibson, Michael K., MD, Schuchert, Matthew J., MD, Landreneau, Rodney J., MD, Luketich, James D., MD

“…Objectives Esophagectomy is the standard treatment for T1 esophageal cancer (EC). Interest in endoscopic therapies, particularly for T1 EC, is increasing. We…”
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A Prospective Phase 2 Trial of Reirradiation With Stereotactic Body Radiation Therapy Plus Cetuximab in Patients With Previously Irradiated Recurrent Squamous Cell Carcinoma of the Head and Neck by Vargo, John A., MD, Ferris, Robert L., MD, PhD, Ohr, James, DO, Clump, David A., MD, PhD, Davis, Kara S., MD, Duvvuri, Umamaheswar, MD, PhD, Kim, Seungwon, MD, Johnson, Jonas T., MD, Bauman, Julie E., MD, MPH, Gibson, Michael K., MD, Branstetter, Barton F., MD, Heron, Dwight E., MD, FACR, FACRO

“…Purpose Salvage options for unresectable locally recurrent, previously irradiated squamous cell carcinoma of the head and neck (rSCCHN) are limited. Although…”
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Editorial Commentary on the Special Issue "Antioxidant Therapy for Cardiovascular Diseases"-Cutting-Edge Insights into Oxidative Stress and Antioxidant Therapy in Cardiovascular Health by Kwon, Guim, Gibson, K Michael, Bi, Lanrong

“…Recent advances in cardiovascular research have increasingly emphasized oxidative stress as a central mechanism in the pathogenesis and progression of…”
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Advances and challenges in the treatment of branched-chain amino/keto acid metabolic defects by Knerr, Ina, Weinhold, Natalie, Vockley, Jerry, Gibson, K. Michael

“…Summary Disorders of branched-chain amino/keto acid metabolism encompass diverse entities, including maple syrup urine disease (MSUD), the ‘classical’ organic…”
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Vigabatrin-Induced Retinal Functional Alterations and Second-Order Neuron Plasticity in C57BL/6J Mice by Chan, Kore, Hoon, Mrinalini, Pattnaik, Bikash R, Ver Hoeve, James N, Wahlgren, Brad, Gloe, Shawna, Williams, Jeremy, Wetherbee, Brenna, Kiland, Julie A, Vogel, Kara R, Jansen, Erwin, Salomons, Gajja, Walters, Dana, Roullet, Jean-Baptiste, Gibson, K Michael, McLellan, Gillian J

“…Vigabatrin (VGB) is an effective antiepileptic that increases concentrations of inhibitory γ-aminobutyric acid (GABA) by inhibiting GABA transaminase. Reports…”
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Highly Stable and Sensitive Fluorescent Probes (LysoProbes) for Lysosomal Labeling and Tracking by Yapici, Nazmiye B., Bi, Yue, Li, Pengfei, Chen, Xin, Yan, Xin, Mandalapu, Srinivas Rao, Faucett, Megan, Jockusch, Steffen, Ju, Jingfang, Gibson, K. Michael, Pavan, William J., Bi, Lanrong

“…We report the design, synthesis and application of several new fluorescent probes (LysoProbes I-VI) that facilitate lysosomal pH monitoring and…”
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The distribution of esophageal cancer patients enrolled in care at the Uganda Cancer Institute by sub-regions, districts and ethnicity by Obayo, Siraji, Mulumba, Yusuf, Thompson, Cheryl L, Gibson, Michael K, Cooney, Matthew M, Orem, Jackson

“…There is limited published data regarding the distribution of esophageal cancer patients by sub-regions, districts and ethnicity in Uganda. To study the…”
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Natural history of succinic semialdehyde dehydrogenase deficiency through adulthood by Lapalme-Remis, Samuel, Lewis, Evan Cole, De Meulemeester, Christine, Chakraborty, Pranesh, Gibson, K Michael, Torres, Carlos, Guberman, Alan, Salomons, Gajja S, Jakobs, Cornelis, Ali-Ridha, Andre, Parviz, Mahsa, Pearl, Phillip L

“…The natural history of succinic semialdehyde dehydrogenase (SSADH) deficiency in adulthood is unknown; we elucidate the clinical manifestations of the disease…”
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Clinical Use of CSF Neurotransmitters by Rodan, Lance H., MD, Gibson, K. Michael, PhD, Pearl, Phillip L., MD

“…Abstract Background Cerebrospinal fluid neurotransmitter collection, analysis, and follow-up are integral to the diagnosis and management of multiple inborn…”
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Succinic semialdehyde dehydrogenase deficiency, a disorder of GABA metabolism: an update on pharmacological and enzyme-replacement therapeutic strategies by Vogel, Kara R., Ainslie, Garrett R., Walters, Dana C., McConnell, Alice, Dhamne, Sameer C., Rotenberg, Alexander, Roullet, Jean-Baptiste, Gibson, K. Michael

“…We present an update to the status of research on succinic semialdehyde dehydrogenase (SSADH) deficiency (SSADHD), a rare disorder of GABA metabolism. This is…”
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Randomized Phase III Evaluation of Cisplatin Plus Fluorouracil Versus Cisplatin Plus Paclitaxel in Advanced Head and Neck Cancer (E1395): An Intergroup Trial of the Eastern Cooperative Oncology Group by GIBSON, Michael K, YI LI, MURPHY, Barbara, HUSSAIN, Maha H. A, DECONTI, Ronald C, ENSLEY, John, FORASTIERE, Arlene A

“…To determine the response rate, survival and toxicity of infusional cisplatin plus fluorouracil (CF) versus cisplatin plus paclitaxel (CP) in patients with…”
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Induction Docetaxel, Cisplatin, and Cetuximab Followed by Concurrent Radiotherapy, Cisplatin, and Cetuximab and Maintenance Cetuximab in Patients With Locally Advanced Head and Neck Cancer by ARGIRIS, Athanassios, HERON, Dwight E, DACIC, Sanja, GOODING, William, GRANDIS, Jennifer R, JOHNSON, Jonas T, FERRIS, Robert L, SMITH, Ryan P, KIM, Seungwon, GIBSON, Michael K, LAI, Stephen Y, BRANSTETTER, Barton F, POSLUSZNY, Donna M, LIN WANG, SEETHALA, Raja R

“…We incorporated cetuximab, a chimeric monoclonal antibody against the epidermal growth factor receptor (EGFR), into the induction therapy and subsequent…”
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Post-mortem tissue analyses in a patient with succinic semialdehyde dehydrogenase deficiency (SSADHD). I. Metabolomic outcomes by Kirby, Trevor, Walters, Dana C., Brown, Madalyn, Jansen, Erwin, Salomons, Gajja S., Turgeon, Coleman, Rinaldo, Piero, Arning, Erland, Ashcraft, Paula, Bottiglieri, Teodoro, Roullet, Jean-Baptiste, Gibson, K. Michael

“…Metabolomic characterization of post-mortem tissues (frontal and parietal cortices, pons, cerebellum, hippocampus, cerebral cortex, liver and kidney) derived…”
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Targeted fluorescent probes for detection of oxidative stress in the mitochondria by Yapici, Nazmiye B., Mandalapu, Srinivas, Michael Gibson, K., Bi, Lanrong

“…[Display omitted] Mitochondrial oxidative stress has been implicated in aging, neurodegenerative diseases, diabetes, stroke, ischemia/reperfusion injury,…”
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Succinic semialdehyde dehydrogenase deficiency: a metabolic and genomic approach to diagnosis by Glinton, Kevin E, Gijavanekar, Charul, Rajagopal, Abbhirami, Mackay, Laura P, Martin, Kirt A, Pearl, Phillip L, Gibson, K Michael, Wilson, Theresa A, Sutton, V Reid, Elsea, Sarah H

“…Genomic sequencing offers an untargeted, data-driven approach to genetic diagnosis; however, variants of uncertain significance often hinder the diagnostic…”
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Enhancing Cardiomyocyte Resilience to Ischemia-Reperfusion Injury: The Therapeutic Potential of an Indole-Peptide-Tempo Conjugate (IPTC) by Hou, Shanshan, Yan, Xin, Gao, Xiang, Jockusch, Steffen, Gibson, K. Michael, Shan, Zhiying, Bi, Lanrong

“…Ischemia/reperfusion (I/R) injury leads to apoptosis and extensive cellular and mitochondrial damage, triggered by the early generation and subsequent…”
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Pharmacologic inhibition of L-tyrosine degradation ameliorates cerebral dopamine deficiency in murine phenylketonuria (PKU) by Harding, Cary O., Winn, Shelley R., Gibson, K. Michael, Arning, Erland, Bottiglieri, Teodoro, Grompe, Markus

“…Monoamine neurotransmitter deficiency has been implicated in the etiology of neuropsychiatric symptoms associated with chronic hyperphenylalaninemia in…”
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Indole-TEMPO conjugates alleviate ischemia-reperfusion injury via attenuation of oxidative stress and preservation of mitochondrial function by Bi, Wei, Bi, Yue, Gao, Xiang, Li, Pengfei, Hou, Shanshan, Zhang, Yanrong, Bammert, Cathy, Jockusch, Steffen, Legalley, Thomas D., Michael Gibson, K., Bi, Lanrong

“…[Display omitted] Mitochondrial oxidative damage contributes to a wide range of pathologies including ischemia/reperfusion injury. Accordingly, protecting…”
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