Search Results - "GIBSON, Bradford W"

SIRT5 Regulates both Cytosolic and Mitochondrial Protein Malonylation with Glycolysis as a Major Target by Nishida, Yuya, Rardin, Matthew J., Carrico, Chris, He, Wenjuan, Sahu, Alexandria K., Gut, Philipp, Najjar, Rami, Fitch, Mark, Hellerstein, Marc, Gibson, Bradford W., Verdin, Eric

“…Protein acylation links energetic substrate flux with cellular adaptive responses. SIRT5 is a NAD+-dependent lysine deacylase and removes both succinyl and…”
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SIRT5 Regulates the Mitochondrial Lysine Succinylome and Metabolic Networks by Rardin, Matthew J., He, Wenjuan, Nishida, Yuya, Newman, John C., Carrico, Chris, Danielson, Steven R., Guo, Ailan, Gut, Philipp, Sahu, Alexandria K., Li, Biao, Uppala, Radha, Fitch, Mark, Riiff, Timothy, Zhu, Lei, Zhou, Jing, Mulhern, Daniel, Stevens, Robert D., Ilkayeva, Olga R., Newgard, Christopher B., Jacobson, Matthew P., Hellerstein, Marc, Goetzman, Eric S., Gibson, Bradford W., Verdin, Eric

“…Reversible posttranslational modifications are emerging as critical regulators of mitochondrial proteins and metabolism. Here, we use a label-free quantitative…”
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Structural, kinetic and proteomic characterization of acetyl phosphate-dependent bacterial protein acetylation by Kuhn, Misty L, Zemaitaitis, Bozena, Hu, Linda I, Sahu, Alexandria, Sorensen, Dylan, Minasov, George, Lima, Bruno P, Scholle, Michael, Mrksich, Milan, Anderson, Wayne F, Gibson, Bradford W, Schilling, Birgit, Wolfe, Alan J

“…The emerging view of Nε-lysine acetylation in eukaryotes is of a relatively abundant post-translational modification (PTM) that has a major impact on the…”
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Multi-laboratory assessment of reproducibility, qualitative and quantitative performance of SWATH-mass spectrometry by Collins, Ben C., Hunter, Christie L., Liu, Yansheng, Schilling, Birgit, Rosenberger, George, Bader, Samuel L., Chan, Daniel W., Gibson, Bradford W., Gingras, Anne-Claude, Held, Jason M., Hirayama-Kurogi, Mio, Hou, Guixue, Krisp, Christoph, Larsen, Brett, Lin, Liang, Liu, Siqi, Molloy, Mark P., Moritz, Robert L., Ohtsuki, Sumio, Schlapbach, Ralph, Selevsek, Nathalie, Thomas, Stefani N., Tzeng, Shin-Cheng, Zhang, Hui, Aebersold, Ruedi

“…Quantitative proteomics employing mass spectrometry is an indispensable tool in life science research. Targeted proteomics has emerged as a powerful approach…”
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Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits by Min, Sang-Won, Chen, Xu, Tracy, Tara E, Li, Yaqiao, Zhou, Yungui, Wang, Chao, Shirakawa, Kotaro, Minami, S Sakura, Defensor, Erwin, Mok, Sue Ann, Sohn, Peter Dongmin, Schilling, Birgit, Cong, Xin, Ellerby, Lisa, Gibson, Bradford W, Johnson, Jeffrey, Krogan, Nevan, Shamloo, Mehrdad, Gestwicki, Jason, Masliah, Eliezer, Verdin, Eric, Gan, Li

“…Acetylation of tau at K174 is identified in Alzheimer's disease (AD) brain tissue and exacerbates tau-mediated neurodegeneration and memory impairments in…”
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Dietary Sugars Alter Hepatic Fatty Acid Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins by Softic, Samir, Meyer, Jesse G, Wang, Guo-Xiao, Gupta, Manoj K, Batista, Thiago M, Lauritzen, Hans P M M, Fujisaka, Shiho, Serra, Dolors, Herrero, Laura, Willoughby, Jennifer, Fitzgerald, Kevin, Ilkayeva, Olga, Newgard, Christopher B, Gibson, Bradford W, Schilling, Birgit, Cohen, David E, Kahn, C Ronald

“…Dietary sugars, fructose and glucose, promote hepatic de novo lipogenesis and modify the effects of a high-fat diet (HFD) on the development of insulin…”
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Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways by Rardin, Matthew J., Newman, John C., Held, Jason M., Cusack, Michael P., Sorensen, Dylan J., Li, Biao, Schilling, Birgit, Mooney, Sean D., Kahn, C. Ronald, Verdin, Eric, Gibson, Bradford W.

“…Large-scale proteomic approaches have identified numerous mitochondrial acetylated proteins; however in most cases, their regulation by acetyltransferases and…”
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Generation of High-Quality SWATH ® Acquisition Data for Label-free Quantitative Proteomics Studies Using TripleTOF ® Mass Spectrometers by Schilling, Birgit, Gibson, Bradford W, Hunter, Christie L

“…Data-independent acquisition is a powerful mass spectrometry technique that enables comprehensive MS and MS/MS analysis of all detectable species, providing an…”
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Regulatory Control or Oxidative Damage? Proteomic Approaches to Interrogate the Role of Cysteine Oxidation Status in Biological Processes by Held, Jason M., Gibson, Bradford W.

“…Oxidation is a double-edged sword for cellular processes and its role in normal physiology, cancer and aging remains only partially understood. Although…”
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Protein acetylation dynamics in response to carbon overflow in Escherichia coli by Schilling, Birgit, Christensen, David, Davis, Robert, Sahu, Alexandria K., Hu, Linda I., Walker‐Peddakotla, Arti, Sorensen, Dylan J., Zemaitaitis, Bozena, Gibson, Bradford W., Wolfe, Alan J.

“…Summary In Escherichia coli, acetylation of proteins at lysines depends largely on a non‐enzymatic acetyl phosphate‐dependent mechanism. To assess the…”
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Sirt3 Regulates Metabolic Flexibility of Skeletal Muscle Through Reversible Enzymatic Deacetylation by ENXUAN JING, O'NEILL, Brian T, GIBSON, Bradford W, KAHN, C. Ronald, RARDIN, Matthew J, KLEINRIDDERS, André, ILKEYEVA, Olga R, USSAR, Siegfried, BAIN, James R, LEE, Kevin Y, VERDIN, Eric M, NEWGARD, Christopher B

“…Sirt3 is an NAD(+)-dependent deacetylase that regulates mitochondrial function by targeting metabolic enzymes and proteins. In fasting mice, Sirt3 expression…”
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Adipose-Specific Deletion of TFAM Increases Mitochondrial Oxidation and Protects Mice against Obesity and Insulin Resistance by Vernochet, Cecile, Mourier, Arnaud, Bezy, Olivier, Macotela, Yazmin, Boucher, Jeremie, Rardin, Matthew J., An, Ding, Lee, Kevin Y., Ilkayeva, Olga R., Zingaretti, Cristina M., Emanuelli, Brice, Smyth, Graham, Cinti, Saverio, Newgard, Christopher B., Gibson, Bradford W., Larsson, Nils-Göran, Kahn, C. Ronald

“…Obesity and type 2 diabetes are associated with mitochondrial dysfunction in adipose tissue, but the role for adipose tissue mitochondria in the development of…”
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SIRT3 and SIRT5 regulate the enzyme activity and cardiolipin binding of very long-chain acyl-CoA dehydrogenase by Zhang, Yuxun, Bharathi, Sivakama S, Rardin, Matthew J, Uppala, Radha, Verdin, Eric, Gibson, Bradford W, Goetzman, Eric S

“…SIRT3 and SIRT5 have been shown to regulate mitochondrial fatty acid oxidation but the molecular mechanisms behind the regulation are lacking. Here, we…”
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SILAC Analysis Reveals Increased Secretion of Hemostasis-Related Factors by Senescent Cells by Wiley, Christopher D., Liu, Su, Limbad, Chandani, Zawadzka, Anna M., Beck, Jennifer, Demaria, Marco, Artwood, Robert, Alimirah, Fatouma, Lopez-Dominguez, Jose-Alberto, Kuehnemann, Chisaka, Danielson, Steven R., Basisty, Natan, Kasler, Herbert G., Oron, Tal Ronnen, Desprez, Pierre-Yves, Mooney, Sean D., Gibson, Bradford W., Schilling, Birgit, Campisi, Judith, Kapahi, Pankaj

“…Cellular senescence irreversibly arrests cell proliferation, accompanied by a multi-component senescence-associated secretory phenotype (SASP) that…”
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Sweetening the Pot: Adding Glycosylation to the Biomarker Discovery Equation by Drake, Penelope M, Cho, Wonryeon, Li, Bensheng, Prakobphol, Akraporn, Johansen, Eric, Anderson, N. Leigh, Regnier, Fred E, Gibson, Bradford W, Fisher, Susan J

“…Cancer has profound effects on gene expression, including a cell's glycosylation machinery. Thus, tumors produce glycoproteins that carry oligosaccharides with…”
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Simultaneous Quantification of the Acetylome and Succinylome by ‘One‐Pot’ Affinity Enrichment by Basisty, Nathan, Meyer, Jesse G, Wei, Lei, Gibson, Bradford W, Schilling, Birgit

“…Protein posttranslational modifications (PTMs) are of increasing interest in biomedical research, yet studies rarely examine more than one PTM. One barrier to…”
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Life Span Extension via eIF4G Inhibition Is Mediated by Posttranscriptional Remodeling of Stress Response Gene Expression in C. elegans by Rogers, Aric N., Chen, Di, McColl, Gawain, Czerwieniec, Gregg, Felkey, Krysta, Gibson, Bradford W., Hubbard, Alan, Melov, Simon, Lithgow, Gordon J., Kapahi, Pankaj

“…Reducing protein synthesis slows growth and development but can increase adult life span. We demonstrate that knockdown of eukaryotic translation initiation…”
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Vitamin D Promotes Protein Homeostasis and Longevity via the Stress Response Pathway Genes skn-1, ire-1, and xbp-1 by Mark, Karla A., Dumas, Kathleen J., Bhaumik, Dipa, Schilling, Birgit, Davis, Sonnet, Oron, Tal Ronnen, Sorensen, Dylan J., Lucanic, Mark, Brem, Rachel B., Melov, Simon, Ramanathan, Arvind, Gibson, Bradford W., Lithgow, Gordon J.

“…Vitamin D has multiple roles, including the regulation of bone and calcium homeostasis. Deficiency of 25-hydroxyvitamin D, the major circulating form of…”
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Temporal dynamics of liver mitochondrial protein acetylation and succinylation and metabolites due to high fat diet and/or excess glucose or fructose by Meyer, Jesse G, Softic, Samir, Basisty, Nathan, Rardin, Matthew J, Verdin, Eric, Gibson, Bradford W, Ilkayeva, Olga, Newgard, Christopher B, Kahn, C Ronald, Schilling, Birgit

“…Dietary macronutrient composition alters metabolism through several mechanisms, including post-translational modification (PTM) of proteins. To connect diet…”
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Repeatability and Reproducibility in Proteomic Identifications by Liquid Chromatography−Tandem Mass Spectrometry by Tabb, David L, Vega-Montoto, Lorenzo, Rudnick, Paul A, Variyath, Asokan Mulayath, Ham, Amy-Joan L, Bunk, David M, Kilpatrick, Lisa E, Billheimer, Dean D, Blackman, Ronald K, Cardasis, Helene L, Carr, Steven A, Clauser, Karl R, Jaffe, Jacob D, Kowalski, Kevin A, Neubert, Thomas A, Regnier, Fred E, Schilling, Birgit, Tegeler, Tony J, Wang, Mu, Wang, Pei, Whiteaker, Jeffrey R, Zimmerman, Lisa J, Fisher, Susan J, Gibson, Bradford W, Kinsinger, Christopher R, Mesri, Mehdi, Rodriguez, Henry, Stein, Stephen E, Tempst, Paul, Paulovich, Amanda G, Liebler, Daniel C, Spiegelman, Cliff

“…The complexity of proteomic instrumentation for LC-MS/MS introduces many possible sources of variability. Data-dependent sampling of peptides constitutes a…”
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