Search Results - "GIBALDI, Daniel"
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Behavioral alterations in long-term Toxoplasma gondii infection of C57BL/6 mice are associated with neuroinflammation and disruption of the blood brain barrier
Published in PloS one (05-10-2021)“…The Apicomplexa protozoan Toxoplasma gondii is a mandatory intracellular parasite and the causative agent of toxoplasmosis. This illness is of medical…”
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CCL3/Macrophage Inflammatory Protein-1α Is Dually Involved in Parasite Persistence and Induction of a TNF- and IFNγ-Enriched Inflammatory Milieu in Trypanosoma cruzi -Induced Chronic Cardiomyopathy
Published in Frontiers in immunology (03-03-2020)“…CCL3, a member of the CC-chemokine family, has been associated with macrophage recruitment to heart tissue and parasite control in the acute infection of mouse…”
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Modulation of miR-145-5p and miR-146b-5p levels is linked to reduced parasite load in H9C2 Trypanosoma cruzi infected cardiomyoblasts
Published in Scientific reports (26-01-2022)“…In the heart tissue of acutely Trypanosoma cruzi -infected mice miR-145-5p and miR-146b-5p are, respectively, downregulated and upregulated. Here, we used the…”
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The beneficial effect of fluoxetine on behavioral and cognitive changes in chronic experimental Chagas disease unveils the role of serotonin fueling astrocyte infection by Trypanosoma cruzi
Published in PLoS neglected tropical diseases (01-05-2024)“…In Chagas disease (CD), a neglected tropical disease caused by the parasite Trypanosoma cruzi, the development of mental disorders such as anxiety, depression,…”
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Sulfadiazine Plus Pyrimethamine Therapy Reversed Multiple Behavioral and Neurocognitive Changes in Long-Term Chronic Toxoplasmosis by Reducing Brain Cyst Load and Inflammation-Related Alterations
Published in Frontiers in immunology (27-04-2022)“…infects one-third of the world population. For decades, it has been considered a silent lifelong infection. However, chronically -infected persons may present…”
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Preclinical evaluation of combined therapy with amiodarone and low-dose benznidazole in a mouse model of chronic Trypanosoma cruzi infection
Published in Biomedicine & pharmacotherapy (01-06-2024)“…Chagasic chronic cardiomyopathy (CCC) is the primary clinical manifestation of Chagas disease (CD), caused by Trypanosoma cruzi. Current therapeutic options…”
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Priming astrocytes with TNF enhances their susceptibility to Trypanosoma cruzi infection and creates a self-sustaining inflammatory milieu
Published in Journal of neuroinflammation (06-09-2017)“…In conditions of immunosuppression, the central nervous sty 5ystem (CNS) is the main target tissue for the reactivation of infection by Trypanosoma cruzi, the…”
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Pentoxifylline reverses chronic experimental Chagasic cardiomyopathy in association with repositioning of abnormal CD8+ T-cell response
Published in PLoS neglected tropical diseases (01-03-2015)“…Chronic chagasic cardiomyopathy (CCC), the main clinical sign of Chagas disease, is associated with systemic CD8+ T-cell abnormalities and CD8-enriched…”
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Physical Exercise Promotes a Reduction in Cardiac Fibrosis in the Chronic Indeterminate Form of Experimental Chagas Disease
Published in Frontiers in immunology (04-11-2021)“…Chagas disease (CD), caused by the protozoan , is a neglected tropical disease and a health problem in Latin America. Etiological treatment has limited…”
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Genetic Polymorphism at CCL5 Is Associated With Protection in Chagas' Heart Disease: Antagonistic Participation of CCR1 + and CCR5 + Cells in Chronic Chagasic Cardiomyopathy
Published in Frontiers in immunology (11-04-2018)“…Chronic cardiomyopathy is the main clinical manifestation of Chagas disease (CD), a disease caused by infection. A hallmark of chronic chagasic cardiomyopathy…”
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CCL2/MCP-1 controls parasite burden, cell infiltration, and mononuclear activation during acute Trypanosoma cruzi infection
Published in Journal of leukocyte biology (01-11-2009)“…CCL2 controls heart inflammation and parasite burden in Trypanosoma cruzi infection through cell recruitment and activation. CCL2/MCP‐1 has emerged recently as…”
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Proinflammatory and Cytotoxic Effects of Hexadecylphosphocholine (Miltefosine) against Drug-Resistant Strains of Trypanosoma cruzi
Published in Antimicrobial Agents and Chemotherapy (01-11-2002)“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Drug Repurposing in Chagas Disease: Chloroquine Potentiates Benznidazole Activity against Trypanosoma cruzi In Vitro and In Vivo
Published in Antimicrobial agents and chemotherapy (15-11-2022)“…Drug combinations and drug repurposing have emerged as promising strategies to develop novel treatments for infectious diseases, including Chagas disease. In…”
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Pentoxifylline Reverses Chronic Experimental Chagasic Cardiomyopathy in Association with Repositioning of Abnormal CD8 + T-Cell Response: e0003659
Published in PLoS neglected tropical diseases (01-03-2015)“…Background Chronic chagasic cardiomyopathy (CCC), the main clinical sign of Chagas disease, is associated with systemic CD8+ T-cell abnormalities and…”
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Pentoxifylline reverses chronic experimental chagasic cardiomyopathy in association with repositioning of abnormal [CD8.sup.+] T-cell response
Published in PLoS neglected tropical diseases (01-03-2015)“…Background Chronic chagasic cardiomyopathy (CCC), the main clinical sign of Chagas disease, is associated with systemic [CD8.sup.+] T-cell abnormalities and…”
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Unraveling the lethal synergism between Trypanosoma cruzi infection and LPS: A role for increased macrophage reactivity
Published in European Journal of Immunology (01-05-2007)“…Various infections sensitize to lethal shock by promoting hyperactivation of macrophages to LPS stimulation. Although macrophages are thought to be deactivated…”
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Effects of perillyl alcohol in glial C6 cell line in vitro and anti-metastatic activity in chorioallantoic membrane model
Published in International journal of molecular medicine (01-12-2002)“…The search for new chemotherapeutic drugs has increased, especially for those that have a natural origin. The monoterpene perillyl alcohol (POH) has been shown…”
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