Search Results - "GIANNAKAKOU, Paraskevi"

A Bayesian machine learning approach for drug target identification using diverse data types by Madhukar, Neel S., Khade, Prashant K., Huang, Linda, Gayvert, Kaitlyn, Galletti, Giuseppe, Stogniew, Martin, Allen, Joshua E., Giannakakou, Paraskevi, Elemento, Olivier

“…Drug target identification is a crucial step in development, yet is also among the most complex. To address this, we develop BANDIT, a Bayesian…”
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Androgen Receptor on the Move: Boarding the Microtubule Expressway to the Nucleus by THADANI-MULERO, Maria, NANUS, David M, GIANNAKAKOU, Paraskevi

“…Recent studies have shown that the microtubule-stabilizing drug paclitaxel, which is commonly used for the treatment of prostate cancer, inhibits signaling…”
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Prospective Multicenter Validation of Androgen Receptor Splice Variant 7 and Hormone Therapy Resistance in High-Risk Castration-Resistant Prostate Cancer: The PROPHECY Study by Armstrong, Andrew J, Halabi, Susan, Luo, Jun, Nanus, David M, Giannakakou, Paraskevi, Szmulewitz, Russell Z, Danila, Daniel C, Healy, Patrick, Anand, Monika, Rothwell, Colin J, Rasmussen, Julia, Thornburg, Blair, Berry, William R, Wilder, Rhonda S, Lu, Changxue, Chen, Yan, Silberstein, John L, Kemeny, Gabor, Galletti, Giuseppe, Somarelli, Jason A, Gupta, Santosh, Gregory, Simon G, Scher, Howard I, Dittamore, Ryan, Tagawa, Scott T, Antonarakis, Emmanuel S, George, Daniel J

“…Androgen receptor splice variant 7 (AR-V7) results in a truncated receptor, which leads to ligand-independent constitutive activation that is not inhibited by…”
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A SIRT2-Selective Inhibitor Promotes c-Myc Oncoprotein Degradation and Exhibits Broad Anticancer Activity by Jing, Hui, Hu, Jing, He, Bin, Negrón Abril, Yashira L., Stupinski, Jack, Weiser, Keren, Carbonaro, Marisa, Chiang, Ying-Ling, Southard, Teresa, Giannakakou, Paraskevi, Weiss, Robert S., Lin, Hening

“…Targeting sirtuins for cancer treatment has been a topic of debate due to conflicting reports and lack of potent and specific inhibitors. We have developed a…”
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Androgen Receptor Splice Variants Determine Taxane Sensitivity in Prostate Cancer by THADANI-MULERO, Maria, PORTELLA, Luigi, SHIHUA SUN, MATTHEW SUNG, MATOV, Alexandre, VESSELLA, Robert L, COREY, Eva, NANUS, David M, PLYMATE, Stephen R, GIANNAKAKOU, Paraskevi

“…Prostate cancer growth depends on androgen receptor signaling. Androgen ablation therapy induces expression of constitutively active androgen receptor splice…”
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Capture of circulating tumor cells from whole blood of prostate cancer patients using geometrically enhanced differential immunocapture (GEDI) and a prostate-specific antibody by Gleghorn, Jason P, Pratt, Erica D, Denning, Denise, Liu, He, Bander, Neil H, Tagawa, Scott T, Nanus, David M, Giannakakou, Paraskevi A, Kirby, Brian J

“…Geometrically enhanced differential immunocapture (GEDI) and an antibody for prostate-specific membrane antigen (PSMA) are used for high-efficiency and…”
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Taxane-Induced Blockade to Nuclear Accumulation of the Androgen Receptor Predicts Clinical Responses in Metastatic Prostate Cancer by DARSHAN, Medha S, LOFTUS, Matthew S, BANDE, Neil H, NANUS, David M, GIANNAKAKOU, Paraskevi, THADANI-MULERO, Maria, LEVY, Benjamin P, ESCUIN, Daniel, KATHY ZHOU, Xi, GJYREZI, Ada, CHANEL-VOS, Chantal, SHEN, Ruoqian, TAGAWA, Scott T

“…Prostate cancer progression requires active androgen receptor (AR) signaling which occurs following translocation of AR from the cytoplasm to the nucleus…”
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Widespread Mitotic Bookmarking by Histone Marks and Transcription Factors in Pluripotent Stem Cells by Liu, Yiyuan, Pelham-Webb, Bobbie, Di Giammartino, Dafne Campigli, Li, Jiexi, Kim, Daleum, Kita, Katsuhiro, Saiz, Nestor, Garg, Vidur, Doane, Ashley, Giannakakou, Paraskevi, Hadjantonakis, Anna-Katerina, Elemento, Olivier, Apostolou, Effie

“…During mitosis, transcription is halted and many chromatin features are lost, posing a challenge for the continuity of cell identity, particularly in fast…”
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Isolation of breast cancer and gastric cancer circulating tumor cells by use of an anti HER2-based microfluidic device by Galletti, Giuseppe, Sung, Matthew S, Vahdat, Linda T, Shah, Manish A, Santana, Steven M, Altavilla, Giuseppe, Kirby, Brian J, Giannakakou, Paraskevi

“…Circulating tumor cells (CTCs) have emerged as a reliable source of tumor cells, and their concentration has prognostic implications. CTC capture offers…”
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Functional characterization of circulating tumor cells with a prostate-cancer-specific microfluidic device by Kirby, Brian J, Jodari, Mona, Loftus, Matthew S, Gakhar, Gunjan, Pratt, Erica D, Chanel-Vos, Chantal, Gleghorn, Jason P, Santana, Steven M, Liu, He, Smith, James P, Navarro, Vicente N, Tagawa, Scott T, Bander, Neil H, Nanus, David M, Giannakakou, Paraskevi

“…Cancer metastasis accounts for the majority of cancer-related deaths owing to poor response to anticancer therapies. Molecular understanding of…”
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AR-V7 exhibits non-canonical mechanisms of nuclear import and chromatin engagement in castrate-resistant prostate cancer by Kim, Seaho, Au, CheukMan C, Jamalruddin, Mohd Azrin Bin, Abou-Ghali, Naira Essam, Mukhtar, Eiman, Portella, Luigi, Berger, Adeline, Worroll, Daniel, Vatsa, Prerna, Rickman, David S, Nanus, David M, Giannakakou, Paraskevi

“…Expression of the AR splice variant, androgen receptor variant 7 (AR-V7), in prostate cancer is correlated with poor patient survival and resistance to AR…”
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A SIRT2-Selective Inhibitor Promotes c-Myc Oncoprotein Degradation and Exhibits Broad Anticancer Activity by Jing, Hui, Hu, Jing, He, Bin, Negrón Abril, Yashira L., Stupinski, Jack, Weiser, Keren, Carbonaro, Marisa, Chiang, Ying-Ling, Southard, Teresa, Giannakakou, Paraskevi, Weiss, Robert S., Lin, Hening

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The importance of p53 location: nuclear or cytoplasmic zip code? by O’Brate, Aurora, Giannakakou, Paraskevi

“…The regulation of p53 functions is tightly controlled through several mechanisms including p53 transcription and translation, protein stability,…”
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RABbing cancer the wrong way by Khade, Prashant K., Giannakakou, Paraskevi

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2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF by Mabjeesh, Nicola J., Escuin, Daniel, LaVallee, Theresa M., Pribluda, Victor S., Swartz, Glenn M., Johnson, Michelle S., Willard, Margaret T., Zhong, Hua, Simons, Jonathan W., Giannakakou, Paraskevi

“…Inhibition of angiogenesis is an important new modality for cancer treatment. 2-methoxyestradiol (2ME2) is a novel antitumor and antiangiogenic agent,…”
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Pharmacodynamic study of radium-223 in men with bone metastatic castration resistant prostate cancer by Armstrong, Andrew J, Gupta, Santosh, Healy, Patrick, Kemeny, Gabor, Leith, Beth, Zalutsky, Michael R, Spritzer, Charles, Davies, Catrin, Rothwell, Colin, Ware, Kathryn, Somarelli, Jason A, Wood, Kris, Ribar, Thomas, Giannakakou, Paraskevi, Zhang, Jiaren, Gerber, Drew, Anand, Monika, Foo, Wen-Chi, Halabi, Susan, Gregory, Simon G, George, Daniel J

“…Radium-223 is a targeted alpha-particle therapy that improves survival in men with metastatic castration resistant prostate cancer (mCRPC), particularly in men…”
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NAD⁺ and SIRT3 control microtubule dynamics and reduce susceptibility to antimicrotubule agents by Harkcom, William T, Ghosh, Ananda K, Sung, Matthew S, Matov, Alexandre, Brown, Kevin D, Giannakakou, Paraskevi, Jaffrey, Samie R

“…Nicotinamide adenine dinucleotide (NAD ⁺) is an endogenous enzyme cofactor and cosubstrate that has effects on diverse cellular and physiologic processes,…”
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Circulating tumor cells from prostate cancer patients interact with E-selectin under physiologic blood flow by Gakhar, Gunjan, Navarro, Vicente N, Jurish, Madelyn, Lee, Guang Yu, Tagawa, Scott T, Akhtar, Naveed H, Seandel, Marco, Geng, Yue, Liu, He, Bander, Neil H, Giannakakou, Paraskevi, Christos, Paul J, King, Michael R, Nanus, David M

“…Hematogenous metastasis accounts for the majority of cancer-related deaths, yet the mechanism remains unclear. Circulating tumor cells (CTCs) in blood may…”
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EF24, a novel curcumin analog, disrupts the microtubule cytoskeleton and inhibits HIF-1 by Thomas, Shala L., Zhong, Diansheng, Zhou, Wei, Malik, Sanna, Liotta, Dennis, Snyder, James P., Hamel, Ernest, Giannakakou, Paraskevi

“…Curcumin, the yellow pigment of the spice turmeric, has emerged as a promising anticancer agent due to its antiproliferative and antiangiogenic properties…”
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Androgen receptor variant shows heterogeneous expression in prostate cancer according to differentiation stage by Gjyrezi, Ada, Galletti, Giuseppe, Zhang, Jiaren, Worroll, Daniel, Sigouros, Michael, Kim, Seaho, Cooley, Victoria, Ballman, Karla V., Ocean, Allyson J., Shah, Manish A., Scandura, Joseph M., Sboner, Andrea, Nanus, David M., Beltran, Himisha, Tagawa, Scott, Giannakakou, Paraskevi

“…Quantitation of androgen receptor variant (AR-V) expression in circulating tumor cells (CTCs) from patients with metastatic castration-resistant prostate…”
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