Search Results - "GIACOVELLI, Giampaolo"

Effects of glucosamine sulfate on the use of rescue non-steroidal anti-inflammatory drugs in knee osteoarthritis: Results from the Pharmaco-Epidemiology of GonArthroSis (PEGASus) study by Rovati, Lucio C., MD, Girolami, Federica, PharmD, MSc, D’Amato, Massimo, MD, Giacovelli, Giampaolo, PhD

“…Abstract Background and objective The use of Symptomatic Slow-Acting Drugs in Osteoarthritis (SYSADOAs) may be expected to decrease the use of concomitant…”
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Intravenous silibinin monotherapy shows significant antiviral activity in HCV-infected patients in the peri-transplantation period by Mariño, Zoe, Crespo, Gonzalo, D’Amato, Massimo, Brambilla, Nadia, Giacovelli, Giampaolo, Rovati, Lucio, Costa, Josep, Navasa, Miquel, Forns, Xavier

“…Background & Aims Hepatitis C recurrence after liver transplantation (LT) is the main problem of most transplant programs. We aimed at assessing the antiviral…”
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Overrunning in clinical trials: some thoughts from a methodological review by Baldi, Ileana, Azzolina, Danila, Soriani, Nicola, Barbetta, Beatrice, Vaghi, Paola, Giacovelli, Giampaolo, Berchialla, Paola, Gregori, Dario

“…In sequential and adaptive trials, the delay that happens after the trial is stopped, by a predetermined stopping criterion, takes the name of overrunning…”
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Efficacy of a nutraceutical combination on lipid metabolism in patients with metabolic syndrome: a multicenter, double blind, randomized, placebo controlled trial by Galletti, Ferruccio, Fazio, Valeria, Gentile, Marco, Schillaci, Giuseppe, Pucci, Giacomo, Battista, Francesca, Mercurio, Valentina, Bosso, Giorgio, Bonaduce, Domenico, Brambilla, Nadia, Vitalini, Cristina, D'Amato, Massimo, Giacovelli, Giampaolo

“…Nutraceuticals represent a new therapeutic frontier in the treatment of metabolic syndrom (MetS) and related cardiovascular risk factors. The aim of this study…”
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The role of diet and exercise and of glucosamine sulfate in the prevention of knee osteoarthritis: Further results from the PRevention of knee Osteoarthritis in Overweight Females (PROOF) study by Runhaar, Jos, PhD, Deroisy, Rita, PhD, van Middelkoop, Marienke, PhD, Barretta, Francesco, MSc, Barbetta, Beatrice, PhD, Oei, Edwin H., MD, PhD, Vroegindeweij, Dammis, MD, PhD, Giacovelli, Giampaolo, PhD, Bruyère, Olivier, PhD, Rovati, Lucio C., MD, Reginster, Jean-Yves, MD, PhD, Bierma-Zeinstra, Sita M.A., PhD

“…Abstract Background and objectives The PRevention of knee Osteoarthritis in Overweight Females (PROOF) study (ISRCTN 42823086) described a trend for a decrease…”
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Efficacy of Andolast in Mild to Moderate Asthma: A Randomized, Controlled, Double-Blind Multicenter Study (The Andast Trial) by Malerba, Mario, D Amato, Massimo, Radaeli, Alessandro, Giacovelli, Giampaolo, Rovati, Lucio, Arshad, Sayed H, Holgate, Stephen T

“…Andolast is a new airway specific anti-inflammatory agent. The aim of the present multicentered, randomized, placebo controlled study is to investigate whether…”
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Cholecystokinin pathways modulate sensations induced by gastric distension in humans by Lal, Simon, McLaughlin, John, Barlow, Josephine, D'Amato, Massimo, Giacovelli, Giampaolo, Varro, Andrea, Dockray, Graham J, Thompson, David G

“…Ingested fat releases CCK, causes gastric relaxation, delays gastric emptying, and limits meal size; however, the mechanistic link among these actions has not…”
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Biochemical markers of bone and cartilage remodeling in prediction of longterm progression of knee osteoarthritis by BRUYERE, Olivier, COLLETTE, Julien H, ETHGEN, Olivier, ROVATI, Lucio C, GIACOVELLI, Giampaolo, HENROTIN, Yves E, SEIDEL, Laurence, REGINSTER, Jean-Yves L

“…OBJECTIVE: To investigate the relationship between biochemical markers of bone and cartilage remodeling and severity or progression (symptoms and structure) of…”
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Association of Pharmacological Treatments With Long-term Pain Control in Patients With Knee Osteoarthritis: A Systematic Review and Meta-analysis by Gregori, Dario, Giacovelli, Giampaolo, Minto, Clara, Barbetta, Beatrice, Gualtieri, Francesca, Azzolina, Danila, Vaghi, Paola, Rovati, Lucio C

“…IMPORTANCE: Even though osteoarthritis is a chronic and progressive disease, pharmacological agents are mainly studied over short-term periods, resulting in…”
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Radiologic features poorly predict clinical outcomes in knee osteoarthritis by Bruyere, Olivier, Honore, Aline, Rovati, Lucio C., Giacovelli, Giampaolo, Henrotin, Yves E., Seidel, Laurence, Reginster, Jean-Yves L.

“…Objectives: To assess the impact of radiographic severity and progression on pain and disability. Methods: Measurements of mean joint space width (JSW),…”
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A randomised, double-blind, controlled trial comparing two intra-articular hyaluronic acid preparations differing by their molecular weight in symptomatic knee osteoarthritis by Berenbaum, Francis, Grifka, Joachim, Cazzaniga, Sara, D'Amato, Massimo, Giacovelli, Giampaolo, Chevalier, Xavier, Rannou, Francois, Rovati, Lucio C, Maheu, Emmanuel

“…To compare the effects of an intermediate molecular weight (MW) intra-articular hyaluronic acid (HA) with a low MW product on knee osteoarthritis (OA)…”
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A nutraceutical combination reduces left ventricular mass in subjects with metabolic syndrome and left ventricular hypertrophy: A multicenter, randomized, double-blind, placebo-controlled trial by Mercurio, Valentina, Pucci, Giacomo, Bosso, Giorgio, Fazio, Valeria, Battista, Francesca, Iannuzzi, Angela, Brambilla, Nadia, Vitalini, Cristina, D'Amato, Massimo, Giacovelli, Giampaolo, Vaudo, Gaetano, Schillaci, Giuseppe, Galletti, Ferruccio, Bonaduce, Domenico

“…Increased left ventricular mass (LVM) is often present in metabolic syndrome (MS), also in the setting of well-controlled blood pressure (BP). Aim of the…”
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A first-in-human trial on the safety and immunogenicity of COVID-eVax, a cellular response-skewed DNA vaccine against COVID-19 by Aurisicchio, Luigi, Brambilla, Nadia, Cazzaniga, Marina E., Bonfanti, Paolo, Milleri, Stefano, Ascierto, Paolo A., Capici, Serena, Vitalini, Cristina, Girolami, Federica, Giacovelli, Giampaolo, Caselli, Gianfranco, Visintin, Michela, Fanti, Francesca, Ghirri, Matteo, Conforti, Antonella, Compagnone, Mirco, Lione, Lucia, Salvatori, Erika, Pinto, Eleonora, Muzi, Alessia, Marra, Emanuele, Palombo, Fabio, Roscilli, Giuseppe, Manenti, Alessandro, Montomoli, Emanuele, Cadossi, Matteo, Rovati, Lucio C.

“…The COVID-19 pandemic and the need for additional safe, effective, and affordable vaccines gave new impetus into development of vaccine genetic platforms. Here…”
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Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial by Reginster, Jean Yves, Deroisy, Rita, Rovati, Lucio C, Lee, Richard L, Lejeune, Eric, Bruyere, Olivier, Giacovelli, Giampaolo, Henrotin, Yves, Dacre, Jane E, Gossett, Christiane

“…Treatment of osteoarthritis is usually limited to short-term symptom control. We assessed the effects of the specific drug glucosamine sulphate on the…”
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Antiviral activity and safety profile of silibinin in HCV patients with advanced fibrosis after liver transplantation: a randomized clinical trial by Rendina, Maria, D'Amato, Massimo, Castellaneta, Antonino, Castellaneta, Nicola Maurizio, Brambilla, Nadia, Giacovelli, Giampaolo, Rovati, Lucio, Rizzi, Salvatore Fabio, Zappimbulso, Marianna, Bringiotti, Roberto Spyridon, Di Leo, Alfredo

“…Response to interferon-based therapies in HCV recurrence after liver transplantation (LT) is unsatisfactory, and major safety issues aroused in preliminary…”
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OARSI/OMERACT Initiative to Define States of Severity and Indication for Joint Replacement in Hip and Knee Osteoarthritis. An OMERACT 10 Special Interest Group by GOSSEC, Laure, PATERNOTTE, Simon, HOCHBERG, Marc C, JORDAN, Joanne M, KATZ, Jeffrey N, KLOPPENBURG, Margreet, LANZAROTTI, Arturo, LIM, Keith, STEFAN LOHMANDER, L, MAHOMED, Nizar N, MAILLEFERT, Jean Francis, MANNO, Rebecca L, BINGHAM, Clifton O, MARCH, Lyn M, MAZZUCA, Steven A, PAVELKA, Karel, PUNZI, Leonardo, ROOS, Ewa M, ROVATI, Lucio C, SHI, Helen, SINGH, Jasvinder A, SUAREZ-ALMAZOR, Maria E, TAJANA-MESSI, Eleonora, CLEGG, Daniel O, DOUGADOS, Maxime, COSTE, Philippe, CONAGHAN, Philip G, DAVIS, Aileen M, GIACOVELLI, Giampaolo, GUNTHER, Klaus-Peter, HAWKER, Gillian

“…To define pain and physical function cutpoints that would, coupled with structural severity, define a surrogate measure of "need for joint replacement…”
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Conclusions not supported by methods and results by Giacovelli, Giampaolo, Rovati, Lucio C

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Glucosamine sulfate reduces osteoarthritis progression in postmenopausal women with knee osteoarthritis: evidence from two 3-year studies by Bruyere, Olivier, Pavelka, Karel, Rovati, Lucio C., Deroisy, Rita, Olejarova, Marta, Gatterova, Jindriska, Giacovelli, Giampaolo, Reginster, Jean-Yves

“…OBJECTIVETo investigate the effect of glucosamine sulfate on long-term symptoms and structure progression in postmenopausal women with knee osteoarthritis…”
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Glucosamine and osteoarthritis. Conclusions not supported by methods and results by Giacovelli, Giampaolo, Rovati, Lucio C

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Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study by Pavelká, Karel, Gatterová, Jindriska, Olejarová, Marta, Machacek, Stanislav, Giacovelli, Giampaolo, Rovati, Lucio C

“…Conventional symptomatic treatments for osteoarthritis do not favorably affect disease progression. The aim of this randomized, placebo-controlled trial was to…”
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