Search Results - "GIACOMETTI, Sarah"

Mathematical modeling of tumor growth and metastatic spreading: validation in tumor-bearing mice by Hartung, Niklas, Mollard, Séverine, Barbolosi, Dominique, Benabdallah, Assia, Chapuisat, Guillemette, Henry, Gerard, Giacometti, Sarah, Iliadis, Athanassios, Ciccolini, Joseph, Faivre, Christian, Hubert, Florence

“…Defining tumor stage at diagnosis is a pivotal point for clinical decisions about patient treatment strategies. In this respect, early detection of occult…”
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Pharmacokinetics and Pharmacodynamics-Based Mathematical Modeling Identifies an Optimal Protocol for Metronomic Chemotherapy by Ciccolini, Joseph, Barbolosi, Dominique, Meille, Christophe, Lombard, Aurélie, Serdjebi, Cindy, Giacometti, Sarah, Padovani, Laetitia, Pasquier, Eddy, André, Nicolas

“…Metronomic chemotherapy is usually associated with better tolerance than conventional chemotherapy, and encouraging response rates have been reported in…”
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From 3D spheroids to tumor bearing mice: efficacy and distribution studies of trastuzumab-docetaxel immunoliposome in breast cancer by Rodallec, Anne, Sicard, Guillaume, Giacometti, Sarah, Carré, Manon, Pourroy, Bertrand, Bouquet, Fanny, Savina, Ariel, Lacarelle, Bruno, Ciccolini, Joseph, Fanciullino, Raphaelle

“…Nanoparticles are of rising interest in cancer research, but in vitro canonical cell monolayer models are not suitable to evaluate their efficacy when…”
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Enhanced Antisense Oligonucleotide Delivery Using Cationic Liposomes Grafted with Trastuzumab: A Proof-of-Concept Study in Prostate Cancer by Sicard, Guillaume, Paris, Clément, Giacometti, Sarah, Rodallec, Anne, Ciccolini, Joseph, Rocchi, Palma, Fanciullino, Raphaëlle

“…Prostate cancer (PCa) is the second most common cancer in men worldwide and the fifth leading cause of death by cancer. The overexpression of TCTP protein…”
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Cytidine Deaminase Residual Activity in Serum Is a Predictive Marker of Early Severe Toxicities in Adults After Gemcitabine-Based Chemotherapies by CICCOLINI, Joseph, DAHAN, Laetitia, ORTIZ, Adrien, FRANCES, Nicolas, ILIADIS, Athanassios, DUFFAUD, Florence, SEITZ, Jean-François, MERCIER, Cédric, ANDRE, Nicolas, EVRARD, Alexandre, DULUC, Muriel, BLESIUS, Aurore, CHENGUANG YANG, GIACOMETTI, Sarah, BRUNET, Caroline, RAYNAL, Caroline

“…PURPOSE Anticipating toxicities with gemcitabine is an ongoing story, and deregulation in cytidine deaminase (CDA) could be associated with increased risk of…”
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Antiproliferative effect of ascorbic acid is associated with the inhibition of genes necessary to cell cycle progression by Belin, Sophie, Kaya, Ferdinand, Duisit, Ghislaine, Giacometti, Sarah, Ciccolini, Joseph, Fontés, Michel

“…Ascorbic acid (AA), or Vitamin C, is most well known as a nutritional supplement with antioxidant properties. Recently, we demonstrated that high…”
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Early severe toxicities after capecitabine intake: possible implication of a cytidine deaminase extensive metabolizer profile by Mercier, Cedric, Dupuis, Charlotte, Blesius, Aurore, Fanciullino, Raphaelle, Yang, Chen Guang, Padovani, Laetitia, Giacometti, Sarah, Frances, Nicolas, Iliadis, Athanassios, Duffaud, Florence, Ciccolini, Joseph

“…We report here the case of a 19-year-old female patient who suffered from extremely severe toxicities (G4 mucitis, fever, diarrhea, alteration of general…”
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Propranolol potentiates the anti-angiogenic effects and anti-tumor efficacy of chemotherapy agents: implication in breast cancer treatment by Pasquier, Eddy, Ciccolini, Joseph, Carre, Manon, Giacometti, Sarah, Fanciullino, Raphaelle, Pouchy, Charlotte, Montero, Marie-Pierre, Serdjebi, Cindy, Kavallaris, Maria, André, Nicolas

“…Recent clinical evidence revealed that the use of beta-blockers such as propranolol, prior to diagnosis or concurrently with chemotherapy, could increase…”
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Pegylated liposome encapsulating docetaxel using microfluidic mixing technique: Process optimization and results in breast cancer models by Dacos, Mathilde, Immordino, Benoît, Diroff, Erwan, Sicard, Guillaume, Kosta, Artemis, Rodallec, Anne, Giacometti, Sarah, Ciccolini, Joseph, Fanciullino, Raphaëlle

“…[Display omitted] The development of nanoparticles could help to improve the efficacy/toxicity balance of drugs. This project aimed to develop liposomes and…”
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Abstract 7173: Animal pharmacokinetics of an anti-Her2+ immunoliposome of docetaxel by Dacos, Mathilde, Diroff, Erwan, Giacometti, Sarah, Ciccolini, Joseph, Fanciullino, Raphaelle

“…Despite the success of docetaxel in combination with trastuzumab in HER2+ breast cancer, docetaxel still has serious limitations, including poor water…”
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Abstract 1856: Pemetrexed-cisplatin-bevacizumab combo in lung cancer models: impact on tumor immunity by Sicard, Guillaume, Giacometti, Sarah, Barlesi, Fabrice, Fanciullino, Raphaelle, Ciccolini, Joseph

“…Dual chemotherapy (i.e., Pemetrexed and Cisplatin, CT) plus anti-VEGF Bevacizumab could be associated with anti-PD1 such as Pembrolizumab in NSCLC patients…”
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In Vivo Bioluminescence Tomography for Monitoring Breast Tumor Growth and Metastatic Spreading: Comparative Study and Mathematical Modeling by Mollard, Séverine, Fanciullino, Raphaelle, Giacometti, Sarah, Serdjebi, Cindy, Benzekry, Sebastien, Ciccolini, Joseph

“…This study aimed at evaluating the reliability and precision of Diffuse Luminescent Imaging Tomography (DLIT) for monitoring primary tumor and metastatic…”
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Abstract 2099: Model-riven optimization of anti-angiogenics combined with chemotherapy: application to bevacizumab + pemetrexed/cisplatin doublet in NSCLC-bearing mice by Ciccolini, Joseph, Benzekry, Sebastien, Giacometti, Sarah, Barlesi, Fabrice, Barbolosi, Dominique

“…Bevacizumab-containing protocols are all based upon the concomitant administration of the drugs given in a row. Bevacizumab is expected to induce a transient…”
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Biodistribution, Tumor Uptake and Efficacy of 5-FU-Loaded Liposomes: Why Size Matters by Fanciullino, Raphaelle, Mollard, Severine, Correard, Florian, Giacometti, Sarah, Serdjebi, Cindy, Iliadis, Athanassios, Ciccolini, Joseph

“…ABSTRACT Purpose We have investigated the impact of particle size on the biodistribution, tumor uptake and antiproliferative efficacy of 5-FU-loaded liposomes…”
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Abstract 4037: Optimizing the efficacy of anti-VEGF/cytotoxics/anti-PD-1 scheduling in a lung cancer mice model through B and T cells monitoring by Sicard, Guillaume, Protzenko, Dorian, Giacometti, Sarah, Fanciullino, Raphaelle, Barlesi, Fabrice, Ciccolini, Joseph

“…The exact modalities of combinatorial regimens associating Immune Checkpoint Inhibitors (ICI) with other treatments are yet to be defined. Understanding how…”
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Tumor uptake and associated greater efficacy of anti-Her2 immunoliposome does not rely on Her2 expression status: study of a docetaxel-trastuzumab immunoliposome on Her2+ breast cancer model (SKBR3) by Rodallec, Anne, Sicard, Guillaume, Giacometti, Sarah, Carre, Manon, Maia, Thomas, Valette, Margaux, Bouquet, Fanny, Savina, Ariel, Lacarelle, Bruno, Ciccolini, Joseph, Fanciullino, Raphaelle

“…Nanoparticles have been used for decades in breast cancer. More recently, anti-human epidermal receptor 2 (Her2) immunoliposomes are of rising interest…”
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Overcoming immuno-resistance by rescheduling anti-VEGF/cytotoxics/anti-PD-1 combination in lung cancer model by Sicard, Guillaume, Protzenko, Dorian, Giacometti, Sarah, Barlési, Fabrice, Ciccolini, Joseph, Fanciullino, Raphaelle

“…Many tumors are refractory to immune checkpoint inhibitors, but their combination with cytotoxics is expected to improve sensitivity. Understanding how and…”
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Abstract 3709: Characterization, in vitro and in vivo efficacy studies of docetaxel trastuzumab stealth immunoliposome in human breast cancer models by Rodallec, Anne, Brunel, Jean Michel, Robert, Stephane, Giacometti, Sarah, Savina, Ariel, Bouquet, Fanny, Lacarelle, Bruno, Ciccolini, Joseph, Fanciullino, Raphaelle

“…In HER2-positive breast cancer, the Trastuzumab + Docetaxel doublet has a significant efficacy but is hampered by frequent toxicities that could be addressed…”
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Abstract 1857: Nanoliposomes harness tumor immunity in breast cancer models by Dacos, Mathilde, Sicard, Guillaume, Immordino, Benoit, Giacometti, Sarah, Ciccolini, Joseph, Rodallec, Anne, Fanciullino, Raphaelle

“…The effect on the immune system of nanoparticles is poorly described. The aim of this study was to analyze in immuno-competent BalbC mice bearing or not 4T1…”
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Abstract 3000: Impact of trastuzumab coating when prototyping immunoliposomes in breast cancer models: The more the merrier by Rodallec, Anne, Franco, Corentin, Robert, Stéphane, Sicard, Guillaume, Giacometti, Sarah, Savina, Ariel, Bouquet, Fanny, Lacarelle, Bruno, Ciccolini, Joseph, Poncelet, Philippe, Fanciullino, Raphaelle

“…Background: Improving drug delivery in oncology by developing antibodies targeted nanoparticles loaded with cytotoxics is a rising strategy in oncology…”
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