Search Results - "GHYSELINCK, NORBERT"

Retinoic acid signaling pathways by Ghyselinck, Norbert B, Duester, Gregg

“…Retinoic acid (RA), a metabolite of retinol (vitamin A), functions as a ligand for nuclear RA receptors (RARs) that regulate development of chordate animals…”
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Local retinoic acid signaling directs emergence of the extraocular muscle functional unit by Comai, Glenda Evangelina, Tesařová, Markéta, Dupé, Valérie, Rhinn, Muriel, Vallecillo-García, Pedro, da Silva, Fabio, Feret, Betty, Exelby, Katherine, Dollé, Pascal, Carlsson, Leif, Pryce, Brian, Spitz, François, Stricker, Sigmar, Zikmund, Tomáš, Kaiser, Jozef, Briscoe, James, Schedl, Andreas, Ghyselinck, Norbert B, Schweitzer, Ronen, Tajbakhsh, Shahragim

“…Coordinated development of muscles, tendons, and their attachment sites ensures emergence of functional musculoskeletal units that are adapted to diverse…”
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Endogenous retinoic acid signaling is required for maintenance and regeneration of cornea by Kumar, Sandeep, Dollé, Pascal, Ghyselinck, Norbert B., Duester, Gregg

“…Retinoic acid (RA) is a biologically active metabolite of vitamin A (retinol) that serves as an important signaling molecule in orchestrating diverse…”
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Multilayer omics analysis reveals a non-classical retinoic acid signaling axis that regulates hematopoietic stem cell identity by Schönberger, Katharina, Obier, Nadine, Romero-Mulero, Mari Carmen, Cauchy, Pierre, Mess, Julian, Pavlovich, Polina V., Zhang, Yu Wei, Mitterer, Michael, Rettkowski, Jasmin, Lalioti, Maria-Eleni, Jäcklein, Karin, Curtis, Jonathan D., Féret, Betty, Sommerkamp, Pia, Morganti, Claudia, Ito, Keisuke, Ghyselinck, Norbert B., Trompouki, Eirini, Buescher, Joerg M., Pearce, Erika L., Cabezas-Wallscheid, Nina

“…Hematopoietic stem cells (HSCs) rely on complex regulatory networks to preserve stemness. Due to the scarcity of HSCs, technical challenges have limited our…”
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Retinoic Acid Receptors Control Spermatogonia Cell-Fate and Induce Expression of the SALL4A Transcription Factor by Gely-Pernot, Aurore, Raverdeau, Mathilde, Teletin, Marius, Vernet, Nadège, Féret, Betty, Klopfenstein, Muriel, Dennefeld, Christine, Davidson, Irwin, Benoit, Gérard, Mark, Manuel, Ghyselinck, Norbert B

“…All-trans retinoic acid (ATRA) is instrumental to male germ cell differentiation, but its mechanism of action remains elusive. To address this question, we…”
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FOXL2 Is a Female Sex-Determining Gene in the Goat by Boulanger, Laurent, Pannetier, Maëlle, Gall, Laurence, Allais-Bonnet, Aurélie, Elzaiat, Maëva, Le Bourhis, Daniel, Daniel, Nathalie, Richard, Christophe, Cotinot, Corinne, Ghyselinck, Norbert B., Pailhoux, Eric

“…The origin of sex reversal in XX goats homozygous for the polled intersex syndrome (PIS) mutation was unclear because of the complexity of the mutation that…”
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DMRT1 Protects Male Gonadal Cells from Retinoid-Dependent Sexual Transdifferentiation by Minkina, Anna, Matson, Clinton K., Lindeman, Robin E., Ghyselinck, Norbert B., Bardwell, Vivian J., Zarkower, David

“…Mammalian sex determination initiates in the fetal gonad with specification of bipotential precursor cells into male Sertoli cells or female granulosa cells…”
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Constitutive WNT/CTNNB1 activation triggers spermatogonial stem cell proliferation and germ cell depletion by Chassot, Anne-Amandine, Le Rolle, Morgane, Jourden, Maxime, Taketo, Maketo M., Ghyselinck, Norbert B., Chaboissier, Marie-Christine

“…The differentiation of germ cells into oogonia or spermatogonia is the first step that eventually gives rise to fully mature gametes. In the female fetal…”
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Function of retinoid nuclear receptors : Lessons from genetic and pharmacological dissections of the retinoic acid signaling pathway during mouse embryogenesis by MARK, Manuel, GHYSELINCK, Norbert B, CHAMBON, Pierre

“…Retinoic acid (RA) is involved in vertebrate morphogenesis, growth, cellular differentiation, and tissue homeostasis. The use of in vitro systems initially led…”
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Retinoic acid induces Sertoli cell paracrine signals for spermatogonia differentiation but cell autonomously drives spermatocyte meiosis by Raverdeau, Mathilde, Gely-Pernot, Aurore, Féret, Betty, Dennefeld, Christine, Benoit, Gérard, Davidson, Irwin, Chambon, Pierre, Mark, Manuel, Ghyselinck, Norbert B

“…Direct evidence for a role of endogenous retinoic acid (RA), the active metabolite of vitamin A in the initial differentiation and meiotic entry of…”
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Two functionally redundant sources of retinoic acid secure spermatogonia differentiation in the seminiferous epithelium by Teletin, Marius, Vernet, Nadège, Yu, Jianshi, Klopfenstein, Muriel, Jones, Jace W, Féret, Betty, Kane, Maureen A, Ghyselinck, Norbert B, Mark, Manuel

“…In mammals, all- retinoic acid (ATRA) is instrumental to spermatogenesis. It is synthesized by two retinaldehyde dehydrogenases (RALDH) present in both Sertoli…”
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Function of retinoic acid receptors during embryonic development by Mark, Manuel, Ghyselinck, Norbert B, Chambon, Pierre

“…Retinoids, the active metabolites of vitamin A, regulate complex gene networks involved in vertebrate morphogenesis, growth, cellular differentiation and…”
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Retinoic acid signaling is dispensable for somatic development and function in the mammalian ovary by Minkina, Anna, Lindeman, Robin E., Gearhart, Micah D., Chassot, Anne-Amandine, Chaboissier, Marie-Christine, Ghyselinck, Norbert B., Bardwell, Vivian J., Zarkower, David

“…Retinoic acid (RA) is a potent inducer of cell differentiation and plays an essential role in sex-specific germ cell development in the mammalian gonad. RA is…”
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Roles of Retinoic Acid in Germ Cell Differentiation by Teletin, Marius, Vernet, Nadège, Ghyselinck, Norbert B, Mark, Manuel

“…The modalities of gametogenesis differ markedly between sexes. Female are born with a definitive reserve of oocytes whose size is crucial to ensure fertility…”
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Retinoic acid signaling is directly activated in cardiomyocytes and protects mouse hearts from apoptosis after myocardial infarction by Da Silva, Fabio, Jian Motamedi, Fariba, Weerasinghe Arachchige, Lahiru Chamara, Tison, Amelie, Bradford, Stephen T, Lefebvre, Jonathan, Dolle, Pascal, Ghyselinck, Norbert B, Wagner, Kay D, Schedl, Andreas

“…Retinoic acid (RA) is an essential signaling molecule for cardiac development and plays a protective role in the heart after myocardial infarction (MI). In…”
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Testicular differentiation occurs in absence of R-spondin1 and Sox9 in mouse sex reversals by Lavery, Rowena, Chassot, Anne-Amandine, Pauper, Eva, Gregoire, Elodie P, Klopfenstein, Muriel, de Rooij, Dirk G, Mark, Manuel, Schedl, Andreas, Ghyselinck, Norbert B, Chaboissier, Marie-Christine

“…In mammals, male sex determination is governed by SRY-dependent activation of Sox9, whereas female development involves R-spondin1 (RSPO1), an activator of the…”
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Retinoic acid improves nephrotoxic serum-induced glomerulonephritis through activation of podocyte retinoic acid receptor α by Dai, Yan, Chen, Anqun, Liu, Ruijie, Gu, Leyi, Sharma, Shuchita, Cai, Weijing, Salem, Fadi, Salant, David J, Pippin, Jeffrey W, Shankland, Stuart J, Moeller, Marcus J, Ghyselinck, Norbert B, Ding, Xiaoqiang, Chuang, Peter Y, Lee, Kyung, He, John Cijiang

“…Proliferation of glomerular epithelial cells, including podocytes, is a key histologic feature of crescentic glomerulonephritis. We previously found that…”
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Role of retinoic acid receptor (RAR) signaling in post-natal male germ cell differentiation by Mark, Manuel, Teletin, Marius, Vernet, Nadège, Ghyselinck, Norbert B.

“…All-trans retinoic acid (atRA), the active metabolite of vitamin A, plays critical functions in spermatogenesis, a complex, highly organized and regulated…”
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Loss of NR5A1 in mouse Sertoli cells after sex determination changes cellular identity and induces cell-death by anoikis by Souali-Crespo, Sirine, Condrea, Diana, Vernet, Nadège, Féret, Betty, Klopfenstein, Muriel, Grandgirard, Erwan, Alunni, Violaine, Cerciat, Marie, Jung, Matthieu, Mayere, Chloé, Nef, Serge, Mark, Manuel, Chalmel, Frédéric, Ghyselinck, Norbert B

“…To investigate the role of the nuclear receptor NR5A1 in testis after sex determination, we have analyzed mice lacking NR5A1 in Sertoli cells (SC) from…”
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Spermatogonia Differentiation Requires Retinoic Acid Receptor γ by Gely-Pernot, Aurore, Raverdeau, Mathilde, Célébi, Catherine, Dennefeld, Christine, Feret, Betty, Klopfenstein, Muriel, Yoshida, Shosei, Ghyselinck, Norbert B, Mark, Manuel

“…Vitamin A is instrumental to mammalian reproduction. Its metabolite, retinoic acid (RA), acts in a hormone-like manner through binding to and activating three…”
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