Search Results - "GHYSDAEL, J"

The calcineurin/NFAT pathway is activated in diagnostic breast cancer cases and is essential to survival and metastasis of mammary cancer cells by Tran Quang, C, Leboucher, S, Passaro, D, Fuhrmann, L, Nourieh, M, Vincent-Salomon, A, Ghysdael, J

“…Nuclear factor of activated T cells 1 (NFAT1) expression has been associated with increased migratory/invasive properties of mammary tumor-derived cell lines…”
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Recurrent JAK1 and JAK3 somatic mutations in T-cell prolymphocytic leukemia by Bellanger, D, Jacquemin, V, Chopin, M, Pierron, G, Bernard, O A, Ghysdael, J, Stern, M-H

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Leukemia-initiating cell activity requires calcineurin in T-cell acute lymphoblastic leukemia by Gachet, S, Genescà, E, Passaro, D, Irigoyen, M, Alcalde, H, Clémenson, C, Poglio, S, Pflumio, F, Janin, A, Lasgi, C, Dodier, S, Soyer, M, Duménil, G, Ghysdael, J

“…Despite their initial efficient response to induction chemotherapy, relapse remains frequent in patients with T-cell acute lymphoblastic leukemia (T-ALL), an…”
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Haploinsufficiency of the IKZF1 (IKAROS) tumor suppressor gene cooperates with BCR-ABL in a transgenic model of acute lymphoblastic leukemia by Virely, C, Moulin, S, Cobaleda, C, Lasgi, C, Alberdi, A, Soulier, J, Sigaux, F, Chan, S, Kastner, P, Ghysdael, J

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The calcineurin protein phosphatase is dispensable for BCR-ABL-induced B-ALL maintenance, propagation and response to dasatinib by Rocchetti, F, Tran Quang, C, Maragno, A L, Nguyen, J, Lasgi, C, Ghysdael, J

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Constitutive STAT5 activation specifically cooperates with the loss of p53 function in B-cell lymphomagenesis by JOLIOT, V, CORMIER, F, MEDYOUF, H, ALCALDE, H, GHYSDAEL, J

“…Signal transducers and activator of transcription 5 (STAT5) A and B are transcriptional regulators that play a central role in cytokine signaling in the…”
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A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFRβ oncoprotein by Jousset, Christine, Carron, Clémence, Boureux, Anthony, Quang, Christine Tran, Oury, Cécile, Dusanter-Fourt, Isabelle, Charon, Martine, Levin, Jonathan, Bernard, Olivier, Ghysdael, Jacques

“…TEL is a novel member of the ETS family of transcriptional regulators which is frequently involved in human leukemias as the result of specific chromosomal…”
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DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma by BAILLY, R.-A, BOSSELUT, R, ZUCMAN, J, CORMIER, F, DELATTRE, O, ROUSSEL, M, THOMAS, G, GHYSDAEL, J

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Combinatorial generation of variable fusion proteins in the Ewing family of tumours by Zucman, J., Melot, T., Desmaze, C., Ghysdael, J., Plougastel, B., Peter, M., Zucker, J.M., Triche, T.J., Sheer, D., Turc‐Carel, C.

“…Balanced translocations involving band q12 of human chromosome 22 are the most frequent recurrent translocations observed in human solid tumours. It has been…”
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Recruitment of the nuclear receptor corepressor N-CoR by the TEL moiety of the childhood leukemia–associated TEL-AML1 oncoprotein by Guidez, Fabien, Petrie, Kevin, Ford, Anthony M., Lu, Huafeng, Bennett, Caroline A., MacGregor, Angus, Hannemann, Jürgen, Ito, Yoshiaki, Ghysdael, Jacques, Greaves, Mel, Wiedemann, Leanne M., Zelent, Arthur

“…The t(12;21)(p13;q22) chromosomal translocation is the most frequent illegitimate gene recombination in a pediatric cancer and occurs in approximately 25% of…”
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Functional analyses of the TEL-ARNT fusion protein underscores a role for oxygen tension in hematopoietic cellular differentiation by NGUYEN-KHAC, F, DELLA VALLE, V, LOPEZ, R. G, RAVET, E, MAUCHAUFFE, M, FRIEDMAN, A. D, HUANG, L. E, FICHELSON, S, GHYSDAEL, J, BERNARD, O. A

“…The transcription factor hypoxia inducible factor 1 (HIF1), an HIF1alpha-aryl hydrocarbon receptor nuclear translocator (ARNT) dimeric factor, is essential to…”
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Calcium-induced phosphorylation of ETS1 inhibits its specific DNA binding activity by Rabault, B, Ghysdael, J

“…Ets1, the founding member of the Ets gene family of transcriptional regulators, is a phosphoprotein which is highly expressed in cells of the T and B lymphoid…”
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Cooperative binding of Ets-1 and core binding factor to DNA by WOTTON, D, GHYSDAEL, J, SHUWEN WANG, SPECK, N. A, OWEN, M. J

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Analysis of the thrombopoietin receptor (MPL) promoter implicates GATA and Ets proteins in the coregulation of megakaryocyte-specific genes by DEVEAUX, S, FILIPE, A, LAMARCHANDEL, V, GHYSDAEL, J, ROMEO, P.-H, MIGNOTTE, V

“…The MPL gene codes for the thrombopoietin receptor, whose ligand specifically controls megakaryocytic differentiation. To understand the molecular basis for…”
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Synergistic activation of the HTLV1 LTR Ets‐responsive region by transcription factors Ets1 and Sp1 by Gégonne, A., Bosselut, R., Bailly, R.A., Ghysdael, J.

“…Ets1 is the prototype of a family of transcriptional activators whose activity depends on the binding to specific DNA sequences characterized by an invariant…”
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GATA and Ets cis-acting sequences mediate megakaryocyte-specific expression by LEMARCHANDEL, V, GHYSDAEL, J, MIGNOTTE, V, RAHUEL, C, ROMEO, P.-H

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Characterization of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/PU.1 by RAY, D, BOSSELUT, R, GHYSDAEL, J, MATTEI, M.-G, TAVITIAN, A, MOREAU-GACHELIN, F

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Identification of Human Granzyme B Promoter Regulatory Elements Interacting with Activated T-Cell-Specific Proteins: Implication of Ikaros and CBF Binding Sites in Promoter Activation by Wargnier, Alain, Legros-Maida, Sabine, Bosselut, Remy, Bourge, Jean Francois, Lafaurie, Clotilde, Ghysdael, Jacques, Sasportes, Marilyne, Paul, Pascale

“…Granzyme B serine protease is found in the granules of activated cytotoxic T cells and in natural and lymphokine-activated killer cells. This protease plays a…”
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Regulation of parathyroid hormone-related protein (PTHrP) gene expression. Sp1 binds through an inverted CACCC motif and regulates promoter activity in cooperation with Ets1 by Dittmer, J, Gégonne, A, Gitlin, S D, Ghysdael, J, Brady, J N

“…We have previously shown that mutations in the GGAA core motif of the Ets1 binding site, EBSI, or deletion of EBSI, reduced basal and Tax1 transactivation of…”
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A domain containing leucine-zipper-like motifs mediate novel in vivo interactions between the thyroid hormone and retinoic acid receptors by Forman, B M, Yang, C R, Au, M, Casanova, J, Ghysdael, J, Samuels, H H

“…The thyroid hormones and retinoic acid are potent modulators of differentiation, development, and gene expression. The transcriptional activities of these…”
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