Search Results - "GHOSH, Shubhra"

Reprogramming of glucose metabolism via PFKFB4 is critical in FGF16-driven invasion of breast cancer cells by Kar, Swarnali, Maji, Nilanjana, Sen, Kamalika, Roy, Stuti, Maity, Atanu, Ghosh Dastidar, Shubhra, Nath, Somsubhra, Basu, Gautam, Basu, Moitri

“…Fibroblast growth factors (FGFs) are expressed in both developing and adult tissues and play important roles in embryogenesis, tissue homeostasis,…”
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In silico analyses of Wnt1 nsSNPs reveal structurally destabilizing variants, altered interactions with Frizzled receptors and its deregulation in tumorigenesis by Mondal, Amalesh, Paul, Debarati, Dastidar, Shubhra Ghosh, Saha, Tanima, Goswami, Achintya Mohan

“…Wnt1 is the first mammalian Wnt gene, which is discovered as proto-oncogene and in human the gene is located on the chromosome 12q13. Mutations in Wnt1 are…”
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Dynamic and Static Water Molecules Complement the TN16 Conformational Heterogeneity inside the Tubulin Cavity by Majumdar, Sarmistha, Maiti, Satyabrata, Ghosh Dastidar, Shubhra

“…TN16 is one of the most promising inhibitors of α, β dimer of tubulin that occupies the cavity in the β-subunit located at the dimeric interface, known as the…”
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HKT1;5 Transporter Gene Expression and Association of Amino Acid Substitutions With Salt Tolerance Across Rice Genotypes by Shohan, Mohammad Umer Sharif, Sinha, Souvik, Nabila, Fahmida Habib, Dastidar, Shubhra Ghosh, Seraj, Zeba I.

“…Plants need to maintain a low Na + /K + ratio for their survival and growth when there is high sodium concentration in soil. Under these circumstances, the…”
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An insight into SARS-CoV-2 structure, pathogenesis, target hunting for drug development and vaccine initiatives by Ghosh, Arijit, Kar, Paritosh K, Gautam, Anupam, Gupta, Rahul, Singh, Rajveer, Chakravarti, Rudra, Ravichandiran, Velayutham, Ghosh Dastidar, Shubhra, Ghosh, Dipanjan, Roy, Syamal

“…SARS-CoV-2, the virus responsible for the COVID-19 pandemic, has been confirmed to be a new coronavirus having 79% and 50% similarity with SARS-CoV and…”
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An evolutionary analysis identifies a conserved pentapeptide stretch containing the two essential lysine residues for rice L-myo-inositol 1-phosphate synthase catalytic activity by Basak, Papri, Maitra-Majee, Susmita, Das, Jayanta Kumar, Mukherjee, Abhishek, Ghosh Dastidar, Shubhra, Pal Choudhury, Pabitra, Lahiri Majumder, Arun

“…A molecular evolutionary analysis of a well conserved protein helps to determine the essential amino acids in the core catalytic region. Based on the chemical…”
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Adaptive Workflows of Machine Learning Illuminate the Sequential Operation Mechanism of the TAK1′s Allosteric Network by Ray Chaudhuri, Nibedita, Ghosh Dastidar, Shubhra

“…Allostery is a fundamental mechanism driving biomolecular processes that holds significant therapeutic concern. Our study rigorously investigates how two…”
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The susceptibility of disulfide bonds towards radiation damage may be explained by S⋯O interactions by Bhattacharyya, Rajasri, Dhar, Jesmita, Ghosh Dastidar, Shubhra, Chakrabarti, Pinak, Weiss, Manfred S

“…Radiation-induced damage to protein crystals during X-ray diffraction data collection is a major impediment to obtaining accurate structural information on…”
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Cholesterol Modulates Membrane Properties and the Interaction of gp41 Fusion Peptide To Promote Membrane Fusion by Meher, Geetanjali, Sinha, Souvik, Pattnaik, Gourab Prasad, Ghosh Dastidar, Shubhra, Chakraborty, Hirak

“…An envelope glycoprotein, gp41, is crucial for the entry of human immunodeficiency virus (HIV) into the host cell. The 20–23 N-terminal amino acid sequence of…”
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Shifting Polar Residues Across Primary Sequence Frames of Transmembrane Domains Calibrates Membrane Permeation Thermodynamics by Sinha, Souvik, Ghosh Dastidar, Shubhra

“…Permeation of the mitochondrial outer membrane (MOM) using the transmembrane domains (TMDs) is the key step of the Bcl-2 family of proteins to control…”
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Conformational States of E7010 Is Complemented by Microclusters of Water Inside the α,β-Tubulin Core by Majumdar, Sarmistha, Basu, Debadrita, Ghosh Dastidar, Shubhra

“…The α,β-tubulin is the building block of microtubules, which is associated with and dissociated from the microtubular architecture complying with the dynamic…”
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Allosteric Boost by TAB1 on the TAK1 Kinase Favorably Sculpts the Thermodynamic Landscape of Activation by Ray Chaudhuri, Nibedita, Ghosh Dastidar, Shubhra

“…The intricate mechanisms of allosteric regulation in kinases are of general interest to the scientific community for potential therapeutic implications…”
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Remote communication between unstructured and structured regions of Bcl-2 tunes its ligand binding capacity: Mechanistic insights by Paul, Debarati, Basak, Premananda, Ghosh Dastidar, Shubhra

“…Bcl-2, the prototypic, anti-apoptotic member of Bcl-2 family possesses a long Intrinsically Disordered Region (IDR) of more than sixty amino acid residues. In…”
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The long unstructured region of Bcl‐xl modulates its structural dynamics by Priya, Prerna, Maity, Atanu, Ghosh Dastidar, Shubhra

“…ABSTRACT Bcl‐xl protein has a long unstructured loop attached to its structured region which joins two helices. The necessity to have this unstructured segment…”
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New insight to structure-function relationship of GalNAc mediated primary interaction between insecticidal Cry1Ac toxin and HaALP receptor of Helicoverpa armigera by Sengupta, Anindita, Sarkar, Anindya, Priya, Prerna, Ghosh Dastidar, Shubhra, Das, Sampa

“…Over the last few decades Cry1Ac toxin has been widely used in controlling the insect attack due to its high specificity towards target insects. The…”
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The susceptibility of disulfide bonds towards radiation damage may be explained by S...O interactions by Bhattacharyya, Rajasri, Dhar, Jesmita, Ghosh Dastidar, Shubhra, Chakrabarti, Pinak, Weiss, Manfred S.

“…Radiation-induced damage to protein crystals during X-ray diffraction data collection is a major impediment to obtaining accurate structural information on…”
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Dynamics of Bcl-xL in water and membrane: molecular simulations by Maity, Atanu, Yadav, Seema, Verma, Chandra S, Ghosh Dastidar, Shubhra

“…The Bcl2 family of proteins is capable of switching the apoptotic machinery by directly controlling the release of apoptotic factors from the mitochondrial…”
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Ligand Binding Swaps between Soft Internal Modes of α,β-Tubulin and Alters Its Accessible Conformational Space by Majumdar, Sarmistha, Ghosh Dastidar, Shubhra

“…The dynamic instability of the microtubule originates from the conformational switching of its building block, that is, the α, β-tubulin dimer. Ligands…”
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BIM Binding Remotely Regulates BAX Activation: Insights from the Free Energy Landscapes by Sinha, Souvik, Maity, Atanu, Ghosh Dastidar, Shubhra

“…Activation of the pro-apoptotic BAX protein, a BCL-2 family member, is known to trigger apoptosis by forming pores in the mitochondrial outer membrane (MOM)…”
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Dissecting the thermodynamic contributions of the charged residues in the membrane anchoring of Bcl-xl C-terminal domain by Maity, Atanu, Sinha, Souvik, Ghosh Dastidar, Shubhra

“…•C-terminal double mutation (R232A and K233A) impedes Bcl-xl C-tail insertion.•Only one C-terminal polar residue (R232 or K233) is able to drive the…”
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