Search Results - "GHOCHIKYAN, A"

Active immunization with tau epitope in a mouse model of tauopathy induced strong antibody response together with improvement in short memory and pSer396-tau pathology by Joly-Amado, A., Davtyan, H., Serraneau, K., Jules, P., Zitnyar, A., Pressman, E., Zagorski, K., Antonyan, T., Hovakimyan, A., Paek, H.J., Gordon, M.N., Cribbs, D.H., Petrovsky, N., Agadjanyan, M.G., Ghochikyan, A., Morgan, D.

“…Abnormal tau hyperphosphorylation and its aggregation into neurofibrillary tangles are a hallmark of tauopathies, neurodegenerative disorders that include…”
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DNA prime-protein boost increased the titer, avidity and persistence of anti-Aβ antibodies in wild-type mice by Davtyan, H, Mkrtichyan, M, Movsesyan, N, Petrushina, I, Mamikonyan, G, Cribbs, D H, Agadjanyan, M G, Ghochikyan, A

“…Recently, we reported that a DNA vaccine, composed of three copies of a self B cell epitope of amyloid-β (Aβ 42 ) and the foreign T-cell epitope, Pan DR…”
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DNA, but not protein vaccine based on mutated BORIS antigen significantly inhibits tumor growth and prolongs the survival of mice by Mkrtichyan, M, Ghochikyan, A, Loukinov, D, Davtyan, H, Ichim, T E, Cribbs, D H, Lobanenkov, V V, Agadjanyan, M G

“…The ideal immunological target for cancer vaccine development would meet the criteria of tumor specificity, immunogenicity and vital dependency of the tumor on…”
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A fresh perspective from immunologists and vaccine researchers: Active vaccination strategies to prevent and reverse Alzheimer's disease by Agadjanyan, Michael G, Petrovsky, Nikolai, Ghochikyan, Anahit

“…Abstract Traditional vaccination against infectious diseases relies on generation of cellular and humoral immune responses that act to protect the host from…”
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Prototype Alzheimer's disease vaccine using the immunodominant B cell epitope from beta-amyloid and promiscuous T cell epitope pan HLA DR-binding peptide by Agadjanyan, Michael G, Ghochikyan, Anahit, Petrushina, Irina, Vasilevko, Vitaly, Movsesyan, Nina, Mkrtichyan, Mikayel, Saing, Tommy, Cribbs, David H

“…Immunization of amyloid precursor protein transgenic mice with fibrillar beta-amyloid (Abeta) prevents Alzheimer's disease (AD)-like neuropathology. The first…”
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Prototype Alzheimer's disease epitope vaccine induced strong Th2-type anti-Aβ antibody response with Alum to Quil A adjuvant switch by Ghochikyan, Anahit, Mkrtichyan, Mikayel, Petrushina, Irina, Movsesyan, Nina, Karapetyan, Adrine, Cribbs, David H., Agadjanyan, Michael G.

“…β-Amyloid (Aβ) peptide has been proposed to be a causal factor in Alzheimer's disease (AD). Currently being investigated, active and passive Aβ-immunotherapy…”
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Selective apoptosis of breast cancer cells by siRNA targeting of BORIS by Dougherty, Christopher J., Ichim, Thomas E., Liu, Liping, Reznik, Gary, Min, Wei-Ping, Ghochikyan, Anahit, Agadjanyan, Michael G., Reznik, Boris N.

“…Brother of the regulator of imprinted sites (BORIS) is an epigenetically acting transcription factor which represses the tumor inhibitor functions of the tumor…”
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Therapeutic replicon-based immunotherapy targeting the breast cancer tumor antigens neu and BORIS: Advantages and constraints by Laust, A. K., Mkrtichyan, M., Davtyan, H., Khlgatyan, J., Ghochikyan, A., Liu, H., Agadjanyan, M. G., Nelson, E. L.

“…Abstract only…”
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DNA epitope vaccine containing complement component C3d enhances anti-amyloid-β antibody production and polarizes the immune response towards a Th2 phenotype by Movsesyan, Nina, Mkrtichyan, Mikayel, Petrushina, Irina, Ross, Ted M, Cribbs, David H, Agadjanyan, Michael G, Ghochikyan, Anahit

“…Abstract We have engineered a DNA epitope vaccine that expresses 3 self-B cell epitopes of Aβ42 (3Aβ1–11 ), a non-self T helper (Th) cell epitope (PADRE), and…”
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DNA prime-protein boost increased the titer, avidity and persistence of anti-A[beta] antibodies in wild-type mice by Davtyan, H, Mkrtichyan, M, Movsesyan, N, Petrushina, I, Mamikonyan, G, Cribbs, D H, Agadjanyan, M G, Ghochikyan, A

“…Recently, we reported that a DNA vaccine, composed of three copies of a self B cell epitope of amyloid-beta (Abeta(42)) and the foreign T-cell epitope, Pan DR…”
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DNA prime-protein boost increased the titer, avidity and persistence of anti-Ab antibodies in wild-type mice by Davtyan, H, Mkrtichyan, M, Movsesyan, N, Petrushina, I, Mamikonyan, G, Cribbs, D H, Agadjanyan, M G, Ghochikyan, A

“…Recently, we reported that a DNA vaccine, composed of three copies of a self B cell epitope of amyloid-b (Ab sub(42)) and the foreign T-cell epitope, Pan DR…”
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Low concentrations of anti-Aβ antibodies generated in Tg2576 mice by DNA epitope vaccine fused with 3C3d molecular adjuvant do not affect AD pathology by Movsesyan, Nina, Davtyan, Hayk, Mkrtichyan, Mikayel, Petrushina, Irina, Tiraturyan, Tigran, Ross, Ted, Agadjanyan, Michael G, Ghochikyan, Anahit, Cribbs, David H

“…It has been demonstrated that an active vaccination strategy with protein- or DNA-based epitope vaccines composed of the immunodominant self B cell epitope of…”
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Generation and characterization of the humoral immune response to DNA immunization with a chimeric β‐amyloid‐interleukin‐4 minigene by Ghochikyan, Anahit, Vasilevko, Vitaly, Petrushina, Irina, Movsesyan, Nina, Babikyan, Davit, Tian, Wenqiang, Sadzikava, Nadya, Ross, Ted M., Head, Elizabeth, Cribbs, David H., Agadjanyan, Michael G.

“…Active immunization with fibrillar β–amyloid peptide (Aβ42) as well as passive transfer of anti‐Aβ antibodies significantly reduces Aβ plaque deposition,…”
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Importance of IgG2c isotype in the immune response to β-amyloid in amyloid precursor protein/transgenic mice by Petrushina, Irina, Tran, Mike, Sadzikava, Nadya, Ghochikyan, Anahit, Vasilevko, Vitaly, Agadjanyan, Michael G., Cribbs, David H.

“…A careful analysis of the immune response to immunization of amyloid precursor protein/transgenic (APP/Tg) mice with β-amyloid (Aβ) may provide insights into…”
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Immunostimulant adjuvant patch enhances humoral and cellular immune responses to DNA immunization by Mkrtichyan, Mikayel, Ghochikyan, Anahit, Movsesyan, Nina, Karapetyan, Adrine, Begoyan, Gayane, Yu, Jianmei, Glenn, Gregory M, Ross, Ted M, Agadjanyan, Michael G, Cribbs, David H

“…The focus of this report is on the development of an improved DNA immunization protocol, which takes advantage of the strengths of DNA immunization, as well as…”
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Dissecting DNA-protein and protein-protein interactions involved in bacterial transcriptional regulation by a sensitive protein array method combining a near-infrared fluorescence detection by Snapyan, Marina, Lecocq, Michèle, Guével, Laetitia, Arnaud, Marie-Claire, Ghochikyan, Anahit, Sakanyan, Vehary

“…The protein array methodology is used to study DNA‐protein and protein‐protein interactions governing gene expression from the Bacillus stearothermophilus…”
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CD80 (B7-1) and CD86 (B7-2) are functionally equivalent in the initiation and maintenance of CD4+ T-cell proliferation after activation with suboptimal doses of PHA by Vasilevko, Vitaly, Ghochikyan, Anahit, Holterman, Mark J, Agadjanyan, Michael G

“…Effective activation of T cells requires engagement of two separate T-cell receptors. The antigen-specific T-cell receptor (TCR) binds foreign peptide…”
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DNA prime―protein boost increased the titer, avidity and persistence of anti-Aβ antibodies in wild-type mice by DAVTYAN, H, MKRTICHYAN, M, MOVSESYAN, N, PETRUSHINA, I, MAMIKONYAN, G, CRIBBS, D. H, AGADJANYAN, M. G, GHOCHIKYAN, A

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DNA prime-protein boost increased the titer, avidity and persistence of anti-Abeta antibodies in wild-type mice by Davtyan, H, Mkrtichyan, M, Movsesyan, N, Petrushina, I, Mamikonyan, G, Cribbs, D H, Agadjanyan, M G, Ghochikyan, A

“…Recently, we reported that a DNA vaccine, composed of three copies of a self B cell epitope of amyloid-beta (Abeta(42)) and the foreign T-cell epitope, Pan DR…”
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Exopolygalacturonate lyase from Thermotoga maritima: cloning, characterization and organic synthesis application by Parisot, Judicaël, Ghochikyan, Anahit, Langlois, Virginie, Sakanyan, Vehary, Rabiller, Claude

“…A new exopolygalacturonate lyase (Pel) gene of the hyperthermophilic bacterium Thermotoga maritima was cloned and overexpressed in Escherichia coli cells. A 42…”
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