Search Results - "GHAZAL, Nabil B"

Asymmetric Synthesis of Cis-Fused Bicyclic Pyrrolidines and Pyrrolidinones via Chiral Polycyclic Lactams by Ennis, Michael D, Hoffman, Robert L, Ghazal, Nabil B, Old, David W, Mooney, Pamela A

“…Condensation of racemic keto-ester 2 and 1.1 equiv of (R)-(−)-phenylglycinol in toluene with azeotropic removal of water and methanol gave rise to a…”
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Structure-Activity Relationships in the 8-Amino-6,7,8,9-tetrahydro-3H-benz[e]indole Ring System. Part 2: Effect of 8-Amino Nitrogen Substitution on Serotonin Receptor Binding and Pharmacology by Ennis, Michael D, Stjernloef, Peter, Hoffman, Robert L, Ghazal, Nabil B, Smith, Martin W, Svensson, Kjell, Wikstroem, Haakan, Haadsma-Svensson, Susanne R, Lin, Chiu-Hong

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Isochroman-6-carboxamides as Highly Selective 5-HT1D Agonists:  Potential New Treatment for Migraine without Cardiovascular Side Effects by Ennis, Michael D, Ghazal, Nabil B, Hoffman, Robert L, Smith, Martin W, Schlachter, Siusaidh K, Lawson, Charles F, Im, Wha Bin, Pregenzer, Jeffrey F, Svensson, Kjell A, Lewis, Richard A, Hall, Edward D, Sutter, Dorothy M, Harris, Lorri T, McCall, Robert B

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2,3,4,5-tetrahydro- and 2,3,4,5,11,11a-hexahydro-1H-[1,4]diazepino[1,7-a]indoles: New templates for 5-HT2C agonists by ENNIS, Michael D, HOFFMAN, Robert L, SVENSSON, Kjell A, MCCALL, Robert B, HABER, Christopher L, KAGEY, Michelle L, DINH, Dac M, GHAZAL, Nabil B, OLSON, Rebecca M, KNAUER, Christopher S, CHIO, Chris L, HYSLOP, Deborah K, CAMPBELL, Jeffery E, FITZGERALD, Lawrence W, NICHOLS, Nanette F

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5-HT1D Receptor Agonist Properties of Novel 2-[5-[[(Trifluoromethyl)sulfonyl]oxy]indolyl]ethylamines and Their Use as Synthetic Intermediates by Barf, Tjeerd A, de Boer, Peter, Wikström, Håkan, Peroutka, Stephen J, Svensson, Kjell, Ennis, Michael D, Ghazal, Nabil B, McGuire, James C, Smith, Martin W

“…2-[5-[[(Trifluoromethyl)sulfonyl]oxy]-1H-indol-3-yl]ethylamine (18), its N,N-di-n-propyl (12), N,N-diethyl (13), and N,N-dimethyl (14) derivatives, and…”
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Structure-Activity Relationships in the 8-Amino-6,7,8,9-tetrahydro-3H-benz[e]indole Ring System. Part 1: Effects of Substituents in the Aromatic System on Serotonin and Dopamine Receptor Subtypes by Stjernloef, Peter, Ennis, Michael D, Hansson, Lars O, Hoffman, Robert L, Ghazal, Nabil B, Sundell, Staffan, Smith, Martin W, Svensson, Kjell, Carlsson, Arvid, Wikstroem, Hkan

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Differential pharmacology between the guinea‐pig and the gorilla 5‐HT 1D receptor as probed with isochromans (5‐HT 1D ‐selective ligands) by Pregenzer, Jeffrey F, Alberts, Glen L, Im, Wha Bin, Slightom, Jerry L, Ennis, Michael D, Hoffman, Robert L, Ghazal, Nabil B, TenBrink, Ruth E

“…Both the 5‐HT 1D and 5‐HT 1B receptors are implicated in migraine pathophysiology. Recently isochromans have been discovered to bind primate 5‐HT 1D receptors…”
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1,4-Dihydronaphthoquinones, hydroindoloquinones, benzofurans, and benzothiophenes as inhibitors of 5-lipoxygenase. Synthesis and structure-activity studies by Yamashita, Ayako, Schaub, Robert G, Bach, Michael K, White, Gordon J, Toy, Arthur, Ghazal, Nabil B, Burdick, Michael D, Brashler, John R, Holm, Marilyn S

“…A series of substituted 1,4-dihydronaphthoquinones, hydroindoloquinones, benzofuran-4,7-dihydroquinones, and benzothiophene-4,7-dihydroquinones were…”
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Differential pharmacology between the guinea‐pig and the gorilla 5‐HT1D receptor as probed with isochromans (5‐HT1D‐selective ligands) by Pregenzer, Jeffrey F, Alberts, Glen L, Im, Wha Bin, Slightom, Jerry L, Ennis, Michael D, Hoffman, Robert L, Ghazal, Nabil B, TenBrink, Ruth E

“…Both the 5‐HT1D and 5‐HT1B receptors are implicated in migraine pathophysiology. Recently isochromans have been discovered to bind primate 5‐HT1D receptors…”
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2,3,4,5-tetrahydro- and 2,3,4,5,11,11a-hexahydro-1H-[1,4]diazepino[1,7-a]indoles: new templates for 5-HT(2C) agonists by Ennis, Michael D, Hoffman, Robert L, Ghazal, Nabil B, Olson, Rebecca M, Knauer, Christopher S, Chio, Chris L, Hyslop, Deborah K, Campbell, Jeffery E, Fitzgerald, Lawrence W, Nichols, Nanette F, Svensson, Kjell A, McCall, Robert B, Haber, Christopher L, Kagey, Michelle L, Dinh, Dac M

“…The design and synthesis of the novel 2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,7-a]indole 5 is described. This azepinoindole has excellent affinity for 5-HT(2C)…”
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2,3,4,5-Tetrahydro- and 2,3,4,5,11,11a-hexahydro-1H-[1,4]diazepino[1,7- a]indoles: new templates for 5-HT 2C agonists by Ennis, Michael D, Hoffman, Robert L, Ghazal, Nabil B, Olson, Rebecca M, Knauer, Christopher S, Chio, Chris L, Hyslop, Deborah K, Campbell, Jeffery E, Fitzgerald, Lawrence W, Nichols, Nanette F, Svensson, Kjell A, McCall, Robert B, Haber, Christopher L, Kagey, Michelle L, Dinh, Dac M

“…The design and synthesis of the novel 2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,7- a]indole 5 is described. This azepinoindole has excellent affinity for 5-HT 2C…”
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Isochroman-6-carboxamides as Highly Selective 5-HT 1D Agonists:  Potential New Treatment for Migraine without Cardiovascular Side Effects by Ennis, Michael D., Ghazal, Nabil B., Hoffman, Robert L., Smith, Martin W., Schlachter, Siusaidh K., Lawson, Charles F., Im, Wha Bin, Pregenzer, Jeffrey F., Svensson, Kjell A., Lewis, Richard A., Hall, Edward D., Sutter, Dorothy M., Harris, Lorri T., McCall, Robert B.

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5-HT 1D Receptor Agonist Properties of Novel 2-[5-[[(Trifluoromethyl)sulfonyl]oxy]indolyl]ethylamines and Their Use as Synthetic Intermediates by Barf, Tjeerd A., de Boer, Peter, Wikström, Håkan, Peroutka, Stephen J., Svensson, Kjell, Ennis, Michael D., Ghazal, Nabil B., McGuire, James C., Smith, Martin W.

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Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 1. Effects of substituents in the aromatic system on serotonin and dopamine receptor subtypes by Stjernlöf, P, Ennis, M D, Hansson, L O, Hoffman, R L, Ghazal, N B, Sundell, S, Smith, M W, Svensson, K, Carlsson, A, Wikström, H

“…A series of 1-, 3-, and 4-substituted analogs to the potent 5-HT1A against 8-(dipropylamino)-6,7,8,9-tetrahydro-3H-benz[e]indole-1-carbaldehyde (5) were…”
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Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 2. Effect of 8-amino nitrogen substitution on serotonin receptor binding and pharmacology by Ennis, MD, Stjernloef, P, Hoffman, R L, Ghazal, N B, Smith, M W, Svensson, K, Wikstroem, H, Haadsma-Svensson, SR, Lin, Chiu-Hong

“…A series of analogs of the potent and selective 5-HT sub(1A) agonist 8-(di-n-propylamino)-6,7,8,9-tetrahydro-3H-benz[e]indole-1-carbald ehyde (2b) (OSU191) was…”
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Synthesis of ( r )‐ and ( s )‐1‐formyl‐6,7,8,9‐tetrahydro‐ N,N ‐(dipropyl)‐3 H ‐benz[ e ]indol‐8‐amines: Potent and orally active 5‐ht 1a receptor agonists by Lin, Chiu‐Hong, Ennis, Michael D., Hoffman, Robert L., Phillips, Gillian, Haadsma‐Svensson, Susanne R., Ghazal, Nabil B., Chidester, Connie G.

“…Abstract An efficient synthesis of the potent and orally active 5‐HT 1A agonists, ( R )‐(+)‐ and ( S )‐(‐)‐1‐formyl‐6,7,8,9‐tetrahydro‐ N,N ‐dipropyl‐3 H…”
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Synthesis of (r)- and (s)-1-formyl-6,7,8,9-tetrahydro- N,N-(dipropyl)-3H-benz[e]indol-8-amines: Potent and orally active 5-ht1a receptor agonists by Lin, Chiu-Hong, Ennis, Michael D., Hoffman, Robert L., Phillips, Gillian, Haadsma-Svensson, Susanne R., Ghazal, Nabil B., Chidester, Connie G.

“…An efficient synthesis of the potent and orally active 5‐HT1A agonists, (R)‐(+)‐ and (S)‐(‐)‐1‐formyl‐6,7,8,9‐tetrahydro‐N,N‐dipropyl‐3H‐benz[e]indol‐8‐amines…”
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