GENETIC CHARACTERIZATION OF NONSTRUCTURAL GENES OF H5N1 AVIAN INFLUENZA VIRUSES ISOLATED IN THAILAND IN 2004-2005

The outbreak of highly pathogenic avian influenza (HPAI) viruses has severely disrupted poultry production and trade. Humans have been infected with HPAI H5N1 viruses and many have died. The nonstructural (NS) proteins of the virus are a factor that determines virulence. In this report, 80 NS genes...

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Bibliographic Details
Published in:	Southeast Asian journal of tropical medicine and public health Vol. 39; no. 5; pp. 837 - 847
Main Authors:	SUWANNAKHON, Narutchala, POOKORN, Sarutsawadee, SANGUANSERMSRI, Donruedee, GHAMNANPOOD, Chanpen, CHAMNANPOOD, Pornchai, WONGVILAIRAT, Rosarin, PONGCHAROEN, Sutatip, NIUMSUP, Pannika R, KUNTHALERT, Duangkamol, SANGUANSERMSRI, Phanchana
Format:	Journal Article
Language:	English
Published:	Bangkok Southeast Asian Ministers of Education Organization, Regional Tropical Medicine and Public Health Network 01-09-2008 Central Coordinating Board, SEAMEO-TROPMED Project
Subjects:	Animals Biological and medical sciences General aspects Genome, Viral Human viral diseases Infectious diseases Influenza A Virus, H5N1 Subtype - genetics Influenza A Virus, H5N1 Subtype - isolation & purification Influenza in Birds - virology Medical sciences Phylogeny Polymerase Chain Reaction Poultry Sequence Analysis, DNA Thailand - epidemiology Viral diseases Viral diseases of the respiratory system and ent viral diseases Viral Nonstructural Proteins - genetics Virulence Factors - genetics Thailand Asia Infection Avian influenza Influenzavirus A(H5N1) Tropical medicine Viral disease
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Summary:	The outbreak of highly pathogenic avian influenza (HPAI) viruses has severely disrupted poultry production and trade. Humans have been infected with HPAI H5N1 viruses and many have died. The nonstructural (NS) proteins of the virus are a factor that determines virulence. In this report, 80 NS genes of H5N1 HPAI viruses isolated from Thailand were completely sequenced and phylogenically analyzed. The percentages of identity and variable site NS1 genes were similar to NS2/nuclear export protein (NEP) genes. All NS1 genes from the samples were located in allelic group A. The NS1 and NS2/NEP proteins possess 225 and 121 amino acids, respectively. All NS1 protein samples had five amino acid deletions typical of avian influenza viruses isolated since 2002. An amino acid substitution at position 92 (G92E) of the NS1 protein, known to promote the inhibition of host immune responses, was also found in the samples.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0125-1562