Search Results - "GHAFFARI, Siavash"

Estrogen Inhibits LDL (Low-Density Lipoprotein) Transcytosis by Human Coronary Artery Endothelial Cells via GPER (G-Protein–Coupled Estrogen Receptor) and SR-BI (Scavenger Receptor Class B Type 1) by Ghaffari, Siavash, Naderi Nabi, Farnoosh, Sugiyama, Michael G, Lee, Warren L

“…OBJECTIVE—The atheroprotective effects of estrogen are independent of circulating lipid levels. Whether estrogen regulates transcytosis of LDL (low-density…”
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Flow dynamics control the location of sprouting and direct elongation during developmental angiogenesis by Ghaffari, Siavash, Leask, Richard L, Jones, Elizabeth A V

“…Angiogenesis is tightly controlled by a number of signalling pathways. Although our understanding of the molecular mechanisms involved in angiogenesis has…”
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Simulating flow induced migration in vascular remodelling by Tabibian, Ashkan, Ghaffari, Siavash, Vargas, Diego A, Van Oosterwyck, Hans, Jones, Elizabeth A.V

“…Shear stress induces directed endothelial cell (EC) migration in blood vessels leading to vessel diameter increase and induction of vascular maturation. Other…”
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Quantifying Endothelial Transcytosis with Total Internal Reflection Fluorescence Microscopy (TIRF) by Jang, Erika, Ghaffari, Siavash, Lee, Warren L

“…Apical-to-basal transcytosis by endothelial cells can be visualized and quantified using total internal reflection fluorescence (TIRF) microscopy of the basal…”
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Cardioprotective GLP-1 metabolite prevents ischemic cardiac injury by inhibiting mitochondrial trifunctional protein-α by Siraj, M Ahsan, Mundil, Dhanwantee, Beca, Sanja, Momen, Abdul, Shikatani, Eric A, Afroze, Talat, Sun, Xuetao, Liu, Ying, Ghaffari, Siavash, Lee, Warren, Wheeler, Michael B, Keller, Gordon, Backx, Peter, Husain, Mansoor

“…Mechanisms mediating the cardioprotective actions of glucagon-like peptide 1 (GLP-1) were unknown. Here, we show in both ex vivo and in vivo models of ischemic…”
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Long noncoding RNA SNHG12 integrates a DNA-PK-mediated DNA damage response and vascular senescence by Haemmig, Stefan, Yang, Dafeng, Sun, Xinghui, Das, Debapria, Ghaffari, Siavash, Molinaro, Roberto, Chen, Lei, Deng, Yihuan, Freeman, Dan, Moullan, Norman, Tesmenitsky, Yevgenia, Wara, A K M Khyrul, Simion, Viorel, Shvartz, Eugenia, Lee, James F, Yang, Tianlun, Sukova, Galina, Marto, Jarrod A, Stone, Peter H, Lee, Warren L, Auwerx, Johan, Libby, Peter, Feinberg, Mark W

“…Long noncoding RNAs (lncRNAs) are emerging regulators of biological processes in the vessel wall; however, their role in atherosclerosis remains poorly…”
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Endothelial HMGB1 Is a Critical Regulator of LDL Transcytosis via an SREBP2–SR-BI Axis by Ghaffari, Siavash, Jang, Erika, Naderinabi, Farnoosh, Sanwal, Rajiv, Khosraviani, Negar, Wang, Changsen, Steinberg, Benjamin E., Goldenberg, Neil M., Ikeda, Jiro, Lee, Warren L.

“…OBJECTIVE:LDL (low-density lipoprotein) transcytosis across the endothelium is performed by the SR-BI (scavenger receptor class B type 1) receptor and…”
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BMP-9 and LDL crosstalk regulates ALK-1 endocytosis and LDL transcytosis in endothelial cells by Tao, Bo, Kraehling, Jan R., Ghaffari, Siavash, Ramirez, Cristina M., Lee, Sungwoon, Fowler, Joseph W., Lee, Warren L., Fernandez-Hernando, Carlos, Eichmann, Anne, Sessa, William C.

“…Bone morphogenetic protein-9 (BMP-9) is a circulating cytokine that is known to play an essential role in the endothelial homeostasis and the binding of BMP-9…”
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Ultrasound-guided transfection of claudin-5 improves lung endothelial barrier function in lung injury without impairing innate immunity by Sanwal, Rajiv, Mintsopoulos, Victoria, Ditmans, Mihails, Lang, Alice, Latreille, Elyse, Ghaffari, Siavash, Khosraviani, Negar, Karshafian, Raffi, Leong-Poi, Howard, Hwang, David M, Brochard, Laurent, Goffi, Alberto, Slutsky, Arthur S, Lee, Warren L

“…In acute lung injury, the lung endothelial barrier is compromised. Loss of endothelial barrier integrity occurs in association with decreased levels of the…”
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Circulating small extracellular vesicles mediate vascular hyperpermeability in diabetes by Gustafson, Dakota, DiStefano, Peter V., Wang, Xue Fan, Wu, Ruilin, Ghaffari, Siavash, Ching, Crizza, Rathnakumar, Kumaragurubaran, Alibhai, Faisal, Syonov, Michal, Fitzpatrick, Jessica, Boudreau, Emilie, Lau, Cori, Galant, Natalie, Husain, Mansoor, Li, Ren-Ke, Lee, Warren L., Parekh, Rulan S., Monnier, Philippe P., Fish, Jason E.

“…Aims/hypothesis A hallmark chronic complication of type 2 diabetes mellitus is vascular hyperpermeability, which encompasses dysfunction of the cerebrovascular…”
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CD36 mediates albumin transcytosis by dermal but not lung microvascular endothelial cells: role in fatty acid delivery by Raheel, Hira, Ghaffari, Siavash, Khosraviani, Negar, Mintsopoulos, Victoria, Auyeung, Derek, Wang, Changsen, Kim, Yun Hye, Mullen, Brendan, Sung, Hoon-Ki, Ho, May, Fairn, Gregory, Neculai, Dante, Febbraio, Maria, Heit, Bryan, Lee, Warren L

“…In healthy blood vessels, albumin crosses the endothelium to leave the circulation by transcytosis. However, little is known about the regulation of albumin…”
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Abstract 452: Estrogen Inhibits LDL Transcytosis by Coronary Artery Endothelial Cells via GPER and SR-BI by Ghaffari, Siavash, Sugiyama, Michael G, Naderi Nabi, Farnoosh, Lee, Warren L

“…Abstract only Objectives: Premenopausal women have a significantly lower rate of atherosclerosis than men, an effect attributed to estrogen. The…”
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Blood flow can signal during angiogenesis not only through mechanotransduction, but also by affecting growth factor distribution by Ghaffari, Siavash, Leask, Richard L., Jones, Elizabeth A. V.

“…Growth factors, such as VEGF, promote the sprouting of new blood vessels. Growth factors are generally produced far from the endothelium, and the transport of…”
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Cardioprotective GLP-1 metabolite prevents ischemic cardiac injury by inhibiting mitochondrial trifunctional protein-[alpha] by Siraj, M. Ahsan, Mundil, Dhanwantee, Beca, Sanja, Momen, Abdul, Shikatani, Eric A, Afroze, Talat, Sun, Xuetao, Liu, Ying, Ghaffari, Siavash, Lee, Warren, Wheeler, Michael B, Keller, Gordon, Backx, Peter, Husain, Mansoor

“…Mechanisms mediating the cardioprotective actions of glucagon-like peptide 1 (GLP-1) were unknown. Here, we show in both ex vivo and in vivo models of ischemic…”
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Simultaneous imaging of blood flow dynamics and vascular remodelling during development by Ghaffari, Siavash, Leask, Richard L, Jones, Elizabeth A V

“…Normal vascular development requires blood flow. Time-lapse imaging techniques have revolutionised our understanding of developmental biology, but measuring…”
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Age‐Related Telomere Uncapping Occurs Independent of Telomere Shortening in Mouse Endothelial Cells by Machin, Daniel, Dobson, Parker, Ghaffari, Siavash, Walker, Ashley, Lesniewski, Lisa, Donato, Anthony

“…Abstract only…”
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The Role of Hemodynamics in Angiogenesis by Ghaffari, Siavash

“…The cardiovascular system is the first functional organ to form during embryonic development. Blood flow provides mechanical and chemical signals that are…”
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BMP-9 and LDL crosstalk regulates ALK-1 endocytosis and LDL transcytosis in endothelial cells by Tao, Bo, Kraehling, Jan R, Ghaffari, Siavash, Ramirez, Cristina M, Lee, Sungwoon, Fowler, Joseph W, Lee, Warren L, Fernandez-Hernando, Carlos, Eichmann, Anne, Sessa, William C

“…Bone morphogenetic protein-9 (BMP-9) is a circulating cytokine that is known to play an essential role in the endothelial homeostasis and the binding of BMP-9…”
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Abstract 1261: A mesodissection system for accurate, rapid, and economical recovery of tissue from slide mounted tissue sections by Adey, Nils B., Parry, Robert J., Birch, Lilia, Paxton, Christian N., Ghaffari, Siavash, Herrmann, Mark G., Geiersbach, Katherine B.

“…Abstract We have developed a prototype system for slide mounted tissue dissection capable of resolution between manual methods (i.e. scraping tissue off of…”
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BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines by WONG, Alexander K. C, SHANAHAN, Frances, SMITH, Richard, SALADA, Grant, CARILLO, Arlene, LAITY, Kirsten, GUPTE, Jamila, SWEDLUND, Brad, TAVTIGIAN, Sean V, TENG, David H-F, LEES, Emma, YUAN CHEN, LUBING LIAN, PHUONG HA, HENDRICKS, Kristin, GHAFFARI, Siavash, ILIEV, Diana, PENN, Brandon, WOODLAND, Anne-Marie

“…Human BRG1 is a component of the evolutionarily conserved SWI-SNF chromatin remodeling complex. BRG1 has been implicated in growth control through its…”
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