Search Results - "GEYER, Christopher B"

The Mammalian Spermatogenesis Single-Cell Transcriptome, from Spermatogonial Stem Cells to Spermatids by Hermann, Brian P., Cheng, Keren, Singh, Anukriti, Roa-De La Cruz, Lorena, Mutoji, Kazadi N., Chen, I-Chung, Gildersleeve, Heidi, Lehle, Jake D., Mayo, Max, Westernströer, Birgit, Law, Nathan C., Oatley, Melissa J., Velte, Ellen K., Niedenberger, Bryan A., Fritze, Danielle, Silber, Sherman, Geyer, Christopher B., Oatley, Jon M., McCarrey, John R.

“…Spermatogenesis is a complex and dynamic cellular differentiation process critical to male reproduction and sustained by spermatogonial stem cells (SSCs)…”
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Mammalian SWI/SNF chromatin remodeler is essential for reductional meiosis in males by Menon, Debashish U., Kirsanov, Oleksandr, Geyer, Christopher B., Magnuson, Terry

“…The mammalian SWI/SNF nucleosome remodeler is essential for spermatogenesis. Here, we identify a role for ARID2, a PBAF (Polybromo - Brg1 Associated…”
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Retinoic acid regulates Kit translation during spermatogonial differentiation in the mouse by Busada, Jonathan T., Chappell, Vesna A., Niedenberger, Bryan A., Kaye, Evelyn P., Keiper, Brett D., Hogarth, Cathryn A., Geyer, Christopher B.

“…In the testis, a subset of spermatogonia retains stem cell potential, while others differentiate to eventually become spermatozoa. This delicate balance must…”
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Marker expression reveals heterogeneity of spermatogonia in the neonatal mouse testis by Niedenberger, Bryan A, Busada, Jonathan T, Geyer, Christopher B

“…Prospermatogonia transition to type A spermatogonia, which provide the source for the spermatogonial stem cell (SSC) pool. A percentage of these type A…”
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Mammalian target of rapamycin complex 1 (mTORC1) Is required for mouse spermatogonial differentiation in vivo by Busada, Jonathan T., Niedenberger, Bryan A., Velte, Ellen K., Keiper, Brett D., Geyer, Christopher B.

“…Spermatogonial stem cells (SSCs) must balance self-renewal with production of transit-amplifying progenitors that differentiate in response to retinoic acid…”
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Cell-autonomous requirement for mammalian target of rapamycin (Mtor) in spermatogonial proliferation and differentiation in the mouse by Serra, Nicholas D., Velte, Ellen K., Niedenberger, Bryan A., Kirsanov, Oleksander, Geyer, Christopher B.

“…Spermatogonial stem cells must balance self-renewal with production of transit-amplifying progenitors that differentiate in response to retinoic acid (RA)…”
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Differential RA responsiveness directs formation of functionally distinct spermatogonial populations at the initiation of spermatogenesis in the mouse by Velte, Ellen K, Niedenberger, Bryan A, Serra, Nicholas D, Singh, Anukriti, Roa-DeLaCruz, Lorena, Hermann, Brian P, Geyer, Christopher B

“…In the mammalian testis, sustained spermatogenesis relies on spermatogonial stem cells (SSCs); their progeny either remain as stem cells (self-renewal) or…”
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Phosphoglycerate Kinase 2 (PGK2) Is Essential for Sperm Function and Male Fertility in Mice by Danshina, Polina V, Geyer, Christopher B, Dai, Qunsheng, Goulding, Eugenia H, Willis, William D, Kitto, G. Barrie, McCarrey, John R, Eddy, E.M, O'Brien, Deborah A

“…Phosphoglycerate kinase 2 (PGK2), an isozyme that catalyzes the first ATP-generating step in the glycolytic pathway, is encoded by an autosomal retrogene that…”
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Advanced immunostaining approaches to study early male germ cell development by Niedenberger, Bryan A., Geyer, Christopher B.

“…Mammalian male germ cell development takes place in the testis under the influence of a variety of somatic cells and an incompletely defined paracrine and…”
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Dynamic cytoplasmic projections connect mammalian spermatogonia in vivo by Niedenberger, Bryan A, Cook, Kenneth, Baena, Valentina, Serra, Nicholas D, Velte, Ellen K, Agno, Julio E, Litwa, Karen A, Terasaki, Mark, Hermann, Brian P, Matzuk, Martin M, Geyer, Christopher B

“…Throughout the male reproductive lifespan, spermatogonial stem cells (SSCs) produce committed progenitors that proliferate and then remain physically connected…”
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The Role of Retinoic Acid (RA) in Spermatogonial Differentiation1 by Busada, Jonathan T, Geyer, Christopher B

“…Retinoic acid (RA) directs the sequential, but distinct, programs of spermatogonial differentiation and meiotic differentiation that are both essential for the…”
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Unique Epigenetic Programming Distinguishes Regenerative Spermatogonial Stem Cells in the Developing Mouse Testis by Cheng, Keren, Chen, I-Chung, Cheng, Ching-Hsun Eric, Mutoji, Kazadi, Hale, Benjamin J., Hermann, Brian P., Geyer, Christopher B., Oatley, Jon M., McCarrey, John R.

“…Spermatogonial stem cells (SSCs) both self-renew and give rise to progenitors that initiate spermatogenic differentiation in the mammalian testis. Questions…”
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A missense mutation in the Capza3 gene and disruption of F-actin organization in spermatids of repro32 infertile male mice by Geyer, Christopher B., Inselman, Amy L., Sunman, Jeffrey A., Bornstein, Sheila, Handel, Mary Ann, Eddy, Edward M.

“…Males homozygous for the repro32 ENU-induced mutation produced by the Reproductive Genomics program at The Jackson Laboratory are infertile, have low…”
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Androgen signaling promotes translation of TMEFF2 in prostate cancer cells via phosphorylation of the α subunit of the translation initiation factor 2 by Overcash, Ryan F, Chappell, Vesna A, Green, Thomas, Geyer, Christopher B, Asch, Adam S, Ruiz-Echevarría, Maria J

“…The type I transmembrane protein with epidermal growth factor and two follistatin motifs 2 (TMEFF2), is expressed mainly in brain and prostate. Expression of…”
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Pharmacological Treatment of Neonatal and Juvenile Mice to Study Spermatogenesis by Kirsanov, Oleksandr, Geyer, Christopher B

“…The delivery, to newborn and juvenile mice, of drugs and other compounds that manipulate the physiology or cellular/molecular state -e.g., by activating or…”
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The Role of Retinoic Acid (RA) in Spermatogonial Differentiation by Busada, Jonathan T, Geyer, Christopher B

“…Retinoic acid (RA) directs the sequential, but distinct, programs of spermatogonial differentiation and meiotic differentiation that are both essential for the…”
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A historical perspective on some “new” discoveries on spermatogenesis from the laboratory of Enrico Sertoli in 1878 by Geyer, Christopher B

“…Enrico Sertoli (1842–1910) was an Italian histologist and physician (Figure 1A, [1–3]) who studied a wide variety of subjects during his 40+ year academic…”
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Retinoic Acid Induces Multiple Hallmarks of the Prospermatogonia-to-Spermatogonia Transition in the Neonatal Mouse1 by Busada, Jonathan T, Kaye, Evelyn P, Renegar, Randall H, Geyer, Christopher B

“…In mammals, most neonatal male germ cells (prospermatogonia) are quiescent and located in the center of the testis cords. In response to an unknown signal,…”
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Transcriptional and Translational Heterogeneity among Neonatal Mouse Spermatogonia1 by Hermann, Brian P, Mutoji, Kazadi N, Velte, Ellen K, Ko, Daijin, Oatley, Jon M, Geyer, Christopher B, McCarrey, John R

“…Spermatogonial stem cells (SSCs) are a subset of undifferentiated spermatogonia responsible for ongoing spermatogenesis in mammalian testes. Spermatogonial…”
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Identification and characterization of Rhox13, a novel X-linked mouse homeobox gene by Geyer, Christopher B., Eddy, Edward M.

“…Homeobox genes encode transcription factors whose expression organizes programs of development. A number of homeobox genes expressed in reproductive tissues…”
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