Search Results - "GEULA, C"

Neurobiology of butyrylcholinesterase by Darvesh, Sultan, Geula, Changiz, Hopkins, David A

“…Butyrylcholinesterase is a serine hydrolase related to acetylcholinesterase that catalyses the hydrolysis of esters of choline, including acetylcholine…”
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Differential Neurotoxicity Related to Tetracycline Transactivator and TDP-43 Expression in Conditional TDP-43 Mouse Model of Frontotemporal Lobar Degeneration by Kukreja, L, Shahidehpour, R, Kim, G, Keegan, J, Sadleir, K R, Russell, T, Csernansky, J, Mesulam, M, Vassar, R J, Wang, L, Dong, H, Geula, C

“…Frontotemporal lobar degeneration (FTLD) is among the most prevalent dementias of early-onset. Pathologically, FTLD presents with tauopathy or TAR DNA-binding…”
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Accumulation and age-related elevation of amyloid-β within basal forebrain cholinergic neurons in the rhesus monkey by Norvin, D, Kim, G, Baker-Nigh, A, Geula, C

“…Highlights • Cholinergic neurons of basal forebrain accumulate amyloid-β peptide in young and old rhesus monkeys. • Quantitatively, amyloid-β40 in cholinergic…”
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Prominent microglial activation in cortical white matter is selectively associated with cortical atrophy in primary progressive aphasia by Ohm, D. T., Kim, G., Gefen, T., Rademaker, A., Weintraub, S., Bigio, E. H., Mesulam, M.‐M., Rogalski, E., Geula, C.

“…Aims Primary progressive aphasia (PPA) is a clinical syndrome characterized by selective language impairments associated with focal cortical atrophy favouring…”
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Asymmetric TDP-43 distribution in primary progressive aphasia with progranulin mutation by GLIEBUS, G, BIGIO, E. H, GASHO, K, MISHRA, M, CAPLAN, D, MESULAM, M.-M, GEULA, C

“…Primary progressive aphasia (PPA) results from an asymmetric degeneration of the language dominant (usually left) hemisphere and can be associated with the…”
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Current understanding of AD pathophysiology by Geula, C.

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Cytoarchitecture and neural afferents of orbitofrontal cortex in the brain of the monkey by Morecraft, R J, Geula, C, Mesulam, M M

“…The orbitofrontal cortex of the monkey can be subdivided into a caudal agranular sector, a transitional dysgranular sector, and an anterior granular sector…”
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Cholinesterases and the pathology of Alzheimer disease by Geula, C, Mesulam, M M

“…Alzheimer disease (AD) is accompanied by a marked loss of acetylcholinesterase (AChE) activity associated with cortical cholinergic axons and cholinoceptive…”
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Effects of lipids and aging on the neurotoxicity and neuronal loss caused by intracerebral injections of the amyloid-β peptide in the rat by Gonzalo-Ruiz, A., Pérez, J.L., Sanz, J.M., Geula, C., Arévalo, J.

“…The influence of diet and age on the area of lesion and on the neuronal density in the cerebral cortex was studied in rats following local injections of the…”
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Alzheimer's disease : Translating neurochemical insights into clinical benefits by Geula, C, Farlow, M

“…This ACADEMIC HIGHLIGHTS section summarizes the highlights of a Continuing Medical Education accredited satellite symposium approved at the World Alzheimer's…”
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Selective vulnerability of spinal cord motor neurons to non-NMDA toxicity by Saroff, D, Delfs, J, Kuznetsov, D, Geula, C

“…We previously reported that α-motor neurons in organotypic cultures of rat spinal cord (OTC-SC) are resistant to excitotoxicity induced through NMDA receptors…”
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Human striatum: chemoarchitecture of the caudate nucleus, putamen and ventral striatum in health and Alzheimer's disease by Selden, N, Geula, C, Hersh, L, Mesulam, M M

“…The morphology and distribution of perikarya positive for choline acetyltransferase, somatostatin, calcium binding protein (calbindin D28K) and nicotinamide…”
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Differential localization of NADPH-diaphorase and calbindin-D28k within the cholinergic neurons of the basal forebrain, striatum and brainstem in the rat, monkey, baboon and human by Geula, C, Schatz, C R, Mesulam, M M

“…The localization of Calbindin-D28k and NADPH-diaphorase in the cholinergic neurons of the basal forebrain, striatum and brainstem was investigated in the rat,…”
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Selective age-related loss of CALBINDIN-D28k from basal forebrain cholinergic neurons in the common marmoset (Callithrix jacchus) by WU, C.-K, NAGYKERY, N, HERSH, L. B, SCINTO, L. F. M, GEULA, C

“…A significant number of the cholinergic neurons in the basal forebrain of the primate, but not the rodent brain contain the calcium binding protein…”
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Panel discussion by Cummings, Jeffrey L., Geula, Changiz, Kaye, Jeffrey, Dunkin, Jennifer, Menken, Matthew, Taylor, Palmer, Farlow, Martin

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Amyloid beta peptide-induced cholinergic fibres loss in the cerebral cortex of the rat is modified by diet high in lipids and by age by Gonzalo-Ruiz, A., Sanz, J.M., Arévalo, J., Geula, C., Gonzalo, P.

“…The influence of diet and age on the effects of intracerebral injection of beta-amyloid peptide (Aβ1–40) in vehicle phosphate-buffered saline (PBS) and on the…”
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Selective cell loss in Edinger-Westphal in asymptomatic elders and Alzheimer's patients by SCINTO, L. F. M, FROSCH, M, WU, C. K, DAFFNER, K. R, GEDI, N, GEULA, C

“…Exaggerated pupillary response to a low concentration of cholinergic antagonists has been suggested as an early marker for Alzheimer's Disease (AD). To examine…”
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Discriminative stimulus effects of morphine: effects of training dose on agonist and antagonist effects of mu opioids by Young, A M, Masaki, M A, Geula, C

“…Experiments examined how training dose of morphine modulates the agonist and antagonist effects of selected mu opioids. Saline and either 3.2 or 5.6 mg/kg…”
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GnRH-immunoreactive fiber changes with unilateral amygdala-kindled seizures by Friedman, M.N, Geula, C, Holmes, G.L, Herzog, A.G

“…Purpose: To assess whether unilateral amygdala seizures are associated with a change in the number and lateral distribution of gonadotropin releasing hormone…”
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Cortical cholinergic fibers in aging and Alzheimer's disease: a morphometric study by Geula, C, Mesulam, M M

“…A histochemical method for acetylcholinesterase was used to assess the regional density of acetylcholinesterase-rich (putatively cholinergic) axons in the…”
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