Search Results - "GERWICK, William H"

Systematic classification of unknown metabolites using high-resolution fragmentation mass spectra by Dührkop, Kai, Nothias, Louis-Félix, Fleischauer, Markus, Reher, Raphael, Ludwig, Marcus, Hoffmann, Martin A., Petras, Daniel, Gerwick, William H., Rousu, Juho, Dorrestein, Pieter C., Böcker, Sebastian

“…Metabolomics using nontargeted tandem mass spectrometry can detect thousands of molecules in a biological sample. However, structural molecule annotation is…”
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Retrospective analysis of natural products provides insights for future discovery trends by Pye, Cameron R., Bertin, Matthew J., Lokey, R. Scott, Gerwick, William H., Linington, Roger G.

“…Understanding of the capacity of the natural world to produce secondary metabolites is important to a broad range of fields, including drug discovery, ecology,…”
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NPClassifier: A Deep Neural Network-Based Structural Classification Tool for Natural Products by Kim, Hyun Woo, Wang, Mingxun, Leber, Christopher A., Nothias, Louis-Félix, Reher, Raphael, Kang, Kyo Bin, van der Hooft, Justin J. J., Dorrestein, Pieter C., Gerwick, William H., Cottrell, Garrison W.

“…Computational approaches such as genome and metabolome mining are becoming essential to natural products (NPs) research. Consequently, a need exists for an…”
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Metabolic engineering of lipid catabolism increases microalgal lipid accumulation without compromising growth by Trentacoste, Emily M., Shrestha, Roshan P., Smith, Sarah R., Glé, Corine, Hartmann, Aaron C., Hildebrand, Mark, Gerwick, William H.

“…Biologically derived fuels are viable alternatives to traditional fossil fuels, and microalgae are a particularly promising source, but improvements are…”
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A Convolutional Neural Network-Based Approach for the Rapid Annotation of Molecularly Diverse Natural Products by Reher, Raphael, Kim, Hyun Woo, Zhang, Chen, Mao, Huanru Henry, Wang, Mingxun, Nothias, Louis-Félix, Caraballo-Rodriguez, Andres Mauricio, Glukhov, Evgenia, Teke, Bahar, Leao, Tiago, Alexander, Kelsey L, Duggan, Brendan M, Van Everbroeck, Ezra L, Dorrestein, Pieter C, Cottrell, Garrison W, Gerwick, William H

“…This report describes the first application of the novel NMR-based machine learning tool “Small Molecule Accurate Recognition Technology” (SMART 2.0) for…”
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Characterization of cyanobacterial hydrocarbon composition and distribution of biosynthetic pathways by Coates, R Cameron, Podell, Sheila, Korobeynikov, Anton, Lapidus, Alla, Pevzner, Pavel, Sherman, David H, Allen, Eric E, Gerwick, Lena, Gerwick, William H

“…Cyanobacteria possess the unique capacity to naturally produce hydrocarbons from fatty acids. Hydrocarbon compositions of thirty-two strains of cyanobacteria…”
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Biologically active secondary metabolites from marine cyanobacteria by Nunnery, Joshawna K, Mevers, Emily, Gerwick, William H

“…Marine cyanobacteria are a rich source of complex bioactive secondary metabolites which derive from mixed biosynthetic pathways. Recently, several marine…”
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Apratoxin Kills Cells by Direct Blockade of the Sec61 Protein Translocation Channel by Paatero, Anja O, Kellosalo, Juho, Dunyak, Bryan M, Almaliti, Jehad, Gestwicki, Jason E, Gerwick, William H, Taunton, Jack, Paavilainen, Ville O

“…Apratoxin A is a cytotoxic natural product that prevents the biogenesis of secretory and membrane proteins. Biochemically, apratoxin A inhibits cotranslational…”
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Molecular Networking as a Dereplication Strategy by Yang, Jane Y, Sanchez, Laura M, Rath, Christopher M, Liu, Xueting, Boudreau, Paul D, Bruns, Nicole, Glukhov, Evgenia, Wodtke, Anne, de Felicio, Rafael, Fenner, Amanda, Wong, Weng Ruh, Linington, Roger G, Zhang, Lixin, Debonsi, Hosana M, Gerwick, William H, Dorrestein, Pieter C

“…A major goal in natural product discovery programs is to rapidly dereplicate known entities from complex biological extracts. We demonstrate here that…”
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Marine natural products as potential anti-tubercular agents by Hou, Xue-Mei, Wang, Chang-Yun, Gerwick, William H., Shao, Chang-Lun

“…Tuberculosis has been one of the greatest global health challenges of all time. Although the current first-line anti-tuberculosis (anti-TB) medicines used in…”
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Survey of marine natural product structure revisions: A synergy of spectroscopy and chemical synthesis by Suyama, Takashi L., Gerwick, William H., McPhail, Kerry L.

“…The structural assignment of new natural product molecules supports research in a multitude of disciplines that may lead to new therapeutic agents and or new…”
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Moorea producens gen. nov., sp. nov. and Moorea bouillonii comb. nov., tropical marine cyanobacteria rich in bioactive secondary metabolites by Engene, Niclas, Rottacker, Erin C, Kaštovský, Jan, Byrum, Tara, Choi, Hyukjae, Ellisman, Mark H, Komárek, Jiří, Gerwick, William H

“…The filamentous cyanobacterial genus Moorea gen. nov., described here under the provisions of the International Code of Botanical Nomenclature, is a…”
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SMART‐Miner: A convolutional neural network‐based metabolite identification from 1H‐13C HSQC spectra by Kim, Hyun Woo, Zhang, Chen, Cottrell, Garrison W., Gerwick, William H.

“…The identification of metabolites from complex biofluids and extracts of tissues is an essential process for understanding metabolic profiles. Nuclear magnetic…”
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Changes in secondary metabolic profiles of Microcystis aeruginosa strains in response to intraspecific interactions by Briand, Enora, Bormans, Myriam, Gugger, Muriel, Dorrestein, Pieter C, Gerwick, William H

“…The cyanobacteria Microcystis proliferate in freshwater ecosystems and produce bioactive compounds including the harmful toxins microcystins (MC). These…”
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Nature's Combinatorial Biosynthesis Produces Vatiamides A–F by Moss, Nathan A., Seiler, Grant, Leão, Tiago F., Castro‐Falcón, Gabriel, Gerwick, Lena, Hughes, Chambers C., Gerwick, William H.

“…Hybrid type I PKS/NRPS biosynthetic pathways typically proceed in a collinear manner wherein one molecular building block is enzymatically incorporated in a…”
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Design of Gallinamide A Analogs as Potent Inhibitors of the Cysteine Proteases Human Cathepsin L and Trypanosoma cruzi Cruzain by Boudreau, Paul D, Miller, Bailey W, McCall, Laura-Isobel, Almaliti, Jehad, Reher, Raphael, Hirata, Ken, Le, Thu, Siqueira-Neto, Jair L, Hook, Vivian, Gerwick, William H

“…Gallinamide A, originally isolated with a modest antimalarial activity, was subsequently reisolated and characterized as a potent, selective, and irreversible…”
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Structural elucidation of recombinant Trichomonas vaginalis 20S proteasome bound to covalent inhibitors by Silhan, Jan, Fajtova, Pavla, Bartosova, Jitka, Hurysz, Brianna M., Almaliti, Jehad, Miyamoto, Yukiko, Eckmann, Lars, Gerwick, William H., O’Donoghue, Anthony J., Boura, Evzen

“…The proteasome is a proteolytic enzyme complex essential for protein homeostasis in mammalian cells and protozoan parasites like Trichomonas vaginalis (Tv) ,…”
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Light-gated integrator for highlighting kinase activity in living cells by Lin, Wei, Phatarphekar, Abhishek, Zhong, Yanghao, Liu, Longwei, Kwon, Hyung-Bae, Gerwick, William H., Wang, Yingxiao, Mehta, Sohum, Zhang, Jin

“…Protein kinases are key signaling nodes that regulate fundamental biological and disease processes. Illuminating kinase signaling from multiple angles can…”
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Small Molecule Accurate Recognition Technology (SMART) to Enhance Natural Products Research by Zhang, Chen, Idelbayev, Yerlan, Roberts, Nicholas, Tao, Yiwen, Nannapaneni, Yashwanth, Duggan, Brendan M., Min, Jie, Lin, Eugene C., Gerwick, Erik C., Cottrell, Garrison W., Gerwick, William H.

“…Various algorithms comparing 2D NMR spectra have been explored for their ability to dereplicate natural products as well as determine molecular structures…”
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1-Octen-3-ol, a self-stimulating oxylipin messenger, can prime and induce defense of marine alga by Chen, Haimin, Yang, Rui, Chen, Juanjuan, Luo, Qijun, Cui, Xiaoshan, Yan, Xiaojun, Gerwick, William H

“…Short chain oxylipins in plants as the main volatile organic carbon have been speculated to playing an important role for plant innate immunity, however, not…”
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