Search Results - "GERWICK, Lena"

Characterization of cyanobacterial hydrocarbon composition and distribution of biosynthetic pathways by Coates, R Cameron, Podell, Sheila, Korobeynikov, Anton, Lapidus, Alla, Pevzner, Pavel, Sherman, David H, Allen, Eric E, Gerwick, Lena, Gerwick, William H

“…Cyanobacteria possess the unique capacity to naturally produce hydrocarbons from fatty acids. Hydrocarbon compositions of thirty-two strains of cyanobacteria…”
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Nature's Combinatorial Biosynthesis Produces Vatiamides A–F by Moss, Nathan A., Seiler, Grant, Leão, Tiago F., Castro‐Falcón, Gabriel, Gerwick, Lena, Hughes, Chambers C., Gerwick, William H.

“…Hybrid type I PKS/NRPS biosynthetic pathways typically proceed in a collinear manner wherein one molecular building block is enzymatically incorporated in a…”
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Bastimolide B, an Antimalarial 24-Membered Marine Macrolide Possessing a tert-Butyl Group by Shao, Chang-Lun, Mou, Xiao-Feng, Cao, Fei, Spadafora, Carmenza, Glukhov, Evgenia, Gerwick, Lena, Wang, Chang-Yun, Gerwick, William H

“…We reported previously the discovery of the potent antimalarial 40-membered macrolide bastimolide A (1) from the tropical marine cyanobacterium Okeania…”
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Digitizing mass spectrometry data to explore the chemical diversity and distribution of marine cyanobacteria and algae by Luzzatto-Knaan, Tal, Garg, Neha, Wang, Mingxun, Glukhov, Evgenia, Peng, Yao, Ackermann, Gail, Amir, Amnon, Duggan, Brendan M, Ryazanov, Sergey, Gerwick, Lena, Knight, Rob, Alexandrov, Theodore, Bandeira, Nuno, Gerwick, William H, Dorrestein, Pieter C

“…Natural product screening programs have uncovered molecules from diverse natural sources with various biological activities and unique structures. However,…”
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Real-Time Metabolomics on Living Microorganisms Using Ambient Electrospray Ionization Flow-Probe by Hsu, Cheng-Chih, ElNaggar, Mariam S, Peng, Yao, Fang, Jinshu, Sanchez, Laura M, Mascuch, Samantha J, Møller, Kirsten A, Alazzeh, Emad K, Pikula, Jiri, Quinn, Robert A, Zeng, Yi, Wolfe, Benjamin E, Dutton, Rachel J, Gerwick, Lena, Zhang, Lixin, Liu, Xueting, Månsson, Maria, Dorrestein, Pieter C

“…Microorganisms such as bacteria and fungi produce a variety of specialized metabolites that are invaluable for agriculture, biological research, and drug…”
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Single cell genome amplification accelerates identification of the apratoxin biosynthetic pathway from a complex microbial assemblage by Grindberg, Rashel V, Ishoey, Thomas, Brinza, Dumitru, Esquenazi, Eduardo, Coates, R Cameron, Liu, Wei-ting, Gerwick, Lena, Dorrestein, Pieter C, Pevzner, Pavel, Lasken, Roger, Gerwick, William H

“…Filamentous marine cyanobacteria are extraordinarily rich sources of structurally novel, biomedically relevant natural products. To understand their…”
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A Multi-Omics Characterization of the Natural Product Potential of Tropical Filamentous Marine Cyanobacteria by Leão, Tiago, Wang, Mingxun, Moss, Nathan, da Silva, Ricardo, Sanders, Jon, Nurk, Sergey, Gurevich, Alexey, Humphrey, Gregory, Reher, Raphael, Zhu, Qiyun, Belda-Ferre, Pedro, Glukhov, Evgenia, Whitner, Syrena, Alexander, Kelsey L, Rex, Robert, Pevzner, Pavel, Dorrestein, Pieter C, Knight, Rob, Bandeira, Nuno, Gerwick, William H, Gerwick, Lena

“…Microbial natural products are important for the understanding of microbial interactions, chemical defense and communication, and have also served as an…”
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Comparative analysis of hapalindole, ambiguine and welwitindolinone gene clusters and reconstitution of indole-isonitrile biosynthesis from cyanobacteria by Micallef, Melinda L, Sharma, Deepti, Bunn, Brittney M, Gerwick, Lena, Viswanathan, Rajesh, Moffitt, Michelle C

“…The hapalindole-type family of natural products is a group of hybrid isoprenoid-indole alkaloids, produced solely by members of the Subsection V cyanobacterial…”
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Heterologous Expression of Cryptomaldamide in a Cyanobacterial Host by Taton, Arnaud, Ecker, Andrew, Diaz, Brienna, Moss, Nathan A, Anderson, Brooke, Reher, Raphael, Leão, Tiago F, Simkovsky, Ryan, Dorrestein, Pieter C, Gerwick, Lena, Gerwick, William H, Golden, James W

“…Filamentous marine cyanobacteria make a variety of bioactive molecules that are produced by polyketide synthases, nonribosomal peptide synthetases, and hybrid…”
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Ketoreductase Domain Dysfunction Expands Chemodiversity: Malyngamide Biosynthesis in the Cyanobacterium Okeania hirsuta by Moss, Nathan A, Leão, Tiago, Rankin, Michael R, McCullough, Tyler M, Qu, Pingping, Korobeynikov, Anton, Smith, Janet L, Gerwick, Lena, Gerwick, William H

“…Dozens of type A malyngamides, principally identified by a decorated six-membered cyclohexanone headgroup and methoxylated lyngbic acid tail, have been…”
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The Phormidolide Biosynthetic Gene Cluster: A trans-AT PKS Pathway Encoding a Toxic Macrocyclic Polyketide by Bertin, Matthew J., Vulpanovici, Alexandra, Monroe, Emily A., Korobeynikov, Anton, Sherman, David H., Gerwick, Lena, Gerwick, William H.

“…Phormidolide is a polyketide produced by a cultured filamentous marine cyanobacterium and incorporates a 16‐membered macrolactone. Its complex structure is…”
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An anti-inflammatory isoflavone from soybean inoculated with a marine fungus Aspergillus terreus C23-3 by Yang, Jing-Ming, Liu, Ya-Yue, Yang, Wen-Cong, Ma, Xiao-Xiang, Nie, Ying-Ying, Glukhov, Evgenia, Gerwick, Lena, Gerwick, William H., Lei, Xiao-Ling, Zhang, Yi

“…A new isoflavone derivative compound 1 (psoralenone) was isolated from soybean inoculated with a marine fungus Aspergillus terreus C23-3, together with seven…”
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The unique mechanistic transformations involved in the biosynthesis of modular natural products from marine cyanobacteria by Jones, Adam C, Monroe, Emily A, Eisman, Eli B, Gerwick, Lena, Sherman, David H, Gerwick, William H

“…Cyanobacteria are abundant producers of natural products well recognized for their bioactivity and utility in drug discovery and biotechnology applications. In…”
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The acute phase response and innate immunity of fish by Bayne, Christopher J, Gerwick, Lena

“…Tissue trauma or invasion by pathogens or parasites induce changes in the quantities of several macromolecules in animal body fluids. These changes comprise…”
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Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula by Jones, Adam C, Monroe, Emily A, Podell, Sheila, Hess, Wolfgang R, Klages, Sven, Esquenazi, Eduardo, Niessen, Sherry, Hoover, Heather, Rothmann, Michael, Lasken, Roger S, Yates, John R. III, Reinhardt, Richard, Kube, Michael, Burkart, Michael D, Allen, Eric E, Dorrestein, Pieter C, Gerwick, William H, Gerwick, Lena

“…Filamentous cyanobacteria of the genus Lyngbya are important contributors to coral reef ecosystems, occasionally forming dominant cover and impacting the…”
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Expanding the Described Metabolome of the Marine Cyanobacterium Moorea producens JHB through Orthogonal Natural Products Workflows by Boudreau, Paul D, Monroe, Emily A, Mehrotra, Suneet, Desfor, Shane, Korobeynikov, Anton, Sherman, David H, Murray, Thomas F, Gerwick, Lena, Dorrestein, Pieter C, Gerwick, William H

“…Moorea producens JHB, a Jamaican strain of tropical filamentous marine cyanobacteria, has been extensively studied by traditional natural products techniques…”
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A Mononuclear Iron-Dependent Methyltransferase Catalyzes Initial Steps in Assembly of the Apratoxin A Polyketide Starter Unit by Skiba, Meredith A, Sikkema, Andrew P, Moss, Nathan A, Tran, Collin L, Sturgis, Rebecca M, Gerwick, Lena, Gerwick, William H, Sherman, David H, Smith, Janet L

“…Natural product biosynthetic pathways contain a plethora of enzymatic tools to carry out difficult biosynthetic transformations. Here, we discover an unusual…”
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Direct detection of fungal siderophores on bats with white-nose syndrome via fluorescence microscopy-guided ambient ionization mass spectrometry by Mascuch, Samantha J, Moree, Wilna J, Hsu, Cheng-Chih, Turner, Gregory G, Cheng, Tina L, Blehert, David S, Kilpatrick, A Marm, Frick, Winifred F, Meehan, Michael J, Dorrestein, Pieter C, Gerwick, Lena

“…White-nose syndrome (WNS) caused by the pathogenic fungus Pseudogymnoascus destructans is decimating the populations of several hibernating North American bat…”
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Polyketide Decarboxylative Chain Termination Preceded by O-Sulfonation in Curacin A Biosynthesis by Gu, Liangcai, Wang, Bo, Kulkarni, Amol, Gehret, Jennifer J., Lloyd, Kayla R., Gerwick, Lena, Gerwick, William H., Wipf, Peter, Håkansson, Kristina, Smith, Janet L., Sherman, David H.

“…Biosynthetic innovation in natural product systems is driven by the recruitment of new genes and enzymes into these complex pathways. Here, an unprecedented…”
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Significant Natural Product Biosynthetic Potential of Actinorhizal Symbionts of the Genus Frankia, as Revealed by Comparative Genomic and Proteomic Analyses by UDWARY, Daniel W, GONTANG, Erin A, ESQUENAZI, Eduardo, EUSTAQUIO, Alessandra S, FREEL, Kelle, GERWICK, Lena, GERWICK, William H, GONZALEZ, David, LIU, Wei-Ting, MALLOY, Karla L, MALONEY, Katherine N, NETT, Markus, JONES, Adam C, NUNNERY, Joshawna K, PENN, Kevin, PRIETO-DAVO, Alejandra, SIMMONS, Thomas L, WEITZ, Sara, WILSON, Micheal C, TISA, Louis S, DORRESTEIN, Pieter C, MOORE, Bradley S, JONES, Carla S, SCHULTZ, Andrew W, WINTER, Jaclyn M, YANG, Jane Y, BEAUCHEMIN, Nicholas, CAPSON, Todd L, CLARK, Benjamin R

“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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