Search Results - "GERSL, Vladimir"

Experimental determination of diagnostic window of cardiac troponins in the development of chronic anthracycline cardiotoxicity and estimation of its predictive value by Adamcova, Michaela, Lencova-Popelova, Olga, Jirkovsky, Eduard, Mazurova, Yvona, Palicka, Vladimir, Simko, Fedor, Gersl, Vladimir, Sterba, Martin

“…Abstract Background Cardiac troponins (cTns) seem to be more sensitive for the detection of anthracycline cardiotoxicity than the currently recommended method…”
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In vitro and in vivo examination of cardiac troponins as biochemical markers of drug-induced cardiotoxicity by ADAMCOVA, Michaela, SIMUNEK, Tomas, KAISEROVA, Helena, POPELOVA, Olga, STERBA, Martin, POTACOVA, Anna, VAVROVA, Jaroslava, MALAKOVA, Jana, GERSL, Vladimir

“…Abstract Cardiac troponin T (cTnT) and troponin I (cTnI) are becoming acknowledged as useful biochemical markers of drug-induced cardiotoxicity. In this study…”
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HPLC determination of a novel aroylhydrazone iron chelator ( o-108) in rabbit plasma and its application to a pilot pharmacokinetic study by KOVARIKOVA, Petra, KLIMES, Jiri, STERBA, Martin, POPELOVA, Olga, GERSL, Vladimir, PONKA, Premysl

“…A high performance liquid chromatographic method for the determination of a biocompatible iron chelator, pyridoxal 2-chlorobenzoyl hydrazone ( o-108), in…”
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Development of high-performance liquid chromatographic determination of salicylaldehyde isonicotinoyl hydrazone in rabbit plasma and application of this method to an in vivo study by KOVARIKOVA, Petra, KLIMES, Jiri, STERBA, Martin, POPELOVA, Olga, MOKRY, Milan, GERSL, Vladimir, PONKA, Premysl

“…An analytical methodology appropriate for the determination of the novel drug candidate salicylaldehyde isonicotinoyl hydrazone (SIH) in rabbit plasma has been…”
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Cardiac troponin T as an indicator of reduced left ventricular contractility in experimental anthracycline-induced cardiomyopathy by SIMUNEK, Tomas, KLIMTOVA, Ivona, ADAMCOVA, Michaela, GERSL, Vladimir, HRDINA, Radomir, STERBA, Martin, KAPLANOVA, Jana, MAZUROVA, Yvona

“…Cardiac troponin T (cTnT) plasma concentration is considered a useful marker of anthracycline-induced cardiomyopathy. In this study we used…”
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Comparative study of chronic toxic effects of daunorubicin and doxorubicin in rabbits by Klimtová, Ivona, Simůnek, Tomás, Mazurová, Yvona, Hrdina, Radomír, Gersl, Vladimír, Adamcová, Michaela

“…This study compares the chronic toxicity of two anthracyclines--daunorubicin and doxorubicin, commonly used for induction of anthracycline cardiomyopathy in…”
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In vivo and in vitro assessment of the role of glutathione antioxidant system in anthracycline-induced cardiotoxicity by VAVROVA, Anna, POPELOVA, Olga, STERBA, Martin, JIRKOVSKY, Eduard, HASKOVA, Pavlina, MERTLIKOVA-KAISEROVA, Helena, GERSL, Vladimír, SIMUNEK, Tomáš

“…The clinical usefulness of anthracycline antineoplastic drugs is limited by their cardiotoxicity. Its mechanisms have not been fully understood, although the…”
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Anthracycline-induced cardiotoxicity: Overview of studies examining the roles of oxidative stress and free cellular iron by Šimůnek, Tomáš, Štěrba, Martin, Popelová, Olga, Adamcová, Michaela, Hrdina, Radomír, Geršl, Vladimír

“…The risk of cardiotoxicity is the most serious drawback to the clinical usefulness of anthracycline antineoplastic antibiotics, which include doxorubicin…”
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Cardiac troponins-Translational biomarkers in cardiology: Theory and practice of cardiac troponin high-sensitivity assays by Adamcova, Michaela, Popelova-Lencova, Olga, Jirkovsky, Eduard, Simko, Fedor, Gersl, Vladimir, Sterba, Martin

“…Tn is a unique translational biomarker in cardiology whose potential has not been diminished in the new era of high sensitive assays. cTns can be valuable…”
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Oxidative stress, redox signaling, and metal chelation in anthracycline cardiotoxicity and pharmacological cardioprotection by Stěrba, Martin, Popelová, Olga, Vávrová, Anna, Jirkovský, Eduard, Kovaříková, Petra, Geršl, Vladimír, Simůnek, Tomáš

“…Anthracyclines (doxorubicin, daunorubicin, or epirubicin) rank among the most effective anticancer drugs, but their clinical usefulness is hampered by the risk…”
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Molecular remodeling of left and right ventricular myocardium in chronic anthracycline cardiotoxicity and post-treatment follow up by Lenco, Juraj, Lencová-Popelová, Olga, Å imůnek, Tomás, Gersl, Vladimír, Jirkovský, Eduard, Mazurová, Yvona, Adamcová, Michaela, Å tÄrba, Martin

“…Chronic anthracycline cardiotoxicity is a serious clinical issue with well characterized functional and histopathological hallmarks. However, molecular…”
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Chronic anthracycline cardiotoxicity: molecular and functional analysis with focus on nuclear factor erythroid 2-related factor 2 and mitochondrial biogenesis pathways by Jirkovsky, Eduard, Popelová, Olga, Kriváková-Stanková, Pavla, Vávrová, Anna, Hroch, Milos, Hasková, Pavlína, Brcáková-Dolezelová, Eva, Micuda, Stanislav, Adamcová, Michaela, Simůnek, Tomás, Cervinková, Zuzana, Gersl, Vladimír, Sterba, Martin

“…Anthracycline anticancer drugs (e.g., doxorubicin or daunorubicin) can induce chronic cardiotoxicity and heart failure (HF), both of which are believed to be…”
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Cardioprotective effects of inorganic nitrate/nitrite in chronic anthracycline cardiotoxicity: Comparison with dexrazoxane by Lenčová-Popelová, Olga, Jirkovský, Eduard, Jansová, Hana, Jirkovská-Vávrová, Anna, Vostatková-Tichotová, Lucie, Mazurová, Yvona, Adamcová, Michaela, Chládek, Jaroslav, Hroch, Miloš, Pokorná, Zuzana, Geršl, Vladimír, Šimůnek, Tomáš, Štěrba, Martin

“…Abstract Dexrazoxane (DEX) is a clinically available cardioprotectant that reduces the toxicity induced by anthracycline (ANT) anticancer drugs; however, DEX…”
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Proteomic insights into chronic anthracycline cardiotoxicity by Štěrba, Martin, Popelová, Olga, Lenčo, Juraj, Fučíková, Alena, Brčáková, Eva, Mazurová, Yvona, Jirkovský, Eduard, Šimůnek, Tomáš, Adamcová, Michaela, Mičuda, Stanislav, Stulík, Jiří, Geršl, Vladimír

“…Abstract Chronic anthracycline cardiotoxicity is a feared complication of cancer chemotherapy. However, despite several decades of primarily hypothesis-driven…”
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Early and delayed cardioprotective intervention with dexrazoxane each show different potential for prevention of chronic anthracycline cardiotoxicity in rabbits by Jirkovský, Eduard, Lenčová-Popelová, Olga, Hroch, Miloš, Adamcová, Michaela, Mazurová, Yvona, Vávrová, Jaroslava, Mičuda, Stanislav, Šimůnek, Tomáš, Geršl, Vladimír, Štěrba, Martin

“…Abstract Despite incomplete understanding to its mechanism of action, dexrazoxane (DEX) is still the only clearly effective cardioprotectant against chronic…”
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Deferiprone does not protect against chronic anthracycline cardiotoxicity in vivo by Popelová, Olga, Sterba, Martin, Simůnek, Tomás, Mazurová, Yvona, Guncová, Ivana, Hroch, Milos, Adamcová, Michaela, Gersl, Vladimír

“…Anthracycline cardiotoxicity ranks among the most severe complications of cancer chemotherapy. Although its pathogenesis is only incompletely understood,…”
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Synthesis and analysis of novel analogues of dexrazoxane and its open-ring hydrolysis product for protection against anthracycline cardiotoxicity in vitroand in vivo by Jirkovska-Vavrova, Anna, Roh, Jaroslav, Lencova-Popelova, Olga, Jirkovsky, Eduard, Hruskova, Katerina, Potuckova-Mackova, Eliska, Jansova, Hana, Haskova, Pavlina, Martinkova, Pavla, Eisner, Tomas, Kratochvil, Marek, Sus, Jan, Machacek, Miloslav, Vostatkova-Tichotova, Lucie, Gersl, Vladimir, Kalinowski, Danuta S, Muller, Mark T, Richardson, Des R, Vavrova, Katerina, Sterba, Martin, Simunek, Tomas

“…Cardiotoxicity is a serious drawback of anthracycline anti-cancer drugs and dexrazoxane is the only cardioprotective agent with clinically established…”
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Protective effects of dexrazoxane against acute ischaemia/reperfusion injury of rat hearts by Neckář, Jan, Boudíková, Adéla, Mandíková, Petra, Stěrba, Martin, Popelová, Olga, Mikšík, Ivan, Dabrowská, Ludmila, Mráz, Jaroslav, Geršl, Vladimír, Kolář, František

“…Dexrazoxane (DEX), an inhibitor of topoisomerase II and intracellular iron chelator, is believed to reduce the formation of reactive oxygen species (ROS) and…”
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Cardioprotective effects of a novel iron chelator, pyridoxal 2-chlorobenzoyl hydrazone, in the rabbit model of daunorubicin-induced cardiotoxicity by Sterba, Martin, Popelová, Olga, Simunek, Tomás, Mazurová, Yvona, Potácová, Anna, Adamcová, Michaela, Kaiserová, Helena, Ponka, Premysl, Gersl, Vladimír

“…Iron chelation is the only pharmacological intervention against anthracycline cardiotoxicity whose effectiveness has been well documented both experimentally…”
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Comparison of protective effects of two iron chelating compounds – deferiprone and dexrazoxane – against chronic anthracycline cardiotoxicity by Popelova, Olga, Sterba, Martin, Simunek, Tomas, Guncova, Ivana, Mazurová, Yvona, Hroch, Milos, Adamcova, Michaela, Gersl, Vladimir

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