Search Results - "GERSHBURG, Edward"

Rational Design of Live-Attenuated Vaccines against Herpes Simplex Viruses by Stanfield, Brent A, Kousoulas, Konstantin G, Fernandez, Agustin, Gershburg, Edward

“…Diseases caused by human herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) affect millions of people worldwide and range from fatal encephalitis in neonates…”
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A live-attenuated HSV-2 ICP0 virus elicits 10 to 100 times greater protection against genital herpes than a glycoprotein D subunit vaccine by Halford, William P, Püschel, Ringo, Gershburg, Edward, Wilber, Andrew, Gershburg, Svetlana, Rakowski, Brandon

“…Glycoprotein D (gD-2) is the entry receptor of herpes simplex virus 2 (HSV-2), and is the immunogen in the pharmaceutical industry's lead HSV-2 vaccine…”
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The Epstein-Barr Virus (EBV)-Encoded Protein Kinase, EBV-PK, but Not the Thymidine Kinase (EBV-TK), Is Required for Ganciclovir and Acyclovir Inhibition of Lytic Viral Production by Meng, Qiao, Hagemeier, Stacy R, Fingeroth, Joyce D, Gershburg, Edward, Pagano, Joseph S, Kenney, Shannon C

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Pan-HSV-2 IgG antibody in vaccinated mice and guinea pigs correlates with protection against herpes simplex virus 2 by Halford, William P, Geltz, Joshua, Gershburg, Edward

“…We lack a correlate of immunity to herpes simplex virus 2 (HSV-2) that may be used to differentiate whether a HSV-2 vaccine elicits robust or anemic protection…”
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Herpes simplex virus 2 (HSV-2) infected cell proteins are among the most dominant antigens of a live-attenuated HSV-2 vaccine by Geltz, Joshua J, Gershburg, Edward, Halford, William P

“…Virion glycoproteins such as glycoprotein D (gD) are believed to be the dominant antigens of herpes simplex virus 2 (HSV-2). We have observed that mice…”
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The UL13 and US3 Protein Kinases of Herpes Simplex Virus 1 Cooperate to Promote the Assembly and Release of Mature, Infectious Virions by Gershburg, Svetlana, Geltz, Joshua, Peterson, Karin E, Halford, William P, Gershburg, Edward

“…Herpes simplex virus type 1 (HSV-1) encodes two bona fide serine/threonine protein kinases, the US3 and UL13 gene products. HSV-1 ΔUS3 mutants replicate with…”
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The Durability of Vaccine Efficacy against Ocular HSV-1 Infection Using ICP0 Mutants 0∆NLS and 0∆RING Is Lost over Time by Carr, Daniel J J, Berube, Amanda, Gershburg, Edward

“…Vaccines to viral pathogens in experimental animal models are often deemed successful if immunization enhances resistance of the host to virus challenge as…”
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Epstein-Barr Virus-Encoded Protein Kinase (BGLF4) Is Involved in Production of Infectious Virus by GERSHBURG, Edward, RAFFA, Salvatore, TORRISI, Maria Rosaria, PAGANO, Joseph S

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Assessment of Two Novel Live-Attenuated Vaccine Candidates for Herpes Simplex Virus 2 (HSV-2) in Guinea Pigs by Joyce, Jonathan D, Patel, Anant K, Murphy, Brandie, Carr, Daniel J J, Gershburg, Edward, Bertke, Andrea S

“…Treatment to ameliorate the symptoms of infection with herpes simplex virus 2 (HSV-2) and to suppress reactivation has been available for decades. However, a…”
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The Epstein-Barr Virus (EBV) Deubiquitinating Enzyme BPLF1 Reduces EBV Ribonucleotide Reductase Activity by WHITEHURST, Christopher B, SHUNBIN NING, BENTZ, Gretchen L, DUFOUR, Florent, GERSHBURG, Edward, SHACKELFORD, Julia, LANGELIER, Yves, PAGANO, Joseph S

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A system for creating stable cell lines that express a gene of interest from a bidirectional and regulatable herpes simplex virus type 1 promoter by Chambers, Christopher B, Halford, William P, Geltz, Joshua, Villamizar, Olga, Gross, Jeffrey, Embalabala, Alison, Gershburg, Edward, Wilber, Andrew

“…Expression systems used to study the biological function of a gene of interest can have limited utility due to three major factors: i) weak or heterogeneous…”
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Maribavir Inhibits Epstein-Barr Virus Transcription in Addition to Viral DNA Replication by WANG, Fu-Zhang, ROY, Debasmita, GERSHBURG, Edward, WHITEHURST, Christopher B, DITTMER, Dirk P, PAGANO, Joseph S

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Hyperphosphorylation of EBNA2 by Epstein-Barr Virus Protein Kinase Suppresses Transactivation of the LMP1 Promoter by Yue, Wei, Gershburg, Edward, Pagano, Joseph S

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ICP0 antagonizes ICP4-dependent silencing of the herpes simplex virus ICP0 gene by Liu, Mingyu, Rakowski, Brandon, Gershburg, Edward, Weisend, Carla M, Lucas, Olivier, Schmidt, Edward E, Halford, William P

“…ICP0 is a regulatory protein that plays a critical role in the replication-latency balance of herpes simplex virus (HSV). Absence of ICP0 renders HSV prone to…”
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Phosphorylation of the Epstein-Barr Virus (EBV) DNA Polymerase Processivity Factor EA-D by the EBV-Encoded Protein Kinase and Effects of the l-Riboside Benzimidazole 1263W94 by Gershburg, Edward, Pagano, Joseph S

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Effects of Maribavir and Selected Indolocarbazoles on Epstein-Barr Virus Protein Kinase BGLF4 and on Viral Lytic Replication by GERSHBURG, Edward, KE HONG, PAGANO, Joseph S

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Vaccine Development Should Be Polytheistic, Not Monotheistic by Plotkin, Stanley A, Robinson, James M, Fitchett, Joseph R A, Gershburg, Edward

“…Vaccines based on mRNA technology have been tremendously successful, but their properties are not necessarily ideal for all pathogens. There is a risk that…”
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Molecular diversity of IgG responses to Epstein-Barr virus proteins in asymptomatic Epstein-Barr virus carriers by Goswami, Ria, Shair, Kathy Ho Yen, Gershburg, Edward

“…The Epstein-Barr virus (EBV) is a ubiquitous pathogen that infects over 90 % of adults. EBV is the primary etiological agent of infectious mononucleosis and is…”
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Noncognate Signals Drive Enhanced Effector CD8 + T Cell Responses through an IFNAR1-Dependent Pathway after Infection with the Prototypic Vaccine, 0ΔNLS, against Herpes Simplex Virus 1 by Gmyrek, Grzegorz B, Predki, Paul, Gershburg, Edward, Carr, Daniel J J

“…Previous studies by our group identified a highly efficacious vaccine 0ΔNLS (deficient in the nuclear localization signal of infected cell protein 0) against…”
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Conserved herpesvirus protein kinases by Gershburg, Edward, Pagano, Joseph S.

“…Conserved herpesviral protein kinases (CHPKs) are a group of enzymes conserved throughout all subfamilies of Herpesviridae. Members of this group are…”
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