Search Results - "GERKE, Volker"

Human endothelial cells display a rapid tensional stress increase in response to tumor necrosis factor-α by Brandt, Matthias, Gerke, Volker, Betz, Timo

“…Endothelial cells form the inner layer of blood vessels, making them the first barrier between the blood and interstitial tissues; thus endothelial cells play…”
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Acidification of endothelial Weibel-Palade bodies is mediated by the vacuolar-type H+-ATPase by Terglane, Julian, Menche, Dirk, Gerke, Volker

“…Weibel-Palade bodies (WPB) are unique secretory granules of endothelial cells that store the procoagulant von-Willebrand factor (VWF) in a highly compacted…”
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Modeling of annexin A2-Membrane interactions by molecular dynamics simulations by Hakobyan, Davit, Gerke, Volker, Heuer, Andreas

“…The annexins are a family of Ca2+-regulated phospholipid binding proteins that are involved in membrane domain organization and membrane trafficking. Although…”
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Targeting the endolysosomal host-SARS-CoV-2 interface by clinically licensed functional inhibitors of acid sphingomyelinase (FIASMA) including the antidepressant fluoxetine by Schloer, Sebastian, Brunotte, Linda, Goretzko, Jonas, Mecate-Zambrano, Angeles, Korthals, Nadia, Gerke, Volker, Ludwig, Stephan, Rescher, Ursula

“…The Coronavirus Disease 2019 (COVID-19) pandemic caused by the Severe Acute Respiratory Syndrome Related Coronavirus 2 (SARS-CoV-2) is a global health…”
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Annexin A4 and A6 induce membrane curvature and constriction during cell membrane repair by Boye, Theresa Louise, Maeda, Kenji, Pezeshkian, Weria, Sønder, Stine Lauritzen, Haeger, Swantje Christin, Gerke, Volker, Simonsen, Adam Cohen, Nylandsted, Jesper

“…Efficient cell membrane repair mechanisms are essential for maintaining membrane integrity and thus for cell life. Here we show that the Ca 2+ - and…”
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Weibel Palade Bodies: Unique Secretory Organelles of Endothelial Cells that Control Blood Vessel Homeostasis by Naß, Johannes, Terglane, Julian, Gerke, Volker

“…Vascular endothelial cells produce and release compounds regulating vascular tone, blood vessel growth and differentiation, plasma composition, coagulation and…”
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Spire1 and Myosin Vc promote Ca2+-evoked externalization of von Willebrand factor in endothelial cells by Holthenrich, Anna, Terglane, Julian, Naß, Johannes, Mietkowska, Magdalena, Kerkhoff, Eugen, Gerke, Volker

“…Weibel–Palade bodies (WPB) are endothelial cell-specific storage granules that regulate vascular hemostasis by releasing the platelet adhesion receptor von…”
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Annexins: From Structure to Function by Gerke, Volker, Moss, Stephen E

“…Institute for Medical Biochemistry, Center for Molecular Biology of Inflammation, University of Münster, Münster, Germany; and Department of Cell Biology,…”
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JAM-A interacts with α3β1 integrin and tetraspanins CD151 and CD9 to regulate collective cell migration of polarized epithelial cells by Thölmann, Sonja, Seebach, Jochen, Otani, Tetsuhisa, Florin, Luise, Schnittler, Hans, Gerke, Volker, Furuse, Mikio, Ebnet, Klaus

“…Junctional adhesion molecule (JAM)-A is a cell adhesion receptor localized at epithelial cell–cell contacts with enrichment at the tight junctions. Its role…”
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PTEN-Mediated Apical Segregation of Phosphoinositides Controls Epithelial Morphogenesis through Cdc42 by Martin-Belmonte, Fernando, Gassama, Ama, Datta, Anirban, Yu, Wei, Rescher, Ursula, Gerke, Volker, Mostov, Keith

“…Formation of the apical surface and lumen is a fundamental, yet poorly understood, step in epithelial organ development. We show that PTEN localizes to the…”
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Rho and Rab Family Small GTPases in the Regulation of Membrane Polarity in Epithelial Cells by Ebnet, Klaus, Gerke, Volker

“…Membrane polarity, defined as the asymmetric distribution of lipids and proteins in the plasma membrane, is a critical prerequisite for the development of…”
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cAMP-induced secretion of endothelial von Willebrand factor is regulated by a phosphorylation/dephosphorylation switch in annexin A2 by Brandherm, Ines, Disse, Jennifer, Zeuschner, Dagmar, Gerke, Volker

“…The large multimeric glyocoprotein von Willebrand factor (VWF) is a crucial component of both primary and secondary hemostasis. It is stored in secretory…”
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Reversible Stabilization of Vesicles: Redox‐Responsive Polymer Nanocontainers for Intracellular Delivery by de Vries, Wilke C., Grill, David, Tesch, Matthias, Ricker, Andrea, Nüsse, Harald, Klingauf, Jürgen, Studer, Armido, Gerke, Volker, Ravoo, Bart Jan

“…We present the self‐assembly of redox‐responsive polymer nanocontainers comprising a cyclodextrin vesicle core and a thin reductively cleavable polymer shell…”
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Annexins—a family of proteins with distinctive tastes for cell signaling and membrane dynamics by Gerke, Volker, Gavins, Felicity N. E., Geisow, Michael, Grewal, Thomas, Jaiswal, Jyoti K., Nylandsted, Jesper, Rescher, Ursula

“…Annexins are cytosolic proteins with conserved three-dimensional structures that bind acidic phospholipids in cellular membranes at elevated Ca 2+ levels…”
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TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation by Fitzian, Katharina, Brückner, Anne, Brohée, Laura, Zech, Reinhard, Antoni, Claudia, Kiontke, Stephan, Gasper, Raphael, Linard Matos, Anna Livia, Beel, Stephanie, Wilhelm, Sabine, Gerke, Volker, Ungermann, Christian, Nellist, Mark, Raunser, Stefan, Demetriades, Constantinos, Oeckinghaus, Andrea, Kümmel, Daniel

“…The TSC complex is a critical negative regulator of the small GTPase Rheb and mTORC1 in cellular stress signaling. The TSC2 subunit contains a catalytic GTPase…”
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Late Endosomal/Lysosomal Cholesterol Accumulation Is a Host Cell-Protective Mechanism Inhibiting Endosomal Escape of Influenza A Virus by Kühnl, Alexander, Musiol, Agnes, Heitzig, Nicole, Johnson, Danielle E, Ehrhardt, Christina, Grewal, Thomas, Gerke, Volker, Ludwig, Stephan, Rescher, Ursula

“…To transfer the viral genome into the host cell cytoplasm, internalized influenza A virus (IAV) particles depend on the fusion of the IAV envelope with host…”
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Evoked Weibel‐Palade Body Exocytosis Modifies the Endothelial Cell Surface by Releasing a Substrate‐Selective Phosphodiesterase by Naß, Johannes, Terglane, Julian, Zeuschner, Dagmar, Gerke, Volker

“…Weibel Palade bodies (WPB) are lysosome‐related secretory organelles of endothelial cells. Commonly known for their main cargo, the platelet and leukocyte…”
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Requirement for Annexin A1 in Plasma Membrane Repair by McNeil, Anna K., Rescher, Ursula, Gerke, Volker, McNeil, Paul L.

“…Ca2+ entering a cell through a torn or disrupted plasma membrane rapidly triggers a combination of homotypic and exocytotic membrane fusion events. These…”
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JAM-A regulates cortical dynein localization through Cdc42 to control planar spindle orientation during mitosis by Tuncay, Hüseyin, Brinkmann, Benjamin F., Steinbacher, Tim, Schürmann, Annika, Gerke, Volker, Iden, Sandra, Ebnet, Klaus

“…Planar spindle orientation in polarized epithelial cells depends on the precise localization of the dynein–dynactin motor protein complex at the lateral…”
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Mislocalized Activation of Oncogenic RTKs Switches Downstream Signaling Outcomes by Choudhary, Chunaram, Olsen, Jesper V., Brandts, Christian, Cox, Jürgen, Reddy, Pavankumar N.G., Böhmer, Frank D., Gerke, Volker, Schmidt-Arras, Dirk-E., Berdel, Wolfgang E., Müller-Tidow, Carsten, Mann, Matthias, Serve, Hubert

“…Inappropriate activation of oncogenic kinases at intracellular locations is frequently observed in human cancers, but its effects on global signaling are…”
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