Search Results - "GERGELY, J"
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A rooted phylogeny resolves early bacterial evolution
Published in Science (American Association for the Advancement of Science) (07-05-2021)“…A rooted bacterial tree is necessary to understand early evolution, but the position of the root is contested. Here, we model the evolution of 11,272 gene…”
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Efficient Exploration of the Space of Reconciled Gene Trees
Published in Systematic biology (01-11-2013)“…Gene trees record the combination of gene-level events, such as duplication, transfer and loss (DTL), and specieslevel events, such as speciation and…”
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The Inference of Gene Trees with Species Trees
Published in Systematic biology (01-01-2015)“…Abstract This article reviews the various models that have been used to describe the relationships between gene trees and species trees. Molecular phylogeny…”
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Integrative modeling of gene and genome evolution roots the archaeal tree of life
Published in Proceedings of the National Academy of Sciences - PNAS (06-06-2017)“…A root for the archaeal tree is essential for reconstructing the metabolism and ecology of early cells and for testing hypotheses that propose that the…”
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ecceTERA: comprehensive gene tree-species tree reconciliation using parsimony
Published in Bioinformatics (01-07-2016)“…: A gene tree-species tree reconciliation explains the evolution of a gene tree within the species tree given a model of gene-family evolution. We describe…”
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Hierarchical tissue organization as a general mechanism to limit the accumulation of somatic mutations
Published in Nature communications (23-02-2017)“…How can tissues generate large numbers of cells, yet keep the divisional load (the number of divisions along cell lineages) low in order to curtail the…”
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Phylogenetic modeling of lateral gene transfer reconstructs the pattern and relative timing of speciations
Published in Proceedings of the National Academy of Sciences - PNAS (23-10-2012)“…The timing of the evolution of microbial life has largely remained elusive due to the scarcity of prokaryotic fossil record and the confounding effects of the…”
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Damage and fluctuations induce loops in optimal transport networks
Published in Physical review letters (29-01-2010)“…Leaf venation is a pervasive example of a complex biological network, endowing leaves with a transport system and mechanical resilience. Transport networks…”
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Quantifying GC-Biased Gene Conversion in Great Ape Genomes Using Polymorphism-Aware Models
Published in Genetics (Austin) (01-08-2019)“…As multi-individual population-scale data become available, more complex modeling strategies are needed to quantify genome-wide patterns of nucleotide usage…”
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GeneRax: A Tool for Species-Tree-Aware Maximum Likelihood-Based Gene Family Tree Inference under Gene Duplication, Transfer, and Loss
Published in Molecular biology and evolution (01-09-2020)“…Abstract Inferring phylogenetic trees for individual homologous gene families is difficult because alignments are often too short, and thus contain…”
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Genome-scale coestimation of species and gene trees
Published in Genome research (01-02-2013)“…Comparisons of gene trees and species trees are key to understanding major processes of genome evolution such as gene duplication and loss. Because current…”
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SpeciesRax: A Tool for Maximum Likelihood Species Tree Inference from Gene Family Trees under Duplication, Transfer, and Loss
Published in Molecular biology and evolution (03-02-2022)“…Abstract Species tree inference from gene family trees is becoming increasingly popular because it can account for discordance between the species tree and the…”
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Emergent neutrality in adaptive asexual evolution
Published in Genetics (Austin) (01-12-2011)“…In nonrecombining genomes, genetic linkage can be an important evolutionary force. Linkage generates interference interactions, by which simultaneously…”
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How Long Does Wolbachia Remain on Board?
Published in Molecular biology and evolution (01-05-2017)“…Wolbachia bacteria infect about half of all arthropods, with diverse and extreme consequences ranging from sex-ratio distortion and mating incompatibilities to…”
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Divergent genomic trajectories predate the origin of animals and fungi
Published in Nature (London) (22-09-2022)“…Animals and fungi have radically distinct morphologies, yet both evolved within the same eukaryotic supergroup: Opisthokonta 1 , 2 . Here we reconstructed the…”
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Joint amalgamation of most parsimonious reconciled gene trees
Published in Bioinformatics (15-03-2015)“…Traditionally, gene phylogenies have been reconstructed solely on the basis of molecular sequences; this, however, often does not provide enough information to…”
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Lateral Gene Transfer from the Dead
Published in Systematic biology (01-05-2013)“…In phylogenetic studies, the evolution of molecular sequences is assumed to have taken place along the phylogeny traced by the ancestors of extant species. In…”
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AleRax: a tool for gene and species tree co-estimation and reconciliation under a probabilistic model of gene duplication, transfer, and loss
Published in Bioinformatics (Oxford, England) (29-03-2024)“…Abstract Motivation Genomes are a rich source of information on the pattern and process of evolution across biological scales. How best to make use of that…”
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Horizontal Gene Transfer and the History of Life
Published in Cold Spring Harbor perspectives in biology (01-04-2016)“…Microbes acquire DNA from a variety of sources. The last decades, which have seen the development of genome sequencing, have revealed that horizontal gene…”
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Trade-off between reducing mutational accumulation and increasing commitment to differentiation determines tissue organization
Published in Nature communications (29-03-2022)“…Species-specific differences control cancer risk across orders of magnitude variation in body size and lifespan, e.g., by varying the copy numbers of tumor…”
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