Search Results - "GERDES, Norbert"

Mini-Review: Immunogenic epitopes in apolipoprotein B-100 for atheroprotective immunization by Gerdes, Norbert, Klingenberg, Roland

“…Here, we provide a concise overview of recent developments in the identification of immunogenic epitopes in human apolipoprotein B-100 for immunization against…”
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Single-cell transcriptomics defines heterogeneity of epicardial cells and fibroblasts within the infarcted murine heart by Hesse, Julia, Owenier, Christoph, Lautwein, Tobias, Zalfen, Ria, Weber, Jonas F, Ding, Zhaoping, Alter, Christina, Lang, Alexander, Grandoch, Maria, Gerdes, Norbert, Fischer, Jens W, Klau, Gunnar W, Dieterich, Christoph, Köhrer, Karl, Schrader, Jürgen

“…In the adult heart, the epicardium becomes activated after injury, contributing to cardiac healing by secretion of paracrine factors. Here, we analyzed by…”
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Rivaroxaban Reduces Arterial Thrombosis by Inhibition of FXa-Driven Platelet Activation via Protease Activated Receptor-1 by Petzold, Tobias, Thienel, Manuela, Dannenberg, Lisa, Mourikis, Philipp, Helten, Carolin, Ayhan, Aysel, M’Pembele, René, Achilles, Alina, Trojovky, Kajetan, Konsek, Daniel, Zhang, Zhe, Regenauer, Ron, Pircher, Joachim, Ehrlich, Andreas, Lüsebrink, Enzo, Nicolai, Leo, Stocker, Thomas J., Brandl, Richard, Röschenthaler, Franz, Strecker, Jan, Saleh, Inas, Spannagl, Michael, Mayr, Christoph H., Schiller, Herbert B., Jung, Christian, Gerdes, Norbert, Hoffmann, Till, Levkau, Bodo, Hohlfeld, Thomas, Zeus, Tobias, Schulz, Christian, Kelm, Malte, Polzin, Amin

“…A reduced rate of myocardial infarction has been reported in patients with atrial fibrillation treated with FXa (factor Xa) inhibitors including rivaroxaban…”
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Artery Tertiary Lymphoid Organs Contribute to Innate and Adaptive Immune Responses in Advanced Mouse Atherosclerosis by Mohanta, Sarajo Kumar, Yin, Changjun, Peng, Li, Srikakulapu, Prasad, Bontha, Vineela, Hu, Desheng, Weih, Falk, Weber, Christian, Gerdes, Norbert, Habenicht, Andreas J.R

“…Tertiary lymphoid organs emerge in tissues in response to nonresolving inflammation. Recent research characterized artery tertiary lymphoid organs in the aorta…”
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Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease by Lacy, Michael, Bürger, Christina, Shami, Annelie, Ahmadsei, Maiwand, Winkels, Holger, Nitz, Katrin, van Tiel, Claudia M., Seijkens, Tom T. P., Kusters, Pascal J. H., Karshovka, Ela, Prange, Koen H. M., Wu, Yuting, Brouns, Sanne L. N., Unterlugauer, Sigrid, Kuijpers, Marijke J. E., Reiche, Myrthe E., Steffens, Sabine, Edsfeldt, Andreas, Megens, Remco T. A., Heemskerk, Johan W. M., Goncalves, Isabel, Weber, Christian, Gerdes, Norbert, Atzler, Dorothee, Lutgens, Esther

“…Atherosclerosis is a major underlying cause of cardiovascular disease. Previous studies showed that inhibition of the co-stimulatory CD40 ligand (CD40L)-CD40…”
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Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis by Lievens, Dirk, Zernecke, Alma, Seijkens, Tom, Soehnlein, Oliver, Beckers, Linda, Munnix, Imke C.A., Wijnands, Erwin, Goossens, Pieter, van Kruchten, Roger, Thevissen, Larissa, Boon, Louis, Flavell, Richard A., Noelle, Randolph J., Gerdes, Norbert, Biessen, Erik A., Daemen, Mat J.A.P., Heemskerk, Johan W.M., Weber, Christian, Lutgens, Esther

“…CD40 ligand (CD40L), identified as a costimulatory molecule expressed on T cells, is also expressed and functional on platelets. We investigated the thrombotic…”
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Colchicine prevents oxidative stress-induced endothelial cell senescence via blocking NF-κB and MAPKs: implications in vascular diseases by Zhou, Huakang, Khan, Dilaware, Hussain, Sajid Muhammad, Gerdes, Norbert, Hagenbeck, Carsten, Rana, Majeed, Cornelius, Jan Frederick, Muhammad, Sajjad

“…BackgroundSmoking, alcohol abuse, and hypertension are – among others, potential risk factors for cardiovascular diseases. These risk factors generate…”
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Full-length transcriptomic analysis in murine and human heart reveals diversity of PGC-1α promoters and isoforms regulated distinctly in myocardial ischemia and obesity by Oehler, Daniel, Spychala, André, Gödecke, Axel, Lang, Alexander, Gerdes, Norbert, Ruas, Jorge, Kelm, Malte, Szendroedi, Julia, Westenfeld, Ralf

“…Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) acts as a transcriptional coactivator and regulates mitochondrial function…”
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Modulation of mTOR Signaling in Cardiovascular Disease to Target Acute and Chronic Inflammation by Kaldirim, Madlen, Lang, Alexander, Pfeiler, Susanne, Fiegenbaum, Pia, Kelm, Malte, Bönner, Florian, Gerdes, Norbert

“…Inflammation is a key component in the pathogenesis of cardiovascular diseases causing a significant burden of morbidity and mortality worldwide. Recent…”
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Quantitative assessment of angioplasty-induced vascular inflammation with 19F cardiovascular magnetic resonance imaging by Nienhaus, Fabian, Walz, Moritz, Rothe, Maik, Jahn, Annika, Pfeiler, Susanne, Busch, Lucas, Stern, Manuel, Heiss, Christian, Vornholz, Lilian, Cames, Sandra, Cramer, Mareike, Schrauwen-Hinderling, Vera, Gerdes, Norbert, Temme, Sebastian, Roden, Michael, Flögel, Ulrich, Kelm, Malte, Bönner, Florian

“…Macrophages play a pivotal role in vascular inflammation and predict cardiovascular complications. Fluorine-19 magnetic resonance imaging (19F MRI) with…”
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Design of a Robust Flow Cytometric Approach for Phenotypical and Functional Analysis of Human Monocyte Subsets in Health and Disease by Ahrazoglu, Talia, Kluczny, Jennifer Isabel, Kleimann, Patricia, Irschfeld, Lisa-Marie, Nienhaus, Fabian Theodor, Bönner, Florian, Gerdes, Norbert, Temme, Sebastian

“…Human monocytes can be subdivided into phenotypically and functionally different classical, intermediate and non-classical monocytes according to the cell…”
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Acute Heart Failure After Reperfused Ischemic Stroke: Association With Systemic and Cardiac Inflammatory Responses by Vornholz, Lilian, Nienhaus, Fabian, Gliem, Michael, Alter, Christina, Henning, Carina, Lang, Alexander, Ezzahoini, Hakima, Wolff, Georg, Clasen, Lukas, Rassaf, Tienush, Flögel, Ulrich, Kelm, Malte, Gerdes, Norbert, Jander, Sebastian, Bönner, Florian

“…Patients with acute ischemic stroke (AIS) present an increased incidence of systemic inflammatory response syndrome and release of Troponin T coinciding with…”
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Colchicine Protects against Ethanol-Induced Senescence and Senescence-Associated Secretory Phenotype in Endothelial Cells by Zhou, Huakang, Khan, Dilaware, Gerdes, Norbert, Hagenbeck, Carsten, Rana, Majeed, Cornelius, Jan Frederick, Muhammad, Sajjad

“…Inflammaging is a potential risk factor for cardiovascular diseases. It results in the development of thrombosis and atherosclerosis. The accumulation of…”
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Mif‐deficiency favors an atheroprotective autoantibody phenotype in atherosclerosis by Schmitz, Corinna, Noels, Heidi, Bounkari, Omar El, Straussfeld, Eva, Megens, Remco T. A., Sternkopf, Marieke, Alampour‐Rajabi, Setareh, Krammer, Christine, Tilstam, Pathricia V., Gerdes, Norbert, Bürger, Christina, Kapurniotu, Aphrodite, Bucala, Richard, Jankowski, Joachim, Weber, Christian, Bernhagen, Jürgen

“…The inflammatory cytokine macrophage migration‐inhibitory factor (MIF) promotes atherosclerosis via lesional monocyte and T‐cell recruitment. B cells have…”
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CD40L Deficiency Ameliorates Adipose Tissue Inflammation and Metabolic Manifestations of Obesity in Mice by Poggi, Marjorie, Engel, David, Christ, Anette, Beckers, Linda, Wijnands, Erwin, Boon, Louis, Driessen, Ann, Cleutjens, Jack, Weber, Christian, Gerdes, Norbert, Lutgens, Esther

“…OBJECTIVE—Obese adipose tissue shows hallmarks of chronic inflammation, which promotes the development of metabolic disorders. The mechanisms by which immune…”
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Editorial: Immune and autoimmune mechanisms in cardiovascular disease by Winkels, Holger, Gerdes, Norbert, Kahles, Florian, Dutta, Partha, Giannarelli, Chiara, Wolf, Dennis

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Phagocytosis of a PFOB-Nanoemulsion for 19F Magnetic Resonance Imaging: First Results in Monocytes of Patients with Stable Coronary Artery Disease and ST-Elevation Myocardial Infarction by Nienhaus, Fabian, Colley, Denise, Jahn, Annika, Pfeiler, Susanne, Flocke, Vera, Temme, Sebastian, Kelm, Malte, Gerdes, Norbert, Flögel, Ulrich, Bönner, Florian

“…Fluorine-19 magnetic resonance imaging (19F MRI) with intravenously applied perfluorooctyl bromide-nanoemulsions (PFOB-NE) has proven its feasibility to…”
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Mast cells control the expansion and differentiation of IL-10-competent B cells by Mion, Francesca, D'Incà, Federica, Danelli, Luca, Toffoletto, Barbara, Guarnotta, Carla, Frossi, Barbara, Burocchi, Alessia, Rigoni, Alice, Gerdes, Norbert, Lutgens, Esther, Tripodo, Claudio, Colombo, Mario P, Rivera, Juan, Vitale, Gaetano, Pucillo, Carlo E

“…The discovery of B cell subsets with regulatory properties, dependent on IL-10 production, has expanded our view on the mechanisms that control inflammation…”
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Novel Fluorescence-Based Methods to Determine Infarct and Scar Size in Murine Models of Reperfused Myocardial Infarction by Duplessis, Ashley, Elster, Christin, Becher, Stefanie, Engel, Christina, Lang, Alexander, Kaldirim, Madlen, Jung, Christian, Grandoch, Maria, Kelm, Malte, Pfeiler, Susanne, Gerdes, Norbert

“…Determination of infarct and scar size following myocardial infarction (MI) is commonly used to evaluate the efficacy of potential cardioprotective treatments…”
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Macrophage CD40 plays a minor role in obesity-induced metabolic dysfunction by Aarts, Suzanne A B M, Reiche, Myrthe E, den Toom, Myrthe, Beckers, Linda, Gijbels, Marion J J, Gerdes, Norbert, de Winther, Menno P J, Lutgens, Esther

“…Obesity is a low-grade inflammatory disease that increases the risk for metabolic disorders. CD40-CD40L signaling plays a central role in obesity-induced…”
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