Search Results - "GERBERICK, G. Frank"

AllerCatPro-prediction of protein allergenicity potential from the protein sequence by Maurer-Stroh, Sebastian, Krutz, Nora L, Kern, Petra S, Gunalan, Vithiagaran, Nguyen, Minh N, Limviphuvadh, Vachiranee, Eisenhaber, Frank, Gerberick, G Frank

“…Due to the risk of inducing an immediate Type I (IgE-mediated) allergic response, proteins intended for use in consumer products must be investigated for their…”
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AllerCatPro 2.0: a web server for predicting protein allergenicity potential by Nguyen, Minh N, Krutz, Nora L, Limviphuvadh, Vachiranee, Lopata, Andreas L, Gerberick, G Frank, Maurer-Stroh, Sebastian

“…Abstract Proteins in food and personal care products can pose a risk for an immediate immunoglobulin E (IgE)-mediated allergic response. Bioinformatic tools…”
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Skin Sensitization to p-Phenylenediamine: The Diverging Roles of Oxidation and N-Acetylation for Dendritic Cell Activation and the Immune Response by Aeby, Pierre, Sieber, Thomas, Beck, Heinz, Frank Gerberick, G., Goebel, Carsten

“…Skin is a target of allergic reactions to aromatic amine hair dye precursors, such as p-phenylenediamine (PPD). As conversion of PPD on or in the skin is…”
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Dendritic Cell IL-1α and IL-1β Are Polyubiquitinated and Degraded by the Proteasome by Ainscough, Joseph S., Frank Gerberick, G., Zahedi-Nejad, Maryam, Lopez-Castejon, Gloria, Brough, David, Kimber, Ian, Dearman, Rebecca J.

“…IL-1α and β are key players in the innate immune system. The secretion of these cytokines by dendritic cells (DC) is integral to the development of…”
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Refinement of the Peroxidase Peptide Reactivity Assay and Prediction Model for Assessing Skin Sensitization Potential by Ryan, Cindy A, Troutman, John A, Kern, Petra S, Quijano, Mike, Dobson, Roy L M, Jian Dai, Hong, Burt, Thomas M, Gerberick, G Frank

“…A peptide reactivity assay with an activation component was developed for use in screening chemicals for skin sensitization potential. A horseradish…”
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The direct peptide reactivity assay: selectivity of chemical respiratory allergens by Lalko, Jon F, Kimber, Ian, Gerberick, G Frank, Foertsch, Leslie M, Api, Anne Marie, Dearman, Rebecca J

“…It is well known that some chemicals are capable of causing allergic diseases of the skin and respiratory tract. Commonly, though not exclusively, chemical…”
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Local lymph node assay (LLNA) for detection of sensitization capacity of chemicals by Frank Gerberick, G., Ryan, Cindy A., Dearman, Rebecca J., Kimber, Ian

“…The local lymph node assay (LLNA) is a murine model developed to evaluate the skin sensitization potential of chemicals. The LLNA is an alternative approach to…”
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Identification and semi-quantification of protein allergens in complex mixtures using proteomic and AllerCatPro 2.0 bioinformatic analyses: a proof-of-concept investigation by Krutz, Nora L, Kimber, Ian, Winget, Jason, Nguyen, Minh N, Limviphuvadh, Vachiranee, Maurer-Stroh, Sebastian, Mahony, Catherine, Gerberick, G Frank

“…The demand for botanicals and natural substances in consumer products has increased in recent years. These substances usually contain proteins and these, in…”
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Local lymph node data for the evaluation of skin sensitization alternatives: a second compilation by Kern, Petra S, Gerberick, G Frank, Ryan, Cindy A, Kimber, Ian, Aptula, Aynur, Basketter, David A

“…Development, evaluation and validation of alternatives to skin sensitisation testing require the availability of reliable databases with which comparative…”
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The microbial gbu gene cluster links cardiovascular disease risk associated with red meat consumption to microbiota l-carnitine catabolism by Buffa, Jennifer A., Romano, Kymberleigh A., Copeland, Matthew F., Cody, David B., Zhu, Weifei, Galvez, Rachel, Fu, Xiaoming, Ward, Kathryn, Ferrell, Marc, Dai, Hong J., Skye, Sarah, Hu, Ping, Li, Lin, Parlov, Mirjana, McMillan, Amy, Wei, Xingtao, Nemet, Ina, Koeth, Robert A., Li, Xinmin S., Wang, Zeneng, Sangwan, Naseer, Hajjar, Adeline M., Dwidar, Mohammed, Weeks, Taylor L., Bergeron, Nathalie, Krauss, Ronald M., Tang, W. H. Wilson, Rey, Federico E., DiDonato, Joseph A., Gogonea, Valentin, Gerberick, G. Frank, Garcia-Garcia, Jose Carlos, Hazen, Stanley L.

“…The heightened cardiovascular disease (CVD) risk observed among omnivores is thought to be linked, in part, to gut microbiota-dependent generation of…”
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Integrating non-animal test information into an adaptive testing strategy - skin sensitization proof of concept case by Jaworska, Joanna, Harol, Artsiom, Kern, Petra S, Gerberick, G Frank

“…There is an urgent need to develop data integration and testing strategy frameworks allowing interpretation of results from animal alternative test batteries…”
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Investigation of Peptide Reactivity of Pro-hapten Skin Sensitizers Using a Peroxidase-Peroxide Oxidation System by Gerberick, G. Frank, Troutman, John A., Foertsch, Leslie M., Vassallo, Jeffrey D., Quijano, Mike, Dobson, Roy L. M., Goebel, Carsten, Lepoittevin, Jean-Pierre

“…Skin protein reactivity is a well established key step in the development of skin sensitization. Understanding the relationship between a chemical's ability to…”
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Application of AllerCatPro 2.0 for protein safety assessments of consumer products by Krutz, Nora L, Kimber, Ian, Winget, Jason, Nguyen, Minh N, Limviphuvadh, Vachiranee, Maurer-Stroh, Sebastian, Mahony, Catherine, Gerberick, G Frank

“…Foreign proteins are potentially immunogenic, and a proportion of these are able to induce immune responses that result in allergic sensitization. Subsequent…”
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Danger, intracellular signaling, and the orchestration of dendritic cell function in skin sensitization by Ainscough, Joseph S, Frank Gerberick, G, Dearman, Rebecca J, Kimber, Ian

“…Allergic contact dermatitis is an important occupational and environmental disease caused by topical exposure to chemical allergens. An area of considerable…”
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Hapten-protein binding: from theory to practical application in the in vitro prediction of skin sensitization by Divkovic, Maja, Pease, Camilla K., Gerberick, G. Frank, Basketter, David A.

“…In view of the forthcoming European Union ban on in vivo testing of cosmetic and toiletry ingredients, following the publication of the 7th amendment to the…”
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Consumer allergy to oxidative hair coloring products: epidemiologic data in the literature by Krasteva, Maya, Bons, Brigitte, Ryan, Cindy, Gerberick, G Frank

“…Oxidative hair dyes have repeatedly come to the attention of the dermatologic community owing to concerns about contact dermatitis. A review of the scientific…”
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Chemical reactivity measurements: Potential for characterization of respiratory chemical allergens by Lalko, Jon F., Kimber, Ian, Dearman, Rebecca J., Gerberick, G. Frank, Sarlo, Katherine, Api, Anne Marie

“…Allergic diseases of the skin and respiratory tract resulting from exposure to low molecular weight chemicals remain important issues for consumer product…”
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A review of critical factors in the conduct and interpretation of the human repeat insult patch test by McNamee, Pauline M., Api, Anne Marie, Basketter, David A., Frank Gerberick, G., Gilpin, Deborah A., Hall, Barbara M., Jowsey, Ian, Robinson, Michael K.

“…This paper reviews key factors that are critical to the conduct and interpretation of Human Repeat Insult Patch Tests (HRIPTs). A methodology for HRIP testing…”
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Dose metrics in the acquisition of skin sensitization: Thresholds and importance of dose per unit area by Kimber, Ian, Dearman, Rebecca J., Basketter, David A., Ryan, Cindy A., Gerberick, G. Frank, McNamee, Pauline M., Lalko, Jon, Api, Anne Marie

“…Allergic contact dermatitis is a common occupational and environmental health problem and many hundreds of chemicals have been implicated as skin sensitizers…”
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Relationship of CD86 surface marker expression and cytotoxicity on dendritic cells exposed to chemical allergen by Hulette, Ben C., Ryan, Cindy A., Gildea, Lucy A., Gerberick, G. Frank

“…Human peripheral blood-derived dendritic cells (DC) respond to a variety of chemical allergens by up-regulating expression of the co-stimulatory molecule CD86…”
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