Search Results - "GERARD, Robert D"

Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ by Wei, Wei, Dutchak, Paul A, Wang, Xunde, Ding, Xunshan, Wang, Xueqian, Bookout, Angie L, Goetz, Regina, Mohammadi, Moosa, Gerard, Robert D, Dechow, Paul C, Mangelsdorf, David J, Kliewer, Steven A, Wan, Yihong

“…The endocrine hormone fibroblast growth factor 21 (FGF21) is a powerful modulator of glucose and lipid metabolism and a promising drug for type 2 diabetes…”
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Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy in mice by Battiprolu, Pavan K, Hojayev, Berdymammet, Jiang, Nan, Wang, Zhao V, Luo, Xiang, Iglewski, Myriam, Shelton, John M, Gerard, Robert D, Rothermel, Beverly A, Gillette, Thomas G, Lavandero, Sergio, Hill, Joseph A

“…The leading cause of death in diabetic patients is cardiovascular disease; diabetic cardiomyopathy is typified by alterations in cardiac morphology and…”
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A Signature Pattern of Stress-Responsive MicroRNAs That Can Evoke Cardiac Hypertrophy and Heart Failure by van Rooij, Eva, Sutherland, Lillian B., Liu, Ning, Williams, Andrew H., McAnally, John, Gerard, Robert D., Richardson, James A., Olson, Eric N.

“…Diverse fors of injury and stress evoke a hypertrophic growth response in adult cardiac myocytes, which is characterized by an increase in cell size, enhanced…”
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miR-200 family and targets, ZEB1 and ZEB2, modulate uterine quiescence and contractility during pregnancy and labor by Renthal, Nora E., Chen, Chien-Cheng, Williams, Koriand'r C., Gerard, Robert D., Prange-Kiel, Janine, Mendelson, Carole R., O'Malley, Bert W.

“…Throughout most of pregnancy, uterine quiescence is maintained by increased progesterone receptor (PR) transcriptional activity, whereas spontaneous labor is…”
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FGF15/19 Regulates Hepatic Glucose Metabolism by Inhibiting the CREB-PGC-1α Pathway by Potthoff, Matthew J., Boney-Montoya, Jamie, Choi, Mihwa, He, Tianteng, Sunny, Nishanth E., Satapati, Santhosh, Suino-Powell, Kelly, Xu, H. Eric, Gerard, Robert D., Finck, Brian N., Burgess, Shawn C., Mangelsdorf, David J., Kliewer, Steven A.

“…Regulation of hepatic carbohydrate homeostasis is crucial for maintaining energy balance in the face of fluctuating nutrient availability. Here, we show that…”
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Myocardin-Related Transcription Factor-A Controls Myofibroblast Activation and Fibrosis in Response to Myocardial Infarction by Small, Eric M, Thatcher, Jeffrey E, Sutherland, Lillian B, Kinoshita, Hideyuki, Gerard, Robert D, Richardson, James A, DiMaio, J. Michael, Sadek, Hesham, Kuwahara, Koichiro, Olson, Eric N

“…RATIONALE:Myocardial infarction (MI) results in loss of cardiac myocytes in the ischemic zone of the heart, followed by fibrosis and scar formation, which…”
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Regulation of PI3-kinase/Akt signaling by muscle-enriched microRNA-486 by Small, Eric M, O'Rourke, Jason R, Moresi, Viviana, Sutherland, Lillian B, McAnally, John, Gerard, Robert D, Richardson, James A, Olson, Eric N

“…microRNAs (miRNAs) play key roles in modulating a variety of cellular processes through repression of mRNA targets. In a screen for miRNAs regulated by…”
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The acetate/ACSS2 switch regulates HIF-2 stress signaling in the tumor cell microenvironment by Chen, Rui, Xu, Min, Nagati, Jason S, Hogg, Richard T, Das, Alok, Gerard, Robert D, Garcia, Joseph A

“…Optimal stress signaling by Hypoxia Inducible Factor 2 (HIF-2) during low oxygen states or hypoxia requires coupled actions of a specific coactivator/lysine…”
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C/EBP Transcription Factors Mediate Epicardial Activation During Heart Development and Injury by Huang, Guo N., Thatcher, Jeffrey E., McAnally, John, Kong, Yongli, Qi, Xiaoxia, Tan, Wei, DiMaio, J. Michael, Amatruda, James F., Gerard, Robert D., Hill, Joseph A., Bassel-Duby, Rhonda, Olson, Eric N.

“…The epicardium encapsulates the heart and functions as a source of multipotent progenitor cells and paracrine factors essential for cardiac development and…”
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The microRNA (miR)-199a/214 Cluster Mediates Opposing Effects of Progesterone and Estrogen on Uterine Contractility during Pregnancy and Labor by Williams, Koriand'r C, Renthal, Nora E, Gerard, Robert D, Mendelson, Carole R

“…Progesterone (P4) and estradiol-17β (E2) play critical and opposing roles in regulating myometrial quiescence and contractility during pregnancy and labor…”
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MicroRNA-200a serves a key role in the decline of progesterone receptor function leading to term and preterm labor by Williams, Koriand’r C, Renthal, Nora E, Condon, Jennifer C, Gerard, Robert D, Mendelson, Carole R

“…During pregnancy, uterine quiescence is maintained by increased progesterone receptor (PR) activity, but labor is facilitated by a series of events that impair…”
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Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis by Inagaki, Takeshi, Choi, Mihwa, Moschetta, Antonio, Peng, Li, Cummins, Carolyn L., McDonald, Jeffrey G., Luo, Guizhen, Jones, Stacey A., Goodwin, Bryan, Richardson, James A., Gerard, Robert D., Repa, Joyce J., Mangelsdorf, David J., Kliewer, Steven A.

“…The liver and intestine play crucial roles in maintaining bile acid homeostasis. Here, we demonstrate that fibroblast growth factor 15 (FGF15) signals from…”
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Autophagy is an adaptive response in desmin-related cardiomyopathy by Tannous, Paul, Zhu, Hongxin, Johnstone, Janet L, Shelton, John M, Rajasekaran, Namakkal S, Benjamin, Ivor J, Nguyen, Lan, Gerard, Robert D, Levine, Beth, Rothermel, Beverly A, Hill, Joseph A

“…A missense mutation in the αB-crystallin (CryAB) gene triggers a severe form of desmin-related cardiomyopathy (DRCM) characterized by accumulation of misfolded…”
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FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases by Ni, Yan G, Wang, Na, Cao, Dian J, Sachan, Nita, Morris, David J, Gerard, Robert D, Kuro-o, Makoto, Rothermel, Beverly A, Hill, Joseph A

“…Insulin resistance and metabolic syndrome are rapidly expanding public health problems. Acting through the PI3K/Akt pathway, insulin and insulin-like growth…”
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Genetic variants of ApoE and ApoER2 differentially modulate endothelial function by Ulrich, Victoria, Konaniah, Eddy S., Herz, Joachim, Gerard, Robert D., Jung, Eunjeong, Yuhanna, Ivan S., Ahmed, Mohamed, Hui, David Y., Mineo, Chieko, Shaul, Philip W.

“…Significance Why genetic variants of the circulating protein apolipoprotein E (apoE) or its receptor apoliprotein E receptor 2 (ApoER2) confer greater…”
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Constitutive Phosphorylation of Cardiac Myosin Regulatory Light Chain in Vivo by Chang, Audrey N., Battiprolu, Pavan K., Cowley, Patrick M., Chen, Guohua, Gerard, Robert D., Pinto, Jose R., Hill, Joseph A., Baker, Anthony J., Kamm, Kristine E., Stull, James T.

“…In beating hearts, phosphorylation of myosin regulatory light chain (RLC) at a single site to 0.45 mol of phosphate/mol by cardiac myosin light chain kinase…”
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An acetate switch regulates stress erythropoiesis by Xu, Min, Nagati, Jason S, Xie, Jian, Li, Jiwen, Walters, Holly, Moon, Young-Ah, Gerard, Robert D, Huang, Chou-Long, Comerford, Sarah A, Hammer, Robert E, Horton, Jay D, Chen, Rui, Garcia, Joseph A

“…Manipulation of acetate levels in mice can affect the activity of the hypoxia-responsive transcription factor HIF-2α and facilitate recovery from anemia. The…”
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Foxo transcription factors blunt cardiac hypertrophy by inhibiting calcineurin signaling by NI, Yan G, BERENJI, Kambeez, GERARD, Robert D, ROTHERMEL, Beverly A, HILL, Joseph A, NA WANG, OH, Misook, SACHAN, Nita, DEY, Asim, JUN CHENG, GUANGRONG LU, MORRIS, David J, CASTRILLON, Diego H

“…Cellular hypertrophy requires coordinated regulation of progrowth and antigrowth mechanisms. In cultured neonatal cardiomyocytes, Foxo transcription factors…”
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TALEN-mediated somatic mutagenesis in murine models of cancer by Zhang, Shuyuan, Li, Lin, Kendrick, Sara L, Gerard, Robert D, Zhu, Hao

“…Cancer genome sequencing has identified numerous somatic mutations whose biologic relevance is uncertain. In this study, we used genome-editing tools to create…”
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Identification of a hormonal basis for gallbladder filling by Kliewer, Steven A, Choi, Mihwa, Moschetta, Antonio, Bookout, Angie L, Peng, Li, Umetani, Michihisa, Holmstrom, Sam R, Suino-Powell, Kelly, Xu, H Eric, Richardson, James A, Gerard, Robert D, Mangelsdorf, David J

“…The cycle of gallbladder filling and emptying controls the flow of bile into the intestine for digestion. Here we show that fibroblast growth factor-15, a…”
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