Search Results - "GERALD, William L"

Impact of proposed IASLC ATS ERS classification of lung adenocarcinoma: prognostic subgroups and implications for further revision of staging based on analysis of 514 stage I cases by Yoshizawa, Akihiko, Motoi, Noriko, Riely, Gregory J, Sima, Cami S, Gerald, William L, Kris, Mark G, Park, Bernard J, Rusch, Valerie W, Travis, William D

“…A new lung adenocarcinoma classification is being proposed by the International Association for the Study of Lung Cancer, American Thoracic Society and…”
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Integrative Genomic Profiling of Human Prostate Cancer by Taylor, Barry S., Schultz, Nikolaus, Hieronymus, Haley, Gopalan, Anuradha, Xiao, Yonghong, Carver, Brett S., Arora, Vivek K., Kaushik, Poorvi, Cerami, Ethan, Reva, Boris, Antipin, Yevgeniy, Mitsiades, Nicholas, Landers, Thomas, Dolgalev, Igor, Major, John E., Wilson, Manda, Socci, Nicholas D., Lash, Alex E., Heguy, Adriana, Eastham, James A., Scher, Howard I., Reuter, Victor E., Scardino, Peter T., Sander, Chris, Sawyers, Charles L., Gerald, William L.

“…Annotation of prostate cancer genomes provides a foundation for discoveries that can impact disease understanding and treatment. Concordant assessment of DNA…”
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Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas by Gao, Sizhi Paul, Mark, Kevin G, Leslie, Kenneth, Pao, William, Motoi, Noriko, Gerald, William L, Travis, William D, Bornmann, William, Veach, Darren, Clarkson, Bayard, Bromberg, Jacqueline F

“…Persistently activated or tyrosine-phosphorylated STAT3 (pSTAT3) is found in 50% of lung adenocarcinomas. pSTAT3 is found in primary adenocarcinomas and cell…”
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Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse model by Kinkade, Carolyn Waugh, Castillo-Martin, Mireia, Puzio-Kuter, Anna, Yan, Jun, Foster, Thomas H, Gao, Hui, Sun, Yvonne, Ouyang, Xuesong, Gerald, William L, Cordon-Cardo, Carlos, Abate-Shen, Cory

“…The AKT/mammalian target of rapamycin (AKT/mTOR) and ERK MAPK signaling pathways have been shown to cooperate in prostate cancer progression and the transition…”
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Lung Adenocarcinoma : Modification of the 2004 WHO Mixed Subtype to Include the Major Histologic Subtype Suggests Correlations Between Papillary and Micropapillary Adenocarcinoma Subtypes, EGFR Mutations and Gene Expression Analysis by MOTOI, Noriko, SZOKE, Janos, RIELY, Gregory J, SESHAN, Venkatraman E, KRIS, Mark G, RUSCH, Valerie W, GERALD, William L, TRAVIS, William D

“…The histologic heterogeneity of lung adenocarcinoma creates a variety of complex challenges to pathologists in analyzing the various subtypes. Current…”
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Association of survival and disease progression with chromosomal instability: A genomic exploration of colorectal cancer by Sheffer, Michal, Bacolod, Manny D, Zuk, Or, Giardina, Sarah F, Pincas, Hanna, Barany, Francis, Paty, Philip B, Gerald, William L, Notterman, Daniel A, Domany, Eytan

“…During disease progression the cells that comprise solid malignancies undergo significant changes in gene copy number and chromosome structure. Colorectal…”
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Identification of PHLPP1 as a Tumor Suppressor Reveals the Role of Feedback Activation in PTEN-Mutant Prostate Cancer Progression by Chen, Muhan, Pratt, Christopher P., Zeeman, Martha E., Schultz, Nikolaus, Taylor, Barry S., O'Neill, Audrey, Castillo-Martin, Mireia, Nowak, Dawid G., Naguib, Adam, Grace, Danielle M., Murn, Jernej, Navin, Nick, Atwal, Gurinder S., Sander, Chris, Gerald, William L., Cordon-Cardo, Carlos, Newton, Alexandra C., Carver, Brett S., Trotman, Lloyd C.

“…Hyperactivation of the PI 3-kinase/AKT pathway is a driving force of many cancers. Here we identify the AKT-inactivating phosphatase PHLPP1 as a prostate tumor…”
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A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer by Lunardi, Andrea, Ala, Ugo, Epping, Mirjam T, Salmena, Leonardo, Clohessy, John G, Webster, Kaitlyn A, Wang, Guocan, Mazzucchelli, Roberta, Bianconi, Maristella, Stack, Edward C, Lis, Rosina, Patnaik, Akash, Cantley, Lewis C, Bubley, Glenn, Cordon-Cardo, Carlos, Gerald, William L, Montironi, Rodolfo, Signoretti, Sabina, Loda, Massimo, Nardella, Caterina, Pandolfi, Pier Paolo

“…Pier Paolo Pandolfi and colleagues report that compound loss of Pten with Zbtb7a or Trp53 leads to de novo resistance to androgen deprivation therapy in…”
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Zbtb7a suppresses prostate cancer through repression of a Sox9-dependent pathway for cellular senescence bypass and tumor invasion by Wang, Guocan, Lunardi, Andrea, Zhang, Jiangwen, Chen, Zhenbang, Ala, Ugo, Webster, Kaitlyn A, Tay, Yvonne, Gonzalez-Billalabeitia, Enrique, Egia, Ainara, Shaffer, David R, Carver, Brett, Liu, Xue-Song, Taulli, Riccardo, Kuo, Winston Patrick, Nardella, Caterina, Signoretti, Sabina, Cordon-Cardo, Carlos, Gerald, William L, Pandolfi, Pier Paolo

“…The transcription factor Zbtb7a was previously described as an oncogene in non-Hodgkin lymphoma. Now, Pier Paolo Pandolfi and colleagues report that loss of…”
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Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors by Minn, Andy J, Kang, Yibin, Serganova, Inna, Gupta, Gaorav P, Giri, Dilip D, Doubrovin, Mikhail, Ponomarev, Vladimir, Gerald, William L, Blasberg, Ronald, Massagué, Joan

“…We used bioluminescence imaging to reveal patterns of metastasis formation by human breast cancer cells in immunodeficient mice. Individual cells from a…”
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ID genes mediate tumor reinitiation during breast cancer lung metastasis by Gupta, Gaorav P, Perk, Jonathan, Acharyya, Swarnali, de Candia, Paola, Mittal, Vivek, Todorova-Manova, Katia, Gerald, William L, Brogi, Edi, Benezra, Robert, Massagué, Joan

“…The establishment of distant metastases depends on the capacity of small numbers of cancer cells to regenerate a tumor after entering a target tissue. The…”
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A gene expression signature predicts survival of patients with stage I non-small cell lung cancer by Lu, Yan, Lemon, William, Liu, Peng-Yuan, Yi, Yijun, Morrison, Carl, Yang, Ping, Sun, Zhifu, Szoke, Janos, Gerald, William L, Watson, Mark, Govindan, Ramaswamy, You, Ming

“…Lung cancer is the leading cause of cancer-related death in the United States. Nearly 50% of patients with stages I and II non-small cell lung cancer (NSCLC)…”
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Oncogenic cooperation and coamplification of developmental transcription factor genes in lung cancer by Kendall, Jude, Liu, Qing, Bakleh, Amy, Krasnitz, Alex, Nguyen, Ken C.Q, Lakshmi, B, Gerald, William L, Powers, Scott, Mu, David

“…We used high-resolution array analysis to discover a recurrent lung cancer amplicon located at 14q13.3. Low-level gain of this region was detected in 15% of…”
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tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers by Veeriah, Selvaraju, Brennan, Cameron, Meng, Shasha, Singh, Bhuvanesh, Fagin, James A, Solit, David B, Paty, Philip B, Rohle, Dan, Vivanco, Igor, Chmielecki, Juliann, Pao, William, Ladanyi, Marc, Gerald, William L, Liau, Linda, Cloughesy, Timothy C, Mischel, Paul S, Sander, Chris, Taylor, Barry, Schultz, Nikolaus, Major, John, Heguy, Adriana, Fang, Fang, Mellinghoff, Ingo K, Chan, Timothy A

“…Tyrosine phosphorylation plays a critical role in regulating cellular function and is a central feature in signaling cascades involved in oncogenesis. The…”
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Breast Cancer Bone Metastasis Mediated by the Smad Tumor Suppressor Pathway by Kang, Yibin, He, Wei, Tulley, Shaun, Gupta, Gaorav P., Serganova, Inna, Chen, Chang-Rung, Manova-Todorova, Katia, Blasberg, Ronald, Gerald, William L., Massagué, Joan

“…TGF-β can signal by means of Smad transcription factors, which are quintessential tumor suppressors that inhibit cell proliferation, and by means of…”
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X Chromosome Gene, WTX, Is Commonly Inactivated in Wilms Tumor by Rivera, Miguel N, Kim, Woo Jae, Wells, Julie, Driscoll, David R, Brannigan, Brian W, Han, Moonjoo, Kim, James C, Feinberg, Andrew P, Gerald, William L, Vargas, Sara O, Chin, Lynda, Iafrate, A. John, Bell, Daphne W, Haber, Daniel A

“…Wilms tumor is a pediatric kidney cancer associated with inactivation of the WT1 tumor-suppressor gene in 5 to 10% of cases. Using a high-resolution screen for…”
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Androgen Receptor Levels and Association with PIK3CA Mutations and Prognosis in Breast Cancer by GONZALEZ-ANGULO, Ana M, STEMKE-HALE, Katherine, MILLS, Gordon B, HENNESSY, Bryan T, PALLA, Shana L, CAREY, Mark, AGARWAL, Roshan, MERIC-BERSTAM, Funda, TRAINA, TiffanyA, HUDIS, Clifford, HORTOBAGYI, Gabriel N, GERALD, William L

“…Purpose: To examine the androgen receptor (AR) levels in breast cancer and to assess the impact of AR expression on patient outcomes. Experimental Design:…”
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Gene expression profiling predicts clinical outcome of prostate cancer by Glinsky, Gennadi V, Glinskii, Anna B, Stephenson, Andrew J, Hoffman, Robert M, Gerald, William L

“…One of the major problems in management of prostate cancer is the lack of reliable genetic markers predicting the clinical course of the disease. We analyzed…”
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Gene Expression Analysis of Human Prostate Carcinoma during Hormonal Therapy Identifies Androgen-Responsive Genes and Mechanisms of Therapy Resistance by Holzbeierlein, Jeff, Lal, Priti, LaTulippe, Eva, Smith, Alex, Satagopan, Jaya, Zhang, Liying, Ryan, Charles, Smith, Steve, Scher, Howard, Scardino, Peter, Reuter, Victor, Gerald, William L.

“…The androgen-signaling pathway is critical to the development and progression of prostate cancer and androgen ablation is a mainstay of therapy for this…”
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The Role of SPINK1 in ETS Rearrangement-Negative Prostate Cancers by Tomlins, Scott A., Rhodes, Daniel R., Yu, Jianjun, Varambally, Sooryanarayana, Mehra, Rohit, Perner, Sven, Demichelis, Francesca, Helgeson, Beth E., Laxman, Bharathi, Morris, David S., Cao, Qi, Cao, Xuhong, Andrén, Ove, Fall, Katja, Johnson, Laura, Wei, John T., Shah, Rajal B., Al-Ahmadie, Hikmat, Eastham, James A., Eggener, Scott E., Fine, Samson W., Hotakainen, Kristina, Stenman, Ulf-Håkan, Tsodikov, Alex, Gerald, William L., Lilja, Hans, Reuter, Victor E., Kantoff, Phillip W., Scardino, Peter T., Rubin, Mark A., Bjartell, Anders S., Chinnaiyan, Arul M.

“…ETS gene fusions have been characterized in a majority of prostate cancers; however, the key molecular alterations in ETS-negative cancers are unclear. Here we…”
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