Search Results - "GEORGAKILAS, Alexandros G"

Induction and Repair of Clustered DNA Lesions: What Do We Know So Far? by Georgakilas, Alexandros G., O'Neill, Peter, Stewart, Robert D.

“…The accumulated evidence in the literature indicates that a cluster of two or more lesions within one or two helical turns of the DNA is more challenging to…”
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Low dose ionizing radiation effects on the immune system by Lumniczky, Katalin, Impens, Nathalie, Armengol, Gemma, Candéias, Serge, Georgakilas, Alexandros G., Hornhardt, Sabine, Martin, Olga A., Rödel, Franz, Schaue, Dörthe

“…•Immune alterations are present in many ionizing radiation-induced adverse health outcomes.•Low doses of ionizing radiation induce subtle but persistent immune…”
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Formation of Clustered DNA Damage after High-LET Irradiation：A Review by Hada, Megumi, Georgakilas, Alexandros G

“…Radiation can cause as well as cure cancer. The risk of developing radiation-induced cancer has traditionally been estimated from cancer incidence among…”
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Ionizing Radiation and Complex DNA Damage: From Prediction to Detection Challenges and Biological Significance by Mavragani, Ifigeneia V, Nikitaki, Zacharenia, Kalospyros, Spyridon A, Georgakilas, Alexandros G

“…Biological responses to ionizing radiation (IR) have been studied for many years, generally showing the dependence of these responses on the quality of…”
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Ionizing radiation-induced circulatory and metabolic diseases by Tapio, Soile, Little, Mark P., Kaiser, Jan Christian, Impens, Nathalie, Hamada, Nobuyuki, Georgakilas, Alexandros G., Simar, David, Salomaa, Sisko

“…•Ionizing radiation causes adverse circulatory and metabolic effects at high doses.•Low-dose radiation is causally associated with circulatory disease.•Impact…”
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Toxicity and adverse effects of Tamoxifen and other anti-estrogen drugs by YANG, Geniey, NOWSHEEN, Somaira, AZIZ, Khaled, GEORGAKILAS, Alexandros G

“…Breast cancer is a heterogeneous disease affecting thousands of people every year. Multiple factors are responsible in causing breast cancer while a number of…”
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Editorial: Metal nanoparticles in cancer: detection, diagnosis, therapy and their pharmacological assessment by Peana, Massimiliano, Georgakilas, Alexandros G

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Codon Usage and Phenotypic Divergences of SARS-CoV-2 Genes by Dilucca, Maddalena, Forcelloni, Sergio, Georgakilas, Alexandros G, Giansanti, Andrea, Pavlopoulou, Athanasia

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which first occurred in Wuhan (China) in December of 2019, causes a severe acute respiratory…”
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Determinants of resistance to chemotherapy and ionizing radiation in breast cancer stem cells by Pavlopoulou, Athanasia, Oktay, Yavuz, Vougas, Konstantinos, Louka, Maria, Vorgias, Constantinos E., Georgakilas, Alexandros G.

“…•Determinants of anti-oncogenic treatment resistance in breast cancer stem cells by the use of bioinformatics.•Mechanisms underlying stemness,…”
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Molecular determinants of radiosensitivity in normal and tumor tissue: A bioinformatic approach by Pavlopoulou, Athanasia, Bagos, Pantelis, Koutsandrea, Vasiliki, Georgakilas, Alexandros G

“…Abstract Although radiation therapy is a treatment of choice for cancer, a high percentage of patients develop adverse effects in normal tissue following…”
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Systemic mechanisms and effects of ionizing radiation: A new ‘old’ paradigm of how the bystanders and distant can become the players by Nikitaki, Zacharenia, Mavragani, Ifigeneia V, Laskaratou, Danae A, Gika, Violeta, Moskvin, Vadim P, Theofilatos, Konstantinos, Vougas, Konstantinos, Stewart, Robert D, Georgakilas, Alexandros G

“…Abstract Exposure of cells to any form of ionizing radiation (IR) is expected to induce a variety of DNA lesions, including double strand breaks (DSBs), single…”
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Ionizing Radiation and Complex DNA Damage: Quantifying the Radiobiological Damage Using Monte Carlo Simulations by Chatzipapas, Konstantinos P, Papadimitroulas, Panagiotis, Emfietzoglou, Dimitris, Kalospyros, Spyridon A, Hada, Megumi, Georgakilas, Alexandros G, Kagadis, George C

“…Ionizing radiation is a common tool in medical procedures. Monte Carlo (MC) techniques are widely used when dosimetry is the matter of investigation. The…”
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Role of oxidatively induced DNA lesions in human pathogenesis by Sedelnikova, Olga A., Redon, Christophe E., Dickey, Jennifer S., Nakamura, Asako J., Georgakilas, Alexandros G., Bonner, William M.

“…Genome stability is essential for maintaining cellular and organismal homeostasis, but it is subject to many threats. One ubiquitous threat is from a class of…”
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Effects of Radiation Quality and Oxygen on Clustered DNA Lesions and Cell Death by Stewart, Robert D., Yu, Victor K., Georgakilas, Alexandros G., Koumenis, Constantinos, Park, Joo Han, Carlson, David J.

“…Radiation quality and cellular oxygen concentration have a substantial impact on DNA damage, reproductive cell death and, ultimately, the potential efficacy of…”
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A Mathematical Radiobiological Model (MRM) to Predict Complex DNA Damage and Cell Survival for Ionizing Particle Radiations of Varying Quality by Kalospyros, Spyridon A, Nikitaki, Zacharenia, Kyriakou, Ioanna, Kokkoris, Michael, Emfietzoglou, Dimitris, Georgakilas, Alexandros G

“…Predicting radiobiological effects is important in different areas of basic or clinical applications using ionizing radiation (IR); for example, towards…”
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Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability by Galanos, Panagiotis, Pappas, George, Polyzos, Alexander, Kotsinas, Athanassios, Svolaki, Ioanna, Giakoumakis, Nickolaos N, Glytsou, Christina, Pateras, Ioannis S, Swain, Umakanta, Souliotis, Vassilis L, Georgakilas, Alexandros G, Geacintov, Nicholas, Scorrano, Luca, Lukas, Claudia, Lukas, Jiri, Livneh, Zvi, Lygerou, Zoi, Chowdhury, Dipanjan, Sørensen, Claus Storgaard, Bartek, Jiri, Gorgoulis, Vassilis G

“…Genomic instability promotes evolution and heterogeneity of tumors. Unraveling its mechanistic basis is essential for the design of appropriate therapeutic…”
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RadPhysBio: A Radiobiological Database for the Prediction of Cell Survival upon Exposure to Ionizing Radiation by Zanni, Vassiliki, Papakonstantinou, Dimitris, Kalospyros, Spyridon A, Karaoulanis, Dimitris, Biz, Gökay Mehmet, Manti, Lorenzo, Adamopoulos, Adam, Pavlopoulou, Athanasia, Georgakilas, Alexandros G

“…Based on the need for radiobiological databases, in this work, we mined experimental ionizing radiation data of human cells treated with X-rays, γ-rays, carbon…”
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Stress-induced DNA damage biomarkers: applications and limitations by Nikitaki, Zacharenia, Hellweg, Christine E, Georgakilas, Alexandros G, Ravanat, Jean-Luc

“…A variety of environmental stresses like chemicals, UV and ionizing radiation and organism's endogenous processes such as replication stress and metabolism can…”
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Clustered DNA Damage Patterns after Proton Therapy Beam Irradiation Using Plasmid DNA by Souli, Maria P, Nikitaki, Zacharenia, Puchalska, Monika, Brabcová, Kateřina Pachnerová, Spyratou, Ellas, Kote, Panagiotis, Efstathopoulos, Efstathios P, Hada, Megumi, Georgakilas, Alexandros G, Sihver, Lembit

“…Modeling ionizing radiation interaction with biological matter is a major scientific challenge, especially for protons that are nowadays widely used in cancer…”
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Tumors induce complex DNA damage in distant proliferative tissues in vivo by Redon, Christophe E., Dickey, Jennifer S., Nakamura, Asako J., Kareva, Irina G., Naf, Dieter, Nowsheen, Somaira, Kryston, Thomas B., Bonner, William M., Georgakilas, Alexandros G., Sedelnikova, Olga A., Hanawalt, Philip C.

“…That tumors cause changes in surrounding tissues is well documented, but whether they also affect distant tissues is uncertain. Such knowledge may be important…”
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