Search Results - "GENTLE, Dean"

Germline mutations in DIS3L2 cause the Perlman syndrome of overgrowth and Wilms tumor susceptibility by Astuti, Dewi, Morris, Mark R, Cooper, Wendy N, Staals, Raymond H J, Wake, Naomi C, Fews, Graham A, Gill, Harmeet, Gentle, Dean, Shuib, Salwati, Ricketts, Christopher J, Cole, Trevor, van Essen, Anthonie J, van Lingen, Richard A, Neri, Giovanni, Opitz, John M, Rump, Patrick, Stolte-Dijkstra, Irene, Müller, Ferenc, Pruijn, Ger J M, Latif, Farida, Maher, Eamonn R

“…Eamonn Maher and colleagues report germline mutations in DIS3L2 causing the Perlman syndrome of overgrowth and susceptibility to Wilms tumor. DIS3L2 encodes a…”
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Mutations in SLC29A3, encoding an equilibrative nucleoside transporter ENT3, cause a familial histiocytosis syndrome (Faisalabad histiocytosis) and familial Rosai-Dorfman disease by Morgan, Neil V, Morris, Mark R, Cangul, Hakan, Gleeson, Diane, Straatman-Iwanowska, Anna, Davies, Nicholas, Keenan, Stephen, Pasha, Shanaz, Rahman, Fatimah, Gentle, Dean, Vreeswijk, Maaike P G, Devilee, Peter, Knowles, Margaret A, Ceylaner, Serdar, Trembath, Richard C, Dalence, Carlos, Kismet, Erol, Köseoğlu, Vedat, Rossbach, Hans-Christoph, Gissen, Paul, Tannahill, David, Maher, Eamonn R

“…The histiocytoses are a heterogeneous group of disorders characterised by an excessive number of histiocytes. In most cases the pathophysiology is unclear and…”
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DNA methylation profiles of long- and short-term glioblastoma survivors by Shinawi, Thoraia, Hill, Victoria K, Krex, Dietmar, Schackert, Gabriele, Gentle, Dean, Morris, Mark R, Wei, Wenbin, Cruickshank, Garth, Maher, Eamonn R, Latif, Farida

“…Glioblastoma (GBM) is the most common and malignant type of primary brain tumor in adults and prognosis of most GBM patients is poor. However, a small…”
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Identification of 5 novel genes methylated in breast and other epithelial cancers by Hill, Victoria K, Hesson, Luke B, Dansranjavin, Temuujin, Dallol, Ashraf, Bieche, Ivan, Vacher, Sophie, Tommasi, Stella, Dobbins, Timothy, Gentle, Dean, Euhus, David, Lewis, Cheryl, Dammann, Reinhard, Ward, Robyn L, Minna, John, Maher, Eammon R, Pfeifer, Gerd P, Latif, Farida

“…There are several high throughput approaches to identify methylated genes in cancer. We utilized one such recently developed approach, MIRA (methylated-CpG…”
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CpG methylation profiling in VHL related and VHL unrelated renal cell carcinoma by McRonald, Fiona E, Morris, Mark R, Gentle, Dean, Winchester, Laura, Baban, Dilair, Ragoussis, Jiannis, Clarke, Noel W, Brown, Michael D, Kishida, Takeshi, Yao, Masahiro, Latif, Farida, Maher, Eamonn R

“…Renal cell carcinoma (RCC) is histopathologically heterogeneous with clear cell and papillary the most common subtypes. The most frequent molecular abnormality…”
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A genome-wide screen identifies frequently methylated genes in haematological and epithelial cancers by Dunwell, Thomas, Hesson, Luke, Rauch, Tibor A, Wang, Lihui, Clark, Richard E, Dallol, Ashraf, Gentle, Dean, Catchpoole, Daniel, Maher, Eamonn R, Pfeifer, Gerd P, Latif, Farida

“…Genetic as well as epigenetic alterations are a hallmark of both epithelial and haematological malignancies. High throughput screens are required to identify…”
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Genome-wide CpG island methylation analysis implicates novel genes in the pathogenesis of renal cell carcinoma by Ricketts, Christopher J., Morris, Mark R., Gentle, Dean, Brown, Michael, Wake, Naomi, Woodward, Emma R., Clarke, Noel, Latif, Farida, Maher, Eamonn R.

“…In order to identify novel candidate tumor suppressor genes (TSGs) implicated in renal cell carcinoma (RCC), we performed genome-wide methylation profiling of…”
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Tumor suppressor activity and epigenetic inactivation of hepatocyte growth factor activator inhibitor type 2/SPINT2 in papillary and clear cell renal cell carcinoma by MORRIS, Mark R, GENTLE, Dean, LATIF, Farida, MAHER, Eamonn R, ABDULRAHMAN, Mahera, MAINA, Esther N, GUPTA, Kunal, BANKS, Rosamonde E, WIESENER, Michael S, KISHIDA, Takeshi, YAO, Masahiro, TEH, Bin

“…Following treatment with a demethylating agent, 5 of 11 renal cell carcinoma (RCC) cell lines showed increased expression of hepatocyte growth factor (HGF)…”
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Mutation Analysis of Hypoxia-inducible Factors HIF1A and HIF2A in Renal Cell Carcinoma by Morris, Mark R, Hughes, David J, Tian, Ya-Min, Ricketts, Christopher J, Lau, Kah Weng, Gentle, Dean, Shuib, Salwati, Serrano-Fernandez, Pablo, Lubinski, Jan, Wiesener, Michael S, Pugh, Christopher W, Latif, Farida, Ratcliffe, Peter J, Maher, Eamonn R

“…Background: Inactivation of the Von Hippel-Lindau (VHL) tumour suppressor gene leading to overexpression of hypoxia-inducible transcription factors (HIF)-1α…”
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Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility by Astuti, Dewi, Ricketts, Christopher J, Chowdhury, Rasheduzzaman, McDonough, Michael A, Gentle, Dean, Kirby, Gail, Schlisio, Susanne, Kenchappa, Rajappa S, Carter, Bruce D, Kaelin, William G, Ratcliffe, Peter J, Schofield, Christopher J, Latif, Farida, Maher, Eamonn R

“…Germline mutations in the von Hippel–Lindau disease (VHL) and succinate dehydrogenase subunit B (SDHB) genes can cause inherited phaeochromocytoma and/or renal…”
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Evaluation of a functional epigenetic approach to identify promoter region methylation in phaeochromocytoma and neuroblastoma by Margetts, Caroline D E, Morris, Mark, Astuti, Dewi, Gentle, Dean C, Cascon, Alberto, McRonald, Fiona E, Catchpoole, Daniel, Robledo, Mercedes, Neumann, Hartmut P H, Latif, Farida, Maher, Eamonn R

“…The molecular genetics of inherited phaeochromocytoma have received considerable attention, but the somatic genetic and epigenetic events that characterise…”
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Comparative evolutionary analysis of VPS33 homologues: genetic and functional insights by Gissen, Paul, Johnson, Colin A., Gentle, Dean, Hurst, Laurence D., Doherty, Aidan J., O'Kane, Cahir J., Kelly, Deirdre A., Maher, Eamonn R.

“…VPS33B protein is a homologue of the yeast class C vacuolar protein sorting protein Vps33p that is involved in the biogenesis and function of vacuoles. Vps33p…”
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Potential role for monocyte chemotactic protein-4 (MCP-4) in monocyte/macrophage recruitment in acute renal inflammation by Chakravorty, Srabasti J., Howie, Alexander J., Girdlestone, John, Gentle, Dean, Savage, Caroline O. S.

“…The CC chemokine, monocyte chemoattractant protein‐4 (MCP‐4), is an important chemoattractant for monocytes and T cells. Recent data indicate a role in renal…”
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Genome-Wide DNA Methylation Profiling of CpG Islands in Breast Cancer Identifies Novel Genes Associated with Tumorigenicity by HILL, Victoria K, RICKETTS, Christopher, BIECHE, Ivan, VACHER, Sophie, GENTLE, Dean, LEWIS, Cheryl, MAHER, Eamonn R, LATIF, Farida

“…Epigenetic profiling of tumor DNAs may reveal important new theranostic targets to improve prognosis and treatment of advanced cancer patients. In this study,…”
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Protocols for high efficiency, stage-specific retroviral transduction of murine fetal thymocytes and thymic epithelial cells by Travers, Helen, Anderson, Graham, Gentle, Dean, Jenkinson, Eric, Girdlestone, John

“…Viral vectors have the potential to provide a fast and economic alternative to transgenic methods for manipulating gene expression in studies of immune system…”
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Germline Mutations in the CDKN2B Tumor Suppressor Gene Predispose to Renal Cell Carcinoma by Jafri, Mariam, Wake, Naomi C, Ascher, David B, Pires, Douglas E V, Gentle, Dean, Morris, Mark R, Rattenberry, Eleanor, Simpson, Michael A, Trembath, Richard C, Weber, Astrid, Woodward, Emma R, Donaldson, Alan, Blundell, Tom L, Latif, Farida, Maher, Eamonn R

“…Familial renal cell carcinoma (RCC) is genetically heterogeneous and may be caused by mutations in multiple genes, including VHL, MET, SDHB, FH, FLCN, PTEN,…”
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Identification of candidate tumour suppressor genes frequently methylated in renal cell carcinoma by Morris, M R, Ricketts, C, Gentle, D, Abdulrahman, M, Clarke, N, Brown, M, Kishida, T, Yao, M, Latif, F, Maher, E R

“…Promoter region hyermethylation and transcriptional silencing is a frequent cause of tumour suppressor gene (TSG) inactivation in many types of human cancers…”
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DNA methylation profiling distinguishes histological subtypes of renal cell carcinoma by Slater, Amy A., Alokail, Majed, Gentle, Dean, Yao, Masahiro, Kovacs, Gyula, Maher, Eamonn R., Latif, Farida

“…Renal cell carcinoma (RCC) accounts for around 3% of cancers in the UK, and both incidence and mortality are increasing with the aging population. RCC can be…”
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Functional epigenetic approach identifies frequently methylated genes in Ewing sarcoma by Alholle, Abdullah, Brini, Anna T, Gharanei, Seley, Vaiyapuri, Sumathi, Arrigoni, Elena, Dallol, Ashraf, Gentle, Dean, Kishida, Takeshi, Hiruma, Toru, Avigad, Smadar, Grimer, Robert, Maher, Eamonn R, Latif, Farida

“…Using a candidate gene approach we recently identified frequent methylation of the RASSF2 gene associated with poor overall survival in Ewing sarcoma (ES). To…”
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Methylation profiling and evaluation of demethylating therapy in renal cell carcinoma by Ricketts, Christopher J, Morris, Mark R, Gentle, Dean, Shuib, Salwati, Brown, Michael, Clarke, Noel, Wei, Wenbin, Nathan, Paul, Latif, Farida, Maher, Eamonn R

“…Despite therapeutic advances in targeted therapy, metastatic renal cell carcinoma (RCC) remains incurable for the vast majority of patients. Key molecular…”
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