Search Results - "GENESTE, O"

Radiosensitization by a novel Bcl-2 and Bcl-XL inhibitor S44563 in small-cell lung cancer by Loriot, Y, Mordant, P, Dugue, D, Geneste, O, Gombos, A, Opolon, P, Guegan, J, Perfettini, J-L, Pierre, A, Berthier, L K, Kroemer, G, Soria, J C, Depil, S, Deutsch, E

“…Radiotherapy has a critical role in the treatment of small-cell lung cancer (SCLC). The effectiveness of radiation in SCLC remains limited as resistance…”
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Bax Activation by Engagement with, Then Release from, the BH3 Binding Site of Bcl-xL by Gautier, F., Guillemin, Y., Cartron, P. F., Gallenne, T., Cauquil, N., Le Diguarher, T., Casara, P., Vallette, F. M., Manon, S., Hickman, J. A., Geneste, O., Juin, P.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Positive regulation of apoptosis by HCA66, a new Apaf-1 interacting protein, and its putative role in the physiopathology of NF1 microdeletion syndrome patients by Piddubnyak, V, Rigou, P, Michel, L, Rain, J-C, Geneste, O, Wolkenstein, P, Vidaud, D, Hickman, J A, Mauviel, A, Poyet, J-L

“…As a component of the apoptosome, a caspase-activating complex, Apaf-1 plays a central role in the mitochondrial caspase activation pathway of apoptosis. We…”
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Various mechanisms cause RET-mediated signaling defects in Hirschsprung's disease by Pelet, A, Geneste, O, Edery, P, Pasini, A, Chappuis, S, Atti, T, Munnich, A, Lenoir, G, Lyonnet, S, Billaud, M

“…Hirschsprung's disease (HSCR) is a common congenital malformation characterized by the absence of intramural ganglion cells of the hindgut. Recently, mutations…”
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43P Immune and tumor cells expression of VISTA in a panel of cancer indications: A strategy to inform selection of patients treated with anti-VISTA by Launay, P., Pillon, A., Bonnet, R., Vinet, D., Alloy, A., Lacastaigneratte, L., Welsch, C., Larzabal, C., Zorza, G., Gueguen Dorbes, G., Geneste, O., Hofmann, F., Roy, M-O.

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Bax activation by the BH3-only protein Puma promotes cell dependence on antiapoptotic Bcl-2 family members by Gallenne, Tristan, Gautier, Fabien, Oliver, Lisa, Hervouet, Eric, Noël, Belinda, Hickman, John A, Geneste, Olivier, Cartron, Pierre-François, Vallette, François M, Manon, Stephen, Juin, Philippe

“…It is still unclear whether the BH3-only protein Puma (p53 up-regulated modulator of apoptosis) can prime cells to death and render antiapoptotic BH3-binding…”
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LIM Kinase and Diaphanous Cooperate to Regulate Serum Response Factor and Actin Dynamics by Geneste, Olivier, Copeland, John W., Treisman, Richard

“…The small GTPase RhoA controls activity of serum response factor (SRF) by inducing changes in actin dynamics. We show that in PC12 cells, activation of SRF…”
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The small organic compound HA14-1 prevents Bcl-2 interaction with bax to sensitize malignant glioma cells to induction of cell death by MANERO, Florence, GAUTIER, Fabien, GALLENNE, Tristan, CAUQUIL, Nicolas, GREE, Danielle, CARTRON, Pierre-Francois, GENESTE, Olivier, GREE, René, VALLETTE, Francois M, JUIN, Philippe

“…A functional imbalance between proapoptotic Bax and antiapoptotic Bcl-2 is likely to participate in the resistance of cancer cells to therapy. We show here…”
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Activation of SRF-Regulated Chromosomal Templates by Rho-Family GTPases Requires a Signal that Also Induces H4 Hyperacetylation by Alberts, Arthur S, Geneste, Olivier, Treisman, Richard

“…Constitutively active forms of the small GTPases RhoA (RhoA.V14) and Cdc42 (Cdc42.V12) induce expression of extrachromosomal SRF reporter genes in…”
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Shooting at survivors: Bcl-2 family members as drug targets for cancer by Juin, Philippe, Geneste, Olivier, Raimbaud, Eric, Hickman, John A

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Radiosensitization by a novel Bcl-2 and Bcl-X sub(L) inhibitor S44563 in small-cell lung cancer by Loriot, Y, Mordant, P, Dugue, D, Geneste, O, Gombos, A, Opolon, P, Guegan, J, Perfettini, J-L, Pierre, A, Berthier, L K, Kroemer, G, Soria, J C, Depil, S, Deutsch, E

“…Radiotherapy has a critical role in the treatment of small-cell lung cancer (SCLC). The effectiveness of radiation in SCLC remains limited as resistance…”
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Comparison of pulmonary DNA adduct levels, measured by 32P-postlabelling and aryl hydrocarbon hydroxylase activity in lung parenchyma of smokers and ex-smokers by Geneste, O, Camus, A M, Castegnaro, M, Petruzzelli, S, Macchiarini, P, Angeletti, C A, Giuntini, C, Bartsch, H

“…In order to compare pulmonary DNA adducts and aryl hydrocarbon hydroxylase (AHH) activity, we have measured these two parameters in non-neoplastic surgical…”
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Analysis of DNA adducts in smokers' lung and urothelium by 32P-postlabelling: metabolic phenotype dependence and comparisons with other exposure markers by Bartsch, H, Castegnaro, M, Camus, A M, Schouft, A, Geneste, O, Rojas, M, Alexandrov, K

“…Carcinogen-DNA adduct levels in lung parenchyma (surgical specimens) and urothelial (exfoliated) cells of smokers, ex-smokers and non-smokers were…”
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The small organic compound HA14-1 sensitizes human glioblastoma cells to induction of cell death through inhibition of Bcl-2 by Manero, F., Gautier, F., Gallenne, T., Cauquil, N., Grée, D., Cartron, P.F., Geneste, O., Grée, R., Vallette, M., Juin, P.

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An improved fluorometric assay for dosimetry of benzo(a)pyrene diol-epoxide-DNA adducts in smokers' lung : comparisons with total bulky adducts and aryl hydrocarbon hydroxylase activity by ALEXANDROV, K, ROJAS, M, GENESTE, O, CASTEGNARO, M, CAMUS, A.-M, PETRUZZELLI, S, GIUNTINI, C, BARTSCH, H

“…An improved high-performance liquid chromatography/fluorometric assay has been established to quantitate the benzo(a)pyrene (BP) tetrols released after acid…”
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Bax Activation by Engagement with, Then Release from, the BH3 Binding Site of Bcl-x L by Gautier, F., Guillemin, Y., Cartron, P. F., Gallenne, T., Cauquil, N., Le Diguarher, T., Casara, P., Vallette, F. M., Manon, S., Hickman, J. A., Geneste, O., Juin, P.

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Oncogenic activation of RET by two distinct FMTC mutations affecting the tyrosine kinase domain by PASINI, A, GENESTE, O, LEGRAND, P, SCHLUMBERGER, M, ROSSEL, M, FOURNIER, L, RUDKIN, B. B, SCHUFFENECKER, I, LENOIR, G. M, BILLAUD, M

“…Multiple endocrine neoplasia type 2A (MEN 2A) and familial medullary thyroid carcinoma (FMTC) are two dominantly inherited disorders caused by germline…”
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Two Distinct Mutations of the RET Receptor Causing Hirschsprung's Disease Impair the Binding of Signalling Effectors to a Multifunctional Docking Site by Geneste, Olivier, Bidaud, Christelle, De Vita, Gabriella, Hofstra, Robert M. W., Tartare-Deckert, Sophie, Buys, Charles H. C. M., Lenoir, Gilbert M., Santoro, Massimo, Billaud, Marc

“…The RET gene codes for a transmembrane tyrosine kinase which is a subunit of a multimeric complex that acts as a receptor for four structurally related…”
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Distinct biological properties of two RET isoforms activated by MEN 2A and MEN 2B mutations by ROSSEL, M, PASINI, A, LENOIR, G. M, BILLAUD, M, CHAPPUIS, S, GENESTE, O, FOURNIER, L, SCHUFFENECKER, I, TAKAHASHI, M, VAN GRUNSVEN, L. A, URDIALES, J. L, RUDKIN, B. B

“…Germline mutations of the RET proto-oncogene, which codes for a receptor tyrosine kinase, cause multiple endocrine neoplasia type 2A (MEN 2A) and 2B (MEN 2B)…”
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Identification and characterization of a 44 kDa protein that binds specifically to the 3'-untranslated region of CYP2a5 mRNA: inducibility, subcellular distribution and possible role in mRNA stabilization by Geneste, O, Raffalli, F, Lang, M A

“…Stabilization of mRNA is important in the regulation of CYP2a5 expression but the factors involved in the process are not known [Aida and Negishi (1991)…”
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