Search Results - "GENCHI, VALENTINA ANNAMARIA"
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Insulin and Insulin Receptors in Adipose Tissue Development
Published in International journal of molecular sciences (11-02-2019)“…Insulin is a major endocrine hormone also involved in the regulation of energy and lipid metabolism via the activation of an intracellular signaling cascade…”
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Adipose Tissue Dysfunction and Obesity-Related Male Hypogonadism
Published in International journal of molecular sciences (25-07-2022)“…Obesity is a chronic illness associated with several metabolic derangements and comorbidities (i.e., insulin resistance, leptin resistance, diabetes, etc.) and…”
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Adipose Tissue Inflammation and Pulmonary Dysfunction in Obesity
Published in International journal of molecular sciences (01-07-2022)“…Obesity is a chronic disease caused by an excess of adipose tissue that may impair health by altering the functionality of various organs, including the lungs…”
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246-OR: Dapagliflozin Counteracts the Proapoptotic Effects of the Secretome of Visceral Adipose Cells from Obese Subjects in Human Cardiac Progenitor Cells via the SGLT2 Cotransporter
Published in Diabetes (New York, N.Y.) (20-06-2023)“…Dapagliflozin (DAPA), an SGLT2 inhibitor, has been shown to counteract heart failure outcomes in subjects with obesity and diabetes. We investigated the…”
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38-OR: Insulin Prevents Palmitate-Induced Stress Kinase Activation, Autophagy, and Apoptosis in Human Cardiac Progenitor Cells
Published in Diabetes (New York, N.Y.) (20-06-2023)“…Abnormal accumulation of saturated fatty acids in the heart results in insulin resistance, stress kinase activation, and increased cardiovascular risk in…”
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Impaired Leptin Signalling in Obesity: Is Leptin a New Thermolipokine?
Published in International journal of molecular sciences (16-06-2021)“…Leptin is a principal adipose-derived hormone mostly implicated in the regulation of energy balance through the activation of anorexigenic neuronal pathways…”
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The p66Shc Redox Protein and the Emerging Complications of Diabetes
Published in International journal of molecular sciences (20-12-2023)“…Diabetes mellitus is a chronic metabolic disease, the prevalence of which is constantly increasing worldwide. It is often burdened by disabling comorbidities…”
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Impact of Dysfunctional Adipose Tissue Depots on the Cardiovascular System
Published in International journal of molecular sciences (18-11-2022)“…Obesity with its associated complications represents a social, economic and health problem of utmost importance worldwide. Specifically, obese patients carry a…”
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Mini Review: Effect of GLP-1 Receptor Agonists and SGLT-2 Inhibitors on the Growth Hormone/IGF Axis
Published in Frontiers in endocrinology (Lausanne) (21-02-2022)“…Accumulating evidence supports the early use of glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium glucose transporter-2 inhibitors (SGLT-2is) for…”
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Diabetes and cancer: Pathophysiological fundamentals of a ‘dangerous affair’
Published in Diabetes research and clinical practice (01-09-2018)“…Diabetes and cancer are worldwide chronic diseases with a major impact on the quality and expectancy of life. Metabolic abnormalities observed during the onset…”
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Glucagon in type 2 diabetes: Friend or foe?
Published in Diabetes/metabolism research and reviews (01-03-2023)“…Hyperglucagonemia is one of the ‘ominous’ eight factors underlying the pathogenesis of type 2 diabetes (T2D). Glucagon is a peptide hormone involved in…”
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1230-P: Isolation of Functional Endothelial Progenitor Cells from Human Adipose Tissue
Published in Diabetes (New York, N.Y.) (01-06-2021)“…Endothelial progenitor cells (EPCs) are key for angiogenic responses in multiple tissues and mediate a coordinate augmentation of the capillary network as…”
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438-P: Glucose-Dependent Insulinotropic Polypeptide Prevents Palmitate-Induced Apoptosis, but Not Autophagy and Stress Kinase Activation in Human Cardiac Progenitor Cells
Published in Diabetes (New York, N.Y.) (01-06-2024)“…Introduction & Objective: The gut incretin hormone glucose-dependent insulinotropic polypeptide (GIP) plays key roles in metabolic regulation. Evidence…”
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307-OR: Defective G-CSF in the Secretome of Epicardial Adipose Cells Favors Apoptosis and Cellular Stress of Cardiac Progenitor Cells in Human Obesity
Published in Diabetes (New York, N.Y.) (01-06-2024)“…Introduction and Objective: Granulocyte colony-stimulating factor (G-CSF) was reported to induce myocardial regeneration by promoting mobilization of bone…”
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Reduced SIRT1 and SIRT2 expression promotes adipogenesis of human visceral adipose stem cells and associates with accumulation of visceral fat in human obesity
Published in International Journal of Obesity (01-02-2020)“…Background/Objectives The histone deacetylases SIRT1 and SIRT2 have been shown to be involved in the differentiation of rodent adipocyte precursors. In light…”
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1414-P: Dapagliflozin Protects Human Cardiac Progenitor Cells from Deleterious Effects of the Secretome from Visceral Adipose Cells of Obese Subjects
Published in Diabetes (New York, N.Y.) (01-06-2022)“…Dysfunction of visceral and epicardial adipose tissue may alter heart performance and promote adverse cardiovascular outcomes in obesity and diabetes. We…”
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441-P: Oleate Prevents Palmitate-Induced Abnormalities in Insulin Signaling in Human Cardiac Progenitor Cells by Inhibiting p38 MAPK and c-Jun Phosphorylation
Published in Diabetes (New York, N.Y.) (01-06-2022)“…Elevated saturated fatty acid deposition in the heart results in insulin resistance, stress kinase activation, and increased cardiovascular risk in humans. The…”
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The p66[sup.Shc] Redox Protein and the Emerging Complications of Diabetes
Published in International journal of molecular sciences (01-12-2023)“…Diabetes mellitus is a chronic metabolic disease, the prevalence of which is constantly increasing worldwide. It is often burdened by disabling comorbidities…”
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374-P: Oleate Prevents Palmitate-Induced Abnormalities in Insulin Signaling in Human Cardiac Progenitor Cells
Published in Diabetes (New York, N.Y.) (01-06-2021)“…Myocardial ectopic lipid deposition has been associated with insulin resistance and cardiovascular risk. Palmitate, one of the most abundant saturated fatty…”
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1762-P: Insulin Receptor Isoforms in Human Adipose Tissue and Adipose Stem Cells
Published in Diabetes (New York, N.Y.) (01-06-2019)“…Insulin regulates the development and metabolism of adipose tissue (AT) by activating its tyrosine kinase receptor in this tissue. The insulin receptor (IR)…”
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